Trental

(Pentoxifylline)

ApprovedSmall molecule

Pentoxifylline is used to improve blood flow and reduce pain and cramping in the legs caused by poor circulation. It helps people with claudication (pain when walking) walk farther without discomfort.[2] Trental is currently approved and in use across 60 indications[4].[1]

Trental is one of 1027 small molecule programs targeting Non-Small Cell Lung Cancer. It is currently in Approved.

Indications

138

Total Trials

Active Trials

1,026

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Non-Small Cell Lung CancerUnknown status

Chronic Renal Failure SyndromeApproved

Hepatic SteatosisApproved

Behcet's SyndromeApproved

Inflammatory Bowel DiseaseApproved

Non-Alcoholic SteatohepatitisApproved

Avascular NecrosisApproved

Crohn's DiseaseApproved

InfertilityApproved

Major Depressive DisorderApproved

Non-Small Cell Lung CancerPhase 2

Unknown status

Chronic Renal Failure SyndromeApproved

Approved

Hepatic SteatosisApproved

Approved

Behcet's SyndromeApproved

Approved

Inflammatory Bowel DiseaseApproved

Approved

Non-Alcoholic SteatohepatitisApproved

Approved

Avascular NecrosisApproved

Approved

Crohn's DiseaseApproved

Approved

InfertilityApproved

Approved

Major Depressive DisorderApproved

Approved

Showing 10 of 60 indications

Competition

Competitive Landscape

706 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Trental

VValidus Pharmaceuticals

Approved

4 2

Lexiscan

Astellas

Preclinical

1 3

Zolymbus

AbbVie

Preclinical

1 4

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 6

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 7

Acupan

YYonsei University

Preclinical

1 8

Nubain

AAultman Health Foundation

Preclinical

1 9

Vfend

PPrism Pharmaceuticals

Preclinical

—10

Beta Blocker

WWeill Medical College of Cornell University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalActive, not recruiting

Radiculopathy

NCT03060434

Phase 3Active, not recruiting

Chronic Kidney Disease

NCT05284656

Q1 2027

Phase 2Not yet recruiting

Ulcerative Colitis

NCT07349472

Q3 2027

Phase 2Recruiting

Rheumatoid Arthritis

NCT06998628

Q4 2027

Phase 2Recruiting

Epilepsy

NCT05637086

Clinical

Trials by Indication[1]

Hepatitis8 trials

Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis

Completed·UUniversity Hospital, Lille·Phase 3·NCT01214226·278 enrolled

Pentoxifylline for Acute Alcoholic Hepatitis (AAH)

Terminated·UUniversity of Wisconsin, Madison·Phase 1·NCT00205049·4 enrolled

Meta-Analysis of Drug Therapy in Patients With Severe Alcoholic Hepatitis

Completed·UUniversity Hospital, Lille··NCT02796469·1,974 enrolled

Show 5 more trials

Pentoxifylline in Patients With Nonalcoholic Steatohepatitis

Completed·—·Phase 2·NCT00590161·55 enrolled

Pentoxifylline in Treatment of Patients With Nonalcoholic Steatohepatitis

Completed·—·Phase 3·NCT05284448·50 enrolled

Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASH

Completed·NNorthwestern University·Phase 2/3·NCT00267670·26 enrolled

Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis

Completed·MMack Mitchell·Phase 2/3·NCT01809132·104 enrolled

Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline

Unknown status·IInje University·Phase 3·NCT01455337·126 enrolled

Chronic Kidney Disease8 trials

Renoprotection by Pentoxifylline and Angiotensin Receptor Blocker in Chronic Kidney Disease (CKD)

Unknown status·NNational Taiwan University Hospital·Phase 4·NCT01377285·350 enrolled

Pentoxifylline on Inflammatory Markers in Non-Diabetic Chronic Kidney Disease Patients

Completed·—·N/A·NCT07315139·42 enrolled

Evaluate the Effect and Safety of Pu Yang Wan Wu Tang and Western Medicine on Chronic Kidney Disease

Unknown status·TTaipei Medical University Hospital·Phase 2/3·NCT05387187·40 enrolled

Show 5 more trials

Efficacy of Pentoxifylline on Chronic Kidney Disease

Completed·NNational Taiwan University Hospital·Phase 4·NCT00155246·60 enrolled

Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease

Active, not recruiting·—·Phase 3·NCT05284656·80 enrolled

Renoprotective Effects of Dapagliflozin Versus Pentoxiphylline in Chronic Kidney Disease Patients

Recruiting·—·Phase 3·NCT06421870·210 enrolled

Impact of Curcumin and Pentoxiphylline on Chronic Kidney Disease Patients

Completed·—·N/A·NCT06458465·60 enrolled

Pentoxifylline and Progression of Chronic Kidney Disease in Moderate-to-high Risk Patients

Completed·WWalter Reed Army Medical Center·Phase 3·NCT00285298·39 enrolled

Treatment4 trials

Bromocriptine and Pentoxifylline in Ophthalmopathy Autoimmune Treatment

Terminated·IInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran·N/A·NCT01893450·31 enrolled

The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain

Terminated·UUniversity Health Network, Toronto·Phase 2·NCT00188669·48 enrolled

The Use of Pentoxifylline and Vitamin E in the Treatment of Late Radiation Related Injuries

Terminated·UUniversity Health Network, Toronto·Phase 2·NCT00188552·50 enrolled

Show 1 more trial

Pentoxifylline in the Treatment of NEC in Premature Neonates

Unknown status·SShaare Zedek Medical Center·Phase 2·NCT00271336·50 enrolled

Breast Cancer4 trials

Clinical Benefit of Spa Care on Severe Radiation-induced Fibrosis After Postoperative Radiotherapy for Breast Cancer

Unknown status·IInstitut de Cancérologie de Lorraine·Phase 3·NCT02898376·142 enrolled

Vitamin E and Pentoxifylline in Treating Women With Lymphedema After Radiation Therapy for Breast Cancer

Completed·RRoyal Marsden NHS Foundation Trust·Phase 2·NCT00022204

Assessing the Clinical Utility of Adding Pentoxifylline to Neoadjuvant Chemotherapy Protocols in Breast Cancer Patients"

Active, not recruiting·MMansoura University·Phase 2·NCT06176339·70 enrolled

Show 1 more trial

The Efficacy of Using Pentoxifylline in Patients Undergoing Breast Cancer Surgery

Completed·MMansoura University·Phase 2·NCT06087237·92 enrolled

Cutaneous Leishmaniasis3 trials

The Association of Miltefosine and Pentoxifylline to Treat Mucosal and Cutaneous Leishmaniasis: A Clinical Trial in Brazil

Active, not recruiting·UUniversity of Brasilia·Phase 2·NCT02530697·160 enrolled

Add-on Study of Pentoxifylline in Cutaneous Leishmaniasis

Completed·CCentro Internacional de Entrenamiento e Investigaciones Médicas·Phase 2/3·NCT01464242·75 enrolled

Antimony Plus Pentoxifylline in Cutaneous Leishmaniasis

Completed·PPaulo Roberto Lima Machado·Phase 2/3·NCT01381055·164 enrolled

95 more indications

Efficacy3 trials

Efficacy of Pentoxifylline as Add on Therapy in COVID19 Patients

Withdrawn·SSadat City University·Phase 1/2·NCT04433988

Efficacy of Intralesional Injection of Pentoxifylline, Platelet-Rich Plasma, and Combined Pentoxifylline With Platelet-Rich Plasma in Patients With Atrophic Acne Scars

Recruiting·SSohag University·N/A·NCT06319768·75 enrolled

Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate

Completed·—·Phase 2·NCT05231980·120 enrolled

Fibrosis2 trials

Trial of Pentoxifylline in Patients With Functional Disability Caused by Radiation-Induced Advanced Regional Fibrosis

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00001437·50 enrolled

Trental & Vitamin E for Radiation-Induced Fibrosis

Completed·UUniversity of Iowa·Phase 2·NCT00583700·54 enrolled

Ulcerative Colitis2 trials

Pentoxifylline in Patients With Ulcerative Colitis

Not yet recruiting·IIhab Elsayed Hassan·Phase 2·NCT07349472·60 enrolled

Pentoxifylline as Adjunctive Therapy in Patients With Ulcerative Colitis

Completed·TTanta University·Phase 2·NCT05558761·50 enrolled

Diabetic Nephropathy2 trials

Pentoxifylline Effect in Patients With Diabetic Nephropathy.(PENFOSIDINE STUDY)

Unknown status·MMaria Eugenia Galván Plata·Phase 4·NCT03664414·196 enrolled

Investigational and Comparative Study in the Management of Diabetic Nephropathy

Completed·TTanta University·Phase 3·NCT05487755·90 enrolled

Nephropathy2 trials

Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy

Completed·TTehran University of Medical Sciences·Phase 4·NCT03006952·59 enrolled

Evaluating the Protective Effect of Pentoxifylline on Contrast Induced Nephropathy

Unknown status·SShiraz University of Medical Sciences·N/A·NCT01469624

Non-Small Cell Lung Cancer2 trials

Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers

Unknown status·UUniversity of Louisville·Phase 2·NCT01871454·59 enrolled

Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol in Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation

Recruiting·UUniversity Health Network, Toronto·Phase 2·NCT06634056·150 enrolled

Anemia2 trials

A Safety Study of Pentoxifylline for the Treatment of Anemia

Terminated·FFresenius Medical Care North America·Phase 2·NCT01102218·48 enrolled

Effect of Pentoxifylline on Anemia in Hemodialysis Patients

Unknown status·—·N/A·NCT05708248·80 enrolled

Acute Pancreatitis2 trials

Pentoxifylline Treatment of Acute Pancreatitis

Completed·MMayo Clinic·Phase 1·NCT01292005·28 enrolled

Pentoxifylline Treatment in Acute Pancreatitis (AP)

Completed·MMayo Clinic·Phase 3·NCT02487225·83 enrolled

Alopecia Areata2 trials

Combined Microneedling and Topical Pentoxifylline Vesrus Intalesional Pentoxifylline in Treatment of Alopecia Areata: Intra-indiviual Comparative Study

Unknown status·SSohag University·N/A·NCT05502952·50 enrolled

Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata.

Unknown status·—·Phase 1·NCT06087796·60 enrolled

Duchenne Muscular Dystrophy2 trials

Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy

Completed·CCooperative International Neuromuscular Research Group·Phase 1/2·NCT00243789·64 enrolled

Pentoxifylline in Duchenne Muscular Dystrophy

Completed·CCooperative International Neuromuscular Research Group·Phase 1/2·NCT00102453·17 enrolled

Kidney Disease2 trials

Pentoxifylline for Vascular Calcification in Kidney Disease

Not yet recruiting·MMansoura University·Phase 1/2·NCT06903689·80 enrolled

Pentoxifylline in Diabetic Kidney Disease

Active, not recruiting·VVA Office of Research and Development·Phase 4·NCT03625648·2,376 enrolled

Glomerulonephritis2 trials

Evaluation of Clinical Efficacy of Pentoxifylline on Patients With Glomerulonephritis

Completed·NNational Taiwan University Hospital·N/A·NCT00154661·20 enrolled

Efficacy of Pentoxifylline on Rapidly Progressive Glomerulonephritis

Terminated·NNational Taiwan University Hospital·Phase 3·NCT00354198·7 enrolled

Hepatopulmonary Syndrome2 trials

Efficacy and Safety of Pentoxifylline in Improving Oxygenation in Hepatopulmonary Syndrome

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT05373134·40 enrolled

Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome

Terminated·UUniversity of Alabama at Birmingham·Phase 1·NCT00593658·9 enrolled

COVID-192 trials

RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine

Completed·UUniversity Health Network, Toronto·Phase 2/3·NCT05513560·460 enrolled

Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19

Completed·UUnidad Temporal COVID-19 en Centro Citibanamex·N/A·NCT04570254·110 enrolled

Toxicity2 trials

The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer Patients

Completed·—·Phase 2·NCT02397486·60 enrolled

Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity

Completed·UUniversity of Magdeburg·Phase 2·NCT01149304·22 enrolled

Peripheral Neuropathy1 trial

"Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"

Completed·—·Phase 2/3·NCT05189535·66 enrolled

Virus1 trial

Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases

Completed·HHospital Universitário Professor Edgard Santos·Phase 3·NCT01472263·48 enrolled

Pregnancy1 trial

Effects of Pentoxifylline and Vitamin E on Pregnancy Rate in Infertile Women Treated by ICSI:

Unknown status·—·Phase 1·NCT03476564·140 enrolled

Oral Submucous Fibrosis1 trial

Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial

Completed·ZZiauddin University·Phase 1/2·NCT06332612·30 enrolled

Major Depression1 trial

Pentoxifylline for Treatment of Resistant Major Depression

Completed·HHawler Medical University·Phase 1/2·NCT05324735·60 enrolled

Proteinuria1 trial

Effect of Pentoxifylline on Proteinuria in Korean Type 2 Diabetic Patients

Completed·—·Phase 4·NCT01382303·174 enrolled

Colorectal Cancer1 trial

Protective Effect of Pentoxifylline Against Chemotherapy Induced Toxicities in Patients With Colorectal Cancer

Unknown status·TTanta University·Phase 1·NCT05590117·48 enrolled

Irritable Bowel Syndrome1 trial

Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS)

Unknown status·HHospital Universitario de Canarias·Phase 4·NCT01542268·59 enrolled

Combination Therapy1 trial

Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men

Not yet recruiting·TTanta University·Phase 2/3·NCT05897034·100 enrolled

Lupus Nephritis1 trial

Pentoxifylline in Lupus Nephritis

Withdrawn·MMetroHealth Medical Center·Phase 4·NCT03859570

Cirrhosis1 trial

Clinical Trial of Pentoxifylline in Patient With Cirrhosis

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00162552·342 enrolled

Neuropathy1 trial

Pentoxifylline Role Against Chemotherapy-induced Neuropathy

Completed·—·N/A·NCT06562998·72 enrolled

Non-Alcoholic Steatohepatitis1 trial

Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) Patients

Completed·KKafrelsheikh University·Phase 4·NCT04977661·102 enrolled

Eisenmenger syndrome1 trial

Pentoxifylline as an Adjunct Therapy for Patients With Eisenmenger Syndrome

Recruiting·UUniversity of Sao Paulo General Hospital·N/A·NCT05611268·48 enrolled

Prostatectomy1 trial

Erectile Recovery After Robotic-Assisted Laparoscopic Prostatectomy

Unknown status·—·Phase 3·NCT03406169·180 enrolled

Asphyxia1 trial

Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial

Not yet recruiting·—·N/A·NCT07088328·30 enrolled

Schizophrenia1 trial

Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia

Completed·SSadat City University·Phase 1/2·NCT04094207·80 enrolled

Endometriosis1 trial

Pentoxifylline and Endometriosis

Completed·HHospital Clinic of Barcelona·Phase 3·NCT00632697·104 enrolled

Intermittent Claudication1 trial

Prostaglandin E1 in Outpatients With Intermittent Claudication

Completed· UCB logo

UCB·Phase 3·NCT01263925·561 enrolled

Biliary Atresia1 trial

Pentoxifylline Therapy in Biliary Atresia

Terminated·—·Phase 2·NCT01774487·17 enrolled

Drug Repurposing1 trial

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Pentoxifylline Versus Cilostazol

Completed·—··NCT05635370·10,398 enrolled

Necrosis1 trial

Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000646·54 enrolled

Acute Coronary Syndrome1 trial

Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome

Completed·—·Phase 2/3·NCT04367935·43 enrolled

Unknown status·—·Phase 2/3·NCT05971667·200 enrolled

AIN1 trial

Cocaine and Pentoxifylline (BED IN 47)

Recruiting·WWilliam Stoops·Phase 1·NCT07086794·30 enrolled

Endothelial Dysfunction1 trial

Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)

Completed·IIndiana University·Phase 2·NCT01625845·36 enrolled

Congestive Heart Failure1 trial

Effects of Pentoxiphylline on Left Ventricular (LV) Systolic Function Indices and Circulating Biomarkers in Patients With Chronic Congestive Heart Failure (CHF)

Withdrawn·HHenry Ford Health System·N/A·NCT01337349

Oral ulcer1 trial

Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers

Completed·IIpekyolu Ilac Ltd. Sti·Phase 2·NCT03888846·41 enrolled

Cognitive impairment1 trial

Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke

Recruiting·TThe First Hospital of Hebei Medical University·Phase 1/2·NCT06344390·200 enrolled

Islet Transplantation1 trial

B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure

No longer available·NNational Institute of Allergy and Infectious Diseases (NIAID)··NCT01049633

Coronavirus Disease 20191 trial

Effect of Pentoxifylline on Prognosis of Coronavirus Disease 2019 (COVID- 19) Infection

Completed·—·N/A·NCT04739345·69 enrolled

Malaria1 trial

Pentoxifylline in Children With Malaria

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00133393·50 enrolled

Glioblastoma1 trial

Radiation Therapy in Treating Patients With Glioblastoma

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00019058·34 enrolled

Fed1 trial

Bioequivalence Study of Pentoxifylline 400 Mg in Healthy Subjects Under Fasting and Fed Conditions

Not yet recruiting·CCentro de Atencion e Investigacion Medica·Phase 4·NCT06823362·40 enrolled

Alcohol1 trial

Pentoxifylline Versus Pioglitazone In Non-Alcoholic Steatohepatiti (NASH)

Unknown status·GGovind Ballabh Pant Hospital·N/A·NCT00681733·20 enrolled

Necrotizing Enterocolitis1 trial

Effect of Pentoxifylline Versus Probiotic on Preterm Neonates With Necrotizing Enterocolitis

Completed·TTanta University·Phase 3·NCT06422000·75 enrolled

Sepsis1 trial

Pentoxifylline and Late Onset Sepsis in Preterm Infants

Completed·AAbd Elazeez Attala Shabaan·Phase 3·NCT02163174·120 enrolled

Cerebral Small Vessel Disease1 trial

Efficacy of Pentoxifylline on Cerebrovascular Function in Patients With Cerebral Small Vessel Disease(PERFORM)

Unknown status·—·Phase 4·NCT05583266·80 enrolled

Leishmaniasis1 trial

Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the Elderly

Recruiting·UUniversity of Brasilia·Phase 2/3·NCT06040489·100 enrolled

Hemolysis1 trial

HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled Trial

Withdrawn·—·Phase 4·NCT04391231

Radiculopathy1 trial

Pentoxifylline and Lumbar Radiculopathy

Active, not recruiting·SSt Joseph University, Beirut, Lebanon·Phase 4·NCT03060434·67 enrolled

Epilepsy1 trial

Clinical Study Evaluating Safety of Pentoxifylline and Celecoxib in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy

Recruiting·MMostafa Bahaa·Phase 2·NCT05637086·90 enrolled

Recurrent aphthous stomatitis1 trial

A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis

Completed·MManchester University NHS Foundation Trust·N/A·NCT00315679·30 enrolled

Behcet's Disease1 trial

Topical Pentoxifylline Gel on Behcet's Disease Genital Ulcers

Unknown status·SSilk Road Therapies, Inc.·Phase 2·NCT04186559·60 enrolled

Acute Kidney Injury1 trial

The Protective Effect of Pentoxifylline on Acute Kidney Injury

Unknown status·TTaipei Medical University Hospital·Phase 2/3·NCT02951299·140 enrolled

Pneumonia1 trial

Pentoxifylline as an Adjuvant Therapy in the Treatment of Pediatric Pneumonia; A New Perspective of an Old Drug

Completed·TTanta University·Phase 4·NCT06265389·100 enrolled

NAFLD1 trial

Follow-up of NAFLD Patients With MRI-PDFF

Completed·AAsmaa Abdelfattah Elsayed·Phase 4·NCT04910178·80 enrolled

Growth1 trial

To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery

Recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT07085806·60 enrolled

Parkinsonism1 trial

Role of Pentoxifylline and Celecoxib in Parkinsonism

Completed·MMostafa Bahaa·Phase 2·NCT05962957·80 enrolled

Fatty Liver Disease1 trial

The Effect of Pentoxifylline on Liver Function Tests in Fatty Liver Disease

Completed·TTehran University of Medical Sciences·Phase 2·NCT02283710·120 enrolled

Osteonecrosis1 trial

Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)

Enrolling by invitation·UUniversity of Washington·Phase 3·NCT03040778·100 enrolled

Pulmonary Sarcoidosis1 trial

Treatment of Pulmonary Sarcoidosis With Pentoxifylline

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00001877·100 enrolled

Dialysis Patients1 trial

Does Oral Pentoxifylline Administration Improve Hemoglobin in Hemodialysis Patients?

Completed·TTanta University·Phase 2·NCT03731741·57 enrolled

Monotherapy1 trial

Pentoxifylline Plus Carvedilol vs Carvedilol Monotherapy in Preventing New Decompensation in Stable Cirrhotic Patients With Prior Decompensation

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06041932·180 enrolled

GIST1 trial

Synergistic Effect of Vedolizumab and Pentoxifylline

Completed·UUniversity of Miami·Phase 1·NCT02953275·37 enrolled

Trial1 trial

Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT01291433·59 enrolled

Obese1 trial

The Effects of Pentoxifylline on PAI-1 in an Obese Population

Completed·VVanderbilt University·Phase 4·NCT00770328·37 enrolled

Erectile Dysfunction1 trial

Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT03830164·14 enrolled

Nephrotic Syndrome1 trial

Efficacy of Pentoxifylline on Primary Nephrotic Syndrome

Completed·NNational Taiwan University Hospital·Phase 3·NCT00354731·62 enrolled

Effectiveness1 trial

Evaluating the Effectiveness of Pentoxifylline at Improving Blood Vessel Function in HIV-infected People Not Receiving Antiretroviral Medications

Completed·IIndiana University·Phase 2·NCT00796822·26 enrolled

Lymphoma1 trial

Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma

Unknown status·UUniversity of Guadalajara·Phase 4·NCT05490953·30 enrolled

Vertigo1 trial

Trental for the Treatment of Vertigo/Dizziness/Imbalance

Terminated·UUniversity of Missouri-Columbia·N/A·NCT02592863·26 enrolled

Bipolar Depression1 trial

Treatment of Bipolar Depression With Pentoxifylline

Completed·UUniversity Health Network, Toronto·Phase 1·NCT04417049·6 enrolled

Function1 trial

Pentoxifylline and Combination Antiretroviral Therapy to Improve Blood Vessel Function in HIV-Infected People

Completed·IIndiana University·Phase 2·NCT00864916·19 enrolled

Neonatal sepsis1 trial

Pentoxifylline Dose Optimization in Neonatal Sepsis

Completed·EErasmus Medical Center·Phase 3·NCT04152980·30 enrolled

Primary Biliary Cirrhosis1 trial

Pentoxifylline for Primary Biliary Cirrhosis

Completed·TThe Cleveland Clinic·Phase 2·NCT01249092·20 enrolled

Patent ductus arteriosus1 trial

Treating the Resistant Patent Ductus Arteriosus (PDA)

Unknown status·SShaare Zedek Medical Center·Phase 2·NCT00616382·68 enrolled

Teratozoospermia1 trial

Effect of Pentoxifylline and Zinc Co-administration in Patients With Oligoasthenoteratozoospermia

Unknown status·—·N/A·NCT05156684·140 enrolled

Prevention1 trial

Pentoxifylline for the Prevention of PEP

Unknown status·—·Phase 1·NCT02992678·110 enrolled

Metastatic Colorectal Carcinoma1 trial

Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer

Completed·TTanta University·Approved·NCT06115174·44 enrolled

Rheumatoid Arthritis1 trial

Clinical Study Evaluating the Effect of Pentoxifylline as Anti Inflammatory in Patients With Rheumatoid Arthritis

Recruiting·TTanta University·Phase 2·NCT06998628·50 enrolled

Hepatobiliary Disorders1 trial

Clinical Study Evaluating Efficacy, Safety and Molecular Mechanism of Pentoxifylline Supplementation in Patients With Hepatic and Post Hepatic Jaundice

Completed·TTanta University·Phase 2·NCT06944704·45 enrolled

Inflammatory Bowel Diseases1 trial

Phosphodiesterase Inhibitors, Pentoxifylline, as Adjunctive Therapy in Patients With Ulcerative Colitis.

Completed·TTanta University·Phase 2·NCT05575505·60 enrolled

Lymphedema1 trial

Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)

Recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT06494111·295 enrolled

Adiposity1 trial

Eficácia,Satisfação e Segurança do Protocolo Mesolipo® no Tratamento da Gordura Localizada: um Estudo Randomizado

Completed·AAntony de Paula Barbosa·Preclinical·NCT07743788·12 enrolled

Fibrosis Syndrome1 trial

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

Recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT06912763·250 enrolled

Unspecified1 trial

The Therapeutic Effect of Co-administration of Pentoxifylline and Zinc in Men With Idiopathic Asthenozoospermia

Unknown status·—·Phase 1·NCT05178953·160 enrolled

Regulatory

FDA Approval Timeline[5]

Aug 30, 1984

TRENTAL

NDA NDA018631

Sources

References

[1]
ClinicalTrials.gov — 138 trial records for Pentoxifylline. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Trental drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Pentoxifylline compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Pentoxifylline. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA018631). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Validus Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Adenosine A2 Receptor Antagonist; 3',5'-Cyclic Phosphodiesterase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: VValidus Pharmaceuticals

Trental

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q3 2027

Q4 2027

Trials by Indication[1]

Hepatitis8 trials

Chronic Kidney Disease8 trials

Treatment4 trials

Breast Cancer4 trials

Cutaneous Leishmaniasis3 trials

Efficacy3 trials

Fibrosis2 trials

Ulcerative Colitis2 trials

Diabetic Nephropathy2 trials

Nephropathy2 trials

Non-Small Cell Lung Cancer2 trials

Anemia2 trials

Acute Pancreatitis2 trials

Alopecia Areata2 trials

Duchenne Muscular Dystrophy2 trials

Kidney Disease2 trials

Glomerulonephritis2 trials

Hepatopulmonary Syndrome2 trials

COVID-192 trials

Toxicity2 trials

Peripheral Neuropathy1 trial

Virus1 trial

Pregnancy1 trial

Oral Submucous Fibrosis1 trial

Major Depression1 trial

Proteinuria1 trial

Colorectal Cancer1 trial

Irritable Bowel Syndrome1 trial

Combination Therapy1 trial

Lupus Nephritis1 trial

Cirrhosis1 trial

Neuropathy1 trial

Non-Alcoholic Steatohepatitis1 trial

Eisenmenger syndrome1 trial

Prostatectomy1 trial

Asphyxia1 trial

Schizophrenia1 trial

Endometriosis1 trial

Intermittent Claudication1 trial

Biliary Atresia1 trial

Drug Repurposing1 trial

Necrosis1 trial

Acute Coronary Syndrome1 trial

HIV infection1 trial

Systemic Inflammation1 trial

Hepatitis C1 trial

Frozen Embryo Transfer1 trial

AIN1 trial

Endothelial Dysfunction1 trial

Congestive Heart Failure1 trial

Oral ulcer1 trial

Cognitive impairment1 trial

Islet Transplantation1 trial

Coronavirus Disease 20191 trial

Malaria1 trial

Glioblastoma1 trial

Fed1 trial

Alcohol1 trial

Necrotizing Enterocolitis1 trial

Sepsis1 trial

Cerebral Small Vessel Disease1 trial

Leishmaniasis1 trial

Hemolysis1 trial

Radiculopathy1 trial

Epilepsy1 trial

Recurrent aphthous stomatitis1 trial

Behcet's Disease1 trial

Acute Kidney Injury1 trial

Pneumonia1 trial

NAFLD1 trial

Growth1 trial