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Carbocaine

(Mepivacaine)

ApprovedSmall molecule

Mepivacaine is a local anesthetic used to numb specific areas of the body during dental procedures, minor surgeries, or other medical treatments so you don't feel pain in that region.[2] Carbocaine is currently approved and in use across 8 indications[4].[1]

Carbocaine is one of 142 small molecule programs targeting Pain Agnosia. It is currently in Approved.

8

Indications

28

Total Trials

3

Active Trials

141

Competitors

2

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Pain AgnosiaActive, not recruiting

Carpal Tunnel SyndromeActive, not recruiting

PulpitisActive, not recruiting

UltrasoundCompleted

Blood PressureCompleted

General AnesthesiaCompleted

Total Knee ArthroplastyCompleted

HypertensionCompleted

Pain AgnosiaApproved

Active, not recruiting

Carpal Tunnel SyndromePreclinical

Active, not recruiting

PulpitisPreclinical

Active, not recruiting

UltrasoundPreclinical

Completed

Blood PressurePreclinical

Completed

General AnesthesiaPreclinical

Completed

Total Knee ArthroplastyApproved

Completed

HypertensionApproved

Completed

Competition

Competitive Landscape

157 competitors in Hypertension

#DrugCompanyPhaseTrials

Carbocaine

Foundayo

Baxfendy

Nitrostat

VViatris Specialty LLC

Minocycline /d

UUniversity of Florida

SGLT2

PProf. Dr. med. Ingo Eitel

Avastin

Winrevair

Alphagan

Deltavit

HHyundai Pharmaceutical Co., LTD.

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Post-ApprovalRecruiting

Hypertension

NCT04454203

Q2 2027

Post-ApprovalNot yet recruiting

Total Knee Arthroplasty

NCT07239999

Clinical

Trials by Indication[1]

Total Knee Arthroplasty3 trials

Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

Completed·HHospital for Special Surgery, New York·Phase 4·NCT05980546·244 enrolled

Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty

Completed·HHenry Ford Health System·Phase 4·NCT02980926·32 enrolled

Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

Not yet recruiting·NNova Scotia Health Authority·Phase 4·NCT07239999·170 enrolled

Regional Anesthesia3 trials

Regional Anesthesia in Total Hip and Knee Arthroplasty

Unknown status·OOttawa Hospital Research Institute·Phase 4·NCT04257682·135 enrolled

Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction

Completed·VVanderbilt University Medical Center·N/A·NCT02584452·59 enrolled

Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers

Completed·—·Phase 1·NCT06005480·40 enrolled

Nerve Block2 trials

Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting

Terminated·—·Phase 3·NCT01522534·26 enrolled

Ultrasound Guided Supraclavicular Nerve Block

Completed·TThe Cleveland Clinic·Phase 3·NCT00825786·103 enrolled

Hypertension2 trials

Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension

Completed·—·Phase 4·NCT03390426·31 enrolled

Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

Recruiting·—·Phase 4·NCT04454203·40 enrolled

Pulpitis2 trials

Anaesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine With Symptomatic Irreversible Pulpitis

Completed·—·N/A·NCT04822415·330 enrolled

Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis

Completed·DDaniel Chavarría Bolaños·Phase 4·NCT02110966·56 enrolled

15 more indications

Local Anesthetic2 trials

Duration of Sciatic Nerve Block After Injection of Local Anesthetic In or Around the Nerve

Completed·UUniversity of Parma·Phase 4·NCT01981291·120 enrolled

Local Anesthetics New Formulations: From Development to Clinical Tests

Completed·UUniversity of Campinas, Brazil·Phase 1·NCT01032798·30 enrolled

Ultrasound1 trial

Dosage of Mepivacaine in Ultrasound Axillary Block

Completed·WWayne State University·N/A·NCT01485653·64 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

General Anesthesia1 trial

Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs

Completed·RResearch Institute of Ophthalmology, Egypt·N/A·NCT05728151·55 enrolled

Degenerative Disc Disease1 trial

Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)

Completed·RRed de Terapia Celular·Phase 1/2·NCT01860417·24 enrolled

Knee Surgery1 trial

Chloroprocaine Spinal for Outpatient Knee Surgery

Terminated·HHospital for Special Surgery, New York·Phase 2·NCT03365752·39 enrolled

Contraception1 trial

Analgesia for Insertion of Intrauterine Contraception

Completed·KKarolinska Institutet·Phase 3·NCT02078063·86 enrolled

Spinal Anesthesia1 trial

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

Completed·PPrisma Health-Upstate·Phase 4·NCT06291727·138 enrolled

AIN1 trial

Uterovaginal Plexus Block With Articaine for Intrauterine Device Placement Patients Who Are Indicated for the Use of Copper IUD as a Contraceptive Method Will be Invited to Participate in This Research.

Unknown status·UUniversidade do Vale do Sapucai·Phase 4·NCT05252117·240 enrolled

Knee Arthroplasty1 trial

Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty

Completed·MMayo Clinic·Phase 2/3·NCT03838874·154 enrolled

Foot Surgery1 trial

The Impact of Chloroprocaine 3% for Ambulatory Foot Surgery on Perioperative Process Costs

Completed·OOspedale Regionale Bellinzona e Valli··NCT02406703·100 enrolled

Femoral Nerve Block1 trial

Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy

Completed·AASST Gaetano Pini-CTO·Phase 4·NCT02384915·100 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of the Application of Local Anaesthetic in Spray to Repair of 1st- 2nd Perineal Lacerations

Completed·AAzienda Sanitaria-Universitaria Integrata di Udine·Phase 3·NCT05201313·136 enrolled

Compartment Syndrome1 trial

Detecting Compartment Syndrome Pain in the Presence of Regional Anesthesia in Healthy Volunteers

Completed·—·Phase 1·NCT04113954·42 enrolled

Ankle Block1 trial

Onset of Sensory Blockade in Ultrasound-Guided Ankle Block With Mepivacaine Versus Bupivacaine: A Randomized Non-Inferiority Clinical Trial

Enrolling by invitation·MMayo Clinic·Approved·NCT05425979·50 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

CARBOCAINE

NDA NDA012125

Jan 1, 1982

CARBOCAINE

NDA NDA012250

Sources

References

[1]
ClinicalTrials.gov — 28 trial records for Mepivacaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Carbocaine drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Mepivacaine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Mepivacaine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA012125). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium Channel Alpha Subunit Blocker[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Pfizer

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