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Cardiovascular/Mitral Regurgitation

Mitral Regurgitation

16

Pipeline Programs↗

29

Active Trials↗

23

Companies Involved↗

Mitral regurgitation is an emerging landscape with 16 programs across 23 companies.

Intelligence

Pipeline Metrics

Competitive Density

52/100

Pipeline Velocity

42/100

Mech. Concentration

14/100

Completion Rate

53/100

Attrition Rate

15/100

Pipeline

Programs by Phase

Preclinical14

Aspirin

Bayer

Spironolactone

Pfizer

Sacubitril/valsartan

Novartis

Captopril

Standard Chem. & Pharm. Co., Ltd.

Clopidogrel

Sanofi

Phase 1

No programs

Phase 22

Cyproheptadine

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Mydfrin

Montefiore Medical Center

Phase 3

No programs

Approved

No programs

Analysis

Trial Status

48

clinical trials

Recruiting17 · 35%

Completed8 · 17%

Active, not recruiting6 · 13%

Not yet recruiting5 · 10%

Terminated4 · 8%

Unknown status4 · 8%

Other4 · 8%

Clinical Trials

Trial Activity

48 trials

A Prospective, Multicenter Clinical Investigation of the Use of Force Feedback Instruments With the da Vinci Surgical System, Model IS5000 for Mitral Valve Repair (MVr)

Recruiting·IIntuitive Surgical·Preclinical·NCT07655505·30 enrolled

Cephea Early Feasibility Study

Recruiting·AAbbott Medical Devices·Preclinical·NCT05061004·90 enrolled

Safety and Efficacy of Transcatheter Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation - The STAR Trial

Recruiting·BBeijing Anzhen Hospital·Preclinical·NCT07414225·400 enrolled

Abbott Cephea Mitral Valve Disease Registry

Recruiting·AAbbott Medical Devices·N/A·NCT07069673·1,000 enrolled

Early Feasibility Experience of Posterior Leaflet Replacement to Reduce Mitral Regurgitation Using the MRace Implant (United States)

Recruiting·PPolares Medical SA·Preclinical·NCT07517588·15 enrolled

Capstan Medical TMVR Study: First-in-Human Evaluation of the Capstan TMVR System

Recruiting·CCapstan Medical·Preclinical·NCT06600191·10 enrolled

Effects of VALsartan On atRIAl Mitral Regurgitation: A Pilot Randomized Controlled Trial

Recruiting·—·Preclinical·NCT07539298·50 enrolled

A First-in-Human Investigational Testing Authorization Study Evaluating the Safety and Performance of the Vesalius Transcatheter Mitral Valve Repair System in Patients With Severe, Symptomatic Degenerative Mitral Regurgitation

Recruiting·VVesalius Cardiovascular Inc.·Preclinical·NCT07470788·5 enrolled

Reduction or Elimination of Mitral Regurgitation With the SATURN Trans-septal TMVR System in Patients With Severe, Symptomatic Mitral Regurgitation (Cassini-US)

Recruiting·IInnovHeart·Preclinical·NCT07130994·15 enrolled

ATLAS (A Transseptal Left Atrial System for Treatment of Mitral Regurgitation) Pivotal Trial

Recruiting·44C Medical Technologies, Inc.·Preclinical·NCT06465745·450 enrolled

A Clinical Study Evaluating the Replacement of the Native Mitral Valve Using the ReValve System

Recruiting·RReValve Solutions Inc.·Phase 1·NCT07450911·20 enrolled

ENHANCE EFS: Early Feasibility Study (EFS) of the Nyra Cardiac Leaflet Enhancer (CARLEN) System

Recruiting·NNyra Medical, Inc.·Preclinical·NCT07503236·30 enrolled

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR Transfemoral System in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial

Recruiting·—·Preclinical·NCT05496998·400 enrolled

Serotonin Receptor Blockers in Ischemic Mitral Regurgitation

Recruiting·LLaval University·Phase 2·NCT05469165·214 enrolled

Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial

Recruiting·—·N/A·NCT06883864·146 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)