VivoSeq
Gastroenterology

Esophageal Stricture

8

Pipeline Programs↗

1

Active Trials↗

2

Companies Involved↗

Esophageal stricture is an early-stage landscape with 8 programs across 2 companies. The most active players are Salix, Nuon Therapeutics, Inc.. 4 therapies are approved.

Intelligence

Pipeline Metrics

Competitive Density

34/100

Pipeline Velocity

0/100

Mech. Concentration

100/100

Completion Rate

60/100

Attrition Rate

20/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

S

Salix

1 program

Phase 2N

Nuon Therapeutics, Inc.

1 program

Phase 2

Pipeline

Programs by Phase

Analysis

Trial Status

10

clinical trials

Unknown status4 · 40%
Completed3 · 30%
Terminated2 · 20%
Not yet recruiting1 · 10%

Clinical Trials

Trial Activity

10 trials

Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) After Endoscopic Resection for Superficial Neoplasms
Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 2·NCT06643689·394 enrolled
Local Triamcinolone Injection Combined With Fibrin Glue Spray in Preventing Esophageal Stricture After Big-range Endoscopic Submucosal Dissection for Esophageal Early Cancer
Completed·SSun Yat-Sen University Cancer Center·Phase 2·NCT06840561·20 enrolled
Effect of a Combination of Local Steroid Injection With Oral Steroid Administration for the Prevention on Esophageal Stricture After Endoscopic Submucosal Dissection for Early Esophageal Neoplasm
Completed·SShanghai Zhongshan Hospital·N/A·NCT03039608·72 enrolled
Prospective Evaluation of Budesonide for Prevention of Esophageal Strictures After Endotherapy
Completed·MMayo Clinic·Phase 2·NCT02069847·90 enrolled
Reduction in Symptomatic Esophageal Stricture Formation
Terminated·AAdventHealth·Phase 4·NCT02039115·3 enrolled
Collagenase Clostridium Histolyticum for Refractory Iatrogenic Esophageal Strictures
Terminated·UUniversity Hospital, Ghent·Phase 1·NCT03898661·2 enrolled
Oral Prednisolone in the Treatment of Esophageal Stricture After Esophageal Surgery
Unknown status·NNagasaki University·Phase 1·NCT02703376·8 enrolled
The Use of Triamcinolone Injection in Treatment of Refractory Benign Esophageal Stricture in Children
Unknown status·—·Phase 4·NCT04524897·20 enrolled
Oral Prednisolone to Prevent Esophageal Stricture After RFA for Long-segment Esophageal Neoplasia
Unknown status·—·Phase 4·NCT05768282·50 enrolled
Intralesional Steroid Injection Versus Oral Prednisolone in Prevention of Esophageal Stricture
Unknown status·IInstituto do Cancer do Estado de São Paulo·Phase 4·NCT04498260·30 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)