Bayer Aspirin

(Aspirin)

ApprovedSmall molecule

Aspirin is used to reduce pain, fever, and inflammation, and is also commonly taken in low doses to help prevent heart attacks and strokes by reducing blood clotting.[2] Bayer Aspirin is currently approved and in use across 190 indications[4].[1]

Bayer Aspirin is one of 1917 small molecule programs targeting Type 2 Diabetes Mellitus. It is currently in Approved.

190

Indications

670

Total Trials

Active Trials

1,916

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Type 2 Diabetes MellitusTerminated

Barrett EsophagusActive, not recruiting

HypertensiveRecruiting

PreeclampsiaCompleted

Metabolic SyndromeCompleted

Renal Artery StenosisActive, not recruiting

Cerebral IschemiaActive, not recruiting

Coronary StenosisActive, not recruiting

Mood DisorderActive, not recruiting

Chagas DiseaseActive, not recruiting

Type 2 Diabetes MellitusApproved

Terminated

Barrett EsophagusPhase 2

Active, not recruiting

HypertensiveApproved

Recruiting

PreeclampsiaApproved

Completed

Metabolic SyndromeApproved

Completed

Renal Artery StenosisApproved

Active, not recruiting

Cerebral IschemiaApproved

Active, not recruiting

Coronary StenosisApproved

Active, not recruiting

Mood DisorderApproved

Active, not recruiting

Chagas DiseaseApproved

Active, not recruiting

Showing 10 of 183 indications

Competition

Competitive Landscape

414 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Alecensa

Roche

Phase 3

22 2

Bayer Aspirin

Bayer

Approved

1 3

Benadryl

PParkedale

Phase 3

2 4

Aumolertinib

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Phase 3

6 5

Remeron

OOrganon and Co

Preclinical

1 6

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Preclinical

—7

Ftorafur

TThe First Affiliated Hospital with Nanjing Medical University

Preclinical

—8

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Treatment

1 10

PD-1 Inhibitors

BBioNTech US Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Lynch Syndrome

NCT05411718

Post-ApprovalRecruiting

Acute Coronary Syndrome

NCT04240834

Recruiting

Pregnancy

NCT04918524

Post-ApprovalRecruiting

Atrial Fibrillation

NCT05955365

Q1 2027

Phase 2Recruiting

Total Joint Arthroplasty

NCT04295486

Post-ApprovalRecruiting

Antiplatelet Therapy

NCT06723145

Clinical

Trials by Indication[1]

Stroke11 trials

Aspirin Or Warfarin To Prevent Stroke

Terminated·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 3·NCT00004728

A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT03766581·2,366 enrolled

Secondary Prevention of Small Subcortical Strokes Trial

Completed·UUniversity of British Columbia·Phase 3·NCT00059306·3,020 enrolled

Show 8 more trials

Cilostazol vs. Aspirin in Acute Non-cardioembolic Stroke With Cerebral mIcrobleeds

Recruiting·ZZhejiang Provincial People's Hospital·Phase 3·NCT06530537·848 enrolled

MidregiOnal Proatrial Natriuretic Peptide to Guide SEcondary Stroke Prevention

Unknown status·UUniversity of Zurich·Phase 3·NCT03961334·620 enrolled

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT02671461·16 enrolled

Edoxaban for TIA and Acute Minor Stroke

Unknown status·XXijing Hospital·Phase 2/3·NCT02221102·3,700 enrolled

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting·YYale University·Phase 3·NCT03907046·700 enrolled

Apixaban for Treatment of Embolic Stroke of Undetermined Source

Completed·UUniversity Hospital Tuebingen·Phase 3·NCT02427126·352 enrolled

Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2)

Completed· Otsuka logo

Otsuka·Phase 4·NCT00234065·2,800 enrolled

Cilostazol Stroke Prevention Study for Antiplatelet Combination

Completed·JJapan Cardiovascular Research Foundation·Phase 4·NCT01995370·1,884 enrolled

Aspirin11 trials

The Effect of Aspirin on Patency of Metal Stent in Malignant Distal Bile Duct Obstruction

Terminated·WWoo Hyun Paik·N/A·NCT03279809·52 enrolled

Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM

Completed·UUniversity of Cape Town·Phase 2·NCT03927313·52 enrolled

Pharmacokinetics of Dipyridamole Administered as Aggrenox® (Dipyridamole Extended Release Plus Aspirin) Capsule Versus Dipyridamole Immediate Release Plus Aspirin Following Alteration of Stomach pH

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 4·NCT02251184·31 enrolled

Show 8 more trials

Peri-operative Aspirin Continuation Versus Discontinuation

Terminated·RRabin Medical Center·Phase 4·NCT02350543·50 enrolled

Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term

Completed·—·N/A·NCT02697916·15,076 enrolled

To Compare the Gastroprotective Effects and Pharmacokinetic Profile of PA Versus Enteric-Coated Aspirin

Completed·PPOZEN·Phase 1·NCT00442052·80 enrolled

Value of Cabergoline and Low Dose Aspirin in Poor Responders Undergoing ICSI-ET With GnRH Agonist Flare-Up-Protocol

Unknown status·—·Phase 4·NCT03263299·120 enrolled

Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT02270242·9,006 enrolled

Aspirin Dosing in Diabetic Patients

Completed·UUniversity of Florida·Phase 4·NCT01201785·20 enrolled

Mobilization of Endothelial Progenitor Cells and Aspirin

Terminated·OOttawa Heart Institute Research Corporation·Phase 3·NCT02674958·6 enrolled

Aspirin for Venous Ulcers: Randomised Trial (AVURT)

Terminated·SSt George's, University of London·Phase 2·NCT02333123·26 enrolled

Atrial Fibrillation6 trials

Atrial Fibrillation (AF) Patients Not Taking Vitamin-K Antagonist (VKA)

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00623779·128 enrolled

S.I.F.A. II: Prevention Of Thromboembolic Events In Patients With Nonrheumatic Atrial Fibrillation

Completed· Pfizer logo

Pfizer·Phase 3·NCT00244426·1,372 enrolled

Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation

Completed·PPopulation Health Research Institute·Phase 4·NCT01938248·4,012 enrolled

Show 3 more trials

The Effect and Safety of Different Intensity Anticoagulation Therapy in Elderly Patients With Non-valvular Atrial Fibrillation

Completed·NNanjing Medical University·Phase 4·NCT01438580·260 enrolled

Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation

Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT05955365·3,010 enrolled

Stroke Prevention In Ischemic Stroke With Covert Atrial Fibrillation

Not yet recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT06486792·1,148 enrolled

Acute Coronary Syndrome6 trials

Trial to Assess the Safety and Effects of Vorapaxar in Japanese Subjects With Acute Coronary Syndrome (P04772; MK-5348-016)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00684203·120 enrolled

IndObufen Versus asPirin After Coronary Drug-eluting Stent implantaTION in Elderly Patients With Acute Coronary Syndrome

Recruiting·SShanghai Zhongshan Hospital·Phase 4·NCT06451198·2,846 enrolled

Evaluation of Safety and Efficacy of Two Ticagrelor-based De-escalation Antiplatelet Strategies in Acute Coronary Syndrome

Unknown status·CCollegium Medicum w Bydgoszczy·Phase 3·NCT04718025·4,500 enrolled

Show 3 more trials

Less Bleeding by Omitting Aspirin in Non-ST-segment Elevation Acute Coronary Syndrome Patients

Unknown status·—·Phase 4·NCT05125276·3,090 enrolled

Aspirin Impact on Platelet Reactivity in Acute Coronary Syndrome Patients on Novel P2Y12 Inhibitors Therapy

Completed·SSheba Medical Center·Phase 4·NCT02049762·29 enrolled

Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention

Recruiting·FFu Wai Hospital, Beijing, China·Phase 4·NCT04240834·1,220 enrolled

Ischemic stroke5 trials

Mildronate for Acute Ischemic Stroke

Completed·XXijing Hospital·Phase 2·NCT01831011·227 enrolled

Cilostazol in Acute Ischemic Stroke Treatment (CAIST)

Completed·KKorea Otsuka Pharmaceutical Co., Ltd.·Phase 4·NCT00272454·468 enrolled

The Effect of Ginkgolide on Clinical Improvement of Patients With Acute Ischemic Stroke

Unknown status·SShanghai Yueyang Integrated Medicine Hospital·Phase 2/3·NCT05663307·80 enrolled

Show 2 more trials

Efficacy of DLBS1033 in Patients With Acute Ischemic Stroke

Completed·DDexa Medica Group·Phase 3·NCT01790997·126 enrolled

Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke Patients

Completed·TTianjin Medical University General Hospital·Phase 2/3·NCT02878772·60 enrolled

105 more indications

Antiplatelet Therapy5 trials

Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis

Completed·—·Phase 4·NCT02053909·250 enrolled

Colonoscopy and Antiplatelet Therapy Trial

Not yet recruiting·OOchsner Health System·Phase 4·NCT06613191·100 enrolled

Double Randomization of a Monitoring Adjusted Antiplatelet Treatment Versus a Common Antiplatelet Treatment for DES Implantation, and Interruption Versus Continuation of Double Antiplatelet Therapy

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT00827411·2,500 enrolled

Show 2 more trials

Antiplatelet Therapy in HIV

Completed·NNYU Langone Health·Phase 2·NCT02559414·55 enrolled

Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent Implantation

Recruiting·KKyoto University·Phase 4·NCT06723145·1,200 enrolled

Clopidogrel5 trials

Aspirin Versus Aspirin + ClopidogRel Following Transcatheter Aortic Valve Implantation: the ARTE Trial

Completed·CCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec·Phase 4·NCT01559298·178 enrolled

Comparative Pharmacokinetics Study of Clopidogrel and Aspirin Fixed-dose Combination Versus Separate Combination

Completed· Chong Kun Dang Pharmaceutical logo

Chong Kun Dang Pharmaceutical·Phase 1·NCT01663038·60 enrolled

Clopidogrel and Aspirin Together: The Effect on C-Reactive Protein Trial

Completed·IIntermountain Health Care, Inc.·Phase 4·NCT00343876·100 enrolled

Show 2 more trials

Resistance to Aspirin and/or Clopidogrel Among Patients With PAD.

Completed·—·Phase 4·NCT00262561·263 enrolled

Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.

Completed·UUllevaal University Hospital·Phase 4·NCT00222261·1,001 enrolled

Preeclampsia4 trials

Combined Multi-marker Screening and Treatment With Aspirin for Pre-eclampsia Prevention

Completed·RRabin Medical Center·Phase 3·NCT02301780·2 enrolled

Low Dose Aspirin for the Prevention of Preeclampsia

Unknown status·SSaint Thomas Hospital, Panama·Phase 3·NCT01890005·476 enrolled

Early Prevention of Preeclampsia Study

Terminated·WWashington University School of Medicine·N/A·NCT01547390·104 enrolled

Show 1 more trial

Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology

Recruiting·UUniversity Hospital, Toulouse·Phase 3·NCT05625724·1,164 enrolled

Atherosclerosis4 trials

Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE)

Completed·—·Phase 2·NCT00054938·150 enrolled

Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis

Recruiting·TTongji Hospital··NCT04847752·1,000 enrolled

Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial

Completed·KKumamoto University·Phase 4·NCT00110448·2,539 enrolled

Show 1 more trial

Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes

Completed·SSeoul National University Bundang Hospital·Phase 4·NCT03248401·50 enrolled

Coronary Artery Disease3 trials

Effect of Sarpogrelate, a Serotonin Receptor Antagonist, on Coronary Artery Disease

Completed·SSeoul National University Bundang Hospital·Phase 4·NCT02607436·40 enrolled

A Study to Evaluate BMS-986141 Added on to Aspirin or Ticagrelor or the Combination, on Thrombus Formation in a Thrombosis Chamber Model in Participants With Stable Coronary Artery Disease and Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT05093790·58 enrolled

The Clopidogrel and Aspirin After Surgery for Coronary Artery Disease

Unknown status·CChina National Center for Cardiovascular Diseases·Phase 3·NCT00776477·300 enrolled

Antithrombotic3 trials

Dual Antithrombotic Therapy With Dabigatran and Ticagrelor in Patients With ACS and Non-valvular AF Undergoing PCI

Recruiting·MMedical University of Gdansk·Phase 4·NCT04695106·2,230 enrolled

Resistance to Antithrombotic Therapy

Completed·MMedical University of Vienna·N/A·NCT00858715·46 enrolled

Aspirin Versus Aspirin+Clopidogrel as Antithrombotic Treatment Following TAVI

Completed·CCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec·Phase 4·NCT02640794·222 enrolled

Antiplatelet3 trials

Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM)

Completed·SSeoul National University Hospital·Phase 4·NCT02044250·5,530 enrolled

The Accuracy Of A Novel Platelet Activity Assay In Humans On Antiplatelet Agents: Pharmacodynamics And Comparison With Light Transmission Aggregometry

Completed·—·Phase 1·NCT04822363·112 enrolled

Pharmacogenomics of Antiplatelet Response

Completed·JJohns Hopkins University·Phase 4·NCT02234427·34 enrolled

Platelet Function3 trials

Impact of isoQUercetin and Aspirin on Platelet Function

Withdrawn·UUniversity of Reading·N/A·NCT02866448

Platelet Function and Safety After IV and Oral Diclofenac, IV Ketorolac and Oral Aspirin in Adult Volunteers

Completed·JJavelin Pharmaceuticals·Phase 1·NCT00548678·30 enrolled

Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate in STEMI Patients

Unknown status·FFundacion Investigacion Interhospitalaria Cardiovascular·Phase 2/3·NCT02929888·60 enrolled

Dual Antiplatelet Therapy3 trials

3-Month Discontinuation of Dual Antiplatelet Therapy After Ultimaster Sirolimus-Eluting Stent Implantation

Unknown status·TTeikyo University··NCT02837003·1,500 enrolled

Reversal of Dual Antiplatelet Therapy With Cold Stored Platelets

Unknown status·BBloodworks·Phase 1/2·NCT03787927·60 enrolled

Additional Benefit of Cilostazol to Dual Antiplatelet Therapy After Biolimus-eluting Stent Implantation

Completed·YYonsei University·Phase 4·NCT01192724·630 enrolled

Cardiac3 trials

Aspirin Responsiveness in Women at Risk for Cardiac Events

Completed·—·Phase 4·NCT00818337·36 enrolled

Multiple Daily Doses of Aspirin to Overcome Hyporesponsiveness Post Cardiac Bypass Surgery (ASACABG)- Part B

Completed·HHamilton Health Sciences Corporation·Phase 2·NCT01902498·70 enrolled

Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial

Completed·—·Phase 3·NCT00041938·2,305 enrolled

Peripheral Arterial Disease3 trials

A Study to Compare the Effects of Sarpogrelate Sustained Release /Aspirin Combination Therapy Versus Aspirin on Blood Viscosity in the Patients With Peripheral Arterial Disease and Coronary Artery Disease

Completed·YYuhan Corporation·Phase 4·NCT05730621·68 enrolled

The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD)

Completed·AArteriogenesis Competence Network·Phase 4·NCT00189618·250 enrolled

Personalizing Aspirin Therapy in Peripheral Arterial Disease Patients

Unknown status·UUnity Health Toronto·N/A·NCT04269863·150 enrolled

Prevention3 trials

ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)

Completed·UUniversity of Ioannina·Phase 4·NCT02616497·1,220 enrolled

Japanese Primary Prevention Project With Aspirin

Unknown status·MMinistry of Health, Labour and Welfare, Japan·Phase 4·NCT00225849·10,000 enrolled

Chronotherapy with Low-dose Aspirin for Primary Prevention

Active, not recruiting·UUnknown Sponsor·Phase 4·NCT00725127·3,200 enrolled

Coronary Artery Bypass3 trials

Antiplatelet Effect of Low Doses of Aspirin Taken Every 12 Hours in Patients Undergoing Coronary Artery Bypass Graft and/or Aortic Valve Surgery

Unknown status·CCentro Cardiologico Monzino·Phase 2·NCT01466452·99 enrolled

The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass

Unknown status·—·Phase 3·NCT01268917·200 enrolled

Preoperative Aspirin and Postoperative Antiplatelets in Coronary Artery Bypass Grafting: The PAPA CABG Study

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT00330772·150 enrolled

Treatment2 trials

Effect of Upstream Treatment With High Intensity Statin on the Outcomes of STMI Patients Treated With PPCI

Unknown status·—·Phase 3·NCT04754789·160 enrolled

Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction

Completed·—·Phase 4·NCT05310968·970 enrolled

Type 2 Diabetes2 trials

Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes

Unknown status·UUniversity of Roma La Sapienza·Phase 3·NCT02895113·418 enrolled

GLP-1 and Microvascular Function in Type 2 Diabetes

Completed·RRoyal Devon and Exeter NHS Foundation Trust·N/A·NCT01740921·39 enrolled

Kawasaki Disease2 trials

Multi-center Prospective Randomized Control Trail of High Dose Aspirin in Acute Stage of Kawasaki Disease

Unknown status·—·N/A·NCT02359643·300 enrolled

Efficacy of Immunoglobulin Plus Infliximab for the Early Regression of Coronary Artery Lesion in Kawasaki Disease

Withdrawn·—·Phase 3·NCT04535518

Lynch syndrome2 trials

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT05411718·40 enrolled

Finding the Best Dose of Aspirin to Prevent Lynch Syndrome Cancers

Not yet recruiting·TTel-Aviv Sourasky Medical Center·Phase 3·NCT02497820·1,800 enrolled

Cardiovascular Disease2 trials

Effect of Apple Flavanols on Risk of Cardiovascular Disease

Completed·QQuadram Institute Bioscience·N/A·NCT00568152·26 enrolled

Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance

Completed·EEmory University·N/A·NCT00122447·84 enrolled

Coronary Artery Lesions2 trials

The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL)

Completed·BBoston Scientific Corporation·Phase 3·NCT01500434·102 enrolled

PLATINUM Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions-Pharmacokinetics (PLATINUM PK)

Completed·BBoston Scientific Corporation·Phase 3·NCT01510327·22 enrolled

Cerebral Small Vessel Disease2 trials

Efficacy Study of Cilostazol and Aspirin on Cerebral Small Vessel Disease

Unknown status·IInha University Hospital·Phase 4·NCT01932203·255 enrolled

Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases

Recruiting·TThe First Affiliated Hospital with Nanjing Medical University··NCT06715007·300 enrolled

Resistance2 trials

Genotypic and Phenotypic Correlates of Resistance to Aspirin

Completed·GGeorge Washington University·N/A·NCT01361620·190 enrolled

The Effects of Omega-3 Fatty Acids on Aspirin Resistance

Completed·UUniversity of Rochester·Phase 1/2·NCT00771914·27 enrolled

Multiple Myeloma2 trials

MTD, Safety, and Efficacy of Pomalidomide (CC-4047) Alone or With Low-dose Dexamethasone in Patients With Relapsed and Refractory Multiple Myeloma

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1/2·NCT00833833·259 enrolled

Bendamustine in Combination With Lenalidomide and Dexamethasone in Refractory or Relapsed Multiple Myeloma

Completed·RRobert Redner, MD·Phase 1·NCT01042704·29 enrolled

Interaction2 trials

Clopidogrel and Aspirin Interaction Study-2

Completed·PPopulation Health Research Institute·Phase 4·NCT01341964·302 enrolled

DS1040b/Aspirin Drug/Drug Interaction Study

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT02071004·18 enrolled

Patent foramen ovale2 trials

Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00562289·664 enrolled

Patent Foramen Ovale in Cryptogenic Stroke Study

Completed·—·Phase 4·NCT00697151·630 enrolled

Trial2 trials

Platelet-Inhibitor Drug Trial in Coronary Angioplasty

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000510

Primary Thrombocythaemia 1 Trial

Completed·UUniversity of Cambridge·N/A·NCT00175838·1,398 enrolled

Type 2 Diabetes Mellitus2 trials

Efficacy and Safety of Dorner Tablets and Aspirin for Prevention of Arteriosclerosis Progress in Type 2 Diabetes Mellitus Patients

Terminated· Astellas logo

Astellas·Phase 4·NCT02786979·190 enrolled

Type 2 Diabetes Mellitus and Atherosclerosis

Unknown status·UUniversity of Roma La Sapienza·Phase 4·NCT01250340·80 enrolled

Colorectal Cancer2 trials

DAILY: Vitamin D, Aspirin, ExercIse, Low Saturated Fat Foods StudY in Colorectal Cancer Patients With Minimal Residual Disease

Completed·MM.D. Anderson Cancer Center·N/A·NCT05036109·16 enrolled

ASPirin Intervention for the REDuction of Colorectal Cancer Risk

Active, not recruiting·MMassachusetts General Hospital·N/A·NCT02394769·180 enrolled

Thrombosis2 trials

CV004-007 Thrombosis Chamber Study

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02439190·42 enrolled

Anti-Platelet and Statin Therapy to Prevent Cancer-Associated Thrombosis

Completed·—·Phase 1·NCT02285738·17 enrolled

Microcirculation2 trials

The Effect of Triflusal on Peripheral Microcirculation Dysfunction

Completed·YYonsei University·Phase 4·NCT01612273·92 enrolled

Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

Completed·UUniversity Hospital, Angers··NCT00152724·85 enrolled

Growth2 trials

Aspirin in Asymmetrically Intrauterine Growth

Completed·—·Phase 2·NCT03038607·60 enrolled

Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction

Unknown status·—·Phase 2·NCT02678221·100 enrolled

Chronic Kidney Disease2 trials

Whole Blood Platelet Aggregation in Chronic Kidney Disease Patients on Aspirin Study

Completed·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT01768637·48 enrolled

Primary Cardiovascular Risk Prevention With Aspirin in Chronic Kidney Disease Patients

Unknown status·FFundación de Ayuda a la Investigación sobre la Hipertensión, Riesgo Cardiovascular y Enfermedades Renales·Phase 3·NCT01709994·97 enrolled

Flushing2 trials

Evaluation of a Flushing ASsessment Tool (FAST) in Subjects Receiving Niacin Extended-release Plus Aspirin

Completed·AAbbott·Phase 3·NCT00630877·276 enrolled

Study to Evaluate the EFFECTS of Acetylsalicylic Acid (ASA) on Niaspan®-Induced Flushing in Subjects With Dyslipidemia

Completed·AAbbott·Phase 3·NCT00626392·277 enrolled

Heart Disease1 trial

Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate Injection

Unknown status·CChina Academy of Chinese Medical Sciences·Phase 4·NCT02694848·120 enrolled

Platelet Aggregation1 trial

Loss of Effect of Aspirin on Platelet Aggregation During Chronic Administration

Terminated·VVanderbilt University·Phase 4·NCT00748371·51 enrolled

Oxidative Stress1 trial

Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization

Completed·UUniversity of Roma La Sapienza·N/A·NCT02630862·240 enrolled

Acute1 trial

Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler

Completed·IInje University·Phase 4·NCT00741286·203 enrolled

Preoperative1 trial

Preoperative Aspirin and Benzydamine Hydrochloride Gargles on Severity and Duration of Post-Operative Sore Throat

Unknown status·RRehman Medical Institute - RMI·Phase 4·NCT05343429·60 enrolled

Effectiveness1 trial

The Effectiveness of Aspirin on Preventing Pre-eclampsia

Unknown status·TThe Third Affiliated Hospital of Guangzhou Medical University·Phase 4·NCT04656665·600 enrolled

Anti-inflammatory Therapy1 trial

Anti-inflammatory Therapy for Recurrent In-stent Restenosis

Recruiting·FFu Wai Hospital, Beijing, China·Phase 4·NCT06090890·252 enrolled

Induction Chemotherapy1 trial

Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer

Terminated·IInstituto Nacional de Cancer, Brazil·Phase 2·NCT03170115·25 enrolled

Rivaroxaban1 trial

INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority

Withdrawn·PPopulation Health Research Institute·Phase 3·NCT02832531

Mood Disorder1 trial

Anti-inflmmation Treatment in Mood Disorder and Deep Learning Prediction Model

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT04685642·180 enrolled

Pregnancy1 trial

The Clinical Features and Pregnancy Outcomes of CTD Patients

Recruiting·QQilu Hospital of Shandong University··NCT04918524·126 enrolled

Hepatocellular Carcinoma1 trial

Sorafenib Combined With Aspirin to Prevent the Recurrence in High-risk Patients With Hepatocellular Carcinoma

Terminated·FFudan University·N/A·NCT02748304·52 enrolled

Asthma1 trial

Electrophilic Fatty Acid Derivatives in Asthma

Completed·SSally E. Wenzel MD·Phase 1·NCT01733485·50 enrolled

Mitral Valve Repair1 trial

Safety and Effectiveness of Early Aspirin Administration After Mitral Valve Repair

Recruiting·GGuangdong Provincial People's Hospital·Phase 4·NCT06738992·384 enrolled

Respiratory Disease1 trial

The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases

Completed·TTehran University of Medical Sciences·Phase 4·NCT01867281·32 enrolled

Heart Failure1 trial

Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients With Assist Device

Recruiting·—·Phase 4·NCT06655376·128 enrolled

Telitacicept1 trial

Telitacicept Followed With Rituximab Therapy on APS Secondary to SLE

Unknown status·QQilu Hospital of Shandong University··NCT05644210·80 enrolled

Anticoagulation1 trial

Anticoagulation Alone Versus Anticoagulation and Aspirin Following Transcatheter Aortic Valve Interventions (1:1)

Completed·—·Phase 4·NCT02735902·170 enrolled

Cerebral Infarction1 trial

Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS)

Completed· Tanabe Pharma Corporation logo

Tanabe Pharma Corporation·Phase 3·NCT00129805·1,510 enrolled

Cognitive impairment1 trial

Efficacy and Safety of Cilostazol in Patients of Vascular Cognitive Impairment-no Dementia (VCIND)

Unknown status·HHuashan Hospital·N/A·NCT01872858·200 enrolled

Cardiomyopathy1 trial

Aspirin Withdrawal in Non-ischaemic Cardiomyopathy Study

Completed·TThe Alfred·Phase 4·NCT01534026·12 enrolled

Coronary Revascularization1 trial

Twelve vs 24 Months of Dual Antiplatelet Therapy in Patients With Coronary Revascularization for In-stent Restenosis

Unknown status·—·Phase 4·NCT02402491·1,000 enrolled

Habitual Abortion1 trial

Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion

Completed·UUniversity of Helsinki·Phase 3·NCT00959621·220 enrolled

COVID-191 trial

Randomised Evaluation of COVID-19 Therapy

Recruiting·UUniversity of Oxford·Phase 3·NCT04381936·70,000 enrolled

Cardiovascular Events1 trial

ASCEND: A Study of Cardiovascular Events iN Diabetes

Active, not recruiting·UUniversity of Oxford·Phase 4·NCT00135226·15,480 enrolled

Vascular Disease1 trial

Anti-Inflammatory and Anti-Platelet Effect of Clopidogrel and Aspirin vs Aspirin Alone in Symptomatic Polyvascular Disease and in Patients With Multiple Recurrent Cardiovascular Events

Unknown status·—·Phase 3·NCT00775762·213 enrolled

Cerebrovascular Event1 trial

Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events

Unknown status·XXijing Hospital·Phase 2/3·NCT01923818·3,700 enrolled

Intrauterine Adhesion1 trial

Effects of Aspirin on Uterine Endometrial Repair Severe Intrauterine Adhesion

Completed·FFirst Affiliated Hospital, Sun Yat-Sen University·N/A·NCT02744716·114 enrolled

Vascular Access1 trial

Antiaggregation in Primary Prevention of Vascular Access for Hemodialysis

Unknown status·TTunis University·Phase 4·NCT02055131·300 enrolled

Intermittent Claudication1 trial

Influence of Rivaroxaban for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic PAD

Unknown status·PPoznan University of Medical Sciences··NCT04305028·100 enrolled

Moyamoya disease1 trial

The Safety and Efficacy of RIC on Adult Moyamoya Disease

Completed·—·N/A·NCT04012268·30 enrolled

Gastrointestinal1 trial

Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants

Completed· Regeneron logo

Regeneron·Phase 1·NCT06444178·224 enrolled

Type 1 Diabetes1 trial

Retinal Blood Flow and Microthrombi in Type 1 Diabetes

Completed·—·Phase 2·NCT00406991·100 enrolled

Intravenous1 trial

A Short and Long Intravenous Infusion Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of BMS-962212 in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03197779·691 enrolled

Enoxaparin1 trial

Aspirin and Enoxaparin for VTE in Trauma

Terminated·UUniversity of Miami·Phase 4·NCT02396732·31 enrolled

Cancer1 trial

ASPREE Cancer Endpoints Study

Unknown status·HHennepin Healthcare Research Institute·Phase 4·NCT01968798·14,500 enrolled

Brain Infarction1 trial

Antiplatelet Therapy for Silent Brain Infarction

Unknown status·FFirst People's Hospital of Shenyang·N/A·NCT03318744·3,400 enrolled

Prostate1 trial

Effects of ASA on Prostate Tissue

Completed·UUniversity of Washington·N/A·NCT00234299·60 enrolled

Hip Arthroplasty1 trial

Outcomes Study in Patients Receiving Aspirin With Mechanical Compression Devices Versus Aspirin Alone Following Knee and Hip Arthroplasty

Withdrawn·WWashington University School of Medicine·Phase 4·NCT03027167

Liver Cancer1 trial

Clinical Study of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery

Unknown status·FFudan University·Phase 3·NCT01936233·112 enrolled

Pericarditis1 trial

Benign Acute Pericarditis: Brief Versus Longer Treatment Using Aspirin

Terminated·UUniversity Hospital, Brest·Phase 4·NCT00946907·34 enrolled

Macular Degeneration1 trial

Randomized Trial of Beta-Carotene and Macular Degeneration

Unknown status·NNational Eye Institute (NEI)·Phase 3·NCT00000152

Portal vein thrombosis1 trial

Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy

Unknown status·YYangzhou University·Phase 4·NCT02238444·60 enrolled

MPR1 trial

Evaluating the Need for Pneumatic Compression Devices

Completed·WWest Virginia University·N/A·NCT02641080·80 enrolled

Paralysis1 trial

The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia

Completed·RRadboud University Medical Center·N/A·NCT02922673·30 enrolled

Total Joint Arthroplasty1 trial

Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty

Recruiting·UUniversity of Miami·Phase 2·NCT04295486·5,478 enrolled

Cerebral ischemia1 trial

The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients

Completed·—·Phase 4·NCT03116269·80 enrolled

Miscarriage1 trial

Aspirin Versus Clopidogrel Effect on Uterine Blood Flow in Women With Unexplained Recurrent Miscarriages

Unknown status·—·Phase 2/3·NCT01635426·32 enrolled

Carotid Stenosis1 trial

Recurrent Carotid Stenosis

Completed·EEmory University·Phase 2·NCT00000527

Aspirin Hypersensitivity1 trial

Aspirin Desensitization Registry in Patients With Aspirin Hypersensitivity

Completed·IItalian Society of Cardiology··NCT02848339·330 enrolled

Diabetic Retinopathy1 trial

Early Treatment Diabetic Retinopathy Study (ETDRS)

Completed·NNational Eye Institute (NEI)·Phase 3·NCT00000151

Gut Microbiome1 trial

Effect of Aspirin on Gut Microbiome

Completed·UUniversity of Minnesota·Phase 1·NCT02761486·50 enrolled

Drug Metabolism1 trial

Alcohol Inhibits Drug Metabolism by Carboxylesterases

Completed·UUniversity of Tennessee·Phase 1·NCT01708369·19 enrolled

Diabetes Mellitus1 trial

Study Design of 'Influence of Sarpogrelate in Patients With Renal Impairment or Diabetes Mellitus' Study

Completed·SSeoul National University Bundang Hospital·Phase 3·NCT02294643·220 enrolled

High Bleeding Risk1 trial

Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen

Completed·EECRI bv·N/A·NCT03023020·4,579 enrolled

High Cardiovascular Risk1 trial

Microvascular and Antiinflammatory Effects of Rivaroxaban Compared to Aspirin in Type-2 Diabetic Patients With Subclinical Inflammation and High Cardiovascular Risk

Completed·GGWT-TUD GmbH·Phase 3·NCT02164578·179 enrolled

ESS1 trial

Immunosuppressant Regimens for Living Fetuses Study

Unknown status·RRenJi Hospital·N/A·NCT03671174·420 enrolled

Idiopathic Pulmonary Arterial Hypertension1 trial

A Study of Aspirin and Clopidogrel in Patients With Idiopathic Pulmonary Arterial Hypertension

Completed·—·Phase 2·NCT00105209·20 enrolled

Postmenopausal Women1 trial

Effect of Aspirin on Mammogram Density in Healthy Postmenopausal Women With a Moderate or High Level of Breast Density

Completed·FFred Hutchinson Cancer Center·N/A·NCT00470561·144 enrolled

Biomarkers1 trial

Impact of COX2 on Sera Biomarkers From Obese Subjects

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT02062255·126 enrolled

Percutaneous Coronary Intervention1 trial

Aspirin Reload Before Percutaneous Coronary Intervention: Reperfusion Indexes Evaluation.

Completed·UUniversity of Roma La Sapienza·Phase 4·NCT01374698·100 enrolled

Bipolar Disorder1 trial

N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder

Completed·TThe University of Texas Health Science Center, Houston·Phase 2·NCT01797575·38 enrolled

Venous Thromboembolism1 trial

Aspirin Prophylaxis for Venous Thromboembolism in Glioblastoma

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT00790452·1 enrolled

Adult1 trial

Asprin Dosing Estimator in Healthy Adults

Completed·UUniversity of Utah·Phase 1·NCT04040465·57 enrolled

Non-Small Cell Lung Cancer1 trial

Combination of Osimertinib and Aspirin to Treat Osimertinib Resistance Non-small Cell Lung Cancer ( NSCLC)

Unknown status·—··NCT03532698·100 enrolled

Ultrasound1 trial

Feasibility of ExAblate MRI Guided High Intensity Focused Ultrasound Tx of Soft Tissue Tumors

Terminated·PPejman Ghanouni·N/A·NCT01965002·5 enrolled

Obesity1 trial

Mediators of Abnormal Reproductive Function in Obesity (MARO)

Completed·UUniversity of Colorado, Denver·Phase 1·NCT01817400·10 enrolled

Septic Shock1 trial

ASpirin for Patients With SEPsis and SeptIc Shock

Terminated·FFederal University of São Paulo·Phase 2·NCT01784159·167 enrolled

Anterior Ischemic Optic Neuropathy1 trial

Effect of EECP on Anterior Ischemic Optic Neuropathy

Unknown status·FFirst Affiliated Hospital, Sun Yat-Sen University·N/A·NCT01768260·40 enrolled

Inflammation1 trial

Physiological Effects of Altering Cancer-related Inflammation

Unknown status·NNHS Greater Glasgow and Clyde·N/A·NCT01786200·60 enrolled

Gefitinib1 trial

Gefitinib Combined With Thalidomide to Treat NSCLC

Unknown status·BBai Jun·Phase 2/3·NCT02387086·380 enrolled

Complication1 trial

Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery.

Active, not recruiting·PPetrovsky National Research Centre of Surgery··NCT07358416·500 enrolled

Unspecified6 trials

Biosynthesis of PGD2 in Vivo

Completed·UUniversity of Pennsylvania·N/A·NCT01275300·9 enrolled

PROMUS Element Plus US Post-Approval Study

Completed·BBoston Scientific Corporation·Phase 4·NCT01589978·2,681 enrolled

Physicians' Health Study

Completed·—·Phase 3·NCT00000500

Show 3 more trials

Preventive Application of Letrozole Decrease Incidence of Early Onset of OHSS

Completed·FFirst Affiliated Hospital, Sun Yat-Sen University·Phase 4·NCT02670304·100 enrolled

Phase I Methodology Study to Validate the Cantharidin Blister Model in Healthy Volunteers

Completed· GSK logo

GSK·Phase 1·NCT01762787·40 enrolled

Simplified Anti-Thrombotic Therapy for FFR

Completed·OOdessa Heart Institute·N/A·NCT02384070·300 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

8-HOUR BAYER

NDA NDA016030

Oct 18, 2001

BAYER EXTRA STRENGTH ASPIRIN FOR MIGRAINE PAIN

NDA NDA021317

Sep 4, 2015

DURLAZA

NDA NDA200671

Feb 26, 2021

VAZALORE

NDA NDA203697

Sources

References

[1]
ClinicalTrials.gov — 670 trial records for Aspirin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Bayer Aspirin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Aspirin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Aspirin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA203697). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Bayer Aspirin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Bayer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Cyclooxygenase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Bayer

Patent Landscape[6]

Patent Cliff

Sep 29, 2032

Earliest patent expiration — generic entry possible after this date

Patent #Expires

9226892Sep 29, 2032

10786444Sep 29, 2032

10646431Sep 29, 2032

9216150Sep 29, 2032