Epsom salt
(Magnesium sulfate)ApprovedSmall molecule
Magnesium sulfate is used to treat severe high blood pressure during pregnancy, prevent seizures in pregnant women with preeclampsia, and as a laxative to relieve constipation. It's also given intravenously in hospitals to treat irregular heartbeats and reduce inflammation in asthma attacks.[2] Epsom salt is currently approved and in use across 100 indications[4].[1]
Epsom salt is one of 1506 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.
100
Indications
212
Total Trials
32
Active Trials
1,505
Competitors
3
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 91 indications
Competition
Competitive Landscape
2828 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Epsom salt
FFresenius Kabi Oncology Ltd.
Approved
Trodelvy
GileadPreclinical
Lexiscan
AstellasPreclinical
Perflutren Lipid Microsphere
IImaRx Therapeutics
Preclinical
Conventional Chemotherapy
SShanghai Jiao Tong University School of Medicine
Preclinical
Vit D
PPost Graduate Institute of Medical Education and Research, Chandigarh
Preclinical
Ibrance
PfizerPreclinical
Aromasin
PfizerPreclinical
Sandostatin
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.Preclinical
Fluorothymidine F-18
MM.D. Anderson Cancer Center
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Magnesium Sulfate25 trials
Show 22 more trials
Nifedipine Plus Magnesium Sulfate Versus Magnesium Sulfate for Very Early Preterm Tocolysifs
Unknown status·—·N/A·NCT05345132·264 enrolled
Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa
Completed·—·Phase 3·NCT03542552·176 enrolled
Nifedipine Versus Magnesium Sulfate for Late Preterm Tocolysis
Unknown status·—·N/A·NCT05343806·264 enrolled
Fetal Middle Cerebral Artery Doppler in Preterm Births Receiving Magnesium Sulfate for Neuroprotection
Completed·—·Phase 1·NCT02506894·60 enrolled
High Versus Low Dose of Magnesium Sulfate as Initial Tocolytic Agent for Preterm Labour in Symptomatic Placenta Previa.
Completed·—·Phase 2·NCT04599868·130 enrolled
Lidocaine Compared to Magnesium Sulfate to Prolong Spinal Anesthesia: Non-inferiority Randomized Clinical Trial
Completed·—·Phase 4·NCT03725228·44 enrolled
Magnesium Sulfate in Neonatal HIE"
Not yet recruiting·—·Phase 4·NCT06342362·102 enrolled
the Use of Magnesium Sulfate for Prevention of Postspinal Shivering
Completed·—·Phase 4·NCT04249804·90 enrolled
Preeclampsia7 trials
Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial
Unknown status·—·Phase 4·NCT03318211·100 enrolled
Dexamedtomidine in Control of Intracranial Pressure in Preeclampsia
Unknown status·—·Phase 1·NCT05119101·100 enrolled
Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia
Completed·—·Phase 2/3·NCT02307201·1,114 enrolled
Asthma7 trials
Show 4 more trials
Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4
Completed·—·N/A·NCT01856959·330 enrolled
Nebulized Versus Intravenous Magnesium Sulfate in Treatment of Asthma Exacerbation
Completed·—··NCT05908864·123 enrolled
Post Operative Pain6 trials
Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain
Completed·—·Phase 4·NCT03479216·62 enrolled
Effect of Intraoperative Magnesium Infusion on Postoperative Pain and Cognitive Function
Unknown status·—·Phase 1·NCT04256057·24 enrolled
Laparoscopic Cholecystectomy5 trials
Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study
Completed·—·Phase 2/3·NCT05850832·60 enrolled
Magnesium Sulfate Effects on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy
Unknown status·—·Phase 2·NCT02669368·75 enrolled
113 more indications
Brain Injury5 trials
Show 2 more trials
Agitation4 trials
Addition of Magnesium Sulfate to Caudal to Prevent Postoperative Emergence Agitation.
Unknown status·—·Phase 4·NCT02164773·70 enrolled
Magnesium Sulphate and Sevoflurane Induced Emergence Agitation in Children
Unknown status·—·Phase 4·NCT01743144·70 enrolled
Atrial Fibrillation4 trials
Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients
Recruiting·—·Phase 4·NCT05829317·200 enrolled
Neuromuscular Blockade3 trials
Hysterectomy3 trials
TAP Block With Magnesium Sulfate Added to Local Anesthetic in Abdominal Hysterectomy
Unknown status·—·Phase 2/3·NCT02930707·60 enrolled
Effect of Intrathecal Magnesium Sulfate Versus Intravenous Magnesium Sulfate on Postoperative Pain After Abdominal Hysterectomy
Not yet recruiting·—·Phase 2·NCT06367595·90 enrolled
Rocuronium3 trials
Stroke3 trials
Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial
Completed·—·Phase 3·NCT00059332·1,700 enrolled
Renal Colic2 trials
Bronchiolitis2 trials
Ischemic stroke2 trials
Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy in Acute Ischemic Stroke
Not yet recruiting·—·Phase 1·NCT06956521·30 enrolled
Intravenous Magnesium Sulphate in Acute Ischemic Stroke
Unknown status·—·Phase 1·NCT04412850·44 enrolled
MPA2 trials
Impact of Body Mass Index on Serum Maternal and Fetal Magnesium Level
Unknown status·—··NCT03928691·400 enrolled
Adductor Canal Block2 trials
Comparison Between Adjuvants Added to Bupivacaine in Adductor Canal Block
Completed·—·Phase 2·NCT04892420·120 enrolled
Spinal Anesthesia2 trials
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
Completed·—·N/A·NCT07445451·93 enrolled
Neuropathic Pain2 trials
Mastectomy2 trials
Colorectal Cancer2 trials
Analgesic Efficacy2 trials
Post Operative Sore Throat2 trials
Effect of Intravenous Magnesium on Postoperative Sore Throat After Thyroidectomy
Completed·—·N/A·NCT02826746·20 enrolled
Headache2 trials
Hypotension2 trials
Treatment2 trials
Chronic Obstructive Pulmonary Disease2 trials
Shivering2 trials
Shivering Control After Percutaneous Nephrolithotomy
Completed·—·Phase 3·NCT04695613·80 enrolled
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT01950520·47 enrolled
Pain2 trials
Peripheral Neuropathy1 trial
Dexmedetomidine1 trial
Dexmedetomidine Versus Magnesium Sulphate in Patients Undergoing Craniotomy for Deeply Settled Intracranial Tumours
Unknown status·—·N/A·NCT05743725·150 enrolled
Asphyxia1 trial
Preoperative1 trial
Intravenous1 trial
Intravenous Magnesium in Patients Receiving Cisplatin
Completed·—·Phase 1·NCT04481672·5 enrolled
Perioperative Pain1 trial
Effects of Intraoperative Magnesium Sulfate on Perioperative Pain Relief After Spine Surgery
Completed·—·Phase 4·NCT04161729·74 enrolled
Liver Transplant1 trial
Cholestatic liver disease1 trial
Functional Endoscopic Sinus Surgery1 trial
Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus Surgery
Not yet recruiting·—·Phase 3·NCT07213037·102 enrolled
Severe Pre-Eclampsia1 trial
Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia
Completed·—·Phase 4·NCT03164304·222 enrolled
Total Intravenous Anesthesia1 trial
Comparison Between Total Intravenous Anesthesia With Magnesium Sulphate Versus Total Intravenous Anesthesia With Dexmedetomidine in Patients Undergoing Lumbar Spine Surgeries
Not yet recruiting·—·Phase 3·NCT07443163·40 enrolled
Women1 trial
Assessment of a Syringe Pump to Pre-eclamptic Women in a Low-resource Hospital
Completed·—·Phase 1/2·NCT02296931·34 enrolled
Radius Fracture1 trial
General Anesthesia1 trial
Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia
Recruiting·—·Phase 3·NCT06979141·300 enrolled
Breast Cancer1 trial
Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery
Completed·—·Phase 2·NCT04275661·60 enrolled
Total Knee Arthroplasty1 trial
Magnesium Sulfate Combined With Intraarticular Cocktail Injection for Analgesia After Simultaneous Bilateral Total Knee Arthroplasty
Not yet recruiting·—·N/A·NCT06445829·80 enrolled
Premature rupture of membranes1 trial
Magnesium Sulphate in Premature Rupture of Membranes
Not yet recruiting·—··NCT05134688·124 enrolled
Intraocular Pressure1 trial
Subarachnoid Hemorrhage1 trial
Magnesium Treating Subarachnoid Hemorrhage Vasospasm
Unknown status·GGeneral Committee of Teaching Hospitals and Institutes, Egypt·Phase 2/3·NCT04613960·200 enrolled
Preterm Labor1 trial
Tocolysis in Prevention of Preterm Labor
Unknown status·—·Phase 4·NCT03298191·300 enrolled
Postpartum Depression1 trial
Caesarean Delivery1 trial
Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery
Unknown status·—·Phase 3·NCT03067896·78 enrolled
Hernia1 trial
Infants1 trial
Erector Spinae Plane Block1 trial
Ketamine and Magnesium in Erector Spinae Plane Block
Completed·—·Phase 4·NCT05855798·60 enrolled
Post-Operative Atrial Fibrillation1 trial
The Effect of Magnesium Therapy to Prevent Post-operative Atrial Fibrillation After Cardiac Surgery in Adults
Completed·—·N/A·NCT02928315·40 enrolled
Acute Bronchiolitis1 trial
Magnesium Sulfate in Bronchial Asthma and Acute Bronchiolitis in Children
Not yet recruiting·—·Phase 3·NCT06955559·60 enrolled
Cognitive Function1 trial
Scoliosis1 trial
Dexmedetomidine Versus Magnesium Sulfate in Ultrasound Guided Bilateral Bi-level Erector Spinae Plane Block in Corrective Scoliosis Surgery
Completed·—·Phase 3·NCT05671081·60 enrolled
Intraperitoneal1 trial
Intraperitoneal Analgesia in Pediatric Laparoscopy
Completed·—·Phase 2·NCT02820610·97 enrolled
Adjuvant1 trial
Magnesium as Adjuvant for Sciatic Block
Completed·—·N/A·NCT02198547·60 enrolled
Pregnancy1 trial
Magnesium Sulfate in Pregnancy and Postpartum
Completed·—·Phase 2/3·NCT02317146·280 enrolled
Epidural Analgesia1 trial
Thoracic Epidural Analgesia in Multiple Traumatic Fracture Ribs
Unknown status·—·N/A·NCT03595397·60 enrolled
Bupivacaine1 trial
Adjuvants for Bupivacaine in Brachial Plexus Block in Pediatrics
Unknown status·—·N/A·NCT06180941·70 enrolled
Gastric Neoplasm1 trial
Sedation1 trial
Magnesium Sulfate as an Adjuvant to Propofol During Consious Sedation in Colonoscopy
Unknown status·—·Phase 2/3·NCT06131905·60 enrolled
Hemodynamic1 trial
Comparison of Fentanyl and Magnesium to Control Reflex Hemodynamics in Patients Aged 50 and Older
Completed·—·N/A·NCT07258628·76 enrolled
Prevention1 trial
MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI
Recruiting·—·Phase 2·NCT05730816·130 enrolled
Prostatectomy1 trial
Effect of Intravenous Magnesium During Robot Assisted Prostatectomy
Completed·—·N/A·NCT02833038·60 enrolled
Diabetic Foot1 trial
POPLITEAL SCIATIC NERVE BLOCK FOR DIABETIC FOOT SURGERIES
Unknown status·—·N/A·NCT04903743·50 enrolled
Post-thoracotomy Pain1 trial
Epidural Magnesium Sulfate for Post-thoracotomy Pain Control
Completed·—·N/A·NCT03343548·80 enrolled
Acute Myeloid Leukemia1 trial
Tachycardia1 trial
Neuromuscular Block1 trial
Valve Replacement Surgery1 trial
Antiarrhythmic and Cardioprotective Effects of Atorvastatin Versus Magnesium Sulfate in Cardiac Valve Replacement Surgery
Unknown status·—·Phase 4·NCT03289429·96 enrolled
Intravenous Lidocaine1 trial
Cesarean Section1 trial
MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section
Not yet recruiting·—·Phase 2/3·NCT06513013·68 enrolled
Infertility1 trial
Neurosurgical Patients1 trial
Tracheal Intubation1 trial
Pulpitis1 trial
Randomized Controlled Trial1 trial
Critically Ill Patients1 trial
Effect of Magnesium Sulfate Infusion Rate on Magnesium Retention in Critically Ill Patients
Terminated·—·N/A·NCT01426165·5 enrolled
Tonsillectomy1 trial
Ketamine Versus Magnesium as Analgesic Adjuvants in Pediatric Adenotonsillectomy
Completed·—·Phase 4·NCT05565664·38 enrolled
Postoperative Recovery1 trial
Neurotoxicity1 trial
Safety and Efficacy1 trial
Pulmonary Hypertension1 trial
Postoperative Analgesia1 trial
Extubation1 trial
Magnesium Sulphate and Extubation Quality
Completed·—·Phase 4·NCT05858957·98 enrolled
Back pain1 trial
Unspecified3 trials
Bilateral Transversus Abdominis Plane Block With or Without Magnesium
Terminated·—·Phase 4·NCT02680626·86 enrolled
Regulatory
FDA Approval Timeline[5]
Sep 8, 1986
MAGNESIUM SULFATE
NDA NDA019316
Jul 11, 1995
MAGNESIUM SULFATE IN DEXTROSE 5% IN PLASTIC CONTAINER
NDA NDA020488
Jan 26, 2007
MAGNESIUM SULFATE IN PLASTIC CONTAINER
NDA NDA020309
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Epsom salt drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Magnesium sulfate. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- FFresenius Kabi Oncology Ltd.