Bayer Aspirin

(Aspirin)

ApprovedSmall molecule

Aspirin is used to reduce pain, fever, and inflammation, and is also commonly taken in low doses to help prevent heart attacks and strokes by reducing blood clotting.[2] Bayer Aspirin is currently approved and in use across 193 indications[4].[1]

Bayer Aspirin is one of 1963 small molecule programs targeting Type 2 Diabetes Mellitus. It is currently in Approved.

193

Indications

664

Total Trials

Active Trials

1,962

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Type 2 Diabetes MellitusCompleted

PreeclampsiaNot yet recruiting

InteractionCompleted

Barrett EsophagusActive, not recruiting

Metabolic SyndromeCompleted

Renal Artery StenosisActive, not recruiting

Cerebral IschemiaActive, not recruiting

Coronary StenosisActive, not recruiting

Mood DisorderActive, not recruiting

Chagas DiseaseActive, not recruiting

Type 2 Diabetes MellitusApproved

Completed

PreeclampsiaApproved

Not yet recruiting

InteractionApproved

Completed

Barrett EsophagusPhase 2

Active, not recruiting

Metabolic SyndromeApproved

Completed

Renal Artery StenosisApproved

Active, not recruiting

Cerebral IschemiaApproved

Active, not recruiting

Coronary StenosisApproved

Active, not recruiting

Mood DisorderApproved

Active, not recruiting

Chagas DiseaseApproved

Active, not recruiting

Showing 10 of 186 indications

Competition

Competitive Landscape

449 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Alimta

EEagle Pharmaceuticals, Inc.

Phase 3

75 2

Bayer Aspirin

Bayer

Approved

1 3

JAB 21822

AAllist Pharmaceuticals, Inc.

Phase 3

1 4

HLX07

Shanghai Henlius Biotech

Phase 3

1 5

Remeron

OOrganon and Co

Preclinical

1 6

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Preclinical

—7

Ftorafur

TThe First Affiliated Hospital with Nanjing Medical University

Preclinical

—8

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Treatment

1 10

Valemetostat Tosylate

Daiichi Sankyo

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Active, not recruiting

Vaccine

NCT04083950

Q4 2026

Phase 3Active, not recruiting

Solid Tumours

NCT02804815

N/ARecruiting

Acute Pancreatitis

NCT06185621

Phase 1Active, not recruiting

Fallopian Tube

NCT03771651

Phase 3Recruiting

Aspirin

NCT05265299

Phase 2Recruiting

Preeclampsia

NCT03667326

Clinical

Trials by Indication[1]

Aspirin17 trials

Mobilization of Endothelial Progenitor Cells and Aspirin

Terminated·OOttawa Heart Institute Research Corporation·Phase 3·NCT02674958·6 enrolled

Effect of Aspirin at the Acute Phase of Cerebral Ischemic Event.

Unknown status·—·N/A·NCT01375400·50 enrolled

Pharmacodynamic Evaluation of PL2200 Versus Enteric-Coated and Immediate Release Aspirin in Diabetic Patients

Completed·PPLx Pharma·Phase 3·NCT01515657·40 enrolled

Show 14 more trials

Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

Recruiting·TThomas Jefferson University·Phase 1/2·NCT06826859·400 enrolled

Timed Aspirin Chronobiome Study

Not yet recruiting·UUniversity of Pennsylvania·Phase 1·NCT03590821·60 enrolled

COMT on Aspirin Platelets Effects (CAPE)

Unknown status·—·Phase 4·NCT03433586·45 enrolled

Aspirin in Reducing Events in the Elderly

Unknown status·HHennepin Healthcare Research Institute··NCT01038583·19,114 enrolled

Trial to Determine Effective Aspirin Dose in COPD

Recruiting·JJohns Hopkins University·Phase 3·NCT05265299·48 enrolled

Serum Thromboxane B2 Assay as a Measure of Platelet Production in Healthy Volunteers Taking Aspirin

Completed·HHamilton Health Sciences Corporation·N/A·NCT03424408·20 enrolled

Aspirin Effects on Emotional Reactions

Completed·OOhio State University·Phase 1·NCT04146532·268 enrolled

Evaluation of Upper GI Ulceration Induced by PL2200 Versus Aspirin in At-Risk Subjects

Completed·PPLx Pharma·Phase 2·NCT01646814·247 enrolled

Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers

Completed·VVanderbilt University·Phase 1·NCT01796951·6 enrolled

Pharmacokinetic and Pharmacodynamic Study of a Novel Sublingual Aspirin Tablet

Unknown status·VVita Green Health Products Co. Ltd·Phase 1·NCT04792723·24 enrolled

NSAIDs vs. Coxibs in the Presence of Aspirin

Recruiting·IInova Health Care Services·Phase 4·NCT03699293·30 enrolled

Comparative Effects of Aspirin and NHP-544C

Completed·VVanderbilt University·N/A·NCT02189122·61 enrolled

A Study to Compare the Effects of Improving the Carotid Artery Intima Media Thickness and Changing Lipid Levels by Cilostazol/Ginkgo Leaf Extract and Aspirin in Diabetic Peripheral Angiopathy.

Completed·SSK Chemicals Co., Ltd.·Phase 4·NCT05906199·105 enrolled

To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets and Aspirin Effervescent Tablets in Healthy Adults.

Completed· Bayer logo

Bayer·Phase 1·NCT02394093·30 enrolled

Ischemic stroke13 trials

Efficacy of BNG-1 to Treat Acute Ischemic Stroke

Completed·—·Phase 3·NCT01675115·129 enrolled

Double Randomized and Placebo Controlled Trail of Sanchitongshu Combined Antiplatelet Drug to Prevent Ischemic Stroke

Unknown status·XXinhua Hospital, Shanghai Jiao Tong University School of Medicine·N/A·NCT04142151·60 enrolled

The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial

Unknown status·PPeking Union Medical College Hospital·Phase 4·NCT00724724·1,000 enrolled

Show 10 more trials

Thrombolysis With rhPro-UK in 4.5-6 Hours After Acute Ischemic Stroke in a Double-blinded,Controlled Trial

Completed·TTasly Biopharmaceuticals Co., Ltd.·Phase 3·NCT03578822·149 enrolled

INdobufen Versus aSpirin in acUte Ischemic stRokE,INSURE

Completed·—·Phase 4·NCT03871517·5,438 enrolled

PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage

Unknown status·—·Phase 4·NCT01013532·1,600 enrolled

Antiplatelet Therapy in Acute Mild-Moderate Ischemic Stroke

Completed·GGeneral Hospital of Shenyang Military Region·Phase 3·NCT02869009·3,000 enrolled

Autologous Hematopoietic Stem Cell Transplantation in Ischemic Stroke

Unknown status·—·Phase 1·NCT01518231·40 enrolled

Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke

Completed·CChina Academy of Chinese Medical Sciences·Phase 4·NCT01762163·622 enrolled

An Investigation Into The Impact Of Enteric Coated Of Aspirin In Patients With Newly Diagnosed Ischemic Stroke.

Completed·HHamad Medical Corporation·Phase 4·NCT04330872·42 enrolled

Ticagrelol Versus Aspirin in Ischemic Stroke

Completed·KKafrelsheikh University·Phase 3·NCT03884530·169 enrolled

Efficacy and Safety of Mildronate for Acute Ischemic Stroke

Unknown status·XXijing Hospital·Phase 2·NCT01800357·240 enrolled

The Benefit of Add On DLBS1033 for Ischemic Stroke Patient

Unknown status·—·Phase 2/3·NCT04425590·180 enrolled

Preeclampsia9 trials

Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort

Unknown status·PPeking Union Medical College Hospital·Phase 4·NCT04631627·1,500 enrolled

Oral Progesterone and Low Dose Aspirin in the Prevention of Preeclampsia

Terminated·JJohn Uckele·N/A·NCT00719537·3 enrolled

Aspirin and Preeclampsia

Recruiting·UUniversity of Chicago·Phase 4·NCT04479072·180 enrolled

Show 6 more trials

Aspirin for Prevention of Preeclampsia

Unknown status·—·N/A·NCT03726177·600 enrolled

Aspirin for Prevention of Preeclampsia in Healthy, Nulliparous Obese and Overweight Pregnant Women

Unknown status·—·N/A·NCT03725891·600 enrolled

Postpartum Low-Dose Aspirin and Preeclampsia

Recruiting·—·Phase 2·NCT03667326·100 enrolled

Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida

Completed·TThe University of Texas Health Science Center, Houston·Phase 2/3·NCT03961360·220 enrolled

Aspirin 150 mg vs 100 mg for Prevention of Preeclampsia in High-Risk Obese Pregnant Women

Not yet recruiting·FFANG HE·Phase 3·NCT06952712·1,300 enrolled

Daily Aspirin Treatment After Preeclampsia

Recruiting·—·Phase 1·NCT06168461·40 enrolled

Coronary Artery Disease8 trials

The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease（AURORA）

Unknown status·SShanghai Zhongshan Hospital··NCT03691688·2,000 enrolled

Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization

Unknown status·JJun Li·Phase 4·NCT03072121·440 enrolled

Aspirin Resistance in Coronary Artery Disease

Completed·VVanderbilt University·Phase 1·NCT00753935·92 enrolled

Show 5 more trials

Edoxaban in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With Aspirin and Clopidogrel

Completed·UUniversity of Florida·Phase 4·NCT02567461·80 enrolled

Comparison of Effect & Safety of Clopidogrel Napadisilate With Clopidogrel Bisulfate in Coronary Artery Disease Patients

Completed· Hanmi Pharmaceutical Company Limited logo

Hanmi Pharmaceutical Company Limited·Phase 4·NCT01830491·162 enrolled

Coronary Artery Disease After Heart Transplantation

Unknown status·—·N/A·NCT03583229·70 enrolled

Curative Effect Evaluation of Danlou Tablet on Coronary Artery Disease Not Amenable to Revascularization

Unknown status·JJun Li·Phase 4·NCT03072082·440 enrolled

Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease

Completed·UUniversity of Florida·Phase 4·NCT04006288·90 enrolled

Stroke7 trials

COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke

Completed· Sanofi logo

Sanofi·Phase 4·NCT00814268·358 enrolled

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

Terminated·—·Phase 3·NCT03192215·1,015 enrolled

Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events

Completed·NNorthwestern University·Phase 2/3·NCT01586975·93 enrolled

Show 4 more trials

Combining Aspirin With Ticagrelor or Cilostazol in Large-vessel Minor Stroke or TIA

Recruiting·KKafrelsheikh University·Phase 3·NCT06591377·900 enrolled

Aspirin for Prevention of Stroke After Endovascular Aortic Arch Repair: a Multicenter, Double-Blind, Randomized Controlled Trial

Not yet recruiting·TThe General Hospital of Western Theater Command·Phase 1·NCT07205250·224 enrolled

Combining Aspirin With Ticagrelor or Clopidogrel in Large-vessel Minor Stroke or TIA

Recruiting·KKafrelsheikh University·Phase 3·NCT06591338·900 enrolled

Platelet Hyperreactivity to Aspirin and Stroke

Completed·UUniversity of Sao Paulo·Phase 4·NCT00766896·203 enrolled

108 more indications

Clopidogrel6 trials

PACT (Platelet Activity After Clopidogrel Termination)

Completed·UUniversity of Massachusetts, Worcester·N/A·NCT00619073·15 enrolled

Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

Completed·UUniversity Hospital, Basel, Switzerland·Phase 2·NCT02677545·210 enrolled

Clopidogrel for Acute Ischaemia of Recent Onset

Completed·—·Phase 4·NCT02776540·188 enrolled

Show 3 more trials

Efficacy of Ticagrelor vs Clopidogrel in High-risk NSTE-ACS Patients Undergoing Early PCI

Unknown status·RRenJi Hospital·Phase 4·NCT02201667·444 enrolled

Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients

Completed·—·N/A·NCT01779401·1,078 enrolled

Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers

Completed·RResearch Associates of New York, LLP·Phase 4·NCT00778193·125 enrolled

Chronic Kidney Disease3 trials

Warfarin Versus Aspirin in Patients With Atrial Fibrillation and Chronic Kidney Disease

Withdrawn·SSeoul National University Hospital·Phase 4·NCT01668901

Aspirin to Target Arterial Events in Chronic Kidney Disease

Terminated·UUniversity of Southampton·Phase 3·NCT03796156·4,633 enrolled

Chronic Kidney Disease (CKD) Platelet Study

Completed·UUniversity of Arkansas·Phase 3·NCT03649711·76 enrolled

COVID-193 trials

Coronavirus Response - Active Support for Hospitalised Covid-19 Patients

Withdrawn·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT04343001

Protective Effect of Aspirin on COVID-19 Patients

Unknown status·XXijing Hospital·Phase 2/3·NCT04365309·128 enrolled

The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations

Withdrawn·LLouisiana State University Health Sciences Center in New Orleans·Phase 2·NCT04363840

Antiplatelet3 trials

The Effect of Celecoxib on the Antiplatelet Effect of Aspirin and Clopidogrel in Normal Volunteers

Completed·SSeoul National University Hospital·Phase 4·NCT00882388·40 enrolled

Pharmacogenomics of Antiplatelet Response - I

Completed·JJohns Hopkins University·Phase 4·NCT01815008·19 enrolled

A Study of the Onset and Offset of Antiplatelet Effects Comparing Ticagrelor, Clopidogrel, and Placebo With Aspirin

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00528411·123 enrolled

Dual Antiplatelet Therapy3 trials

Optimal Duration of Dual Antiplatelet Therapy After Drug-eluting Stent Implantation

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT00822536·1,798 enrolled

A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND PILOT STUDY)

Terminated·OOttawa Heart Institute Research Corporation·Phase 4·NCT03224923·5 enrolled

Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling

Completed·SSeoul National University Bundang Hospital·Phase 4·NCT05257824·528 enrolled

Cardiovascular Disease3 trials

Anti-platelet Therapy in the Prevention of Cardiovascular Disease in Patients With COPD (APPLE-COPD: ICON 2)

Completed·NNewcastle-upon-Tyne Hospitals NHS Trust·Phase 2·NCT03487406·120 enrolled

A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease

Completed· Bayer logo

Bayer·Phase 3·NCT00501059·12,546 enrolled

Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes

Recruiting·SSteno Diabetes Center Copenhagen·Phase 3·NCT06082063·2,000 enrolled

Pregnancy3 trials

Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Unknown status·MMinistry of Science and Technology of the People´s Republic of China·Phase 4·NCT04051567·425 enrolled

Aspirin Role for Preventing Clinical Risks Related to High Risk Pregnancy

Completed·GGalala University·N/A·NCT07087067·87 enrolled

Antenatal Platelet Response On Aspirin and Correlation With HDP (Hypertensive Disorders of Pregnancy)

Completed·TThomas Jefferson University··NCT04295850·130 enrolled

Acute Coronary Syndrome3 trials

To Assess the Efficacy and Safety of Dual Anticoagulants i.e. Rivaroxaban Plus Aspirin and Clopidogrel Plus Aspirin in Patients Suffering From an Acute Coronary Syndrome

Unknown status·SSarmad Zahoor·Phase 4·NCT05573958·90 enrolled

Preventing Cardiac Complication of COVID-19 Disease With Early Acute Coronary Syndrome Therapy: A Randomised Controlled Trial.

Terminated·IImperial College London·N/A·NCT04333407·320 enrolled

Platelet Aggregation in Diabetic Patients With Acute Coronary Syndrome Treated With Different Doses of Aspirin

Completed·FFederico II University·Phase 4·NCT05293808·60 enrolled

Hypertension3 trials

Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy

Recruiting·—·Phase 3·NCT04356326·500 enrolled

Aspirin to Prevent Preeclampsia in Women With Elevated Blood Pressure and Stage 1 Hypertension (ASPPIRE)

Terminated·YYale University·Phase 2·NCT04402385·50 enrolled

Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension

Unknown status·—·Phase 4·NCT04908982·60 enrolled

Platelet Function2 trials

Effect of Herbal Products on Platelet Function and Clotting

Completed·SSingapore General Hospital·Phase 3·NCT02008981·75 enrolled

Effects of Recombinant Human Erythropoietin on Platelet Function in Healthy Subjects

Completed·YYale University·Phase 2·NCT00368238·96 enrolled

Inflammatory Mediators2 trials

Role of Inflammatory Mediators in AERD

Completed·—··NCT02824523·40 enrolled

Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects

Completed·—·N/A·NCT00898222·4 enrolled

Prevention2 trials

Cilostazol Versus Aspirin for Primary Prevention of Atherosclerotic Events

Unknown status·HHanyang University·Phase 4·NCT00886574·400 enrolled

Prevention of Venous Obstruction After Implantation of Cardiac Pacemaker and Defibrillator

Unknown status·SShahid Beheshti University of Medical Sciences·N/A·NCT02331511·100 enrolled

Multiple Myeloma2 trials

A Study to Compare MPR With MP in Newly Diagnosed Multiple Myeloma Subjects 65 Years Old or Older.

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 3·NCT00405756·459 enrolled

Aspirin or Rivaroxaban Thromboprophylaxis for Patients With Multiple Myeloma

Not yet recruiting·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 3·NCT06580223·530 enrolled

Migraine2 trials

COMParison of the EffecT of dEvice Closure in Alleviating Migraine With PFO (COMPETE-2)

Unknown status·—·Phase 4·NCT05561660·460 enrolled

Aspirin Resistance in Women With Migraine

Withdrawn·SSwedish Medical Center·N/A·NCT01257893

Rivaroxaban2 trials

Rivaroxaban or Aspirin for Biological Aortic Prosthesis

Unknown status·CChristian Torp-Pedersen·Phase 4·NCT02974920·1,000 enrolled

Rivaroxaban Plus Aspirin to Manage Recurrent Venous Thromboembolic Events

Completed·IInstituto Mexicano del Seguro Social·Phase 2/3·NCT05515120·58 enrolled

Systemic Lupus Erythematosus2 trials

Aspirin and Statins for Prevention of Atherosclerosis and Arterial Thromboembolism in Systemic Lupus Erythematosus

Completed·TTuen Mun Hospital·Phase 4·NCT00371501·72 enrolled

Dipyridamole Assessment for Flare Reduction in Systemic Lupus Erythematosus (SLE)

Terminated·OOklahoma Medical Research Foundation·N/A·NCT01781611·18 enrolled

Prophylaxis2 trials

LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

Enrolling by invitation·MMassachusetts General Hospital·Phase 4·NCT03244020·2,868 enrolled

Aspirin for Prophylaxis of TTP

Not yet recruiting·TThe First Affiliated Hospital of Soochow University·Phase 2/3·NCT05568147·100 enrolled

Inflammation2 trials

Hormones Inflammation and Thrombosis

Terminated·JJohns Hopkins University·Phase 4·NCT01875185·100 enrolled

Synergistic Influence of Rivaroxaban on Inflammation and Coagulation Biomarkers in Patients With CAD and PAD on Aspirin Therapy

Unknown status·LLifeBridge Health·Phase 4·NCT04059679·30 enrolled

Melanoma2 trials

Aspirin as an Ultraviolet (UV) Protectant in Human Subjects at Risk for Melanoma

Completed·UUniversity of Utah·Phase 2·NCT04066725·95 enrolled

Metabolomic and Inflammatory Effects of Oral Aspirin (ASA) in Subjects at Risk for Melanoma

Completed·UUniversity of Utah·Phase 2·NCT04062032·41 enrolled

Atrial Fibrillation2 trials

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT01830543·2,124 enrolled

Aspirin Discontinuation After Left Atrial Appendage Occlusion in Atrial Fibrillation

Unknown status·XXinhua Hospital, Shanghai Jiao Tong University School of Medicine·N/A·NCT03821883·1,120 enrolled

Interaction2 trials

Mechanism of Drug-drug Interaction Between Salvianolate Injection and Aspirin

Unknown status·XXiyuan Hospital of China Academy of Chinese Medical Sciences·N/A·NCT03306550·18 enrolled

Clopidogrel/Aspirin Interaction Study

Completed·PPopulation Health Research Institute·Phase 4·NCT01102439·82 enrolled

Metabolic Syndrome1 trial

Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome

Completed·—·Phase 4·NCT00272311·70 enrolled

Vascular Disease1 trial

Anti-Inflammatory and Anti-Platelet Effect of Clopidogrel and Aspirin vs Aspirin Alone in Symptomatic Polyvascular Disease and in Patients With Multiple Recurrent Cardiovascular Events

Unknown status·—·Phase 3·NCT00775762·213 enrolled

Cerebrovascular Event1 trial

Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events

Unknown status·XXijing Hospital·Phase 2/3·NCT01923818·3,700 enrolled

Intrauterine Adhesion1 trial

Effects of Aspirin on Uterine Endometrial Repair Severe Intrauterine Adhesion

Completed·FFirst Affiliated Hospital, Sun Yat-Sen University·N/A·NCT02744716·114 enrolled

Vascular Access1 trial

Antiaggregation in Primary Prevention of Vascular Access for Hemodialysis

Unknown status·TTunis University·Phase 4·NCT02055131·300 enrolled

HIV infection1 trial

Targeting Platelets in Chronic HIV Infection

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT02578706·27 enrolled

Bleeding1 trial

Aspirin Use and Postoperative Bleeding From Dental Extractions in a Healthy Population

Completed·WWake Forest University Health Sciences·Phase 2·NCT00405613·36 enrolled

Unknown status·GGyeongsang National University Hospital·Phase 3·NCT00891670·80 enrolled

Transient Ischemic Attack1 trial

Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER)

Completed·UUniversity of Calgary·Phase 2/3·NCT00109382·500 enrolled

Nasopharyngeal Carcinoma1 trial

Aspirin Improve Survival of N2-3 Nasopharyngeal Carcinoma Patients

Unknown status·SSun Yat-sen University·Phase 2·NCT03290820·184 enrolled

Atherosclerosis1 trial

Aspirin Dose and Atherosclerosis in Patients With Heart Disease

Completed·—·Phase 4·NCT00272337·37 enrolled

TIPS1 trial

The Indian POLYCAP Study (TIPS)

Completed·SSt. John's Research Institute·N/A·NCT00443794·2,050 enrolled

Peripheral Artery Disease1 trial

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Completed· Bayer logo

Bayer·Phase 3·NCT01776424·27,395 enrolled

Platelet Reactivity1 trial

Effect of Aspirin on Abacavir-induced Platelet Reactivity in HIV-infected Patients

Completed·AAzienda Ospedaliera di Perugia·Phase 2·NCT03316534·40 enrolled

Metastatic Colorectal Cancer1 trial

Regorafenib With Low-dose Chemotherapies and Aspirin Followed by Standard Chemotherapies in Metastatic Colorectal Cancer

Recruiting·—·Phase 2/3·NCT05462613·446 enrolled

Immune Response1 trial

The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin

Completed·SSheffield Teaching Hospitals NHS Foundation Trust·Phase 4·NCT03869268·72 enrolled

Islet Transplantation1 trial

B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure

No longer available·NNational Institute of Allergy and Infectious Diseases (NIAID)··NCT01049633

Vascular Dementia1 trial

Cilostazol Verse Asprin for Vascular Dementia in Poststroke Patients With White Matter Lesions

Completed·PPeking University First Hospital·Phase 4·NCT00847860·200 enrolled

Mitral regurgitation1 trial

Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation

Completed·—·N/A·NCT00224809·250 enrolled

Venous Thromboembolism1 trial

Efficacy of Aspirin in Preventing Venous Thromboembolism

Completed·IInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado·Phase 4·NCT06635317·60 enrolled

ART1 trial

Distal Venous Arterialisation of Ischemic Limb

Unknown status·CClinical Centre of Serbia·Phase 2/3·NCT01211925·30 enrolled

Chest pain1 trial

Women With Chest Pain and Normal Coronary Arteries Study

Terminated·NNorthwestern University·N/A·NCT00743197·3 enrolled

Sleep1 trial

Sleep and Inflammatory Resolution Pathway

Active, not recruiting·—·Phase 1·NCT03377543·66 enrolled

Platelet Aggregation1 trial

Effect of Indobufen and Aspirin on Platelet Aggregation and Long Term Prognosis in Patients With Coronary Heart Disease

Withdrawn·HHenan Institute of Cardiovascular Epidemiology·N/A·NCT04308551

Type 2 Diabetic Patients1 trial

Evaluation of Antiplatelet Effects of Different Dosages of Aspirin in Type 2 Diabetic Patients

Completed·KKarolinska Institutet·Phase 4·NCT00812032·25 enrolled

Adult1 trial

Intensified Short Course Regimen for TBM in Adults

Not yet recruiting·IIndian Council of Medical Research·Phase 3·NCT05917340·372 enrolled

Angina Pectoris1 trial

Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris

Unknown status·GGuang'anmen Hospital of China Academy of Chinese Medical Sciences·Phase 4·NCT04661709·502 enrolled

Intracerebral Haemorrhage1 trial

Reducing the Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage

Not yet recruiting·—·Phase 3·NCT07243704·5,676 enrolled

Colorectal Polyps1 trial

The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin

Unknown status·MMaria Sklodowska-Curie National Research Institute of Oncology·Phase 4·NCT01549418·760 enrolled

Stent Thrombosis1 trial

Aspirin® Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With PTS

Terminated·UUniversity of Zurich·Phase 2·NCT04128956·172 enrolled

Anticoagulation1 trial

Prophylactic Anticoagulation for Catheter-related Thrombosis

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT04256525·1,640 enrolled

Fallopian Tube1 trial

Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube

Active, not recruiting·UUniversity of Oklahoma·Phase 1·NCT03771651·18 enrolled

Heart1 trial

The ARIES HeartMate 3 Pump IDE Study

Completed·AAbbott Medical Devices·N/A·NCT04069156·628 enrolled

Coronary Artery Ectasia1 trial

Coronary Artery Ectasia, Efficacy of Various Anti Thrombotic Regimens.

Unknown status·—·Phase 3·NCT05718531·200 enrolled

Flushing1 trial

Alternative Options to Minimize Niacin-Induced Flushing

Completed·PPatrick Moriarty, MD, FACP, FACC·N/A·NCT00895193·100 enrolled

Monotherapy1 trial

Ticagrelor Monotherapy Compared to Aspirin Monotherapy in Patients With History of ACS

Completed·TThe University of Hong Kong·Phase 4·NCT03881943·200 enrolled

Ataxia1 trial

Acetyl-leucine in Post-stroke Ataxia

Recruiting·KKafrelsheikh University·Phase 3·NCT07275749·200 enrolled

Essential Hypertension1 trial

Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension

Terminated·UUnknown Sponsor·Phase 4·NCT00449618·23 enrolled

Thromboembolism1 trial

Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity

Completed·UUniversity of Calgary·Phase 1·NCT04153760·257 enrolled

SARS CoV 2 Infection1 trial

Long-term Aspirin Therapy as a Predictor of Decreased Susceptibility to SARS-CoV-2 Infection in Aspirin-Exacerbated Respiratory Disease

Unknown status·LLucyna Mastalerz·Phase 3·NCT05797597·76 enrolled

Coronary Stenosis1 trial

A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis

Completed·GGuang'anmen Hospital of China Academy of Chinese Medical Sciences·Phase 4·NCT01513070·120 enrolled

Preterm Birth1 trial

Comparative Study Between Vaginal Progesterone Alone or Combined With Aspirin in Prevention of Recurrent Preterm Birth

Completed·MMenoufia University·Phase 4·NCT05319834·256 enrolled

Antiphospholipid Syndrome1 trial

AntiPhospholipid Syndrome Low-molecular-weight Heparin Pregnancy Loss Evaluation: The Pilot Study

Terminated·OOttawa Hospital Research Institute·Phase 1·NCT03100123·1 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Tirofiban for Patients With BAD (BRANT)

Completed·PPeking Union Medical College Hospital·Phase 3·NCT06037889·516 enrolled

Alcoholic Fatty Liver Disease1 trial

Aspirin for the Treatment of Nonalcoholic Fatty Liver Disease

Completed·MMassachusetts General Hospital·Phase 1/2·NCT04031729·80 enrolled

MPA1 trial

Chlorthalidone and HCTZ Impacts on Platelet Activation

Unknown status·—·Phase 4·NCT02100462·30 enrolled

Multiple Sclerosis1 trial

Aspirin for Exercise in Multiple Sclerosis (ASPIRE)

Completed·—·Phase 3·NCT03824938·60 enrolled

Treatment1 trial

ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial

Terminated·BBelfast Health and Social Care Trust·Phase 2·NCT02326350·49 enrolled

Pomalidomide1 trial

Pomalidomide as an Immune-enhancing Agent for the Control of HIV

Recruiting·UUniversity of Aarhus·Phase 1/2·NCT06660498·32 enrolled

Acute Lung Injury1 trial

The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury

Completed·BBelfast Health and Social Care Trust·Phase 2·NCT01659307·33 enrolled

Lung Cancer1 trial

The Effect Of Aspirin On Survival in Lung Cancer

Withdrawn·LLiverpool Heart and Chest Hospital NHS Foundation Trust·Phase 3·NCT01058902

Cerebral Infarction1 trial

The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction

Suspended·SSclnow Biotechnology Co., Ltd.·Phase 1·NCT03186456·40 enrolled

Breast Cancer1 trial

L-NMMA Plus Taxane Chemotherapy in Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients

Completed·TThe Methodist Hospital Research Institute·Phase 1/2·NCT02834403·37 enrolled

Gut Microbiota1 trial

Influence of Aspirin on Human Gut Microbiota Composition and Metabolome

Unknown status·—·N/A·NCT03450317·100 enrolled

Acute Pancreatitis1 trial

The Effect of Aspirin on Recurrent Acute Pancreatitis

Recruiting·—·N/A·NCT06185621·23 enrolled

EGFR Mutation1 trial

Combination of Osimertinib and Aspirin to Treat EGFR Mutation NSCLC Patients

Completed·—·Phase 2·NCT04184921·216 enrolled

Oral Cancer1 trial

Addition of Aspirin to Standard of Care in Oral Cancer

Completed·—·Phase 2/3·NCT05865548·60 enrolled

Adult Subject1 trial

Comparative Pharmacokinetic, Pharmacodynamic, and Safety Study of 1 Dose of Aspirin for Injection and Oral Aspirin Tablets in Healthy Adult Subjects

Enrolling by invitation·RRhoshan Pharmaceuticals Inc·Phase 1·NCT07323680·40 enrolled

Placental Insufficiency1 trial

Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women

Completed·LLes Laboratoires des Médicaments Stériles·Phase 4·NCT03528967·89 enrolled

Gastric Cancer1 trial

Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients

Recruiting·NNational Cancer Center, Korea·Phase 3·NCT04214990·1,700 enrolled

Solid Tumours1 trial

Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours

Active, not recruiting·UUniversity College, London·Phase 3·NCT02804815·11,000 enrolled

Renal artery stenosis1 trial

Efficacy and Safety Study of Aspirin for the Prevention of Renal Artery Stenosis in Renal Transplantation Recipients

Unknown status·HHenan Provincial People's Hospital·Phase 4·NCT04260828·368 enrolled

Myeloproliferative Neoplasm1 trial

Assessing Feasibility of Thromboprophylaxis With Apixaban in JAK2-positive Myeloproliferative Neoplasm Patients

Completed·OOttawa Hospital Research Institute·Phase 2·NCT04243122·44 enrolled

Eczema1 trial

PGE2/IL-22 Pathway in Various Forms of Eczema

Completed·NNHS Lothian··NCT04133506·38 enrolled

Patent foramen ovale1 trial

Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen Ovale

Unknown status·—·Phase 4·NCT05546320·1,000 enrolled

Analgesic1 trial

Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing

Completed·—·Phase 1·NCT03130153·60 enrolled

Cardiovascular Events1 trial

Aspirin Continuation or Interruption in Patients at Moderate Risk for Cardiovascular Events Undergoing Colonoscopy and/or Polypectomy

Recruiting·—·Phase 3·NCT07052799·2,514 enrolled

Adverse Effect1 trial

Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease

Recruiting·RRajaie Cardiovascular Medical and Research Center·N/A·NCT06541691·3,000 enrolled

Endothelial Function1 trial

ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts

Completed·UUniversity Hospital of Ferrara·Phase 2·NCT02519608·44 enrolled

Meningitis1 trial

A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis

Completed·OOxford University Clinical Research Unit, Vietnam·Phase 2·NCT02237365·120 enrolled

Common Cold1 trial

Symptomatic Treatment of Common Cold Symptoms

Completed· Bayer logo

Bayer·Phase 4·NCT01033526·388 enrolled

Intestinal Cancer1 trial

EffectiveNess of Low Dose Aspirin in GastrointEstinal Cancer Prevention - Taiwan

Completed· Bayer logo

Bayer··NCT03579732·4,710,504 enrolled

Left Atrial Appendage Closure1 trial

Head-to-head Comparison of Single Versus Dual Antiplatelet Treatment Strategy After Percutaneous Left Atrial Appendage Closure: a Multicenter, Randomized Study

Unknown status·AAzienda Ospedaliero Universitaria Maggiore della Carita·Phase 3·NCT05554822·574 enrolled

Body Weight1 trial

Body Weight, Aspirin Dose and Pro-resolving Mediators

Completed·NNYU Langone Health·Phase 4·NCT04697719·103 enrolled

Pulmonary Embolism1 trial

Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

Completed·—·Phase 4·NCT02810704·18,883 enrolled

Preterm Delivery1 trial

Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

Recruiting·TThe George Washington University Biostatistics Center·Phase 3·NCT06980025·1,800 enrolled

Vascular Function1 trial

Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting

Completed·UUniversity of Illinois at Urbana-Champaign·Phase 4·NCT01276691·24 enrolled

Acute Myocardial Infarction1 trial

Adjunctive Cilostazol Versus High Maintenance-dose ClopidogrEL in Acute Myocardial Infarction (AMI) Patients According to CYP2C19 Polymorphism

Completed·GGyeongsang National University Hospital·Phase 4·NCT00915733·80 enrolled

Chronic Coronary Syndromes1 trial

WILL lOWer Dose Aspirin be Better With Rivaroxaban in Patients With Chronic Coronary Syndromes?

Completed·SSheffield Teaching Hospitals NHS Foundation Trust·Phase 4·NCT04990791·48 enrolled

Ototoxicity1 trial

Does Aspirin Have a Protective Role Against Chemotherapeutically Induced Ototoxicity?

Unknown status·UUniversity Health Network, Toronto·N/A·NCT00578760·110 enrolled

Psychosis1 trial

Randomized Controlled Trial of Aspirin vs Placebo in the Treatment of Pre-psychosis

Terminated·YYale University·Phase 1·NCT02047539·1 enrolled

Vaccine1 trial

Induction of Gut Permeability by an Oral Vaccine

Active, not recruiting·UUSDA, Western Human Nutrition Research Center·Phase 1·NCT04083950·10 enrolled

Type 2 Diabetes1 trial

Effects of Different Doses of Aspirin on Pathophysiological Markers in Type 2 Diabetes

Completed·—·N/A·NCT00898950·21 enrolled

Angiogenesis1 trial

The Effect of Aspirin on Angiogenesis Proteins in Women on Tamoxifen Therapy

Completed·UUniversity of Vermont·Phase 1·NCT00727948·11 enrolled

Unspecified6 trials

Measurement of Platelet Dense Granule Release in Healthy Volunteers

Withdrawn·VVanderbilt University·N/A·NCT00942617

Effects of Psyllium on Niacin Tolerability

Completed·VVA Greater Los Angeles Healthcare System·Phase 4·NCT03370848·26 enrolled

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT02164864·2,725 enrolled

Show 3 more trials

Weak Pulse at Yang and Wiry Pulse at Yin Theory

Completed·XXikun Li·N/A·NCT07378228·70 enrolled

Low-dose NOAC Versus GDMT After LAAO

Recruiting·XXijing Hospital·N/A·NCT05960721·4,220 enrolled

Establishing and Validating a Meal-provoked Intestinal Permeability Test for Nutritional and Metabolic Health Clinical Research.

Completed·LLaval University·N/A·NCT07066176·10 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

8-HOUR BAYER

NDA NDA016030

Oct 18, 2001

BAYER EXTRA STRENGTH ASPIRIN FOR MIGRAINE PAIN

NDA NDA021317

Sep 4, 2015

DURLAZA

NDA NDA200671

Feb 26, 2021

VAZALORE

NDA NDA203697

Sources

References

[1]
ClinicalTrials.gov — 664 trial records for Aspirin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Bayer Aspirin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Aspirin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Aspirin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA203697). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Bayer Aspirin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Bayer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Cyclooxygenase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Bayer

Patent Landscape[6]

Patent Cliff

Sep 29, 2032

Earliest patent expiration — generic entry possible after this date

Patent #Expires

9226892Sep 29, 2032

10786444Sep 29, 2032

10646431Sep 29, 2032

9216150Sep 29, 2032

Bayer Aspirin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Aspirin17 trials

Ischemic stroke13 trials

Preeclampsia9 trials

Coronary Artery Disease8 trials

Stroke7 trials

Clopidogrel6 trials

Chronic Kidney Disease3 trials

COVID-193 trials

Antiplatelet3 trials

Dual Antiplatelet Therapy3 trials

Cardiovascular Disease3 trials

Pregnancy3 trials

Acute Coronary Syndrome3 trials

Hypertension3 trials

Platelet Function2 trials

Inflammatory Mediators2 trials

Prevention2 trials

Multiple Myeloma2 trials

Migraine2 trials

Rivaroxaban2 trials

Systemic Lupus Erythematosus2 trials

Prophylaxis2 trials

Inflammation2 trials

Melanoma2 trials

Atrial Fibrillation2 trials

Interaction2 trials

Metabolic Syndrome1 trial

Vascular Disease1 trial

Cerebrovascular Event1 trial

Intrauterine Adhesion1 trial

Vascular Access1 trial

HIV infection1 trial

Bleeding1 trial

Disease Progression1 trial

Neurodevelopment1 trial

Platelet Inhibition1 trial

Transient Ischemic Attack1 trial

Nasopharyngeal Carcinoma1 trial

Atherosclerosis1 trial

TIPS1 trial

Peripheral Artery Disease1 trial

Platelet Reactivity1 trial

Metastatic Colorectal Cancer1 trial

Immune Response1 trial

Islet Transplantation1 trial

Vascular Dementia1 trial

Mitral regurgitation1 trial

Venous Thromboembolism1 trial

ART1 trial

Chest pain1 trial

Sleep1 trial

Platelet Aggregation1 trial

Type 2 Diabetic Patients1 trial

Adult1 trial

Angina Pectoris1 trial

Intracerebral Haemorrhage1 trial

Colorectal Polyps1 trial

Stent Thrombosis1 trial

Anticoagulation1 trial

Fallopian Tube1 trial

Heart1 trial

Coronary Artery Ectasia1 trial

Flushing1 trial

Monotherapy1 trial

Ataxia1 trial

Essential Hypertension1 trial

Thromboembolism1 trial

SARS CoV 2 Infection1 trial

Coronary Stenosis1 trial

Preterm Birth1 trial

Antiphospholipid Syndrome1 trial

Efficacy and Safety1 trial

Alcoholic Fatty Liver Disease1 trial