VivoSeq
Psychiatry

Cocaine Dependence

99

Pipeline Programs↗

0

Active Trials↗

45

Companies Involved↗

Cocaine Dependence is a moderately active landscape with 99 programs across 45 companies. The most active players are Omnivium, Alnylam Pharmaceuticals, McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.. 23 therapies are approved with 4 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

69/100

Pipeline Velocity

0/100

Mech. Concentration

8/100

Completion Rate

91/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

O

Omnivium

1 program

Phase 1Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

1 program

Phase 1M

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

Phase 1W

Wanbangde Pharmaceutical Group Co., LTD

1 program

Phase 1Bristol-Myers Squibb logo

Bristol-Myers Squibb

2 programs

Phase 2Eisai logo

Eisai

2 programs

Phase 2

Pipeline

Programs by Phase

Analysis

Modality Breakdown

99%

Small molecule

101 of 102 classified programs — the dominant modality here.

1%ALL OTHERSProtein / enzyme1<1%

Small molecule leads; the ring shows all 102 classified programs, each share of the total. Modality classified for 100% of 102 pipeline programs.

Analysis

Trial Status

90

clinical trials

Completed79 · 88%
Terminated4 · 4%
Unknown status3 · 3%
Withdrawn3 · 3%
Suspended1 · 1%

Clinical Trials

Trial Activity

90 trials

Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7
Completed·National Institute on Drug Abuse (NIDA)·Phase 2·NCT00015106
Reserpine for the Treatment of Cocaine Dependence - 1
Completed·National Institute on Drug Abuse (NIDA)·Phase 2·NCT00033033·140 enrolled
Use of Donepezil for Treatment of Cocaine Dependence
Completed·US Department of Veterans Affairs·Phase 2·NCT00467389·12 enrolled
A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence
Completed·UUniversity of Pennsylvania·Phase 2·NCT01680887·156 enrolled
Neural Substrates of Emotion: Impact of Cocaine Dependence
Completed·MMedical University of South Carolina·Phase 2·NCT02682784·138 enrolled
A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
Completed·NNew York State Psychiatric Institute·Phase 2·NCT00421603·81 enrolled
Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence
Completed·TThe University of Texas Health Science Center, Houston·Phase 2·NCT00218075·200 enrolled
Carbamazepine Treatment for Cocaine Dependence - 5
Completed·UUniversity of Pennsylvania·Phase 2·NCT00000191
Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
Completed·NNew York State Psychiatric Institute·Phase 2/3·NCT01811940·169 enrolled
Improving Learning-based Treatment of Cocaine Dependence With Medication
Completed·JJohns Hopkins University·Phase 2·NCT01526538·52 enrolled
Psychopharmacology for Cocaine Dependence - Buspirone
Completed·TThe University of Texas Health Science Center, Houston·Phase 2·NCT01267292·50 enrolled
Modafinil for the Treatment of Cocaine Dependence - 1
Completed·National Institute on Drug Abuse (NIDA)·Phase 2·NCT00100100·210 enrolled
Prepulse Inhibition of Startle in Cocaine Dependence - 7
Completed·National Institute on Drug Abuse (NIDA)·Phase 1·NCT00015249
Selegiline in Treatment of Cocaine Dependence - 2
Completed·UUniversity of Pennsylvania·Phase 2·NCT00000188·50 enrolled
Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone
Completed·UUniversity of Arkansas·Phase 2·NCT00218608·158 enrolled
Page 1 of 6

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)