VivoSeq
Ophthalmology

Keratoconus

18

Pipeline Programs↗

5

Active Trials↗

8

Companies Involved↗

Keratoconus is an emerging landscape with 18 programs across 8 companies. The most active players are Novartis, Merck & Co., Viatris Specialty LLC. 4 therapies are approved with 7 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

46/100

Pipeline Velocity

15/100

Mech. Concentration

33/100

Completion Rate

67/100

Attrition Rate

20/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Novartis logo

Novartis

2 programs

Phase 1Merck & Co. logo

Merck & Co.

2 programs

Phase 3V

Viatris Specialty LLC

1 program

ApprovedU

UroGen Pharma Ltd.

1 program

ApprovedJ

Javelin Pharmaceuticals

1 program

ApprovedR

Revance Therapeutics, Inc.

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

41

clinical trials

Completed16 · 39%
Unknown status12 · 29%
Terminated6 · 15%
Withdrawn2 · 5%
Recruiting2 · 5%
Not yet recruiting2 · 5%
Other1 · 2%

Clinical Trials

Trial Activity

41 trials

Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus
Recruiting·UUniversity of Campinas, Brazil·Phase 3·NCT06601101·36 enrolled
Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus
Recruiting·GGlaukos Corporation·Phase 2·NCT07400952·100 enrolled
A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients
Not yet recruiting·JJoseph B. Ciolino, MD·N/A·NCT04584125·216 enrolled
Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and Keratoconus
Not yet recruiting·—·Preclinical·NCT07559188·16 enrolled
Study of TN-001 Topical Eyedrops for Keratoconus
Enrolling by invitation·TTheiaNova Ltd.·Phase 1/2·NCT07388069·20 enrolled
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
Completed·PPrice Vision Group·Phase 2·NCT01143389·510 enrolled
Epi-On Corneal Crosslinking for Keratoconus
Completed·CComprehensive EyeCare of Central Ohio·Phase 4·NCT03245853·20 enrolled
Pain Management in Corneal Collagen Crosslinking for Keratoconus
Completed·IInstituto de Oftalmología Fundación Conde de Valenciana·Phase 4·NCT02867176·25 enrolled
Intracameral Gas SF6 (Sulfur Hexafluoride) Injection for Acute Hydrops in Keratoconus
Completed·HHaEmek Medical Center, Israel·N/A·NCT00593190·8 enrolled
Combined CXL//UV and PRK or LASIK in Forme Fruste Keratoconus or Eyes With Potential Risk of Ectasia
Completed·CCxlusa·N/A·NCT01726283·22 enrolled
Botulinum Toxin A for the Treatment of Keratoconus
Completed·FFederal University of São Paulo·N/A·NCT01691651·40 enrolled
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
Completed·GGlaukos Corporation·Phase 3·NCT01344187·236 enrolled
Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus
Completed·CCornea and Laser Eye Institute·Phase 3·NCT01672814·3 enrolled
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
Completed·GGlaukos Corporation·Phase 3·NCT01643226·230 enrolled
Treatment of Keratoconus With PALK Versus PK
Completed·IInstituto de Oftalmología Fundación Conde de Valenciana·Phase 1·NCT02625467·28 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)