VivoSeq
Other

Recurrent Aphthous Stomatitis

9

Pipeline Programs↗

2

Active Trials↗

2

Companies Involved↗

Recurrent aphthous stomatitis is an early-stage landscape with 9 programs across 2 companies. The most active players are Amgen, Validus Pharmaceuticals. 2 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

36/100

Pipeline Velocity

0/100

Mech. Concentration

33/100

Completion Rate

90/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Amgen logo

Amgen

1 program

Phase 3V

Validus Pharmaceuticals

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Modality Breakdown

93%

Small molecule

13 of 14 classified programs — the dominant modality here.

7%ALL OTHERSProtein / enzyme17%

Small molecule leads; the ring shows all 14 classified programs, each share of the total. Modality classified for 100% of 14 pipeline programs.

Analysis

Trial Status

16

clinical trials

Completed9 · 56%
Unknown status4 · 25%
Not yet recruiting1 · 6%
Terminated1 · 6%
Recruiting1 · 6%

Clinical Trials

Trial Activity

16 trials

Randomized Double Blind Controlled Trial Comparing the Safety and Efficacy of Apremilast Versus Placebo in Severe Forms of Recurrent Aphthous Stomatitis
Recruiting·UUniversity Hospital, Rouen·Phase 3·NCT04227314·134 enrolled
Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis
Not yet recruiting·—·Phase 2·NCT06993337·63 enrolled
Topical Hyaluronic Acid and Recurrent Aphthous Stomatitis.
Completed·—·Phase 3·NCT04265001·34 enrolled
A Study on Sumac Mouth Rinse for Treating Recurrent Aphthous Stomatitis
Completed·—·N/A·NCT07229469·38 enrolled
Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis
Completed·PPeking University·Phase 2·NCT01652625·227 enrolled
Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis
Completed·SSoroka University Medical Center·N/A·NCT00288769
A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis
Completed·MManchester University NHS Foundation Trust·N/A·NCT00315679·30 enrolled
Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis
Completed·—·Phase 2·NCT02789605·20 enrolled
Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis
Completed·QQazvin University Of Medical Sciences·Phase 2·NCT01293968·37 enrolled
Probiotic Lozenges for Treatment of Recurrent Aphthous Stomatitis
Completed·—·N/A·NCT04383236·120 enrolled
The Efficacy of Erythropoietin Oral Gel Versus Erythropoietin Mouthwash in the Management of Recurrent Aphthous Stomatitis
Completed·FFuture University in Egypt·Phase 4·NCT06923605·60 enrolled
Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis
Terminated·MMeir Medical Center·N/A·NCT01127724·8 enrolled
α-Mangostin Hydrogel Film With Chitosan Alginate Base for Recurrent Aphthous Stomatitis (RAS)
Unknown status·UUniversitas Padjadjaran·Phase 2·NCT06039774·48 enrolled
Efficacy and Safety of BNP105 in the Treatment of Recurrent Aphthous Stomatitis
Unknown status·EEMS·N/A·NCT05772338·102 enrolled
Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients
Unknown status·OOctober 6 University·Phase 2·NCT01831453·50 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)