Bupivacaine only

Phase 3Small molecule

Pacira Pharmaceuticals, Inc

Bupivacaine only is one of 246 small molecule programs targeting Hemorrhoid. It is currently in Phase 3.

Indications

121

Total Trials

Active Trials

245

Competitors

Pipeline

Status by Indication[3][1]

Indication

HemorrhoidActive, not recruiting

Inguinal HerniaActive, not recruiting

MigraineActive, not recruiting

Diabetic FootActive, not recruiting

Efficacy and SafetyCompleted

MPACompleted

Spine SurgeryCompleted

Cleft PalateRecruiting

EndometriosisRecruiting

Labor PainCompleted

HemorrhoidPreclinical

Active, not recruiting

Inguinal HerniaPreclinical

Active, not recruiting

MigrainePreclinical

Active, not recruiting

Diabetic FootPreclinical

Active, not recruiting

Efficacy and SafetyPreclinical

Completed

MPAPreclinical

Completed

Spine SurgeryPreclinical

Completed

Cleft PalatePhase 3

Recruiting

EndometriosisPhase 3

Recruiting

Labor PainPhase 3

Completed

Showing 10 of 13 indications

Competition

Competitive Landscape

242 competitors in Efficacy and Safety

#DrugCompanyPhaseTrials

Rinvoq

AbbVie

Phase 3

4 2

Savaysa

Daiichi Sankyo

Phase 3

3 3

Platinol

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 3

7 4

Rapamune

PPrism Pharmaceuticals

Phase 3

5 5

Rilutek

AAzurity Pharmaceuticals

Phase 3

3 6

Kineret

SSwedish Orphan Biovitrum

Phase 3

2 7

UPLIZNA

HHorizon Therapeutics Ireland DAC

Phase 3

1 8

Bupivacaine only

Pacira Pharmaceuticals, Inc

Phase 3

1 9

Becotatug Vedotin

FFudan University

Phase 3

1 10

Apatinib Mesylate

BBukwang Pharmaceutical

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Recruiting

Liposomal Bupivacaine

NCT06179004

Phase 2Recruiting

Thoracoscopic Surgery

NCT06529432

Phase 3Recruiting

Cleft Palate

NCT04928352

Q1 2027

Post-ApprovalNot yet recruiting

Interscalene Brachial Plexus Block

NCT06692010

Q2 2027

N/ARecruiting

Hemorrhoid

NCT07442539

N/ARecruiting

Video-Assisted Thoracoscopic Surgery

NCT07441902

Clinical

Trials by Indication[1]

Liposomal Bupivacaine12 trials

Liposomal Bupivacaine in Benign Soft Tissue Tumor Resection

Unknown status·SSamaritan Health Services·Phase 4·NCT05082441·140 enrolled

Liposomal Bupivacaine in Shoulder Arthroscopy

Withdrawn·UUniversity of Pennsylvania·Phase 3·NCT04461028

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

Recruiting·UUniversity of North Carolina, Chapel Hill·Phase 3·NCT06179004·100 enrolled

Show 9 more trials

Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT04897841·60 enrolled

A Study of Liposomal Bupivacaine Versus 0.25% Bupivacaine Hydrochloride Post Breast Reduction

Completed·MMayo Clinic·Phase 4·NCT05891613·32 enrolled

Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride

Completed·UUnknown Sponsor·Phase 3·NCT03270514·60 enrolled

Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain

Recruiting·UUniversity of Kansas Medical Center·Phase 4·NCT03854344·75 enrolled

The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology

Recruiting·—·N/A·NCT07458295·110 enrolled

The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery

Recruiting·—·N/A·NCT07458282·318 enrolled

Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty

Completed·MMayo Clinic·Phase 4·NCT03663283·104 enrolled

Comparing Liposomal Bupivacaine Versus Standard Bupivacaine in Colorectal Surgery

Completed·IIndiana University·Phase 3·NCT03702621·90 enrolled

The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery

Recruiting·—·N/A·NCT07458256·190 enrolled

Erector Spinae Plane Block5 trials

Erector Spinae Plane Block and Ankle and Foot Surgery

Completed·FFayoum University Hospital·N/A·NCT05708742·68 enrolled

Ultrasound Guided Sacral Erector Spinae Plane Block in Pediatric Anorectal Surgery

Completed·SSameh Fathy·N/A·NCT04921007·60 enrolled

Erector Spinae Plane Block Versus Thoracic Epidural Analgesia in Patients With Multiple Fracture Ribs

Completed·—·N/A·NCT03853330·108 enrolled

Show 2 more trials

Erector Spinae Plane Block Versus Serratus Plane Block for Breast Surgery

Completed·—·N/A·NCT03538483·60 enrolled

Comparison Between the Quadratus Lumborum Block ,Erector Spinae Plane Block in Lower Abdominal Surgery

Completed·FFayoum University Hospital·N/A·NCT05524038·48 enrolled

Laparoscopic Cholecystectomy4 trials

TAP Block in Laparoscopic Cholecystectomy.

Completed·—·Phase 2·NCT03612947·60 enrolled

The Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Pain in Laparoscopic Cholecystectomy

Completed·KKasr El Aini Hospital·Phase 2·NCT04244097·56 enrolled

Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy

Completed·—·N/A·NCT04609033·110 enrolled

Show 1 more trial

Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia

Unknown status·FFederal University of São Paulo·Phase 4·NCT02953210·40 enrolled

Postoperative Analgesia4 trials

Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery

Recruiting·ZZhejiang Cancer Hospital·N/A·NCT06704698·132 enrolled

Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl As Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries

Not yet recruiting·—·Phase 4·NCT06685705·66 enrolled

PAIN - Postoperative Analgesia INvestigation

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT02111746·350 enrolled

Show 1 more trial

Efficacy of Liposomal Bupivacaine for Prolonged Postoperative Analgesia in Patient Undergoing Breast Reconstruction With Tissue Expander

Completed·TThe Cleveland Clinic·Phase 4·NCT04278846·50 enrolled

Cesarean Section4 trials

A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain

Terminated·TThe University of Texas Health Science Center, Houston·Phase 4·NCT04368364·3 enrolled

Intrathecal Dexmedetomidine With Bupivacaine for Spinal Anesthesia in Cesarean Section

Completed·—·Phase 4·NCT02365857·120 enrolled

Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine.

Unknown status·MMinia University·N/A·NCT04618146·60 enrolled

Show 1 more trial

Dose Escalation of Dexamethasone to Increase Duration of Transversus Abdominal Plane Block Following Cesarean Section

Terminated·UUniversity of Alabama at Birmingham·Phase 2/3·NCT03098420·29 enrolled

72 more indications

Spinal Anesthesia3 trials

Effect of Intrathecal Fentanyl on Spinal Anesthesia During Dexmedetomidine Infusion

Completed·SSeoul National University Hospital·N/A·NCT03105115·56 enrolled

The Effect of Some Parturients' Characteristics on Sensory Block Level After Spinal Anesthesia

Unknown status·—·Phase 4·NCT03164096·100 enrolled

Comparative Study to Evaluate the Efficacy of Ultrasound-Guided Pericapsular Nerve Group (PENG) Block Versus Fascia Iliaca Compartment (FIC) Block on the Postoperative Analgesic Effect in Patients Undergoing Hip Surgeries Under Spinal Anesthesia.

Unknown status·SSohag University·N/A·NCT05751291·42 enrolled

Surgery3 trials

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.

Completed·HHeron Therapeutics·Phase 4·NCT06109415·30 enrolled

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE

Completed·HHeron Therapeutics·Phase 4·NCT06109428·30 enrolled

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

Unknown status·HHeron Therapeutics·Phase 4·NCT05109312·90 enrolled

Hypotension3 trials

Comparison of Vasopressor Boluses for Management of Hypotension After Spinal Anesthesia

Unknown status·—·Phase 4·NCT03712111·86 enrolled

Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension

Completed·MMersin University·Phase 4·NCT05502146·200 enrolled

Comparison of Two Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Cesarean Delivery

Completed·—·Phase 4·NCT03792906·110 enrolled

Mastectomy3 trials

PEMF and PEC Blocks in Mastectomy Reconstruction Patients

Completed·—·Phase 4·NCT03360214·60 enrolled

Dexmedetomedine and Ketamine in Erector Spinae Block for Postoperative Analgesia Following Mastectomy.

Completed·NNational Cancer Institute, Egypt·Phase 2/3·NCT05727098·75 enrolled

Effectiveness of Combined Erector Spinae and Pecto-intercostal Fascial Plane Blocks Versus Thoracic Paravertebral Block in Perioperative Pain in Modified Radical Mastectomy

Completed·KKasr El Aini Hospital·Phase 4·NCT04778267·30 enrolled

Labor Pain3 trials

A Trial to Determine the Optimal Bupivacaine Dose for Initiation of Labor Epidural Pain Relief

Completed·BBrigham and Women's Hospital·Approved·NCT04814537·100 enrolled

A Trial to Determine the Optimal Bupivacaine Dose for Initiation of Labor Epidural Pain Relief With a Lidocaine Test Dose

Recruiting·BBrigham and Women's Hospital·Approved·NCT06146842·120 enrolled

ED90 of Epidural Bupivacaine for the Initiation of Labor Analgesia: A Randomized Biased Coin Sequential Allocation Trial With a Lidocaine Test Dose

Recruiting·BBrigham and Women's Hospital·Approved·NCT05543694·120 enrolled

Local Anesthetic2 trials

4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans

Completed·BBrian Williams·Phase 3·NCT02891798·98 enrolled

Efficacy Of Magnesium In Radicular Pain When Added To Local Anesthetics And Steroids In Transforaminal Epidural Injection

Unknown status·FFayoum University·Phase 1·NCT04532775·100 enrolled

Erector Spinae Block2 trials

Continuous Erector Spinae Block for Post Analgesia in Pediatric Patients

Completed·—·Phase 3·NCT04613830·60 enrolled

Systemic Versus Local Dexmedetomidine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block

Recruiting·—·Phase 3·NCT06386770·75 enrolled

ACL Reconstruction2 trials

Impact of Opioid Avoidance Protocol for ACL Reconstruction

Completed·MMatthew Varacallo··NCT06340932·32 enrolled

Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction

Unknown status·CCarilion Clinic·Phase 3·NCT04764916·60 enrolled

Postsurgical Analgesia2 trials

Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT04518462·121 enrolled

Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries

Withdrawn· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT03954639

Bunion2 trials

Open-Label CA-008 (Vocacapsaicin) in Bunionectomy

Completed·CConcentric Analgesics·Phase 2·NCT03885596·36 enrolled

Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients

Completed·CConcentric Analgesics·Phase 2·NCT03599089·147 enrolled

Dexamethasone2 trials

Pharmacokinetic Analysis of Bupivacaine in the Presence and Absence of Perineural Dexamethasone in Axillary Blockade

Completed·UUniversity of Chile·Phase 4·NCT05359731·20 enrolled

Comparison of the Effects of Dexamethasone and magnesıum Sulphate Used as Adjuvant in Infraclavicular Nerve Block.

Completed·YYuzuncu Yil University·N/A·NCT06085417·90 enrolled

Abdominal Surgeries2 trials

The Hemodynamic Effects of Different Volumes of Bupivacaine 0.25% Caudal Blocks in Pediatrics Undergoing Lower Abdominal Surgeries as Measured by Electrical Cardiometry

Completed·KKasr El Aini Hospital·Phase 3·NCT05133687·105 enrolled

Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) in Major Abdominal Surgeries

Completed·SSameh Fathy·N/A·NCT04920994·80 enrolled

Dexmedetomidine2 trials

Dexmedetomidine in Obturator Nerve Block as an Analgesic in Transurethral Surgeries

Completed·—·Phase 1·NCT06229054·56 enrolled

Comparison of Doses of Dexmedetomidine With Bupivacaine in Caudal Block for Duration of Analgesia in Paediatric Infraumblical Surgeries.

Unknown status·—·Phase 4·NCT04700228·162 enrolled

Quadratus Lumborum Block2 trials

Transmuscular Quadratus Lumborum Block Plus Pericapsular Injection vs Pericapsular Injection

Completed·NNYU Langone Health·Phase 4·NCT04353414·104 enrolled

Posterior Quadratus Lumborum Block Using 0.125% Versus 0.25% Bupivacaine for Analgesia in Children Undergoing LPEC

Unknown status·QQueen Sirikit National Institute of Child Health·N/A·NCT04998071·50 enrolled

Post Operative Pain2 trials

Postoperative Pain Alleviation in Open Heart Surgery

Completed·—·N/A·NCT03106818·90 enrolled

Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled Trial

Withdrawn·MMaimonides Medical Center·Approved·NCT05823363

Orthopedic Procedures1 trial

Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash

Completed·MMedical University of South Carolina·N/A·NCT02619409·30 enrolled

Laparoscopic Appendectomy1 trial

"Analgesic Efficacy of Combined Transversus Abdominis Plane Block and Posterior Rectus Sheath Block in Patients Undergoing Laparoscopic Appendectomy"

Unknown status·KKing Saud Medical City·Phase 3·NCT06088082·100 enrolled

Tics1 trial

Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT04173611·20 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction

Completed·HHospital for Special Surgery, New York·Phase 4·NCT01586806·195 enrolled

Postoperative Pain Relief1 trial

Presternal Magnesium With Bupivacain Versus Bupivacain Only for Postoperative Pain Relief in Open Heart Surgery

Completed·—·N/A·NCT03230227·40 enrolled

Hip Fracture1 trial

EXPAREL Facia Iliaca Compartment Block for Intertrochanteric Hip Fracture

Withdrawn· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT03955458

Chronic Knee Pain1 trial

Intra-Articular Dexmedetomidine: A Treatment for Chronic Knee Pain

Recruiting·TTanta University·N/A·NCT06641206·70 enrolled

Inguinal hernia1 trial

The Efficacy of Transversalis Fascia Plane Block in Pediatric Inguinal Hernia Repair

Completed·—·N/A·NCT04272320·60 enrolled

Serratus Anterior Plane Block1 trial

Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Completed·—·N/A·NCT02962024·40 enrolled

Thoracic Surgery1 trial

Pectoralis and Serratus Nerves Block in Thoracic Surgery

Unknown status·SSoroka University Medical Center·Phase 2·NCT03023982·168 enrolled

Efficacy and Safety1 trial

Compartment Psoas Block Efficacy and Safety

Completed·—·N/A·NCT04648332·90 enrolled

Pediatric1 trial

Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel

Terminated·JJohns Hopkins University·Phase 3·NCT04826484·104 enrolled

Lung Cancer1 trial

Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades

Unknown status·JJannie Bisgaard Stæhr·Phase 2·NCT05038007·50 enrolled

Endometriosis1 trial

Superior Hypogastric Nerve Plexus Block With Bupivacaine After Robotic Resection of Endometriosis

Recruiting·—·Phase 4·NCT06577233·60 enrolled

Surgical1 trial

Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain

Enrolling by invitation·RRutgers, The State University of New Jersey·Phase 2/3·NCT06077422·150 enrolled

MPA1 trial

Comparison Between (GNB) Combined With (IPACK) Block Versus ACB in TKA

Completed·—·N/A·NCT06423339·50 enrolled

Suprascapular Nerve Block1 trial

Peng Block or Suprascapular Nerve Block for Postoperative Analgesia in Shoulder Artroscopy ?

Completed·—·N/A·NCT05666076·74 enrolled

Bupivacaine1 trial

Fentanyl Versus Midazolam as an Adjunct to Intrathecal Bupivacaine In Children

Completed·—·Phase 2/3·NCT03592537·90 enrolled

Thoracic Paravertebral Block1 trial

Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain

Recruiting·YYongtao Sun·Phase 4·NCT06165991·496 enrolled

Total Knee Arthroplasty1 trial

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT05139030·167 enrolled

Hot flashes1 trial

Stellate Ganglion Nerve Block in Treating Women With Hot Flashes

Completed·MMayo Clinic·Phase 1·NCT00879164·10 enrolled

Supraclavicular Brachial Plexus Block1 trial

Efficacy and Safety of Dexmedetomidine to Bupivacaine in Supraclavicular Brachial Plexus Block

Completed·KKafrelsheikh University·N/A·NCT06020781·75 enrolled

Axillary Nerve Block1 trial

Suprazygomatic Maxillary Nerve Block for Management of Postoperative Pain in Adenotonsillectomy Patients

Not yet recruiting·—·Phase 4·NCT06694077·80 enrolled

Hemorrhoid1 trial

The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery

Recruiting·—·N/A·NCT07442539·156 enrolled

Video-Assisted Thoracoscopic Surgery1 trial

The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery

Recruiting·—·N/A·NCT07441902·134 enrolled

Major Depressive Disorder1 trial

Stellate Ganglion Block for Major Depressive Disorder.

Completed·UUnity Health Toronto·Phase 4·NCT04727229·10 enrolled

Arthroscopic Shoulder Surgery1 trial

Interscalene Single Shot With Plain Bupivacaine Versus Liposomal Bupivacaine for Arthroscopic Shoulder Surgery

Completed·UUniversity of Southern California·Phase 4·NCT03638960·40 enrolled

Chronic pain1 trial

Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute and Chronic Pain After Thoracoscopic Pneumonectomy: A Multicenter, Randomized, Double-blind, Controlled Clinical Trial

Recruiting·TThe Second Affiliated Hospital of Chongqing Medical University·Phase 4·NCT06569953·284 enrolled

Migraine1 trial

Transcutaneous Pulsed Radiofrequency in Migraine

Unknown status·—·N/A·NCT05499689·60 enrolled

Concentration1 trial

Dose and Concentration Relationship for PENG Block in Hip Surgery

Completed·—··NCT05400148·112 enrolled

Opioid Use Disorder1 trial

PROUD Study - Preventing Opioid Use Disorders

Terminated·EEmory University·Phase 4·NCT04766996·57 enrolled

Total Hip Replacement1 trial

The Influence of Local Infiltration Analgesia by Catheter in Postoperative Control Pain After Total Hip Replacement

Completed·PParc de Salut Mar·Phase 4·NCT02630160·100 enrolled

Spine Surgery1 trial

Inter-semispinal Plane Block and Cervical Spine Surgery

Completed·YYasser S Mostafa, MD·N/A·NCT06003933·50 enrolled

Aesthetic1 trial

Study of Peri-Articular Anaesthetic for Replacement of the Knee

Completed·UUniversity of Leeds·Phase 3·NCT03326180·533 enrolled

Pediatric Patients1 trial

The Effect of Caudal Block on Optic Nerve Sheath Diameter in Pediatric Patients

Completed·—·N/A·NCT05216211·60 enrolled

Hernia1 trial

Erector Spinae Plane Block For Lumbar Disc Hernia Repair

Completed·KKocaeli University·N/A·NCT03744689·60 enrolled

Abdominoplasty1 trial

Study in Subjects Undergoing Complete Abdominoplasty

Completed·CConcentric Analgesics·Phase 2·NCT03789318·54 enrolled

Hysterectomy1 trial

Liposomal Bupivacaine in Vaginal Hysterectomy

Terminated·MMayo Clinic·Phase 4·NCT03907033·28 enrolled

General Anesthesia1 trial

Topical Bupivacaine Effect On The Response To Awake Extubation During Emergence From General Anesthesia

Completed·ZZagazig University·N/A·NCT04471597·48 enrolled

Injury1 trial

Investigation of Corticosteroid Versus Placebo Injection in Patients With Syndesmotic Ligament Injury or High Ankle Sprain

Terminated·SSanford Health·Phase 2·NCT02892500·1 enrolled

Immunogenicity1 trial

A Phase I Safety and Immunogenicity Trial of the Facilitated HIV-1 Gag-Pol DNA Vaccine (APL-400-047, Apollon, Inc.) Given Intramuscularly by Needle and Syringe or Biojector 2000 Needle-Free Jet Injection System in HIV-1 Uninfected Adult Volunteers

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00001088·40 enrolled

Pain1 trial

Study Assessing Pain Relief After Replacement of the Knee

Completed·AAllay Therapeutics, Inc.·Phase 2·NCT06799845·226 enrolled

Thoracoscopic Surgery1 trial

A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery

Recruiting·JJiangsu HengRui Medicine Co., Ltd.·Phase 2·NCT06529432·96 enrolled

Rectus Sheath Block1 trial

Rectus Sheath Block for Analgesia After Gynecological Laparotomy

Completed·—·Phase 4·NCT06575699·90 enrolled

Breast Surgery1 trial

ICNBs for Post-op Pain in Breast Surgery

Unknown status·—·Phase 4·NCT04606836·40 enrolled

Elderly Patients1 trial

Effect of Intrathecal Dexamethasone on Intra-operative Hemodynamic in Elderly Patients Undergoing Urologic Endoscopic Surgery

Unknown status·—·Phase 4·NCT05549895·90 enrolled

Interscalene Brachial Plexus Block1 trial

Comparison Between Clavipectoral Fascia Block & Interscalene Brachial Plexus Block As Regard Adequacy of Anesthesia in Clavicle Surgeries

Not yet recruiting·—·Phase 4·NCT06692010·42 enrolled

Diabetic Foot1 trial

Effect of Adding Dexamethasone to Intrathecal Bupivacaine on Blood Sugar of Patients Undergoing Diabetic Foot Surgeries

Completed·—·N/A·NCT03871049·60 enrolled

Adductor Canal Block1 trial

Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)

Completed·HHospital for Special Surgery, New York·Phase 4·NCT03094663·86 enrolled

Gynecologic Surgery1 trial

Comparison of Efficacy of Bupivacaine for Relief Postoperative Pain in Women Undergoing Laparoscopic Gynecologic Surgery

Completed·DDepartment of Medical Services Ministry of Public Health of Thailand·Phase 4·NCT03259243·100 enrolled

Breast1 trial

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT04293809·30 enrolled

Intrathecal Dexmedetomidine1 trial

A Comparative Study of Intrathecal Dexmedetomidine and Fentanyl As Additives to Bupivacaine in Pott's Fracture

Completed·—·Phase 1·NCT06502262·60 enrolled

Orthopedic Surgeries1 trial

Intrathecal Pethidine Plus Dexamethasone for Distal Lower Orthopedic Surgeries

Completed·ZZagazig University·Phase 4·NCT05303311·46 enrolled

Fractures1 trial

Pain Palliation in Forearm Fractures in the Emergency Department

Completed·—·N/A·NCT06588907·85 enrolled

Cleft Palate1 trial

Preemptive Nebulized Bupivacaine for Pain Control After Cleft Palate Repair in Children: A Randomized Double Blind Controlled Trial

Recruiting·AAssiut University·Phase 3·NCT04928352·60 enrolled

Video-assisted Thoracoscopic Surgery (VATS)1 trial

The Efficacy and Safety of Liposomal Bupivacaine Plus Bupivacaine Local Incisional Infiltration for Postoperative Pain in Patients Undergoing Video-assisted Thoracoscopic Surgery:A Multi-Center Randomized Controlled Trial

Recruiting·BBeijing Tiantan Hospital·Preclinical·NCT07432711·100 enrolled

Pain, Postoperative1 trial

Locally Administered Bupivacaine Hydrochloride for Post-operative Pain Control in Cutaneous Surgery: A Randomized Controlled Trial

Enrolling by invitation·NNorthwestern University·Phase 1·NCT04260854·100 enrolled

Sources

References

[1]
ClinicalTrials.gov — 121 trial records for Bupivacaine only. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Bupivacaine only compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Bupivacaine only. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pacira Pharmaceuticals, Inc company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Pacira Pharmaceuticals, Inc