VivoSeq
Other

Ototoxicity

24

Pipeline Programs↗

2

Active Trials↗

19

Companies Involved↗

Ototoxicity is an emerging landscape with 24 programs across 19 companies. The most active players are MC2 Therapeutics, LEO Pharma, Vyne Therapeutics Inc.. 3 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

49/100

Pipeline Velocity

0/100

Mech. Concentration

20/100

Completion Rate

82/100

Attrition Rate

14/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

M

MC2 Therapeutics

2 programs

Phase 1LEO Pharma logo

LEO Pharma

1 program

Phase 1V

Vyne Therapeutics Inc.

1 program

Phase 1P

Prism Pharmaceuticals

1 program

Phase 1P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

Phase 1D

Deciphera Pharmaceuticals, LLC

1 program

Phase 1

Pipeline

Programs by Phase

Analysis

Trial Status

28

clinical trials

Completed18 · 64%
Unknown status4 · 14%
Withdrawn2 · 7%
Terminated2 · 7%
Recruiting2 · 7%

Clinical Trials

Trial Activity

28 trials

Protective Effect of Acetylcysteine Against Cisplatinum-Induced Ototoxicity: A Randomized Controlled Trial
Recruiting·SSiriraj Hospital·Phase 2·NCT07364747·40 enrolled
Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
Recruiting·SSunnybrook Health Sciences Centre·Phase 2·NCT05129748·92 enrolled
A Study Evaluating Skin Irritation, Phototoxicity and Safety After Administration of LEO 90105 on Intact Skin of Healthy Japanese Male Subjects
Completed·LEO Pharma logoLEO Pharma·Phase 1·NCT01293357·20 enrolled
Protective Role of N-acetylcisteine From Cisplatin-induced Ototoxicity in Patients With Head and Neck Cancer
Completed·—·N/A·NCT03400709·45 enrolled
Human Phototoxicity Test
Completed·Bayer logoBayer·N/A·NCT02750475·35 enrolled
Evaluation of Potential Phototoxicity Skin Reaction After Use of MC2-01 Cream
Completed·MMC2 Therapeutics·Phase 1·NCT03892564·35 enrolled
Prevention of Drug Induced Ototoxicity in Peritoneal Dialysis Patients by N-Acetylcysteine
Completed·TTC Erciyes University·Phase 2·NCT01131468·60 enrolled
Human Phototoxicity Test (823/2016)
Completed·Bayer logoBayer·N/A·NCT02962856·38 enrolled
The Protective Effect of Ginkgo Biloba Extract on Cisplatin-induced Ototoxicity in Humans
Completed·UUniversity of Brasilia·Phase 2·NCT01139281·15 enrolled
Test the Phototoxicity of Sunscreen Products
Completed·Bayer logoBayer·N/A·NCT02802930·32 enrolled
Human Phototoxicity Test
Completed·Bayer logoBayer·N/A·NCT02751541·35 enrolled
Ototoxicity of Artemether / Lumefantrine (Coartem) and Other Antimalarials
Completed·JJimma University·Phase 4·NCT00451139
Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin
Completed·—·Phase 2·NCT04541355·16 enrolled
Phototoxicity of Frequently Prescribed Medicines
Completed·MMedical University of Vienna·N/A·NCT06710600·12 enrolled
Phototoxicity Test of Dapsone Gel in Healthy Volunteers
Completed·—·Phase 1·NCT02108483·33 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)