VivoSeq
Other

Spinal Fusion

40

Pipeline Programs↗

8

Active Trials↗

20

Companies Involved↗

Spinal Fusion is a moderately active landscape with 40 programs across 20 companies. The most active players are Bone Therapeutics S.A, Ankasa Regenerative Therapeutics, Inc., Fresenius Kabi Oncology Ltd.. 24 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

57/100

Pipeline Velocity

11/100

Mech. Concentration

27/100

Completion Rate

64/100

Attrition Rate

25/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

B

Bone Therapeutics S.A

1 program

Phase 2A

Ankasa Regenerative Therapeutics, Inc.

1 program

Phase 2F

Fresenius Kabi Oncology Ltd.

1 program

Phase 2E

Exela Pharma Sciences, LLC.

1 program

Phase 3K

Kenvue Brands

1 program

Phase 3Chiesi Farmaceutici S.p.A. logo

Chiesi Farmaceutici S.p.A.

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

93%

Small molecule

43 of 46 classified programs — the dominant modality here.

7%ALL OTHERSPeptide24%Vaccine12%

Small molecule leads; the ring shows all 46 classified programs, each share of the total. Modality classified for 100% of 49 pipeline programs.

Analysis

Trial Status

48

clinical trials

Completed23 · 48%
Terminated10 · 21%
Recruiting6 · 13%
Unknown status4 · 8%
Withdrawn2 · 4%
Active, not recruiting2 · 4%
Other1 · 2%

Clinical Trials

Trial Activity

48 trials

Abaloparatide vs. Placebo in Post-Menopausal Women and Abaloparatide in Men Receiving Initial Spinal Fusion Surgery
Recruiting·HHospital for Special Surgery, New York·Phase 2·NCT03841058·96 enrolled
Pooled Human Plasma vs Crystalloid in The Management of Children Undergoing Instrumented Spinal Fusion for Scoliosis
Recruiting·TTurku University Hospital·Phase 3·NCT06934278·194 enrolled
Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion
Recruiting·—·Phase 4·NCT06744907·60 enrolled
Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion
Recruiting·UUniversity of Iowa·Phase 1·NCT05461092·50 enrolled
Pulse-width Modulation During Pedicle Screw Stimulation
Recruiting·DDartmouth-Hitchcock Medical Center·Preclinical·NCT06120231·50 enrolled
Durability of Supplementary Rod Constructs-SuppleMentAry Rod Technique (SMART)-for Long-segment Posterior Instrumented Spinal Fusion Procedures: A Multicenter Retrospective Comparative Study With Dual-rod Constructs
Recruiting·AO Foundation, AO Spine·N/A·NCT06368245·1,244 enrolled
Suprafascial Vancomycin Powder for Prevention of Surgical Site Infections After Instrumented Posterior Spinal Fusion
Active, not recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 2·NCT04017468·450 enrolled
Lumbar Fusion With Porous Titanium Versus Non-Porous Titanium-Coated PEEK Interbody Cages - A Randomized Controlled Trial
Active, not recruiting·—·Preclinical·NCT05583864·108 enrolled
A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion
Completed·NNYU Langone Health·Phase 4·NCT02424591·46 enrolled
Intrawound Vancomycin Powder in Spinal Fusion Surgery
Completed·—·Phase 4·NCT02631408·308 enrolled
Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion
Completed·BBone Therapeutics S.A·Phase 2·NCT02205138·38 enrolled
A Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal Fusion
Completed·NNYU Langone Health·Phase 2·NCT03274453·129 enrolled
PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery
Completed·Pacira Pharmaceuticals, Inc logoPacira Pharmaceuticals, Inc·Phase 1·NCT02985762·15 enrolled
Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion
Completed·MMedical College of Wisconsin·N/A·NCT00726999·63 enrolled
Postoperative subQ Pain Control for Spinal Fusion Surgery
Completed·UUniversity of Arizona·Phase 2·NCT03476811·11 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)