Active comparator

Phase 3Small molecule

Moderna

Active comparator is one of 95 small molecule programs targeting Sedation. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Rotator Cuff TearActive, not recruiting

Pancreatic CancerActive, not recruiting

FibromyalgiaActive, not recruiting

Metastatic Clear Cell Renal Cell CarcinomaRecruiting

Rotator Cuff TearPreclinical

Active, not recruiting

Pancreatic CancerPreclinical

Active, not recruiting

FibromyalgiaPreclinical

Active, not recruiting

Metastatic Clear Cell Renal Cell CarcinomaPhase 3

Recruiting

Competition

Competitive Landscape

306 competitors in Pancreatic Cancer

#DrugCompanyPhaseTrials

Active comparator

Moderna

Phase 3

1 2

Byetta

AstraZeneca

Preclinical

1 3

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

1 4

Ayvakit Sprinkle

MMemorial Sloan Kettering Cancer Center

Preclinical

1 5

Xylocaine

MMEDRx USA, Inc.

Preclinical

1 6

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 7

Secretin-Ferring

Ferring

Preclinical

1 8

Sulfonylureas

Eli Lilly

Preclinical

1 9

Concurrent Lenvatinib

TTrans Tasman Radiation Oncology Group

Preclinical

1 10

HS-20093

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 1Recruiting

Total Hip Arthroplasty

NCT05247255

Phase 1/2Not yet recruiting

Radiotherapy

NCT06195670

Q2 2027

Phase 2Recruiting

Low Dose Radiotherapy

NCT06714708

PreclinicalNot yet recruiting

Ebola Hemorrhagic Fever

NCT07842107

Q3 2027

Phase 2Not yet recruiting

Cachexia

NCT07168226

Q1 2028

Phase 3Recruiting

Psoriatic Arthritis

NCT06671483

Clinical

Trials by Indication[1]

COVID-194 trials

Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)

Completed·—·Phase 2/3·NCT04553705·150 enrolled

COVID-19 Paediatric VLA2001-321 Study

Withdrawn·VValneva Austria GmbH·Phase 2/3·NCT05298644

Immuno-bridging Study of COVID-19 Protein Subunit Recombinant Vaccine

Completed·PPT Bio Farma·Phase 3·NCT05433285·4,050 enrolled

Show 1 more trial

Booster Study of COVID-19 Protein Subunit Recombinant Vaccine

Completed·PPT Bio Farma·Phase 2·NCT05525208·696 enrolled

Rheumatoid Arthritis2 trials

A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)

Completed·AAsahi Kasei Pharma Corporation·Phase 2·NCT01285752·240 enrolled

A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)

Completed·AAsahi Kasei Pharma Corporation·Phase 2·NCT00902369·130 enrolled

Influenza2 trials

A Study of mRNA-1010 Seasonal Influenza Vaccine in Healthy Adults

Completed· Moderna logo

Moderna·Phase 1/2·NCT04956575·885 enrolled

A Study of mRNA-1020 and mRNA-1030 Seasonal Influenza Vaccines in Healthy Adults

Completed· Moderna logo

Moderna·Phase 1/2·NCT05333289·572 enrolled

Total Hip Arthroplasty1 trial

Quadratus Lumborum Block for Total Hip Arthroplasty

Recruiting·UUniversity of California, Los Angeles·Phase 1·NCT05247255·80 enrolled

Total Knee Replacement1 trial

Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?

Completed·NNew Lexington Clinic·N/A·NCT00492973·101 enrolled

41 more indications

Type 1 Diabetes1 trial

Efficacy & Safety of Inhaled Insulin in Type 1 Diabetes

Completed·MMannkind Corporation·Phase 3·NCT00308308·589 enrolled

Adult1 trial

Bioavailability of DFN-15 at 3 Different Doses vs. Comparator and to Determine Dose-proportionality of DFN-15 in Fasting Healthy Adults

Completed·—·Phase 1·NCT03051685·16 enrolled

Fibromyalgia1 trial

ESKETamine for FIBromyalgia Treatment

Terminated·GGrand Hôpital de Charleroi·N/A·NCT04436250·23 enrolled

Morphine1 trial

Staccato Apomorphine Single and Multi Dose PK

Completed·AAlexza Pharmaceuticals, Inc.·Phase 1·NCT03822364·56 enrolled

COPD1 trial

A Safety, Pharmacokinetic and Pharmacodynamic Study of PUR0200 in COPD Patients

Completed·PPulmatrix Inc.·Phase 1·NCT01921712·38 enrolled

Pancreatic Cancer1 trial

Epidemiological Assessment of the Risk for Pancreatic Cancer Associated With the Use of Semaglutide in Patients With Type 2 Diabetes - A Cohort Study Based on Nordic Registry Data

Unknown status· Novo Nordisk logo

Novo Nordisk··NCT04572165·600,000 enrolled

SARS-CoV-21 trial

Phase 2b/3 Trial of VSV-ΔG SARS-CoV-2 Vaccine (BRILIFE) Against Approved Comparator Vaccine.

Withdrawn·NNeuroRx, Inc.·Phase 2/3·NCT04990466

Cachexia1 trial

Phase 2 Cachexia Clinical Trial to Evaluate the Efficacy and Safety of ASCA101

Not yet recruiting·MMetaFines·Phase 2·NCT07168226·135 enrolled

Eye Disease1 trial

A Study to Evaluate the Safety, Tolerability, and Efficacy of A197 in Subjects With Dry Eye Disease

Completed·AAramis Biosciences, Inc.·Phase 2·NCT05238597·207 enrolled

Low Dose Radiotherapy1 trial

Low Dose Radiotherapy Combined With Sintilimab and Chemotherapy as Neoadjuvant Therapy for Stage II-III NSCLC

Recruiting·—·Phase 2·NCT06714708·86 enrolled

Dermatitis1 trial

Green Banana Peel Extract for Stasis Dermatitis Treatment

Completed·UUniversidade do Vale do Sapucai·Phase 1·NCT06427733·20 enrolled

Sedation1 trial

Use of Dexmedetomidine for Deep Sedation in Patients Undergoing Outpatient Hysteroscopic Surgery

Terminated·NNorthwestern University·N/A·NCT01337739·8 enrolled

Immunogenicity1 trial

Safety and Immunogenicity of SARS-CoV-2 Protein Subunit Recombinant Vaccine in Healthy Children

Completed·PPT Bio Farma·Phase 3·NCT05546502·1,050 enrolled

Narcolepsy1 trial

A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1

Completed· Eisai logo

Eisai·Phase 1·NCT06462404·22 enrolled

Chronic Obstructive Pulmonary Disease1 trial

A Study To Examine The Safety, Pharmacokinetics And Pharmacodynamics Of PF-03635659 In Patients With Chronic Obstructive Pulmonary Disease

Completed· Pfizer logo

Pfizer·Phase 2·NCT01033487·22 enrolled

Helicobacter Pylori1 trial

ERADICATE Hp2 - Treating Helicobacter Pylori With RHB-105 Compared to Active Comparator

Completed·RRedHill Biopharma Limited·Phase 3·NCT03198507·455 enrolled

Gingivitis1 trial

The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis

Completed·CColgate Palmolive·Phase 2·NCT02243046·162 enrolled

Clostridioides difficile Infection1 trial

Evaluation of CRS3123 vs. Oral Vancomycin in Adult Patients With Clostridioides Difficile Infection

Completed·CCrestone, Inc·Phase 2·NCT04781387·43 enrolled

Efficacy1 trial

Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste

Completed·CChurch & Dwight Company, Inc.·N/A·NCT07419763·30 enrolled

SGLT2 Inhibitors1 trial

Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)

Active, not recruiting·OOhio State University··NCT07188545·23,280,000 enrolled

Radiotherapy1 trial

Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC

Not yet recruiting·ZZhejiang Cancer Hospital·Phase 1/2·NCT06195670·220 enrolled

Whitening1 trial

Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste

Completed·CChurch & Dwight Company, Inc.·N/A·NCT07419685·31 enrolled

Allergic Rhinitis1 trial

Clinical Trial to Evaluate the Safety and Efficacy of AGR Tablet as a Treatment of Perennial Allergic Rhinitis in Korean

Completed· Ahn-Gook Pharmaceuticals Co.,Ltd logo

Ahn-Gook Pharmaceuticals Co.,Ltd·Phase 3·NCT01982916·324 enrolled

Venous thrombosis1 trial

Oral Rivaroxaban in Children With Venous Thrombosis

Completed· Bayer logo

Bayer·Phase 2·NCT01684423·64 enrolled

Gastritis1 trial

Clinical Study of Manpixiao in the Treatment of Chronic Atrophic Gastritis

Unknown status·—·Phase 1·NCT05493124·180 enrolled

Insomnia1 trial

SM-1 vs. an Active Comparator in A Model of Transient Insomnia

Not yet recruiting·SSequential Medicine Ltd·Phase 2·NCT04396327·14 enrolled

Actinic Keratosis1 trial

Safety, Tolerability, and Efficacy Study of LFX453 in Actinic Keratosis Patients

Completed· Novartis logo

Novartis·Phase 2·NCT02404389·82 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Oral BT-11 in Crohn's Disease Patients With Moderate to Severe Disease

Withdrawn·NNImmune Biopharma·Phase 2·NCT05057273

Chlorhexidine1 trial

Irritation and Sensitization of Chlorhexidine Gluconate (CHG) Cloth

Completed·MMedline Industries·Phase 3·NCT02224625·249 enrolled

Rotator Cuff Tear1 trial

Perioperative Polmacoxib Reduce Opioid Consumption for Post Operative Pain After Rotator Cuff Tear.

Recruiting·EEulji University Hospital·N/A·NCT06590714·150 enrolled

Acute Myeloid Leukemia1 trial

GOELAMS SA4 Study: the Role of Fludarabine in the Treatment of Acute Myeloid Leukemia in the Elderly

Completed·FFrench Innovative Leukemia Organisation·Phase 3·NCT00925873·303 enrolled

Non-Small Cell Lung Cancer1 trial

ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer

Completed· Pfizer logo

Pfizer·Phase 3·NCT01360554·878 enrolled

Fabry Disease1 trial

Evaluate the Safety and Efficacy of Fabagal® (Agalsidase Beta) in Patients With Fabry Disease

Recruiting·IISU Abxis Co., Ltd.·Phase 3·NCT06081062·24 enrolled

Clinical Trial1 trial

A Clinical Trial to Compare Safety and Pharmacokinetic Characteristics of CKD-337

Completed· Chong Kun Dang Pharmaceutical logo

Chong Kun Dang Pharmaceutical·Phase 1·NCT03346187·60 enrolled

Treatment1 trial

Ketamine, SGB and Combination Treatment for TBI

Recruiting·NNorthwestern University·Phase 2·NCT06608277·175 enrolled

Tics1 trial

A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12470

Completed· Hanmi Pharmaceutical Company Limited logo

Hanmi Pharmaceutical Company Limited·Phase 1·NCT02302443·100 enrolled

Double-blind1 trial

Randomized, Double-blind Study to Evaluate the Tolerability of 2 Different Titration Methods of Rivastigmine Patch in AD Patients (MMSE 10-20)

Completed· Novartis logo

Novartis·Phase 3·NCT01614886·216 enrolled

Psoriatic Arthritis1 trial

A Multi-Center, Randomized, Double-Blind, Placebo- and Active-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Zasocitinib (TAK-279) in Subjects With Active Psoriatic Arthritis Who Are Naïve to Biologic Disease-Modifying Antirheumatic Drugs (LATITUDE-PsA-3001)

Recruiting· Takeda logo

Takeda·Phase 3·NCT06671483·1,088 enrolled

Metastatic Clear Cell Renal Cell Carcinoma1 trial

Phase III Trial of Immunotherapy-Based Combination Therapy With or Without Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma (PROBE Trial)

Recruiting·SSWOG Cancer Research Network·Phase 3·NCT04510597·364 enrolled

Ebola hemorrhagic fever1 trial

A Phase 2/3 Randomized, Controlled, Adaptive Platform Trial to Evaluate the Efficacy, Safety, and Immunogenicity of Vaccine Candidates Against Bundibugyo Virus Disease (BVD) in Contacts of Cases

Not yet recruiting·JJean-Pierre Van geertruyden·Preclinical·NCT07842107·3,620 enrolled

Unspecified1 trial

CT 327 in the "Atopy Patch Test" Model

Withdrawn·CCreabilis SA·Phase 1·NCT01368315·20 enrolled

Sources

References

[1]
ClinicalTrials.gov — 51 trial records for Active comparator. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Active comparator compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Active comparator. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Moderna company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Moderna

Active comparator

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Q2 2027

Q3 2027

Q1 2028

Trials by Indication[1]

COVID-194 trials

Rheumatoid Arthritis2 trials

Influenza2 trials

Total Hip Arthroplasty1 trial

Total Knee Replacement1 trial

Type 1 Diabetes1 trial

Adult1 trial

Fibromyalgia1 trial

Morphine1 trial

COPD1 trial

Pancreatic Cancer1 trial

SARS-CoV-21 trial

Cachexia1 trial

Eye Disease1 trial

Low Dose Radiotherapy1 trial

Dermatitis1 trial

Sedation1 trial

Immunogenicity1 trial

Narcolepsy1 trial

Chronic Obstructive Pulmonary Disease1 trial

Helicobacter Pylori1 trial

Gingivitis1 trial

Clostridioides difficile Infection1 trial

Efficacy1 trial

SGLT2 Inhibitors1 trial

Radiotherapy1 trial

Whitening1 trial

Allergic Rhinitis1 trial

Venous thrombosis1 trial

Gastritis1 trial

Insomnia1 trial

Actinic Keratosis1 trial

Safety and Efficacy1 trial

Chlorhexidine1 trial

Rotator Cuff Tear1 trial

Acute Myeloid Leukemia1 trial

Non-Small Cell Lung Cancer1 trial

Fabry Disease1 trial

Clinical Trial1 trial

Treatment1 trial

Tics1 trial

Double-blind1 trial

Psoriatic Arthritis1 trial

Metastatic Clear Cell Renal Cell Carcinoma1 trial

Ebola hemorrhagic fever1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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