VivoSeq
Other

Lactic Acidosis

10

Pipeline Programs↗

1

Active Trials↗

5

Companies Involved↗

Lactic Acidosis is an early-stage landscape with 10 programs across 5 companies. The most active players are Tisento Therapeutics, Santhera Pharmaceuticals, Karuna Therapeutics, Inc., a Bristol Myers Squibb company. 3 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

37/100

Pipeline Velocity

6/100

Mech. Concentration

100/100

Completion Rate

67/100

Attrition Rate

25/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

T

Tisento Therapeutics

1 program

Phase 2S

Santhera Pharmaceuticals

1 program

Phase 2K

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

1 program

ApprovedGSK logo

GSK

1 program

ApprovedS

Saol Therapeutics Inc

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

8

clinical trials

Completed4 · 50%
Terminated2 · 25%
No longer available1 · 13%
Recruiting1 · 13%

Clinical Trials

Trial Activity

8 trials

A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
Recruiting·GGeorge Washington University·Phase 1/2·NCT06792500·24 enrolled
Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital
Completed·MMakerere University·N/A·NCT01580111·74 enrolled
Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis
Completed·UUniversity of Florida·Phase 3·NCT00004490·45 enrolled
RBC Transfusion in Severe Anemia With Lactic Acidosis
Completed·MMassachusetts General Hospital·Phase 3·NCT01586923·290 enrolled
Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes
Completed·—·Phase 2·NCT00887562·27 enrolled
Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)
Terminated·TTisento Therapeutics·Phase 2·NCT04475549·8 enrolled
Lactic Acidosis During Entecavir(ETV)Treatment
Terminated·—·Phase 4·NCT01354652·5 enrolled
Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
No longer available·UUniversity of Florida·N/A·NCT01797276

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)