VivoSeq
Cardiovascular

Post-Operative Atrial Fibrillation

18

Pipeline Programs↗

3

Active Trials↗

14

Companies Involved↗

Post-Operative Atrial Fibrillation is an emerging landscape with 18 programs across 14 companies. The most active players are AbbVie, Revance Therapeutics, Inc., Viking Therapeutics, Inc.. 1 therapy is approved with 9 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

45/100

Pipeline Velocity

6/100

Mech. Concentration

11/100

Completion Rate

88/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

AbbVie logo

AbbVie

1 program

Phase 2R

Revance Therapeutics, Inc.

1 program

Phase 2V

Viking Therapeutics, Inc.

1 program

Phase 2Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

1 program

Phase 3Pfizer logo

Pfizer

1 program

Phase 3I

Iperboreal Pharma Srl

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Trial Status

16

clinical trials

Completed7 · 44%
Unknown status5 · 31%
Recruiting2 · 13%
Withdrawn1 · 6%
Not yet recruiting1 · 6%

Clinical Trials

Trial Activity

16 trials

Post-Operative Atrial Fibrillation After Surgical Aortic Valve Replacement and the Influence of Statins
Recruiting·—·N/A·NCT05062239·100 enrolled
Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation
Recruiting·UUniversity of Michigan·Phase 1/2·NCT05991700·70 enrolled
Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients
Not yet recruiting·UUniversity of Calgary·Phase 3·NCT04748991·50 enrolled
Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures
Completed·—·Phase 3·NCT01107730·33 enrolled
Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG
Completed·—·N/A·NCT03871647·256 enrolled
Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)
Completed·VVanderbilt University·Phase 2/3·NCT00141778·455 enrolled
Apixaban Versus Warfarin for the Management of Post-operative Atrial Fibrillation
Completed·SSanford Health·Phase 2/3·NCT02889562·56 enrolled
Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation
Completed·—·Phase 3·NCT00970489·1,516 enrolled
Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)
Completed·AbbVie logoAbbVie·Phase 2·NCT03779841·323 enrolled
The Effect of Magnesium Therapy to Prevent Post-operative Atrial Fibrillation After Cardiac Surgery in Adults
Completed·—·N/A·NCT02928315·40 enrolled
Gene Therapy for Post-Operative Atrial Fibrillation
Withdrawn·UUniversity of Massachusetts, Worcester·Phase 1·NCT05223725
Empagliflozin to Prevent Post-Operative Atrial Fibrillation
Unknown status·RRajaie Cardiovascular Medical and Research Center·Phase 3·NCT06124937·492 enrolled
Intensive Statin Therapy Effect on Post-Operative Atrial Fibrillation (POAF)
Unknown status·—·Phase 4·NCT02029534·200 enrolled
Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation
Unknown status·OOttawa Hospital Research Institute·N/A·NCT04392921·80 enrolled
COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial)
Unknown status·—·Phase 3·NCT01552187·360 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)