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Other/Metabolism

Metabolism

26

Pipeline Programs↗

32

Active Trials↗

43

Companies Involved↗

Metabolism is an emerging landscape with 26 programs across 43 companies. The most active players are NewAmsterdam Pharma. 3 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

56/100

Pipeline Velocity

30/100

Mech. Concentration

20/100

Completion Rate

91/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

NewAmsterdam Pharma

1 program

Pipeline

Programs by Phase

Preclinical12

Iron Preparation

HaEmek Medical Center, Israel

Mirbetriq (mirabegron)

Université de Sherbrooke

Acipimox

Boehringer Ingelheim

Exogenous LEAP2 Hormone

University Hospital, Gentofte, Copenhagen

Bisoprolol Fumarate

IPCA Laboratories Ltd.

Phase 19

Exendin-(9-39)

Eiger BioPharmaceuticals

I.V. Nicotine

Yale University

Obicetrapib

NewAmsterdam Pharma

Atropine

Fresenius Kabi Taiwan Ltd.

GIPNH2

Frederikke Koefoed-Hansen

Phase 22

Glucagon Response Study

Adrian Vella

Donepezil

Eisai

Phase 33

Ethanol

Roche

Alogliptin and Actoplus MET

The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Triptorelin Pamoate（）

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Approved

No programs

Analysis

Trial Status

320

clinical trials

Completed236 · 74%

Unknown status29 · 9%

Recruiting15 · 5%

Withdrawn11 · 3%

Active, not recruiting10 · 3%

Terminated9 · 3%

Other10 · 3%

Clinical Trials

Trial Activity

320 trials

Study of the Impact of Phosphate Supplementation on FGF23 Concentrations in Patients With Hypophosphatemia

Recruiting·UUniversity Hospital, Clermont-Ferrand·Preclinical·NCT07827989·60 enrolled

MULTIcentric Study About RESistance to CLOpidogrel in Dual Antiplatelet Therapy for Carotid Stenting

Recruiting·IIRCCS Policlinico S. Donato·N/A·NCT05566301·1,140 enrolled

Neural and Metabolic Factors in Carbohydrate Reward: An Examination of Speed

Recruiting·VVirginia Polytechnic Institute and State University·Preclinical·NCT06053294·64 enrolled

Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15

Recruiting·UUniversity of Pennsylvania·Phase 1·NCT06032026·70 enrolled

Variations in Ketone Metabolism

Recruiting·OOhio State University·N/A·NCT05924295·400 enrolled

Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT01803451·80 enrolled

Effect of Acetylcholinesterase Inhibitors on Bone Metabolism

Recruiting·—·Phase 2·NCT06041789·45 enrolled

Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503

Recruiting·UUniversity of Pennsylvania·Phase 1·NCT06303921·70 enrolled

The Effects of Bariatric Surgeries on Glucose Metabolism

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT02823665·200 enrolled

Bone Metabolism in 12-21 Year Olds Undergoing GLP-1 Receptor Agonist Therapy

Recruiting·UUniversity of Virginia·N/A·NCT06903923·120 enrolled

Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A

Recruiting·UUniversity of Pennsylvania·Phase 1·NCT06932809·90 enrolled

Microbiome Derived Metabolism and Pharmacokinetics

Recruiting·RRutgers, The State University of New Jersey·Phase 1·NCT05065671·14 enrolled

Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells

Recruiting·VVanderbilt University Medical Center·N/A·NCT06930976·12 enrolled

Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism

Recruiting·UUniversity of North Carolina, Chapel Hill·Phase 1/2·NCT04328337·40 enrolled

Effect of Nutritional Ketosis on Alcohol Metabolism

Recruiting·UUniversity of Pennsylvania·Phase 2/3·NCT06065657·20 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)