VivoSeq
Rare Disease

Hereditary Hemorrhagic Telangiectasia

24

Pipeline Programs

8

Active Trials

18

Companies Involved

Hereditary Hemorrhagic Telangiectasia is an emerging landscape with 24 programs across 18 companies. The most active players are Terremoto Biosciences Inc., Karuna Therapeutics, Inc., a Bristol Myers Squibb company, Alnylam Pharmaceuticals. 2 therapies are approved with 3 more in late-stage development.

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

15/100

Mech. Concentration

15/100

Completion Rate

82/100

Attrition Rate

13/100

Programs by Phase

Modality Breakdown

84%

Small molecule

21 of 25 classified programs — the dominant modality here.

16%ALL OTHERSMonoclonal antibody312%Peptide14%

Small molecule leads; the ring shows all 25 classified programs, each share of the total. Modality classified for 93% of 28 pipeline programs.

Trial Status

31

clinical trials

Completed18 · 58%
Recruiting5 · 16%
Terminated3 · 10%
Active, not recruiting2 · 6%
Withdrawn1 · 3%
Enrolling by invitation1 · 3%
Other1 · 3%

Trial Activity

31 trials

Bevacizumab In Hereditary Hemorrhagic Telangiectasia
Active, not recruiting··Phase 2·NCT04404881·33 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)