VivoSeq
Other

Skin Infection

32

Pipeline Programs↗

0

Active Trials↗

16

Companies Involved↗

Skin Infection is a moderately active landscape with 32 programs across 16 companies. The most active players are Melinta Therapeutics, Inc., Lytix Biopharma AS, Innovation Pharmaceuticals, Inc.. 9 therapies are approved with 7 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

52/100

Pipeline Velocity

0/100

Mech. Concentration

50/100

Completion Rate

92/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

M

Melinta Therapeutics, Inc.

4 programs

Phase 2L

Lytix Biopharma AS

1 program

Phase 2I

Innovation Pharmaceuticals, Inc.

1 program

Phase 2Astellas logo

Astellas

1 program

Phase 3K

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

1 program

Phase 3P

Prism Pharmaceuticals

1 program

Approved

Pipeline

Programs by Phase

Preclinical5

Azithromycin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Ceftriaxone

Conrado Roberto Hoffmann Filho

Clindamycin

Pfizer

Flucloxacillin

AbbVie

Antivenom Serum

Guangzhou Institute of Respiratory Disease

Phase 11

S. Aureus

National Institute of Allergy and Infectious Diseases (NIAID)

Phase 210

Linezolid

Pfizer

LTX-109

Lytix Biopharma AS

Brilacidin

Innovation Pharmaceuticals, Inc.

Delafloxacin

Melinta Therapeutics, Inc.

Debio 025

Debiopharm International SA

Phase 37

Alcohol

Astellas

Levofloxacin

Wim Janssens

Ceftaroline

Pfizer

Ceftaroline Fosamil

AbbVie

Aztreonam

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Approved9

Daptomycin

Baxter Healthcare Corporation

Povidone-Iodine

Becton, Dickinson and Company

Tigecycline

Prism Pharmaceuticals

Clotrimazole

Bayer

Vancomycin

Hikma Pharmaceuticals LLC

Analysis

Trial Status

25

clinical trials

Completed23 · 92%
Terminated2 · 8%

Clinical Trials

Trial Activity

25 trials

Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections
Completed·CCellceutix Corporation·Phase 2·NCT02052388·215 enrolled
China Registration Study in Patients With Skin Infections
Completed·AstraZeneca logoAstraZeneca·Phase 3·NCT00772447·265 enrolled
Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections
Completed·—·Phase 4·NCT00352612·200 enrolled
Human Immunity Against Staphylococcus Aureus Skin Infection
Completed·National Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT02262819·49 enrolled
Comparing the Intravenous Treatment of Skin Infections in Children, Home Versus Hospital
Completed·MMurdoch Childrens Research Institute·N/A·NCT02334124·190 enrolled
Predictive Modeling of Necrotizing Skin Infections in Snakebite Patients
Completed·GGuangzhou Institute of Respiratory Disease·N/A·NCT06622343·99 enrolled
A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections
Completed·MMelinta Therapeutics, Inc.·Phase 2·NCT01283581·256 enrolled
Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA
Completed·Merck & Co. logoMerck & Co.·Phase 4·NCT01419184·250 enrolled
Safety and Efficacy of CEM-102 Compared to Linezolid in Acute Bacterial Skin Infections
Completed·AArrevus Inc.·Phase 2·NCT00948142·198 enrolled
Initial Treatment for Acute Bacterial Skin Infections (ABSSSI) Caused by Staphylococcus Aureus
Completed·PPolyMedix, Inc.·Phase 2·NCT01211470·215 enrolled
Study Comparing the Safety and Efficacy of Tigecycline With Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Skin Infections
Completed·Pfizer logoPfizer·Phase 4·NCT00368537·550 enrolled
Evaluation of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections
Completed·Pfizer logoPfizer·Phase 3·NCT01499277·802 enrolled
A Study to Evaluate Safety, Tolerability and Efficacy of Lytixar™ (LTX-109) on Uncomplicated, Gram-positive, Skin Infection
Completed·LLytix Biopharma AS·Phase 2·NCT01223222·24 enrolled
Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.
Completed·GSK logoGSK·Phase 4·NCT00555061·60 enrolled
A Study of the Safety and Effectiveness of Levofloxacin Compared to Ticarcillin/Clavulanate Alone or Followed by Amoxicillin/Clavulanate in the Treatment of Complicated Skin Infections
Completed·Johnson & Johnson Pharmaceutical Research & Development, L.L.C. logoJohnson & Johnson Pharmaceutical Research & Development, L.L.C.·Phase 3·NCT00249197·413 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)