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Other/Pulpitis

Pulpitis

17

Pipeline Programs↗

29

Active Trials↗

9

Companies Involved↗

Pulpitis is an emerging landscape with 17 programs across 9 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

52/100

Pipeline Velocity

46/100

Mech. Concentration

40/100

Completion Rate

95/100

Attrition Rate

2/100

Pipeline

Programs by Phase

Preclinical15

Celecoxib

Philadelphia Eye Associates

Intervention 1: Endocem

British University In Egypt

Trinase

Fayoum University

Mepivacaine

Pfizer

Mepivacaine HCL

Cairo University

Phase 11

Trypsin-Chymotrypsin

Dow University of Health Sciences

Phase 2

No programs

Phase 31

Diclofenac Potassium

Novartis

Approved

No programs

Analysis

Modality Breakdown

94%

Small molecule

15 of 16 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 16 classified programs, each share of the total. Modality classified for 100% of 17 pipeline programs.

Analysis

Trial Status

84

clinical trials

Completed42 · 50%

Recruiting11 · 13%

Unknown status11 · 13%

Not yet recruiting10 · 12%

Active, not recruiting8 · 10%

Withdrawn1 · 1%

Other1 · 1%

Clinical Trials

Trial Activity

84 trials

Clinical and Radiographic Evaluation of Pelargonium Graveolens Essential Oil as a Pulpotomy Agent in Primary Teeth

Recruiting·TTanta University·Preclinical·NCT07386925·30 enrolled

"The Relationship Between Pulpal Inflammatory Marker Levels in Moderate and Severe Pulpitis and Outcome of Full Pulpotomy in Mandibular Molars With Extremely Deep Caries: A Prospective Cohort Study."

Recruiting·PPostgraduate Institute of Dental Sciences Rohtak·Preclinical·NCT07825415·86 enrolled

Comparison of Postoperative Pain Following Root Canal Treatment Using AH Plus, ProRoot Bio Sealer, and BC Sealer Ion+: A Randomized Clinical Trial

Recruiting·EEuropean University of Lefke·Preclinical·NCT07608939·135 enrolled

Outcome of Partial Pulpotomy in Permanent Mandibular Molars With Symptomatic Irreversible Pulpitis After Wound Lavage With Calcium Hypochlorite or Sodium Hypochlorite

Recruiting·PPostgraduate Institute of Dental Sciences Rohtak·Preclinical·NCT07748676·106 enrolled

Comparing the Effect of Acetaminophen, NSAIDs, Trypsin-chymotrypsin + Acetaminophen on Post-endodontic Pain Using Visual Analog Scale (VAS) After Single Visit Endodontic Treatment: A Randomized Controlled Trial

Recruiting·DDow University of Health Sciences·Phase 1·NCT07759349·90 enrolled

Treatment Outcomes of Pulpotomy Versus Pulpectomy in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis: A Non-inferiority Randomised Controlled Trial

Recruiting·Qatar University·Preclinical·NCT06904781·80 enrolled

Comparative Evaluation of Direct Pulp Capping Between Deep and Extremely Deep Caries in Mature Permanent Mandibular Molars With Reversible Pulpitis: A Prospective Study

Recruiting·PPostgraduate Institute of Dental Sciences Rohtak·Preclinical·NCT07696702·130 enrolled

Comparison of the Effects of Submucosal and Intraligamentary Dexamethasone Administration on Anesthetic Success and Pain Control in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

Recruiting·MMarmara University·Preclinical·NCT07672873·84 enrolled

Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

Recruiting·SSuez Canal University·N/A·NCT06457828·40 enrolled

Postoperative Pain Comparison of Two Root Canal Sealers in Irreversible Pulpitis

Recruiting·—·Phase 2·NCT06975761·62 enrolled

A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.

Recruiting·FFayoum University·N/A·NCT07239505·182 enrolled

Comparison of Postoperative Pain After Root Canal Irrigation, With and Without Dexamethasone, for Symptomatic Irreversible Pulpitis

Active, not recruiting·CCMH Lahore Medical College and Institute of Dentistry·Preclinical·NCT07821359·72 enrolled

Clinical and Radiographic Outcomes of Pulpotomy Versus Pulpectomy in Primary Molars With Symptomatic Irreversible Pulpitis: a Parallel Randomized Clinical Trial

Active, not recruiting·MMinia University·Preclinical·NCT07783217·110 enrolled

Comparative Evaluation of Diode Laser-Assisted Pulpotomy Versus MTA Pulpotomy in Permanent Teeth With Irreversible Pulpitis: A Randomized Clinical Trial

Active, not recruiting·KKing Abdullah University Hospital·Preclinical·NCT07761962·70 enrolled

Treatment Outcomes of Pulpotomy in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis: An International Multi-centre Study

Active, not recruiting·Qatar University·Preclinical·NCT06149845·120 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)