Dichloroacetate

PreclinicalSmall molecule

SSaol Therapeutics Inc

Dichloroacetate is one of 95 small molecule programs targeting Lactic Acidosis. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Lactic AcidosisActive, not recruiting

ToxicityActive, not recruiting

EndometriosisActive, not recruiting

Lactic AcidosisPreclinical

Active, not recruiting

ToxicityPreclinical

Active, not recruiting

EndometriosisPreclinical

Active, not recruiting

Competition

Competitive Landscape

62 competitors in Toxicity

#DrugCompanyPhaseTrials

Zyvox

Pfizer

Approved

1 2

Norvir

AbbVie

Approved

1 3

Oncovin

Eli Lilly

Approved

1 4

Aldactone

Pfizer

Approved

1 5

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

3 6

Xeloda

EEngelhard Arzneimittel GmbH & Co.KG

Approved

2 7

Atropen

FFresenius Kabi Taiwan Ltd.

Approved

1 8

Ativan

BBausch Health Americas, Inc.

Approved

1 9

Cubicin

BBaxter Healthcare Corporation

Approved

1 10

Vancocin

HHikma Pharmaceuticals LLC

Approved

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Glioblastoma2 trials

Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors

Completed·UUniversity of Florida·Phase 1·NCT01111097·15 enrolled

Combining Radiotherapy and Temozolomide With Dichloroacetate in Patients With Newly Diagnosed Glioblastoma

Withdrawn·AAHS Cancer Control Alberta·Phase 1·NCT00703859

Type 1 Diabetes2 trials

Regulation of Brain Glucose Metabolism in Type 1 Diabetes

Recruiting·YYale University·Phase 1·NCT05317455·16 enrolled

Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes

Completed·YYale University·Phase 1·NCT03356457·21 enrolled

Lactic Acidosis1 trial

Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access

No longer available·UUniversity of Florida··NCT01797276

Endometriosis1 trial

A Clinical Trial to Evaluate Dichloroacetate (DCA) as a Treatment for Endometriosis-associated Pain

Completed·UUniversity of Edinburgh·N/A·NCT04046081·30 enrolled

Effectiveness1 trial

Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome

Unknown status·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 2·NCT00068913·35 enrolled

13 more indications

Toxicity1 trial

Prevention of Dichloroacetate Toxicity

Completed·UUniversity of Florida·N/A·NCT00031161·30 enrolled

Recurrent Head and Neck Cancer1 trial

Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers

Completed·—·Phase 1·NCT01163487·17 enrolled

Non-Small Cell Lung Cancer1 trial

Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small Cell Lung Cancer (NSCL)

Terminated·JJonsson Comprehensive Cancer Center·Phase 2·NCT01029925·7 enrolled

Pilot Study1 trial

A Pilot Study of Rapid Haplotyping Procedure for Personalized Dosing of Dichloroacetate (DCA) in Healthy Volunteers

Completed·UUniversity of Florida·Phase 1·NCT02690285·45 enrolled

Treatment1 trial

Expanded Access Treatment Protocol With DCA for Patients With PDCD

Available·SSaol Therapeutics Inc··NCT06931262

Solid Tumours1 trial

A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours

Completed·AAHS Cancer Control Alberta·Phase 1·NCT00566410·23 enrolled

Trial1 trial

Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:

Active, not recruiting·SSaol Therapeutics Inc·Phase 3·NCT02616484·34 enrolled

Metabolism1 trial

Dichloroacetate Kinetics, Metabolism and Toxicology

Completed·NNational Institute of Environmental Health Sciences (NIEHS)··NCT00015015·100 enrolled

Brain Cancer1 trial

The Safety and Efficacy of DCA for the Treatment of Brain Cancer

Completed·UUniversity of Alberta·Phase 2·NCT00540176·40 enrolled

Insulin resistance1 trial

Role of Preoperative Carbohydrates Drinks, Dichloroacetate and Exercise on Postoperative Muscle Insulin Resistance

Unknown status·UUniversity of Nottingham·Phase 4·NCT02469337·40 enrolled

Hypoxia1 trial

Imaging and Biomarkers of Hypoxia in Solid Tumors

Terminated·SStanford University·Phase 1·NCT01123005·28 enrolled

Glioblastoma Multiforme1 trial

Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)

Active, not recruiting·UUniversity of Florida·Phase 2·NCT05120284·40 enrolled

Unspecified2 trials

Pharmacotoxicology of Trichloroethylene Metabolites

Completed·UUniversity of Florida·N/A·NCT00874276·21 enrolled

Pharmacotoxicology of Trichloroethylene Metabolites

Terminated·UUniversity of Florida·N/A·NCT00865514·2 enrolled

Sources

References

[1]
ClinicalTrials.gov — 21 trial records for Dichloroacetate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Dichloroacetate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Dichloroacetate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Saol Therapeutics Inc company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: SSaol Therapeutics Inc

Dichloroacetate

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Glioblastoma2 trials

Type 1 Diabetes2 trials

Lactic Acidosis1 trial

Endometriosis1 trial

Effectiveness1 trial

Toxicity1 trial

Recurrent Head and Neck Cancer1 trial

Non-Small Cell Lung Cancer1 trial

Pilot Study1 trial

Treatment1 trial

Solid Tumours1 trial

Trial1 trial

Metabolism1 trial

Brain Cancer1 trial

Insulin resistance1 trial

Hypoxia1 trial

Glioblastoma Multiforme1 trial

Unspecified2 trials

References

Drug Info

Quick Facts

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