Bayer Aspirin

(Aspirin)

ApprovedSmall molecule

Aspirin is used to reduce pain, fever, and inflammation, and is also commonly taken in low doses to help prevent heart attacks and strokes by reducing blood clotting.[2] Bayer Aspirin is currently approved and in use across 226 indications[4].[1]

Bayer Aspirin is one of 2942 small molecule programs targeting Polycythemia Vera. It is currently in Approved.

226

Indications

654

Total Trials

Active Trials

2,941

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Polycythemia VeraActive, not recruiting

Acute PancreatitisActive, not recruiting

Cerebral Amyloid AngiopathyActive, not recruiting

Coronary Artery DiseaseActive, not recruiting

Total Joint ArthroplastyActive, not recruiting

Premature BirthApproved

Metabolic SyndromeActive, not recruiting

HIV InfectionActive, not recruiting

Systemic Lupus ErythematosusApproved

Disorder of Lipid MetabolismApproved

Polycythemia VeraPhase 2

Active, not recruiting

Acute PancreatitisPreclinical

Active, not recruiting

Cerebral Amyloid AngiopathyPreclinical

Active, not recruiting

Coronary Artery DiseaseApproved

Active, not recruiting

Total Joint ArthroplastyPhase 2

Active, not recruiting

Premature BirthApproved

Approved

Metabolic SyndromeApproved

Active, not recruiting

HIV InfectionPhase 2

Active, not recruiting

Systemic Lupus ErythematosusApproved

Approved

Disorder of Lipid MetabolismApproved

Approved

Showing 10 of 219 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Bayer Aspirin

Bayer

Approved

5 2

Trodelvy

Gilead

Preclinical

37 3

Megace

Bristol-Myers Squibb

Preclinical

4 4

MS Contin

Merck & Co.

Preclinical

2 5

Blenoxane

Bristol-Myers Squibb

Preclinical

1 6

Chantix

PPrism Pharmaceuticals

Preclinical

1 7

Vfend

PPrism Pharmaceuticals

Paracetamol

1 9

Motexafin Gadolinium

PPharmacyclics LLC.

Preclinical

1 10

Dextromethorphan Hydrobromide

Boehringer Ingelheim

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Percutaneous Coronary Intervention

NCT03378934

Q4 2026

Post-ApprovalRecruiting

Acute Coronary Syndrome

NCT04240834

Phase 2Active, not recruiting

Colorectal Adenoma

NCT02965703

Recruiting

Pregnancy

NCT04918524

Post-ApprovalNot yet recruiting

Preeclampsia

NCT07373756

Post-ApprovalRecruiting

Atrial Fibrillation

NCT05955365

Clinical

Trials by Indication[1]

Aspirin12 trials

Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM

Completed·UUniversity of Cape Town·Phase 2·NCT03927313·52 enrolled

Aspirin Statins Or Both For The Reduction Of Thrombin Generation In Diabetic People

Completed·FFundacion GESICA·Phase 4·NCT00793754·30 enrolled

Pharmacodynamics and Pharmacokinetics of Aspirin Inhalation Powder With Non-Enteric-Coated Chewable Aspirin

Completed·IInova Health Care Services·Phase 1·NCT04328883·19 enrolled

Show 9 more trials

Peri-operative Aspirin Continuation Versus Discontinuation

Terminated·RRabin Medical Center·Phase 4·NCT02350543·50 enrolled

An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03341390·20 enrolled

Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT02270242·9,006 enrolled

Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation

Completed·SSara Varea·Phase 2·NCT01616615·190 enrolled

Platelet Enzymatically Oxidized Phospholipids (eoxPL) Characterisation in a Healthy Cohort on and Off Aspirin

Completed·—·N/A·NCT05604118·28 enrolled

Aspirin for Venous Ulcers: Randomised Trial (AVURT)

Terminated·SSt George's, University of London·Phase 2·NCT02333123·26 enrolled

The Effect of Aspirin on Patency of Metal Stent in Malignant Distal Bile Duct Obstruction

Terminated·WWoo Hyun Paik·N/A·NCT03279809·52 enrolled

A Study of Aleglitazar in Combination With Aspirin in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01188304·44 enrolled

Aspirin in Young Psychotic Patients

Completed·CClinic for Psychiatric Disorders, Dr Laza Lazarevic·Phase 2/3·NCT02685748·60 enrolled

Stroke11 trials

Enoxaparin Versus Aspirin in Patients With Cancer and Stroke

Completed·MMemorial Sloan Kettering Cancer Center·N/A·NCT01763606·20 enrolled

Secondary Prevention of Small Subcortical Strokes Trial

Completed·UUniversity of British Columbia·Phase 3·NCT00059306·3,020 enrolled

Combining Aspirin With Ticagrelor or Clopidogrel in Large-vessel Minor Stroke or TIA

Recruiting·KKafrelsheikh University·Phase 3·NCT06591338·900 enrolled

Show 8 more trials

Platelet Hyperreactivity to Aspirin and Stroke

Completed·UUniversity of Sao Paulo·Phase 4·NCT00766896·203 enrolled

Cilostazol vs. Aspirin in Acute Non-cardioembolic Stroke With Cerebral mIcrobleeds

Recruiting·ZZhejiang Provincial People's Hospital·Phase 3·NCT06530537·848 enrolled

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT02671461·16 enrolled

Aspirin Combined With Clopidogrel Versus Intravenous Alteplase for Acute Minor Stroke

Not yet recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 4·NCT05910125·472 enrolled

Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2)

Completed· Otsuka logo

Otsuka·Phase 4·NCT00234065·2,800 enrolled

A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT03766581·2,366 enrolled

MidregiOnal Proatrial Natriuretic Peptide to Guide SEcondary Stroke Prevention

Unknown status·UUniversity of Zurich·Phase 3·NCT03961334·620 enrolled

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

Terminated·—·Phase 3·NCT03192215·1,015 enrolled

Ischemic stroke6 trials

Mildronate for Acute Ischemic Stroke

Completed·XXijing Hospital·Phase 2·NCT01831011·227 enrolled

Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime)

Recruiting·UUniversity of Alberta·Phase 2·NCT06638151·200 enrolled

Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke Patients

Completed·TTianjin Medical University General Hospital·Phase 2/3·NCT02878772·60 enrolled

Show 3 more trials

PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage

Unknown status·—·Phase 4·NCT01013532·1,600 enrolled

Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)

Recruiting·—·Phase 3·NCT06548971·1,184 enrolled

PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study

Unknown status·—·Phase 4·NCT02483169·800 enrolled

Atrial Fibrillation5 trials

The Effect and Safety of Different Intensity Anticoagulation Therapy in Elderly Patients With Non-valvular Atrial Fibrillation

Completed·NNanjing Medical University·Phase 4·NCT01438580·260 enrolled

Stroke Prevention In Ischemic Stroke With Covert Atrial Fibrillation

Not yet recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT06486792·1,148 enrolled

Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation

Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT05955365·3,010 enrolled

Show 2 more trials

S.I.F.A. II: Prevention Of Thromboembolic Events In Patients With Nonrheumatic Atrial Fibrillation

Completed· Pfizer logo

Pfizer·Phase 3·NCT00244426·1,372 enrolled

Atrial Fibrillation (AF) Patients Not Taking Vitamin-K Antagonist (VKA)

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00623779·128 enrolled

Clopidogrel5 trials

Aspirin Versus Aspirin + ClopidogRel Following Transcatheter Aortic Valve Implantation: the ARTE Trial

Completed·CCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec·Phase 4·NCT01559298·178 enrolled

Comparative Pharmacokinetics Study of Clopidogrel and Aspirin Fixed-dose Combination Versus Separate Combination

Completed· Chong Kun Dang Pharmaceutical logo

Chong Kun Dang Pharmaceutical·Phase 1·NCT01663038·60 enrolled

Clopidogrel Use and Long-term Safety After Drug-Eluting Stents Implantation

Completed·SSeung-Jung Park·Phase 4·NCT00590174·1,175 enrolled

Show 2 more trials

Resistance to Aspirin and/or Clopidogrel Among Patients With PAD.

Completed·—·Phase 4·NCT00262561·263 enrolled

Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.

Completed·UUllevaal University Hospital·Phase 4·NCT00222261·1,001 enrolled

111 more indications

Pregnancy4 trials

The Clinical Features and Pregnancy Outcomes of CTD Patients

Recruiting·QQilu Hospital of Shandong University··NCT04918524·126 enrolled

The Novel Immunomodulatory and Anticoagulant Therapies for Recurrent Pregnancy Loss

Unknown status·SShanghai First Maternity and Infant Hospital·Phase 4·NCT02990403·500 enrolled

Antenatal Platelet Response On Aspirin and Correlation With HDP (Hypertensive Disorders of Pregnancy)

Completed·TThomas Jefferson University··NCT04295850·130 enrolled

Show 1 more trial

Low Dose Aspirin for Prevention of Early Pregnancy Loss

Unknown status·EEgymedicalpedia·N/A·NCT06261203·250 enrolled

Preeclampsia4 trials

Randomized Controlled Study to Compare Efficacy of Aspirin 75mg and 150mg In the Prevention of Preeclampsia In High Risk Pregnant Women

Not yet recruiting·—·Phase 4·NCT07373756·86 enrolled

Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida

Completed·TThe University of Texas Health Science Center, Houston·Phase 2/3·NCT03961360·220 enrolled

Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology

Recruiting·UUniversity Hospital, Toulouse·Phase 3·NCT05625724·1,164 enrolled

Show 1 more trial

Combined Multi-marker Screening and Treatment With Aspirin for Pre-eclampsia Prevention

Completed·RRabin Medical Center·Phase 3·NCT02301780·2 enrolled

Peripheral Arterial Disease4 trials

A Study to Compare the Effects of Sarpogrelate Sustained Release /Aspirin Combination Therapy Versus Aspirin on Blood Viscosity in the Patients With Peripheral Arterial Disease and Coronary Artery Disease

Completed·YYuhan Corporation·Phase 4·NCT05730621·68 enrolled

Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study)

Completed·—·Phase 4·NCT00687076·102 enrolled

The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD)

Completed·AArteriogenesis Competence Network·Phase 4·NCT00189618·250 enrolled

Show 1 more trial

Personalizing Aspirin Therapy in Peripheral Arterial Disease Patients

Unknown status·UUnity Health Toronto·N/A·NCT04269863·150 enrolled

Platelet Function3 trials

Impact of isoQUercetin and Aspirin on Platelet Function

Withdrawn·UUniversity of Reading·N/A·NCT02866448

Platelet Function and Safety After IV and Oral Diclofenac, IV Ketorolac and Oral Aspirin in Adult Volunteers

Completed·JJavelin Pharmaceuticals·Phase 1·NCT00548678·30 enrolled

Effects of Omacor and Aspirin on Platelet Function

Completed·SSanford Research·Phase 1·NCT00688961·10 enrolled

Antiplatelet3 trials

Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM)

Completed·SSeoul National University Hospital·Phase 4·NCT02044250·5,530 enrolled

Pharmacogenomics of Antiplatelet Response - II (PARes-II)

Completed·JJohns Hopkins University·Phase 4·NCT01894555·33 enrolled

The Accuracy Of A Novel Platelet Activity Assay In Humans On Antiplatelet Agents: Pharmacodynamics And Comparison With Light Transmission Aggregometry

Completed·—·Phase 1·NCT04822363·112 enrolled

Interaction3 trials

Clopidogrel and Aspirin Interaction Study-2

Completed·PPopulation Health Research Institute·Phase 4·NCT01341964·302 enrolled

DS1040b/Aspirin Drug/Drug Interaction Study

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT02071004·18 enrolled

Study to Evaluate the Interaction Between Aspirin and Nexium

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01199328·34 enrolled

Percutaneous Coronary Intervention3 trials

Platelet Inhibition of Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients After Elective Percutaneous Coronary Intervention

Completed·PPeking Union Medical College Hospital·Phase 4·NCT02748330·40 enrolled

Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary Intervention

Recruiting·PPeking Union Medical College Hospital·Phase 4·NCT03378934·64 enrolled

Aspirin Reload Before Percutaneous Coronary Intervention: Reperfusion Indexes Evaluation.

Completed·UUniversity of Roma La Sapienza·Phase 4·NCT01374698·100 enrolled

Antiplatelet Therapy3 trials

Postpolypectomy Bleeding in Patients With Antiplatelet Therapy

Unknown status·SSoonchunhyang University Hospital·N/A·NCT01465256·500 enrolled

Antiplatelet Therapy in HIV

Completed·NNYU Langone Health·Phase 2·NCT02559414·55 enrolled

A Study to Assess Administration of an Oral Anti-thrombotic With Antiplatelet Therapy in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03698513·113 enrolled

Atherosclerosis3 trials

The Effect and Safety of Combined Anti-platelet Treatment in Acute Ischemic Stroke Due to Large Artery Atherosclerosis

Recruiting·—·Phase 4·NCT06757764·2,340 enrolled

Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis

Recruiting·TTongji Hospital··NCT04847752·1,000 enrolled

Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes

Completed·SSeoul National University Bundang Hospital·Phase 4·NCT03248401·50 enrolled

Coronary Artery Bypass3 trials

Antiplatelet Effect of Low Doses of Aspirin Taken Every 12 Hours in Patients Undergoing Coronary Artery Bypass Graft and/or Aortic Valve Surgery

Unknown status·CCentro Cardiologico Monzino·Phase 2·NCT01466452·99 enrolled

Preoperative Aspirin and Postoperative Antiplatelets in Coronary Artery Bypass Grafting: The PAPA CABG Study

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT00330772·150 enrolled

Aspirin and Plavix Following Coronary Artery Bypass Grafting

Terminated·AAhmad Slim·Phase 4·NCT01158703·20 enrolled

Coronary Artery Disease3 trials

The Clopidogrel and Aspirin After Surgery for Coronary Artery Disease

Unknown status·CChina National Center for Cardiovascular Diseases·Phase 3·NCT00776477·300 enrolled

Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·Phase 1·NCT03078257·90 enrolled

Effect of Sarpogrelate, a Serotonin Receptor Antagonist, on Coronary Artery Disease

Completed·SSeoul National University Bundang Hospital·Phase 4·NCT02607436·40 enrolled

Colorectal Cancer3 trials

ASPirin Intervention for the REDuction of Colorectal Cancer Risk

Active, not recruiting·MMassachusetts General Hospital·N/A·NCT02394769·180 enrolled

Aspirin on CTCs of Advanced Breast and Colorectal Cancer

Unknown status·ZZhejiang Provincial People's Hospital·Phase 2·NCT02602938·40 enrolled

Trial of Aspirin and Arginine Restriction in Colorectal Cancer

Completed·UUniversity of California, Irvine·Phase 2·NCT00578721·24 enrolled

Cardiovascular Disease2 trials

Effect of Apple Flavanols on Risk of Cardiovascular Disease

Completed·QQuadram Institute Bioscience·N/A·NCT00568152·26 enrolled

Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance

Completed·EEmory University·N/A·NCT00122447·84 enrolled

Type 2 Diabetes2 trials

COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes

Recruiting·MMontreal Heart Institute·Phase 3·NCT05633810·10,000 enrolled

Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes

Unknown status·UUniversity of Roma La Sapienza·Phase 3·NCT02895113·418 enrolled

Antithrombotic2 trials

Resistance to Antithrombotic Therapy

Completed·MMedical University of Vienna·N/A·NCT00858715·46 enrolled

Dual Antithrombotic Therapy With Dabigatran and Ticagrelor in Patients With ACS and Non-valvular AF Undergoing PCI

Recruiting·MMedical University of Gdansk·Phase 4·NCT04695106·2,230 enrolled

Myocardial Infarction2 trials

Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor

Completed·UUniversity of Florida·Phase 4·NCT02545933·130 enrolled

Safety of Ticagrelor Monotherapy After Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction and the Effect on Intramyocardial Haemorrhage

Recruiting·RRadboud University Medical Center·N/A·NCT05986968·200 enrolled

Rivaroxaban2 trials

INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority

Withdrawn·PPopulation Health Research Institute·Phase 3·NCT02832531

Rivaroxaban or Aspirin for Biological Aortic Prosthesis

Unknown status·CChristian Torp-Pedersen·Phase 4·NCT02974920·1,000 enrolled

Dual Antiplatelet Therapy2 trials

Reversal of Dual Antiplatelet Therapy With Cold Stored Platelets

Unknown status·BBloodworks·Phase 1/2·NCT03787927·60 enrolled

Additional Benefit of Cilostazol to Dual Antiplatelet Therapy After Biolimus-eluting Stent Implantation

Completed·YYonsei University·Phase 4·NCT01192724·630 enrolled

Venous Thromboembolism2 trials

Aspirin for the Prevention of Recurrent Venous Thromboembolism

Unknown status·UUniversity Of Perugia·Phase 2/3·NCT00222677·70 enrolled

Aspirin Prophylaxis for Venous Thromboembolism in Glioblastoma

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT00790452·1 enrolled

Inflammation2 trials

Synergistic Influence of Rivaroxaban on Inflammation and Coagulation Biomarkers in Patients With CAD and PAD on Aspirin Therapy

Unknown status·LLifeBridge Health·Phase 4·NCT04059679·30 enrolled

Physiological Effects of Altering Cancer-related Inflammation

Unknown status·NNHS Greater Glasgow and Clyde·N/A·NCT01786200·60 enrolled

Type 2 Diabetes Mellitus2 trials

Efficacy and Safety of Alogliptin vs. Acarbose in Chinese Type 2 Diabetes Mellitus (T2DM) Patients With High CV Risk or CHD Treated With Aspirin and Inadequately Controlled With Metformin Monotherapy or Drug Naive

Completed· Sanofi logo

Sanofi·Phase 4·NCT03794336·1,293 enrolled

Type 2 Diabetes Mellitus and Atherosclerosis

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01250340·80 enrolled

Multiple Myeloma2 trials

MTD, Safety, and Efficacy of Pomalidomide (CC-4047) Alone or With Low-dose Dexamethasone in Patients With Relapsed and Refractory Multiple Myeloma

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1/2·NCT00833833·259 enrolled

Bendamustine in Combination With Lenalidomide and Dexamethasone in Refractory or Relapsed Multiple Myeloma

Completed·RRobert Redner, MD·Phase 1·NCT01042704·29 enrolled

Portal vein thrombosis2 trials

Apixaban, Warfarin and Aspirin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy（ESAWAAPT）

Completed·NNorthern Jiangsu People's Hospital·Phase 4·NCT04645550·120 enrolled

Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy

Unknown status·YYangzhou University·Phase 4·NCT02238444·60 enrolled

Microcirculation2 trials

Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

Completed·UUniversity Hospital, Angers··NCT00152724·85 enrolled

The Effect of Triflusal on Peripheral Microcirculation Dysfunction

Completed·YYonsei University·Phase 4·NCT01612273·92 enrolled

Biomarkers2 trials

A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 1·NCT06378398·21 enrolled

Impact of COX2 on Sera Biomarkers From Obese Subjects

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT02062255·126 enrolled

Colorectal Adenoma2 trials

Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT02965703·81 enrolled

APACC Study:Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence

Terminated·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00224679·300 enrolled

Acute Coronary Syndrome2 trials

Aspirin Impact on Platelet Reactivity in Acute Coronary Syndrome Patients on Novel P2Y12 Inhibitors Therapy

Completed·SSheba Medical Center·Phase 4·NCT02049762·29 enrolled

Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention

Recruiting·FFu Wai Hospital, Beijing, China·Phase 4·NCT04240834·1,220 enrolled

ART2 trials

Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3)

Completed·UUniversity of Edinburgh·N/A·NCT01096706·10 enrolled

Distal Venous Arterialisation of Ischemic Limb

Unknown status·CClinical Centre of Serbia·Phase 2/3·NCT01211925·30 enrolled

Intestinal Cancer1 trial

EffectiveNess of Low Dose Aspirin in GastrointEstinal Cancer Prevention - Taiwan

Completed· Bayer logo

Bayer··NCT03579732·4,710,504 enrolled

Asthma1 trial

Electrophilic Fatty Acid Derivatives in Asthma

Completed·SSally E. Wenzel MD·Phase 1·NCT01733485·50 enrolled

MPA1 trial

Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT02169271·109 enrolled

Preoperative1 trial

Preoperative Aspirin and Benzydamine Hydrochloride Gargles on Severity and Duration of Post-Operative Sore Throat

Unknown status·RRehman Medical Institute - RMI·Phase 4·NCT05343429·60 enrolled

Myelosuppression1 trial

A Study of Low Dose Lenalidomide and Dexamethasone in Relapsed/Refractory Myeloma in Patients at High Risk for Myelosuppression

Completed·PPeter MacCallum Cancer Centre, Australia·Phase 2·NCT00482261·150 enrolled

Heart Disease1 trial

Length of Effect of Extended Release Aspirin on Platelets in Patients With Diabetes and Heart Disease

Completed·NNew Haven Pharmaceuticals, Inc.·Phase 1·NCT02370680·41 enrolled

Moyamoya disease1 trial

The Safety and Efficacy of RIC on Adult Moyamoya Disease

Completed·—·N/A·NCT04012268·30 enrolled

Polycythemia Vera1 trial

Clopidogrel and Aspirin for the Treatment of Polycythemia Vera

Withdrawn·RRonald Hoffman·Phase 2·NCT00940784

Cardiovascular Events1 trial

ASCEND: A Study of Cardiovascular Events iN Diabetes

Active, not recruiting·UUniversity of Oxford·Phase 4·NCT00135226·15,480 enrolled

Cardiac1 trial

Multiple Daily Doses Of Aspirin To Overcome Aspirin Hyporesponsiveness Post Cardiac Bypass Surgery

Completed·HHamilton Health Sciences Corporation·Phase 2·NCT01618006·120 enrolled

Mitral Valve Repair1 trial

Safety and Effectiveness of Early Aspirin Administration After Mitral Valve Repair

Recruiting·GGuangdong Provincial People's Hospital·Phase 4·NCT06738992·384 enrolled

Anticoagulation1 trial

Anticoagulation Alone Versus Anticoagulation and Aspirin Following Transcatheter Aortic Valve Interventions (1:1)

Completed·—·Phase 4·NCT02735902·170 enrolled

Triple-Negative Breast Cancer1 trial

A Proof of Concept Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer

Withdrawn·TThe Christie NHS Foundation Trust·Phase 2·NCT04188119

Pneumonia1 trial

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting·UUMC Utrecht·Phase 3·NCT02735707·20,000 enrolled

Cerebral Infarction1 trial

Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS)

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 3·NCT00129805·1,510 enrolled

Mood Disorder1 trial

Anti-inflmmation Treatment in Mood Disorder and Deep Learning Prediction Model

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT04685642·180 enrolled

Aneurysm1 trial

Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).

Unknown status·UUniversity Hospital Southampton NHS Foundation Trust·Phase 2·NCT03661463·58 enrolled

Common Cold1 trial

Symptomatic Treatment of Common Cold Symptoms

Completed· Bayer logo

Bayer·Phase 4·NCT01033526·388 enrolled

Miscarriage1 trial

Aspirin, Heparin and Miscarriage

Unknown status·UUniversity of Khartoum·Phase 4·NCT01917799·150 enrolled

Coronary Artery Lesions1 trial

The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL)

Completed·BBoston Scientific Corporation·Phase 3·NCT01500434·102 enrolled

Cataract1 trial

Randomized Trial of Aspirin and Cataracts in U.S. Physicians

Terminated·NNational Eye Institute (NEI)·Phase 3·NCT00000157

Respiratory Disease1 trial

The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases

Completed·TTehran University of Medical Sciences·Phase 4·NCT01867281·32 enrolled

Drug Interactions1 trial

Drug-drug Interactions Between DWP14012 and Aspirin in Healthy Subjects

Completed· Daewoong Pharmaceutical Co. LTD. logo

Daewoong Pharmaceutical Co. LTD.·Phase 1·NCT05304845·24 enrolled

Unknown status·QQilu Hospital of Shandong University··NCT05644210·80 enrolled

Cardiac Surgery1 trial

Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery

Unknown status·WWestern University, Canada·N/A·NCT03128346·100 enrolled

Intermittent Claudication1 trial

Influence of Rivaroxaban for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic PAD

Unknown status·PPoznan University of Medical Sciences··NCT04305028·100 enrolled

Oral Anticoagulation1 trial

Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation

Unknown status·DDeutsches Herzzentrum Muenchen·Phase 4·NCT00776633·614 enrolled

Gastrointestinal1 trial

Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants

Completed· Regeneron logo

Regeneron·Phase 1·NCT06444178·224 enrolled

Type 1 Diabetes1 trial

Retinal Blood Flow and Microthrombi in Type 1 Diabetes

Completed·—·Phase 2·NCT00406991·100 enrolled

Enoxaparin1 trial

Aspirin and Enoxaparin for VTE in Trauma

Terminated·UUniversity of Miami·Phase 4·NCT02396732·31 enrolled

Non-Small Cell Lung Cancer1 trial

Combination of Osimertinib and Aspirin to Treat Osimertinib Resistance Non-small Cell Lung Cancer ( NSCLC)

Unknown status·—··NCT03532698·100 enrolled

Platelet Aggregation1 trial

Effect of Steady State Meloxicam on Low Dose Aspirin Induced Inhibition of Platelet Aggregation and Thromboxane Synthesis in Healthy Males and Females

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02187562·16 enrolled

Thrombosis1 trial

CV004-007 Thrombosis Chamber Study

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02439190·42 enrolled

Osimertinib1 trial

Combination of Osimertinib and Aspirin to Treat 1st Generation EGFR-TKI Resistance in NSCLC

Completed·—·Phase 2·NCT03543683·115 enrolled

Venous Leg Ulcers1 trial

Low Dose Aspirin for Venous Leg Ulcers

Completed·UUniversity of Auckland, New Zealand·Phase 3·NCT02158806·251 enrolled

Macular Degeneration1 trial

Randomized Trial of Beta-Carotene and Macular Degeneration

Unknown status·NNational Eye Institute (NEI)·Phase 3·NCT00000152

Osteonecrosis1 trial

Aspirin in the Prevention of Collapse in Osteonecrosis of the Hip

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT03405974·114 enrolled

Anticoagulant1 trial

Anticoagulant After Implantation of Biological Aortic Valve Comparing With Aspirin

Completed·RRigshospitalet, Denmark·Phase 4·NCT01452568·370 enrolled

Cerebral ischemia1 trial

The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients

Completed·—·Phase 4·NCT03116269·80 enrolled

Carotid Stenosis1 trial

Recurrent Carotid Stenosis

Completed·EEmory University·Phase 2·NCT00000527

Uterine Cancer1 trial

Study of Pembrolizumab, Radiation and Immune Modulatory Cocktail in Cervical/Uterine Cancer

Completed·UUniversity Hospital, Ghent·Phase 2·NCT03192059·43 enrolled

Breast Cancer1 trial

Study of Aspirin and Exemestane as Adjuvant Treatment in Breast Cancer

Unknown status·CChinese Academy of Medical Sciences·Phase 2·NCT01431053·160 enrolled

Diabetic Retinopathy1 trial

Early Treatment Diabetic Retinopathy Study (ETDRS)

Completed·NNational Eye Institute (NEI)·Phase 3·NCT00000151

High Cardiovascular Risk1 trial

Microvascular and Antiinflammatory Effects of Rivaroxaban Compared to Aspirin in Type-2 Diabetic Patients With Subclinical Inflammation and High Cardiovascular Risk

Completed·GGWT-TUD GmbH·Phase 3·NCT02164578·179 enrolled

ESS1 trial

Immunosuppressant Regimens for Living Fetuses Study

Unknown status·RRenJi Hospital·N/A·NCT03671174·420 enrolled

Idiopathic Pulmonary Arterial Hypertension1 trial

A Study of Aspirin and Clopidogrel in Patients With Idiopathic Pulmonary Arterial Hypertension

Completed·—·Phase 2·NCT00105209·20 enrolled

Aggressive Periodontitis1 trial

Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis

Completed·UUniversidade Estadual Paulista Júlio de Mesquita Filho·Phase 2/3·NCT03093207·34 enrolled

Postmenopausal Women1 trial

Effect of Aspirin on Mammogram Density in Healthy Postmenopausal Women With a Moderate or High Level of Breast Density

Completed·FFred Hutchinson Cancer Center·N/A·NCT00470561·144 enrolled

Growth1 trial

Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction

Unknown status·—·Phase 2·NCT02678221·100 enrolled

Bipolar Disorder1 trial

N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder

Completed·TThe University of Texas Health Science Center, Houston·Phase 2·NCT01797575·38 enrolled

Adult1 trial

Asprin Dosing Estimator in Healthy Adults

Completed·UUniversity of Utah·Phase 1·NCT04040465·57 enrolled

Ultrasound1 trial

Feasibility of ExAblate MRI Guided High Intensity Focused Ultrasound Tx of Soft Tissue Tumors

Terminated·PPejman Ghanouni·N/A·NCT01965002·5 enrolled

Obesity1 trial

Mediators of Abnormal Reproductive Function in Obesity (MARO)

Completed·UUniversity of Colorado, Denver·Phase 1·NCT01817400·10 enrolled

Septic Shock1 trial

ASpirin for Patients With SEPsis and SeptIc Shock

Terminated·FFederal University of São Paulo·Phase 2·NCT01784159·167 enrolled

Gefitinib1 trial

Gefitinib Combined With Thalidomide to Treat NSCLC

Unknown status·BBai Jun·Phase 2/3·NCT02387086·380 enrolled

Anterior Ischemic Optic Neuropathy1 trial

Effect of EECP on Anterior Ischemic Optic Neuropathy

Unknown status·FFirst Affiliated Hospital, Sun Yat-Sen University·N/A·NCT01768260·40 enrolled

Prevention1 trial

Chronotherapy with Low-dose Aspirin for Primary Prevention

Active, not recruiting·UUnknown Sponsor·Phase 4·NCT00725127·3,200 enrolled

Anti-inflammatory Therapy1 trial

Anti-inflammatory Therapy for Recurrent In-stent Restenosis

Recruiting·FFu Wai Hospital, Beijing, China·Phase 4·NCT06090890·252 enrolled

Cerebral Small Vessel Disease1 trial

Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases

Recruiting·TThe First Affiliated Hospital with Nanjing Medical University··NCT06715007·300 enrolled

Resistance1 trial

The Effects of Omega-3 Fatty Acids on Aspirin Resistance

Completed·UUniversity of Rochester·Phase 1/2·NCT00771914·27 enrolled

Hepatocellular Carcinoma1 trial

Sorafenib Combined With Aspirin to Prevent the Recurrence in High-risk Patients With Hepatocellular Carcinoma

Terminated·FFudan University·N/A·NCT02748304·52 enrolled

Heart Failure1 trial

Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients With Assist Device

Recruiting·—·Phase 4·NCT06655376·128 enrolled

Induction Chemotherapy1 trial

Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer

Terminated·IInstituto Nacional de Cancer, Brazil·Phase 2·NCT03170115·25 enrolled

Acute1 trial

Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler

Completed·IInje University·Phase 4·NCT00741286·203 enrolled

Oxidative Stress1 trial

Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization

Completed·UUniversity of Roma La Sapienza·N/A·NCT02630862·240 enrolled

Kawasaki Disease1 trial

Multi-center Prospective Randomized Control Trail of High Dose Aspirin in Acute Stage of Kawasaki Disease

Unknown status·—·N/A·NCT02359643·300 enrolled

Effectiveness1 trial

The Effectiveness of Aspirin on Preventing Pre-eclampsia

Unknown status·TThe Third Affiliated Hospital of Guangzhou Medical University·Phase 4·NCT04656665·600 enrolled

TIPS1 trial

The International Polycap Study 3 (TIPS-3)

Completed·PPopulation Health Research Institute·Phase 3·NCT01646437·7,793 enrolled

Vascular Dementia1 trial

Cilostazol Verse Asprin for Vascular Dementia in Poststroke Patients With White Matter Lesions

Completed·PPeking University First Hospital·Phase 4·NCT00847860·200 enrolled

Ankle Fracture1 trial

Postoperative Aspirin and Ankle Fracture Healing

Completed·UUniversity of Alabama at Birmingham·Phase 1·NCT03765619·500 enrolled

Chest pain1 trial

Women With Chest Pain and Normal Coronary Arteries Study

Terminated·NNorthwestern University·N/A·NCT00743197·3 enrolled

Thromboembolism1 trial

The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity

Not yet recruiting·UUniversity of Calgary·Phase 3·NCT06494878·8,805 enrolled

Treatment1 trial

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT02081638·53 enrolled

Diabetes Mellitus1 trial

Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus

Completed·UUniversity of Florida·Phase 4·NCT02548650·66 enrolled

Plaque1 trial

Effect of Cilostazol on Coronary Artery Stenosis and Plaque Characteristics in Patients With T2DM

Completed·SSeoul National University Bundang Hospital·Phase 3·NCT02266030·100 enrolled

Inflammatory Response1 trial

Preventing the Inflammatory Response to Experimentally-induced Insomnia Symptoms

Completed·—·Phase 1·NCT02268565·8 enrolled

Essential Thrombocythemia1 trial

Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

Completed·RRonald Hoffman·Phase 3·NCT01259856·168 enrolled

Oral1 trial

Dose-escalation, Repeated and Single Oral Dosing Study

Terminated· IlDong Pharmaceutical Co Ltd logo

IlDong Pharmaceutical Co Ltd·Phase 1·NCT02419820·104 enrolled

Platelet Reactivity1 trial

Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty

Completed·LLifeBridge Health·Phase 4·NCT01809054·54 enrolled

Ventricular Tachycardia1 trial

DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation

Completed·KKansas City Heart Rhythm Institute·Phase 4·NCT02666742·246 enrolled

Unspecified8 trials

Pioglitazone vs Placebo in Combination With Niacin Extended Release on Low HDL

Completed·UUniversity of Pennsylvania·Phase 2·NCT00300365·38 enrolled

Biosynthesis of PGD2 in Vivo

Completed·UUniversity of Pennsylvania·N/A·NCT01275300·9 enrolled

Physicians' Health Study

Completed·—·Phase 3·NCT00000500

Show 5 more trials

Genetic and Dietary Predictors of Anti-platelet Response

Terminated·UUniversity of Washington·Phase 4·NCT04456608·126 enrolled

Preventive Application of Letrozole Decrease Incidence of Early Onset of OHSS

Completed·FFirst Affiliated Hospital, Sun Yat-Sen University·Phase 4·NCT02670304·100 enrolled

Phase I Methodology Study to Validate the Cantharidin Blister Model in Healthy Volunteers

Completed· GSK logo

GSK·Phase 1·NCT01762787·40 enrolled

PROMUS Element Plus US Post-Approval Study

Completed·BBoston Scientific Corporation·Phase 4·NCT01589978·2,681 enrolled

Cilostazol Following Peripheral Endovascular Procedures

Unknown status·—·Phase 3·NCT02770274·200 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

8-HOUR BAYER

NDA NDA016030

Oct 18, 2001

BAYER EXTRA STRENGTH ASPIRIN FOR MIGRAINE PAIN

NDA NDA021317

Sep 4, 2015

DURLAZA

NDA NDA200671

Feb 26, 2021

VAZALORE

NDA NDA203697

Sources

References

[1]
ClinicalTrials.gov — 654 trial records for Aspirin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Bayer Aspirin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Aspirin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Aspirin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA203697). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Bayer Aspirin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Bayer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Cyclooxygenase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Bayer

Patent Landscape[6]

Patent Cliff

Sep 29, 2032

Earliest patent expiration — generic entry possible after this date

Patent #Expires

9226892Sep 29, 2032

10786444Sep 29, 2032

10646431Sep 29, 2032

9216150Sep 29, 2032

Bayer Aspirin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Aspirin12 trials

Stroke11 trials

Ischemic stroke6 trials

Atrial Fibrillation5 trials

Clopidogrel5 trials

Pregnancy4 trials

Preeclampsia4 trials

Peripheral Arterial Disease4 trials

Platelet Function3 trials

Antiplatelet3 trials

Interaction3 trials

Percutaneous Coronary Intervention3 trials

Antiplatelet Therapy3 trials

Atherosclerosis3 trials

Coronary Artery Bypass3 trials

Coronary Artery Disease3 trials

Colorectal Cancer3 trials

Cardiovascular Disease2 trials

Type 2 Diabetes2 trials

Antithrombotic2 trials

Myocardial Infarction2 trials

Rivaroxaban2 trials

Dual Antiplatelet Therapy2 trials

Venous Thromboembolism2 trials

Inflammation2 trials

Type 2 Diabetes Mellitus2 trials

Multiple Myeloma2 trials

Portal vein thrombosis2 trials

Microcirculation2 trials

Biomarkers2 trials

Colorectal Adenoma2 trials

Acute Coronary Syndrome2 trials

ART2 trials

Intestinal Cancer1 trial

Asthma1 trial

MPA1 trial

Preoperative1 trial

Myelosuppression1 trial

Heart Disease1 trial

Moyamoya disease1 trial

Polycythemia Vera1 trial

Cardiovascular Events1 trial

Cardiac1 trial

Mitral Valve Repair1 trial

Anticoagulation1 trial

Triple-Negative Breast Cancer1 trial

Pneumonia1 trial

Cerebral Infarction1 trial

Mood Disorder1 trial

Aneurysm1 trial

Common Cold1 trial

Miscarriage1 trial

Coronary Artery Lesions1 trial

Cataract1 trial

Respiratory Disease1 trial

Drug Interactions1 trial

Endometriosis1 trial

Chronic Kidney Disease1 trial

Telitacicept1 trial

Cardiac Surgery1 trial

Intermittent Claudication1 trial

Oral Anticoagulation1 trial

Gastrointestinal1 trial

Type 1 Diabetes1 trial

Enoxaparin1 trial

Non-Small Cell Lung Cancer1 trial

Platelet Aggregation1 trial

Thrombosis1 trial

Osimertinib1 trial

Venous Leg Ulcers1 trial

Macular Degeneration1 trial

Osteonecrosis1 trial

Anticoagulant1 trial