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Other/Respiratory Distress Syndrome

Respiratory Distress Syndrome

25

Pipeline Programs↗

84

Active Trials↗

39

Companies Involved↗

Respiratory Distress Syndrome is an emerging landscape with 25 programs across 39 companies. 7 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

63/100

Pipeline Velocity

67/100

Mech. Concentration

13/100

Completion Rate

58/100

Attrition Rate

19/100

Pipeline

Programs by Phase

Preclinical15

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Spironolactone

Pfizer

Ruxolitinib

Incyte

Nacl

Bayer

Angiotensin II

La Jolla Pharmaceutical Company

Phase 11

Matriplax

BioSpring Medical Co., Ltd

Phase 22

Atibuclimab

Implicit Bioscience

PRS CK STORM

PEACHES BIOTECH

Phase 37

Surfactant

NICHD Neonatal Research Network

Aprotinin

Bayer

Esmolol

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Metoprolol

Bp Consulting, Inc

Supportive Care

BeiGene

Approved

No programs

Analysis

Modality Breakdown

90%

Small molecule

19 of 21 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 21 classified programs, each share of the total. Modality classified for 100% of 25 pipeline programs.

Analysis

Trial Status

225

clinical trials

Completed63 · 28%

Recruiting48 · 21%

Unknown status32 · 14%

Terminated27 · 12%

Not yet recruiting23 · 10%

Withdrawn15 · 7%

Other17 · 8%

Clinical Trials

Trial Activity

225 trials

The Rate and Predictors of Respiratory Distress Among Neonates Delivered by Elective Cesarean Section at Term

Recruiting·AAssiut University·N/A·NCT06874478·210 enrolled

A Phase 2 Randomized Double-blind Placebo-controlled Study To Evaluate The Efficacy And Safety Of Adjunctive Recombinant Human Plasma Gelsolin With Standard Care For Moderate-to-Severe ARDS Due To Pneumonia Or Other Infections

Recruiting·BBioAegis Therapeutics Inc.·Phase 2·NCT05947955·600 enrolled

Spontaneous Versus Controlled Mechanical Ventilation in Patients With Acute Hypoxemic Respiratory Failure: A Feasibility Study and Pilot Trial

Recruiting·OOslo University Hospital·Preclinical·NCT07463885·80 enrolled

A Randomized, Controlled, Blinded, Parallel Group Study of the Safety and Efficacy of APC-0101 (SF-RI 1 Surfactant for Inhalation Combined With a Dedicated Delivery System) in Preterm Infants With Respiratory Distress Syndrome

Recruiting·AAerogen Pharma Limited·Phase 3·NCT06776783·520 enrolled

Regional Vascular Recruitment With Inhaled Nitric Oxide in Patients With ARDS

Recruiting·MMassachusetts General Hospital·Preclinical·NCT05801224·70 enrolled

Early Use of Airway Pressure Release Ventilation (APRV) in Patients With Acute Respiratory Distress Syndrome

Recruiting·HHospital Civil de Guadalajara·Preclinical·NCT04221737·150 enrolled

A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+ in Chinese Critically Ill Patients: a Prospective Randomized Controlled Clinical Trial

Recruiting·VVantive Health LLC·Preclinical·NCT07326215·99 enrolled

Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE Ventilator in Patients Requiring Assisted/Controlled Mechanical Ventilation and Weaning.

Recruiting·IIconic Solutions By Murcia SL·Preclinical·NCT07432191·81 enrolled

Personalized Ventilatory Strategy Based on Ventilation-perfusion Mismatch and Lung Recruitability in Moderate-to-severe ARDS Patients

Recruiting·ZZhongda Hospital·N/A·NCT06430554·40 enrolled

Impact of Trunk Inclination on Lung Mechanics According to PEEP and Reruitability

Recruiting·ZZhongda Hospital·N/A·NCT07504731·40 enrolled

Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled Trial

Recruiting·SSoutheast University, China·Phase 3·NCT07576660·1,704 enrolled

Role of Dyspnea in the Progression of Pediatric Acute Respiratory Distress Syndrome

Recruiting·UUniversidad Nacional Andres Bello·N/A·NCT07750288·68 enrolled

Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol

Recruiting·AAssistance Publique - Hôpitaux de Paris·Preclinical·NCT06849570·1,200 enrolled

The Arise Study - Use of Vertical Positioning

Recruiting·UUniversity of Alabama at Birmingham·Preclinical·NCT07025421·40 enrolled

PrePAP: Pre-Extubation Continuous Positive Airway Pressure in Very Preterm Infants: A Randomised Controlled Trial

Recruiting·MMurdoch Childrens Research Institute·Preclinical·NCT07251790·134 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)