VivoSeq
Other

Pulpitis

40

Pipeline Programs↗

10

Active Trials↗

12

Companies Involved↗

Pulpitis is a moderately active landscape with 40 programs across 12 companies. The most active players are Astellas, Novartis, Meitheal. 11 therapies are approved with 9 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

57/100

Pipeline Velocity

19/100

Mech. Concentration

29/100

Completion Rate

96/100

Attrition Rate

2/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Astellas logo

Astellas

1 program

Phase 1Novartis logo

Novartis

1 program

Phase 2M

Meitheal

1 program

Phase 3Johnson & Johnson logo

Johnson & Johnson

1 program

Phase 3P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

2 programs

Phase 3Pfizer logo

Pfizer

2 programs

Phase 3

Pipeline

Programs by Phase

Preclinical13

Celecoxib

Philadelphia Eye Associates

Intervention 1: Endocem

British University In Egypt

Trinase

Fayoum University

Mepivacaine

Pfizer

Mepivacaine HCL

Cairo University

Phase 14

Alcohol

Astellas

Dexamethasone

Aspen Global Incorporated

Ibuprofen /kg

Inonu University

Metapex

Aga Khan University

Phase 23

Diclofenac Potassium

Novartis

Resin Based Sealer

Armed Forces Institute of Dentistry, Pakistan

Zno Eugenol Based Sealers

Armed Forces Institute of Dentistry, Pakistan

Phase 39

Prednisolone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Methylprednisolone

Pfizer

Epinephrine

Samson Clinical Operations Pty Ltd

Ibuprofen

Kenvue Brands

Sodium Bicarbonate

Abbott

Approved11

Mannitol

B. Braun Medical Inc.

Ketorolac Tromethamine

Roche

Acetaminophen

Kenvue Brands

Lidocaine

MEDRx USA, Inc.

Bupivacaine

Innocoll

Analysis

Modality Breakdown

98%

Small molecule

49 of 50 classified programs — the dominant modality here.

2%ALL OTHERSProtein / enzyme12%

Small molecule leads; the ring shows all 50 classified programs, each share of the total. Modality classified for 100% of 51 pipeline programs.

Analysis

Trial Status

48

clinical trials

Completed26 · 54%
Unknown status11 · 23%
Not yet recruiting4 · 8%
Recruiting3 · 6%
Active, not recruiting3 · 6%
Terminated1 · 2%

Clinical Trials

Trial Activity

48 trials

Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
Recruiting·SSuez Canal University·N/A·NCT06457828·40 enrolled
Postoperative Pain Comparison of Two Root Canal Sealers in Irreversible Pulpitis
Recruiting·—·Phase 2·NCT06975761·62 enrolled
A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.
Recruiting·FFayoum University·N/A·NCT07239505·182 enrolled
Evaluation of Two Different Calcium Silicate Cements as a Treatment for Irreversible Pulpitis in Mature Molars
Active, not recruiting·—·N/A·NCT07066410·50 enrolled
Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis
Active, not recruiting·—·N/A·NCT07233564·44 enrolled
Clinical and Radiographic Evaluation of Lesion Sterilization With Triple Antibiotic Paste Versus Root Canal Treatment With Calcium Hydroxide-iodoform Paste in Mandibular Primary Molars Diagnosed With Necrotic Pulp or Irreversible Pulpitis
Active, not recruiting·Çanakkale Onsekiz Mart University·Preclinical·NCT06811636·59 enrolled
Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis
Not yet recruiting·—·Phase 1·NCT06925490·50 enrolled
Evaluation of the Effect of Intra-ligamentary Injection of Diclofenac Potassium Versus Articaine on Anaesthetic Efficacy in Mandibular Molars With Symptomatic Irreversible Pulpitis.
Not yet recruiting·—·Phase 1·NCT06500871·40 enrolled
Comparison of Post Operative Endodontic Pain in Patients with Irreversible Pulpitis Treated with and Without Dexamethasone.
Not yet recruiting·—·Phase 1·NCT06432712·140 enrolled
To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless
Not yet recruiting·—·Phase 2/3·NCT07266974·60 enrolled
Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis
Completed·—·Phase 3·NCT02226913·80 enrolled
Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis
Completed·OOctober 6 University·N/A·NCT06304259·45 enrolled
How Successful is Supplemental Intraseptal Anaesthesia in Patients With Mandibular Teeth Extraction or Irreversible Pulpitis
Completed·TTaibah University·Phase 1·NCT03880409·100 enrolled
Assessment of Different Medications in Modifying the Efficacy of Anesthesia in Mandibular Molars With Acute Irreversible Pulpitis
Completed·—·Phase 4·NCT07088042·60 enrolled
Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis
Completed·—·N/A·NCT04202406·69 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)