VivoSeq
Oncology

Desmoplastic Small Round Cell Tumor

23

Pipeline Programs↗

7

Active Trials↗

14

Companies Involved↗

Desmoplastic Small Round Cell Tumor is an emerging landscape with 23 programs across 14 companies. The most active players are Novartis, Eli Lilly, Pfizer.

Intelligence

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

0/100

Mech. Concentration

18/100

Completion Rate

100/100

Attrition Rate

0/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Novartis logo

Novartis

1 program

Phase 1Eli Lilly logo

Eli Lilly

3 programs

Phase 2Pfizer logo

Pfizer

2 programs

Phase 2Daiichi Sankyo logo

Daiichi Sankyo

1 program

Phase 2M

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

Phase 2Bristol-Myers Squibb logo

Bristol-Myers Squibb

1 program

Phase 2

Pipeline

Programs by Phase

Analysis

Modality Breakdown

78%

Small molecule

18 of 23 classified programs — the dominant modality here.

22%ALL OTHERSMonoclonal antibody29%Antibody–drug conjugate14%Protein / enzyme14%Cell therapy14%

Small molecule leads; the ring shows all 23 classified programs, each share of the total. Modality classified for 100% of 23 pipeline programs.

Analysis

Trial Status

14

clinical trials

Completed7 · 50%
Active, not recruiting4 · 29%
Recruiting3 · 21%

Clinical Trials

Trial Activity

14 trials

Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor
Recruiting·UUniversity Hospital Heidelberg·Phase 2·NCT06456359·28 enrolled
Safety and Efficacy of CAR-T Cell Therapy for Relapsed/refractory Neuroblastoma and Desmoplastic Small Round Cell Tumors: a Single-arm, Open-label Trial.
Recruiting·SSun Yat-Sen University Cancer Center·Phase 1/2·NCT06836505·10 enrolled
A Phase 1/2 Study of DS-8201a (NSC# 807708) in Children, Adolescents, or Young Adults With Recurrent Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor
Recruiting·National Cancer Institute (NCI)·Preclinical·NCT04616560·55 enrolled
A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum
Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT04022213·31 enrolled
Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors
Active, not recruiting·SSt. Jude Children's Research Hospital·Phase 2·NCT01946529·24 enrolled
Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor
Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT01189643·15 enrolled
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor
Active, not recruiting·Eli Lilly logoEli Lilly·Phase 1/2·NCT04145349·30 enrolled
Exatecan Mesylate in Treating Patients With Ewing's Sarcoma, Primitive Neuroectodermal Tumor, or Desmoplastic Small Round Cell Tumor
Completed·Daiichi Sankyo logoDaiichi Sankyo·Phase 2·NCT00055952
Trial of Nab-paclitaxel in Patients With Desmoid Tumors and Multiply Relapsed/Refractory Desmoplastic Small Round Cell Tumors and Ewing Sarcoma
Completed·GGrupo Espanol de Investigacion en Sarcomas·Phase 2·NCT03275818·69 enrolled
Pilot Study of Hyperthermic Peritoneal Perfusion (HIPEC) for Adolescent and Young Adults With Desmoplastic Small Round Cell Tumor
Completed·MM.D. Anderson Cancer Center·Phase 2·NCT01277744·22 enrolled
A Study of LY2880070 and Gemcitabine in People With Ewing Sarcoma,Ewing-Like Sarcoma, and Desmoplastic Small Round Cell Tumor
Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT05275426·14 enrolled
QUILT-3.025: A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors
Completed·NNantCell, Inc.·Phase 2·NCT00563680·38 enrolled
A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma
Completed·MMemorial Sloan Kettering Cancer Center·Phase 1/2·NCT04095221·21 enrolled
Imatinib Mesylate in Patients With Refractory Desmoplastic Small Round Cell Tumors
Completed·Novartis logoNovartis·Phase 1/2·NCT00417807·9 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)