VivoSeq
Musculoskeletal

Rotator Cuff Tear

31

Pipeline Programs↗

12

Active Trials↗

20

Companies Involved↗

Rotator Cuff Tear is a moderately active landscape with 31 programs across 20 companies. The most active players are Taiwan Bio Therapeutics Inc., Eli Lilly, Vitae Pharmaceuticals Inc., an Allergan affiliate. 13 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

54/100

Pipeline Velocity

25/100

Mech. Concentration

13/100

Completion Rate

59/100

Attrition Rate

22/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

T

Taiwan Bio Therapeutics Inc.

1 program

Phase 1Eli Lilly logo

Eli Lilly

1 program

Phase 1V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2Ferring logo

Ferring

1 program

Phase 2J

Jiangsu Topcel-KH Pharmaceutical Co., Ltd.

1 program

Phase 2J

Javelin Pharmaceuticals

1 program

Phase 3

Pipeline

Programs by Phase

Preclinical8

Ergocalciferol

Alnylam Pharmaceuticals

Platelet Rich Plasma

Zagazig University

Active Comparator

Moderna

Experimental

Biogen

Cortisone

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 11

Stem Cell Therapy

University Hospital, Basel, Switzerland

Phase 27

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Clomiphene Citrate

Ferring

Mesenchymal Stem Cells

Jiangsu Topcel-KH Pharmaceutical Co., Ltd.

TISSEEL

University Hospital, Ghent

Orthadapt

Hospital San Carlos, Madrid

Phase 32

Ketorolac

Javelin Pharmaceuticals

TPX-114

Tego Science, Inc.

Approved13

Indocyanine Green

CHX Technologies Inc.

Celecoxib

Philadelphia Eye Associates

Diazepam

Akero Therapeutics

Gabapentin

Viatris Specialty LLC

Testosterone Cypionate

Azurity Pharmaceuticals

Analysis

Modality Breakdown

94%

Small molecule

30 of 32 classified programs — the dominant modality here.

6%ALL OTHERSCell therapy26%

Small molecule leads; the ring shows all 32 classified programs, each share of the total. Modality classified for 98% of 42 pipeline programs.

Analysis

Trial Status

32

clinical trials

Completed10 · 31%
Not yet recruiting6 · 19%
Withdrawn5 · 16%
Recruiting4 · 13%
Unknown status3 · 9%
Terminated2 · 6%
Other2 · 6%

Clinical Trials

Trial Activity

32 trials

Bioinductive Patch for Full-Thickness Rotator Cuff Tears
Recruiting·HHenry Ford Health System·Phase 4·NCT05439850·78 enrolled
Perioperative Polmacoxib Reduce Opioid Consumption for Post Operative Pain After Rotator Cuff Tear.
Recruiting·EEulji University Hospital·N/A·NCT06590714·150 enrolled
A Phase 2b/3 Study of TPX-115 on Partial-thickness Rotator Cuff Tear
Recruiting·TTego Science, Inc.·Phase 2/3·NCT06414005·166 enrolled
FiberLocker® System Augmentation of Rotator Cuff Repairs
Recruiting·ZZuriMED Technologies Inc.·Preclinical·NCT06918041·60 enrolled
Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
Active, not recruiting·IInGeneron, Inc.·N/A·NCT03752827·168 enrolled
Effectiveness of Treatments for Massive Rotator Cuff Tears: Mixed Methodology.
Active, not recruiting·PParc de Salut Mar·N/A·NCT05780229·200 enrolled
Clinical Study on the Safety and Efficacy of Tendon Stem Progenitor Cells Therapy for Rotator Cuff Tears
Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1·NCT07320378·107 enrolled
Efficacy and Safety Study of TPX-115 on Partial-thickness Rotator Cuff Tear
Not yet recruiting·TTego Science, Inc.·Phase 2·NCT07219654·60 enrolled
Effect of Vitamin D Supplementation on the Rehabilitation of Patients After Rotator Cuff Tear Repair
Not yet recruiting·—·N/A·NCT06984068·44 enrolled
Pre-Procedure Versus Post-Procedure Administration of Interscalene Block in Arthroscopic Rotator Cuff Repair: Effects on Early Pain Control and Functional Outcomes
Not yet recruiting·IIstinye University·N/A·NCT07689448·42 enrolled
Effect of Central Sensitization on Postoperative Clinical Outcomes in Patients Undergoing Arthroscopic Rotator Cuff Repair
Not yet recruiting·MMedipol University·N/A·NCT07667257·50 enrolled
THE EFFECT OF TASK-ORIENTED OCCUPATIONAL THERAPY INTERVENTION ON ACTIVITY PARTICIPATION AFTER ROTATOR CUFF SURGERY: PRE- AND POST-INTERVENTION EVALUATION
Not yet recruiting·MMedipol University·Preclinical·NCT07665541·30 enrolled
A Phase I/III Clinical Study of TPX-114 for the Treatment of Full-Thickness Rotator Cuff Tear
Completed·TTego Science, Inc.·Phase 3·NCT03668028·93 enrolled
Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells (Rotator Cuff Tear)
Completed·SSeoul National University Hospital·Phase 2·NCT02298023·24 enrolled
The Effect of Platelet Rich Plasma Injection Combined With Exercise Rehabilitation in Patients With Rotator Cuff Tear
Completed·TTaipei Veterans General Hospital, Taiwan·Phase 1·NCT03548662·30 enrolled
Page 1 of 3

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)