Ethanol

Phase 3Small molecule

Roche

Ethanol is one of 93 small molecule programs targeting Arrhythmia. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

ArrhythmiaActive, not recruiting

Alcohol Use DisorderRecruiting

Catheter InfectionRecruiting

Atrial Fibrillation (AF)Not yet recruiting

AlcoholismCompleted

MetabolismRecruiting

ImagingCompleted

DrivingCompleted

Facial PainActive, not recruiting

ArrhythmiaPreclinical

Active, not recruiting

Alcohol Use DisorderPhase 1

Recruiting

Catheter InfectionPhase 3

Recruiting

Atrial Fibrillation (AF)Preclinical

Not yet recruiting

AlcoholismPreclinical

Completed

MetabolismPhase 3

Recruiting

ImagingPreclinical

Completed

DrivingPreclinical

Completed

Facial PainPreclinical

Active, not recruiting

Competition

Competitive Landscape

31 competitors in Imaging

#DrugCompanyPhaseTrials

Nicorette

Pfizer

Approved

1 2

Ethanol

Roche

Phase 3

1 3

Obicetrapib

NNewAmsterdam Pharma

Phase 3

1 4

F-Arag

CCellSight Technologies, Inc.

Phase 2

2 5

Hyperpolarized 13c Pyruvate

UUniversity of Maryland, Baltimore

Phase 2

1 6

PET Scan With VAT

SStony Brook University

Phase 3

1 7

XTR006

SSinotau Pharmaceutical Group

Phase 3

2 8

Ga-FAPI-46

UUniversität Münster

Phase 2

1 9

Ga-HA-DOTATATE

UUniversity of Alberta

Phase 2

1 10

Methylreboxetine

BBrigham and Women's Hospital

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Phase 3Recruiting

Catheter Infection

NCT03083184

Phase 1Recruiting

Study completion

NCT06819189

Q1 2028

Phase 1Not yet recruiting

Study completion

NCT04999631

Q1 2029

Phase 1Recruiting

Alcohol Use Disorder

NCT07027839

Q2 2029

Phase 2/3Recruiting

Metabolism

NCT06065657

Clinical

Trials by Indication[1]

Alcohol6 trials

Neural Mechanisms Underlying Alcohol Induced Disinhibition

Completed·TTechnische Universität Dresden··NCT01097213·50 enrolled

Alcohol, Behavior, and Brain Imaging

Completed·UUniversity of Chicago·Phase 1·NCT03930446·80 enrolled

Neuroendocrine Response to Oral Alcohol Administration

Completed·YYale University·Phase 1·NCT03165942·64 enrolled

Show 3 more trials

Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans

Completed·YYale University·Phase 1·NCT00616746·18 enrolled

Genetics of the Acute Response to Alcohol in Social Drinkers

Terminated·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 1·NCT01375556·33 enrolled

Acute Neuroimmune Effects of Alcohol Using Free Water Imaging

Completed·—·N/A·NCT03370783·25 enrolled

Pancreatic cysts2 trials

The CHARM Trial: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts

Completed·MMilton S. Hershey Medical Center·Phase 2·NCT01475331·46 enrolled

CHARM II: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts

Active, not recruiting·MMilton S. Hershey Medical Center·Phase 3·NCT03085004·75 enrolled

Driving2 trials

Driving Simulator Performance After Intake of Zopiclone Sleeping Pills

Withdrawn·SSt. Olavs Hospital·N/A·NCT01257165

Development of a Valid Test Battery for Assessing Driving Ability When Influenced by Drugs.

Completed·SSt. Olavs Hospital·N/A·NCT00967421·20 enrolled

Endometrioma2 trials

Relation Between Ethanol Sclerotherapy for Endometrioma Systemic Immune Milieu

Completed·TTanta University·Phase 1·NCT05470972·69 enrolled

Efficacy of Aspiration and Sclerotherapy During Laparoscopy Using 95% Ethanol for the Treatment of Endometriomas

Unknown status·MMeir Medical Center·N/A·NCT02472873·120 enrolled

Catheter Infection2 trials

Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients

Recruiting·UUniversity Hospital, Clermont-Ferrand·Phase 3·NCT03083184·400 enrolled

Ethanol in the Prevention of Central Venous Catheter Infections

Terminated·HHospital General Universitario Gregorio Marañon·N/A·NCT01229592·200 enrolled

26 more indications

Interaction2 trials

Evaluation of the Pharmacodynamic and Pharmacokinetic Interactions of Tasimelteon and Ethanol

Completed·VVanda Pharmaceuticals·Phase 1·NCT01578057·28 enrolled

A Study to Assess the Pharmacodynamic Interaction Between Gabapentin and Ethanol in Healthy Subjects

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00666796·20 enrolled

Alcohol Use Disorder2 trials

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

Recruiting·NNational Institute of Mental Health (NIMH)·Phase 1·NCT07027839·30 enrolled

Sex and Sex Hormone Factors Influencing Acute Alcohol Effects on Sleep Physiology

Suspended·LLauren Whitehurst·Phase 3·NCT06143059·130 enrolled

Malignancies1 trial

Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT01101412

Atrial Fibrillation1 trial

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation

Completed·TThe Methodist Hospital Research Institute·Phase 3·NCT01898221·343 enrolled

Arrhythmia1 trial

The HOLIDAY (HOw ALcohol InDuces Atrial TachYarrhythmias) Study

Completed·UUniversity of California, San Francisco·N/A·NCT01996943·100 enrolled

Parenteral Nutrition1 trial

Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition

Terminated·MMayo Clinic·Phase 1/2·NCT02227329·39 enrolled

Drug Metabolism1 trial

Alcohol Inhibits Drug Metabolism by Carboxylesterases

Completed·UUniversity of Tennessee·Phase 1·NCT01708369·19 enrolled

Social Behavior1 trial

The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship Quality

Unknown status·MMaastricht University·Phase 1/2·NCT05670184·60 enrolled

Neuroblastoma1 trial

Ethanol-Lock Treatment in Preventing Central Venous Catheter Infections in Patients With High-Risk Neuroblastoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT00471679·12 enrolled

Metabolism1 trial

Effect of Nutritional Ketosis on Alcohol Metabolism

Recruiting·UUniversity of Pennsylvania·Phase 2/3·NCT06065657·20 enrolled

COVID-191 trial

Efficacy and Safety of Ethanol Inhalation on COVID-19 Treatment (a Clinical Trial Study)

Completed·AAli Amoushahi·Phase 3·NCT05268419·150 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold Sores

Completed·TTopical Remedy·Phase 2·NCT03192306·451 enrolled

Bloodstream Infection1 trial

Ethanol Lock Therapy for Treatment and Secondary Prophylaxis of Central Line-Associated Bloodstream Infection

Completed·SSt. Jude Children's Research Hospital·Phase 3·NCT01472965·95 enrolled

Testosterone1 trial

Steroid Profile: Differentiating Testosterone Administration From (Simultaneous) Ethanol Consumption

Completed·PParc de Salut Mar·Phase 1·NCT04166786·4 enrolled

Sleep1 trial

Hangover, Congeners, Sleep and Occupational Performance

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT00247585·140 enrolled

Thyroid Nodule1 trial

Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules

Completed·Hhassan harby mohamed·Phase 1·NCT03257930·1 enrolled

Facial Pain1 trial

Acute Effects of Alcohol Use on Chronic Orofacial Pain

Completed·UUniversity of Florida·N/A·NCT04019093·48 enrolled

Imaging1 trial

Using Imaging to Assess Effects of THC on Brain Activity

Completed·MMassachusetts General Hospital·N/A·NCT03655717·316 enrolled

AIN1 trial

Behavior Brain Responses

Completed·UUniversity of Chicago·Phase 1·NCT03964350·30 enrolled

Type 2 Diabetes1 trial

A Study of the Pharmacokinetics/Pharmacodynamics of GK Activator (2) in Type 2 Diabetes Patients With Hepatic Impairment.

Terminated· Roche logo

Roche·Phase 1·NCT00437606·2 enrolled

Dialysis Patients1 trial

Catheters Dysfunction Rate After Instillation of Ethanol 60% Lock Solution in Tunneled Silicone Catheter of Chronic Hemodialysis Patients

Terminated·UUniversity Hospital, Clermont-Ferrand·Phase 2·NCT00563342·40 enrolled

Alcohol Consumption1 trial

Internalized Stress in Relation to Alcohol Consumption

Terminated·TTexas Tech University·Phase 1·NCT06091189·165 enrolled

Alcoholism1 trial

Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia

Completed·UUniversity of Florida·N/A·NCT04925076·125 enrolled

Pancreatic Cystic Neoplasm1 trial

Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms

Completed·MMayo Clinic·Phase 1·NCT02158039·33 enrolled

Atrial Fibrillation (AF)1 trial

A Multicenter, Prospective, Randomized Controlled Trial of Combined Pulsed-Field and Radiofrequency-Modified Linear Ablation Versus Pulsed-Field Ablation Alone for Long-Standing Persistent Atrial Fibrillation

Not yet recruiting·YYunlong Wang·Preclinical·NCT07633509·430 enrolled

Unspecified4 trials

Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon

Completed·MMassachusetts General Hospital·Phase 4·NCT02516150·26 enrolled

Chicago Social Drinking Project

Active, not recruiting·UUniversity of Chicago·N/A·NCT00961792·800 enrolled

SADBE for Congenital Melanocytic Nevi

Not yet recruiting·MMassachusetts General Hospital·Phase 1·NCT04999631·30 enrolled

Show 1 more trial

Role of Metal Ion Transporter ZIP8 in Alcohol Related Behaviors

Recruiting·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 1·NCT06819189·50 enrolled

Sources

References

[1]
ClinicalTrials.gov — 45 trial records for Ethanol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ethanol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ethanol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Roche company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Roche

Ethanol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Q1 2028

Q1 2029

Q2 2029

Trials by Indication[1]

Alcohol6 trials

Pancreatic cysts2 trials

Driving2 trials

Endometrioma2 trials

Catheter Infection2 trials

Interaction2 trials

Alcohol Use Disorder2 trials

Malignancies1 trial

Atrial Fibrillation1 trial

Arrhythmia1 trial

Parenteral Nutrition1 trial

Drug Metabolism1 trial

Social Behavior1 trial

Neuroblastoma1 trial

Metabolism1 trial

COVID-191 trial

Safety and Efficacy1 trial

Bloodstream Infection1 trial

Testosterone1 trial

Sleep1 trial

Thyroid Nodule1 trial

Facial Pain1 trial

Imaging1 trial

AIN1 trial

Type 2 Diabetes1 trial

Dialysis Patients1 trial

Alcohol Consumption1 trial

Alcoholism1 trial

Pancreatic Cystic Neoplasm1 trial

Atrial Fibrillation (AF)1 trial

Unspecified4 trials

References

Drug Info

Quick Facts

Related News