VivoSeq
Psychiatry

Respiratory Depression

18

Pipeline Programs↗

4

Active Trials↗

12

Companies Involved↗

Respiratory Depression is an emerging landscape with 18 programs across 12 companies. The most active players are Purdue Pharma LP, Pfizer's Upjohn has merged with Mylan to form Viatris Inc., GSK. 5 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

46/100

Pipeline Velocity

6/100

Mech. Concentration

36/100

Completion Rate

67/100

Attrition Rate

19/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

P

Purdue Pharma LP

2 programs

Phase 1P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

Phase 1GSK logo

GSK

1 program

Phase 1E

Enalare Therapeutics Inc.

1 program

Phase 2V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2AbbVie logo

AbbVie

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Trial Status

16

clinical trials

Completed6 · 38%
Unknown status3 · 19%
Terminated2 · 13%
Not yet recruiting2 · 13%
Active, not recruiting1 · 6%
Withdrawn1 · 6%
Other1 · 6%

Clinical Trials

Trial Activity

16 trials

Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists
Recruiting·LLeiden University Medical Center·Phase 1·NCT05338632·24 enrolled
ENA-001 for Opioid Induced Respiratory Depression
Active, not recruiting·EEnalare Therapeutics Inc.·Phase 1·NCT06967259·36 enrolled
ENA-001 for Post Operative Respiratory Depression (PORD)
Not yet recruiting·EEnalare Therapeutics Inc.·Phase 2·NCT06137638·200 enrolled
Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression
Not yet recruiting·SSecond Affiliated Hospital of Wenzhou Medical University·Phase 4·NCT06816173·96 enrolled
Predictors of Opioid-Induced Respiratory Depression (OIRD)
Completed·—·Phase 1·NCT02473354·30 enrolled
Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Completed·—·Phase 2·NCT02929667·30 enrolled
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
Completed·UUniversity of Saskatchewan·Phase 3·NCT02987985·50 enrolled
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
Completed·UUniversity of California, San Francisco·Phase 1·NCT04301895·20 enrolled
Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care
Completed·—·Phase 4·NCT07076628·76 enrolled
The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine.
Completed·UUniversity College Dublin·Phase 4·NCT02885948·96 enrolled
Study of Respiratory Depression When Using a Hydromorphone Pain Protocol
Terminated·AAlbert Einstein Healthcare Network·N/A·NCT01784991·116 enrolled
Precision Medicine in Anesthesia: Genetic Component in Opioid-induced Respiratory Depression
Terminated·UUniversity of Alabama at Birmingham·N/A·NCT03441282·26 enrolled
Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose
Withdrawn·UUniversity of New Mexico·Phase 3·NCT06408714
Respiratory Depression During an Analgosedation Combining Remifentanil and Ketamine in TCI for Oocyte Retrieval
Unknown status·EErasme University Hospital·N/A·NCT03458143·20 enrolled
Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective C-section
Unknown status·RRambam Health Care Campus·N/A·NCT02819661·30 enrolled
Page 1 of 2

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)