Botox
(Botulinum toxin type A)ApprovedSmall molecule
Botulinum toxin type A is used to reduce the appearance of wrinkles by temporarily paralyzing facial muscles, and it's also used to treat medical conditions like chronic migraines, excessive sweating, and muscle spasms.[2] Botox is currently approved and in use across 87 indications[4].[1]
Botox is one of 1163 small molecule programs targeting Arthropathy. It is currently in Approved.
87
Indications
319
Total Trials
15
Active Trials
1,162
Competitors
2
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 85 indications
Competition
Competitive Landscape
778 competitors in Osteoarthritis
#DrugCompanyPhaseTrials
1Botox
RRevance Therapeutics, Inc.
Approved
Ilaris
NovartisPreclinical
Platelet Rich Plasma
ZZagazig University
Preclinical
Enbrel
IImmunex
Preclinical
Protonix
WWyeth-Lederle Vaccines
Preclinical
Catapres
Boehringer IngelheimPreclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Decadron
QQuince Therapeutics S.p.A.
Preclinical
Ozone
TTanta University
Preclinical
Lornoxicam
PPOZEN
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Botulinum Toxin33 trials
Show 30 more trials
Occlusal Splints or Botulinum Toxin?
Completed·—·N/A·NCT03891121·73 enrolled
The Effect of Botulinum Toxin A In Patients With Excessive Gingival Display With And Without Zinc Supplementation
Completed·—·Phase 3·NCT03717987·26 enrolled
Assessment of Botulinum Toxin Injection for Treatment of Temporomandibular Joint Dislocation
Unknown status·—·N/A·NCT05863286·28 enrolled
Botulinum Toxin Injection for the Management of BPH
Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT00451191·134 enrolled
Botulinum Toxin Injections by Ultrasounds Guidance and Stretching Exercise in Spastic Toe Clawing
Completed·—·Phase 3·NCT02586142·30 enrolled
Botulinum Toxin to Improve Results in Cleft Lip Repair
Unknown status·—·Phase 3·NCT01429402·120 enrolled
Spasticity15 trials
Comparative Hybrid Effects of Combining BoNT-A With Robot-assisted or Mirror Therapy for U/E Spasticity Stroke Patients
Completed·—·Phase 3·NCT02749591·37 enrolled
Show 12 more trials
Dry Needling and Botulinum Toxin in the Management of Poststroke Spasticity
Completed·SSultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey·N/A·NCT03747900·30 enrolled
CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN TREATMENT OF SPASTICITY
Unknown status·—··NCT04673240·70 enrolled
Cerebral Palsy9 trials
Show 6 more trials
Botulinum Toxin (BOTOX) for Cerebral Palsy
Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 2·NCT00060957·40 enrolled
Cervical Dystonia8 trials
Show 5 more trials
Lower limb spasticity7 trials
Show 4 more trials
72 more indications
Migraine6 trials
Show 3 more trials
Safety and Efficacy6 trials
Show 3 more trials
Overactive Bladder5 trials
Hyperhidrosis5 trials
Hypertrophy5 trials
Headache5 trials
Lateral Canthal Lines4 trials
Urinary incontinence4 trials
Mixed Urinary Incontinence Symptoms Before and After Treatment With Botox and Bulkamid
Completed·—··NCT02815046·58 enrolled
Show 1 more trial
Efficacy and Safety4 trials
Osteoarthritis3 trials
Botox3 trials
Myofascial Pain Syndrome3 trials
Moderate to Severe Glabellar Lines3 trials
Cluster headache3 trials
Multiple Sclerosis3 trials
Benign Prostatic Hyperplasia2 trials
Hemorrhoid2 trials
Bruxism2 trials
Study of the Safety and Efficacy of Botox in Bruxism
Completed·—·Phase 4·NCT00908050·23 enrolled
Parkinson's Disease2 trials
Treatment2 trials
Achalasia2 trials
Thoracic Outlet Syndrome2 trials
Crow's Feet2 trials
Low back pain1 trial
Effectiveness1 trial
Glabellar Frown Lines1 trial
Scoliosis1 trial
Concentration1 trial
Hypertrophic Scars1 trial
Trigeminal Neuralgia1 trial
Botulinum Toxin for Trigeminal Neuralgia
Unknown status·TThe First Affiliated Hospital of Zhengzhou University·Phase 3·NCT03331913·150 enrolled
Back pain1 trial
Lateral Epicondylitis1 trial
Botulinum Toxin Versus Active Strength Training in the Treatment of Lateral Epicondylitis
Completed·—·N/A·NCT00930709·103 enrolled
Intra Articular Injection1 trial
Stroke1 trial
Effects of EMG-driven Robot-assisted Therapy for the Distal Upper Limb Motor Function in the Chronic Stroke Patients With Botox Injections
Completed·—·Phase 2·NCT04502264·24 enrolled
Erectile Dysfunction1 trial
Intracavernosal Injection of Botulinum Toxin Type A (50 and 100 Unit) in the Treatment of Erectile Dysfunction
Completed·—·Phase 2·NCT03355963·200 enrolled
Atrial Flutter1 trial
Radiofrequency Ablation Plus Botulinum Toxin Injection Versus Radiofrequency Ablation Only in Patients With Atrial Flutter
Unknown status·MMeshalkin Research Institute of Pathology of Circulation·Phase 2·NCT02002962·60 enrolled
Rehabilitation1 trial
Moderate to Severe Glabellar Frown Lines1 trial
Psoriasis Vulgaris1 trial
Adult1 trial
Strabismus1 trial
Sleep Disorder1 trial
Botulinum Toxin Relieves Anxiety, Depression and Sleep Disorderes in Patients With Blepharospasm
Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1·NCT04939909·50 enrolled
Atrial Fibrillation1 trial
Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery
Completed·—·Phase 1/2·NCT02498769·130 enrolled
Carpal Tunnel Syndrome1 trial
Shoulder pain1 trial
Ultrasound Guided Botulinum Toxin Type A Injection of Subacromial-Subdeltoid Bursa in Hemiplegic Shoulder Pain
Unknown status·—·Phase 1·NCT04467450·36 enrolled
Spinal Cord Injury1 trial
Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients
Completed·—·Phase 4·NCT01579500·40 enrolled
Pancreatectomy1 trial
Benign Essential Blepharospasm1 trial
Unspecified1 trial
Regulatory
FDA Approval Timeline[5]
Apr 29, 2009
DYSPORT
BLA BLA125274
Sep 7, 2022
DAXXIFY
BLA BLA761127
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Botox drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Botulinum toxin type A. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Synaptosomal Nerve-Associated Protein 25 (SNAP-25) Hydrolytic Enzyme[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- RRevance Therapeutics, Inc.