NaCl

ApprovedSmall molecule

Bayer

NaCl is one of 564 small molecule programs targeting Fatigue. It is currently in Approved.

Indications

Total Trials

Active Trials

563

Competitors

Pipeline

Status by Indication[3][1]

Indication

Cardiac ArrestActive, not recruiting

Respiratory FailureActive, not recruiting

IschemiaActive, not recruiting

Intracranial HypertensionActive, not recruiting

Idiopathic ScoliosisActive, not recruiting

Cancer PainActive, not recruiting

Kidney TransplantActive, not recruiting

SepsisActive, not recruiting

Allergic RhinitisActive, not recruiting

Nausea and VomitingActive, not recruiting

Cardiac ArrestPhase 2/Phase 3

Active, not recruiting

Respiratory FailurePhase 2

Active, not recruiting

IschemiaPreclinical

Active, not recruiting

Intracranial HypertensionPreclinical

Active, not recruiting

Idiopathic ScoliosisApproved

Active, not recruiting

Cancer PainPhase 3

Active, not recruiting

Kidney TransplantPreclinical

Active, not recruiting

SepsisPreclinical

Active, not recruiting

Allergic RhinitisPhase 2

Active, not recruiting

Nausea and VomitingApproved

Active, not recruiting

Showing 10 of 24 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

NaCl

Bayer

Approved

1 2

Prolia

Amgen

Preclinical

14 3

Adenocard

Astellas

Preclinical

1 4

Blenoxane

Bristol-Myers Squibb

Preclinical

1 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 6

Zinecard

CChildren's Oncology Group

Preclinical

2 7

Acupan

YYonsei University

Preclinical

1 8

Paracetamol

GSK

Preclinical

1 9

QS21

MMemorial Sloan Kettering Cancer Center

Preclinical

3 10

Diuretic

RReprieve Cardiovascular, Inc

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 3Recruiting

Kidney Biopsy

NCT05467033

Q4 2026

Post-ApprovalRecruiting

Erector Spinae Plane Block

NCT07180940

Q1 2027

N/ANot yet recruiting

Dexamethasone

NCT07474909

N/ARecruiting

Acute Respiratory Distress Syndrome

NCT05857891

Q4 2032

Phase 2Not yet recruiting

Randomized Controlled Trial

NCT07214103

Clinical

Trials by Indication[1]

Ischemia2 trials

Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model

Unknown status·UUniversity Medical Center Groningen·N/A·NCT00691613·12 enrolled

Arginase Inhibition in Ischemia-reperfusion Injury

Completed·KKarolinska Institutet·Phase 1·NCT02009527·24 enrolled

Immunogenicity2 trials

Safety & Immunogenicity of Immunisations With EN41-UGR7C HIV Vaccine

Completed·PPX'Therapeutics·Phase 1·NCT01827397·24 enrolled

Study to Evaluate Safety, Reactogenicity and Immunogenicity of the Pneumococcal Protein PhtD Vaccine in Healthy Adults

Completed· GSK logo

GSK·Phase 1·NCT01767402·150 enrolled

Efficacy and Safety2 trials

Study Evaluating the Efficacy and Safety of Remifentanil in a Rapid Sequence Induction for Fragile Subjects

Completed·—·Phase 4·NCT01259648·75 enrolled

Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea

Completed·UUniversity Hospital, Limoges·Phase 3·NCT01501760·38 enrolled

Idiopathic Scoliosis2 trials

Dexmedetomidine for ESPB in Pain Management After Pediatric Idiopathic Scoliosis Surgery

Not yet recruiting·PPoznan University of Medical Sciences·Phase 4·NCT06789016·60 enrolled

Dexamethasone for ESPB in Pain Management After Pediatric Idiopathic Scoliosis Surgery

Completed·PPoznan University of Medical Sciences·Phase 4·NCT06616220·60 enrolled

Kidney Transplant2 trials

Effects of Dexmedetomidine on Postoperative Renal Function Recovery After Kidney Transplantation in Adult Patients

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·N/A·NCT02874378·100 enrolled

Edaravone on the Ischemia-Reperfusion(I/R) Injury in Kidney Transplantation Patients

Unknown status·XXijing Hospital·N/A·NCT02644915·150 enrolled

44 more indications

GLP-11 trial

The Effect of GLP-1 on the Inhibition of Glucagon Secretion

Completed·UUniversity Hospital, Gentofte, Copenhagen·N/A·NCT01507597·30 enrolled

Cardiac Arrest1 trial

Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest

Completed·LLars Wiuff Andersen·Phase 2/3·NCT03640949·501 enrolled

Asthma1 trial

Treatment With the Anti-IgE Monoclonal Antibody Omalizumab in Women With Asthma Undergoing Fertility Treatment. - A Proof of Concept Study.

Completed·RRigshospitalet, Denmark·Phase 2·NCT03727971·66 enrolled

Fatigue1 trial

Role of Interleukin (IL)-1 in Postprandial Fatigue - The Chäschüechli 2 Study

Completed·UUniversity Hospital, Basel, Switzerland·N/A·NCT02916355·16 enrolled

Nanoparticle1 trial

A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment

Completed·UUniversity of Pennsylvania·Phase 4·NCT06110494·44 enrolled

AIN1 trial

Nasal Allergen Challenge Test as a Method to Detect Clinical Reactivity Against Birch Pollen

Completed·KKarolinska Institutet·N/A·NCT06085963·89 enrolled

Complication1 trial

Balloon Aortic Valvuloplasty Performed Without Heparin to Decrease Vascular and Bleeding Complications of the Procedure

Terminated·UUniversity Hospital, Montpellier·Phase 4·NCT01823393·94 enrolled

Advanced Cancer1 trial

Phase 1 Study of PI3 (Phosphatidylinositol-3)-Kinase Inhibitor Copanlisib With Gemcitabine or Cisplatin Plus Gemcitabine in Patients With Advanced Cancer

Completed· Bayer logo

Bayer·Phase 1·NCT01460537·50 enrolled

Abdominal Surgery1 trial

Efficacy of Local Anesthesic on Diaphragmatic Function After Upper Abdominal Surgery

Completed·UUniversity Hospital, Rouen·Phase 3·NCT02353702·31 enrolled

Breast Cancer1 trial

Nerveblocks for Persistent Pain After Breast Cancer Surgery

Unknown status·KKenneth Geving Andersen·Phase 3·NCT02336529·48 enrolled

Respiratory Failure1 trial

Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19

Completed·RRegion Skane·Phase 2·NCT04541979·76 enrolled

Preperitoneal Infiltration1 trial

Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT01077752·95 enrolled

Botulinum Toxin1 trial

Botulinum Toxin A as a Treatment for Provoked Vestibulodynia

Completed·KKarolinska Institutet·Phase 3·NCT04057755·90 enrolled

Nephropathy1 trial

Prevention of Contrast Induced Nephropathy in Oncology Patients With Sodium Bicarbonate

Completed·—·Phase 2·NCT00540904·27 enrolled

Intracranial Hypertension1 trial

Osmotic Therapy for Treatment of Intracranial Hypertension for Traumatic Brain Injury

Withdrawn·IIndiana University·N/A·NCT01215019

Angioedema1 trial

Randomized, Double-blind, Two Arms, Multicenter, Phase III Study of Berinert for Treatment of ACE Induced Angioedema

Completed·TTechnical University of Munich·Phase 3·NCT01843530·31 enrolled

Trial1 trial

Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT00734214·258 enrolled

Hepatocellular Carcinoma1 trial

Arsenic Trioxide TACE and Intravenous Administration in Unresectable Hepatocellular Carcinoma

Unknown status·GGuangdong Provincial People's Hospital·Phase 2/3·NCT01861912·258 enrolled

Lidocaine1 trial

Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)

Unknown status·SSecond Hospital of Shanxi Medical University·Phase 4·NCT05899127·80 enrolled

COVID-191 trial

BCG Vaccination to Protect Healthcare Workers Against COVID-19

Completed·MMurdoch Childrens Research Institute·Phase 3·NCT04327206·6,828 enrolled

Allergic Rhinitis1 trial

PILOT STUDY OF THE EFFICACY AND SAFETY OF WF10 IN SUBJECTS SUFFERING FROM PERSISTENT ALLERGIC RHINITIS

Completed·NNuvo Research GmbH·Phase 2·NCT01586468·60 enrolled

Intravenous1 trial

Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl

Completed·OOslo University Hospital·Phase 4·NCT03894800·12 enrolled

Radius Fracture1 trial

Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block

Completed·OOslo University Hospital·Phase 3·NCT03011905·53 enrolled

Infertility1 trial

Iron Deficiency as an Ignored Cause of Infertility

Unknown status·DDextra Fertility Clinic·Phase 4·NCT04510870·62 enrolled

Total Hip Arthroplasty1 trial

Dexamethasone for ESPB in Total Hip Arthroplasty

Completed·PPoznan University of Medical Sciences·Phase 4·NCT06789042·60 enrolled

Tolerance1 trial

Clinical Study of ALT-BB4 to Determine Tolerance, Safety and Pharmacokinetics in Healthy Volunteer

Completed·AAlteogen, Inc.·Phase 1·NCT05232175·290 enrolled

Kidney Biopsy1 trial

Safety Outcomes Post Kidney Biopsy - Randomized Clinical Evaluation of Efficacy of Desmopressin

Recruiting·MMedical University of Bialystok·Phase 3·NCT05467033·424 enrolled

Randomized Controlled Trial1 trial

Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy

Not yet recruiting·UUniversity Hospital, Strasbourg, France·Phase 2·NCT07214103·120 enrolled

Dexamethasone1 trial

Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery

Not yet recruiting·PPoznan University of Medical Sciences·N/A·NCT07474909·150 enrolled

Sepsis1 trial

Study on the Improvement of Microcirculation in Patients With Sepsis by Vitamin B6, Vitamin B12 and Vitamin C

Recruiting·FFan Zeng·N/A·NCT06749756·296 enrolled

Acute Respiratory Distress Syndrome1 trial

The Effect of Erythropoietin on Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome

Recruiting·SSecond Affiliated Hospital of Wenzhou Medical University·N/A·NCT05857891·40 enrolled

Erector Spinae Plane Block1 trial

Comparison of Perineural Dexamethasone Versus Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Lumbar Spine Surgery: A Randomized, Double-blind, Controlled Trial

Recruiting·PPoznan University of Medical Sciences·Phase 4·NCT07180940·150 enrolled

Heart Disease1 trial

Effects of Dexmedetomidine on Patients With Coronary Heart Disease After Percutaneous Coronary Intervention

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 1·NCT03095469·200 enrolled

Cancer Pain1 trial

Efficacy of Low Analgesic Doses of Ketamine Associated With Opioids in Refractory Cancer Pain Treatment

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT01326325·24 enrolled

Nausea and vomiting1 trial

Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia

Completed·RRWTH Aachen University·Phase 4·NCT00793663·220 enrolled

CABG1 trial

Short-term Endothelin A Receptor Blockade in Patients With On-pump CABG

Unknown status·MMedical University of Vienna·Phase 2·NCT01658410·120 enrolled

Septic Shock1 trial

ILOPROST in Septic Shock With Persistent Microperfusion Defects (I-MICRO)

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT03788837·240 enrolled

Anemia1 trial

Intravenous Iron Versus Oral Iron for Severe Postpartum Anemia

Completed·HHospital Clinic of Barcelona·Phase 4·NCT00660933·70 enrolled

Hereditary Hemorrhagic Telangiectasia1 trial

Intranasal Submucosal Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)

Completed·MMedical University of Vienna·Phase 2·NCT01314274·15 enrolled

Surgical Wound1 trial

Levobupivacaine to the Surgical Wound Following Cesarean

Completed·MManuel Ángel Gómez-Ríos·Phase 3·NCT01458431·70 enrolled

Premedication1 trial

Premedication on Sevoflurane Induction

Completed·MMaisonneuve-Rosemont Hospital·N/A·NCT00723164·80 enrolled

Humans1 trial

Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans

Completed·UUniversity Hospital, Strasbourg, France·Phase 4·NCT02117206·60 enrolled

Polytrauma1 trial

Treatment of Polytraumatisms With Corticoids

Completed·NNantes University Hospital·Phase 2/3·NCT00563303·150 enrolled

Unspecified1 trial

Effects of Moxaverine and Placebo on Ocular Blood Flow

Completed·MMedical University of Vienna·Phase 2·NCT00709423·16 enrolled

Sources

References

[1]
ClinicalTrials.gov — 54 trial records for NaCl. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — NaCl compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for NaCl. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Bayer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Bayer

NaCl

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q1 2027

Q4 2032

Trials by Indication[1]

Ischemia2 trials

Immunogenicity2 trials

Efficacy and Safety2 trials

Idiopathic Scoliosis2 trials

Kidney Transplant2 trials

GLP-11 trial

Cardiac Arrest1 trial

Asthma1 trial

Fatigue1 trial

Nanoparticle1 trial

AIN1 trial

Complication1 trial

Advanced Cancer1 trial

Abdominal Surgery1 trial

Breast Cancer1 trial

Respiratory Failure1 trial

Preperitoneal Infiltration1 trial

Botulinum Toxin1 trial

Nephropathy1 trial

Intracranial Hypertension1 trial

Angioedema1 trial

Trial1 trial

Hepatocellular Carcinoma1 trial

Lidocaine1 trial

COVID-191 trial

Allergic Rhinitis1 trial

Intravenous1 trial

Radius Fracture1 trial

Infertility1 trial

Total Hip Arthroplasty1 trial

Tolerance1 trial

Kidney Biopsy1 trial

Randomized Controlled Trial1 trial

Dexamethasone1 trial

Sepsis1 trial

Acute Respiratory Distress Syndrome1 trial

Erector Spinae Plane Block1 trial

Heart Disease1 trial

Cancer Pain1 trial

Nausea and vomiting1 trial

CABG1 trial

Septic Shock1 trial

Anemia1 trial

Hereditary Hemorrhagic Telangiectasia1 trial

Surgical Wound1 trial

Premedication1 trial

Humans1 trial

Polytrauma1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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