Lidocain

PreclinicalSmall molecule

Bayer

Lidocain is one of 113 small molecule programs targeting Neuropathic Pain. It is currently in Preclinical.

Indications

Total Trials

Active Trials

112

Competitors

Pipeline

Status by Indication[3][1]

Indication

Neuropathic PainActive, not recruiting

Spinal FusionActive, not recruiting

Periodontal PocketActive, not recruiting

Femur FractureActive, not recruiting

MigraineActive, not recruiting

UltrasoundUnknown status

Gastrointestinal FunctionUnknown status

Neuropathic PainPreclinical

Active, not recruiting

Spinal FusionPreclinical

Active, not recruiting

Periodontal PocketPreclinical

Active, not recruiting

Femur FracturePreclinical

Active, not recruiting

MigrainePreclinical

Active, not recruiting

UltrasoundPreclinical

Unknown status

Gastrointestinal FunctionPreclinical

Unknown status

Competition

Competitive Landscape

102 competitors in Migraine

#DrugCompanyPhaseTrials

Zonegran

AAzurity Pharmaceuticals

Phase 3

3 2

Avicel

SSanthera Pharmaceuticals

Phase 3

2 3

Effient

CCosette Pharmaceuticals, Inc.

Phase 3

1 4

Magnesium

SSpherium Biomed

Phase 3

3 5

Aspirin /d

TThe First Affiliated Hospital with Nanjing Medical University

Phase 3

1 6

Flunarizine

AAspartes Pharmaceuticals, Inc.

Phase 3

9 7

Bayer Aspirin

Bayer

Preclinical

2 8

Cervidil

Pfizer

Preclinical

1 9

Cymbalta

Jazz Pharmaceuticals

Preclinical

1 10

Adempas

Bayer

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2028

Phase 3Recruiting

Vaso-Occlusive Pain Episode in Sickle Cell Disease

NCT07274254

Q3 2029

Phase 3Not yet recruiting

Chronic Pain

NCT07869173

Clinical

Trials by Indication[1]

Ultrasound2 trials

Ultrasound-guided LMBB by Caudal-cranial Approach: Radiographic Comparison of a New Ultrasound-guided Method

Unknown status·EErasme University Hospital·N/A·NCT05930236·40 enrolled

The Effects of Ultrasound Guided Ozone and Lidocaine Injections in Piriformis Syndrome

Unknown status·—·N/A·NCT06130618·28 enrolled

Anesthesia2 trials

Buffered vs Plain Lidocaine for Local Nasal Anesthesia

Unknown status·KKfir Siag·Phase 1·NCT04583137·80 enrolled

The Use of Infiltrative Anesthesia Instead of Inferior Alveolar Block

Completed·KKonya Necmettin Erbakan Üniversitesi·Phase 4·NCT06439186·60 enrolled

After Cardiac Surgery1 trial

Dexmedetomidine Enhancing the Recovery After Cardiac Surgery

Completed·—·N/A·NCT06907277·75 enrolled

Femur Fracture1 trial

PENG Versus Femoral Nerve Block in Neck of Femur Fracture

Unknown status·UUniversity College Cork·N/A·NCT05002725·64 enrolled

Migraine1 trial

Mesotherapy in the Treatment of Chronic Migraine

Completed·KKanuni Sultan Suleyman Training and Research Hospital·N/A·NCT06118190·27 enrolled

21 more indications

Periodontal Pocket1 trial

Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment

Completed·UUniversity of Roma La Sapienza·N/A·NCT04702334·144 enrolled

Laparoscopic Cholecystectomy1 trial

Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic Cholecystectomy

Unknown status·MMenoufia University·Phase 4·NCT05937282·80 enrolled

Local Anesthetic1 trial

Comparison of the Efficacy of Prolotherapy Injection Therapy & Local Anesthetic Injection Therapy.

Completed·IIstanbul Physical Medicine Rehabilitation Training and Research Hospital·N/A·NCT05239091·28 enrolled

Neuropathic Pain1 trial

Infusion Treatments of Chronic Peripheral Neuropathic Pain

Completed·HHacettepe University··NCT06297915·102 enrolled

Bariatric Surgery1 trial

Analgesia Management in Bariatric Surgery

Completed·OOndokuz Mayıs University·N/A·NCT04836819·78 enrolled

Common Cold1 trial

Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold

Completed· Bayer logo

Bayer·Phase 3·NCT01361399·1,088 enrolled

Spinal Fusion1 trial

Effect of Introperative Ketamine and Lidocaine Infusion on Postoperative Opioid Consumption in Posterior Spinal Fusion Surgery

Completed·—·N/A·NCT04711668·75 enrolled

Pain Perception1 trial

Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8

Completed·MMedical University of Vienna·Phase 1·NCT05935280·36 enrolled

Dexmedetomidine1 trial

Comparison of the Effects of Dexmedetomidine and Lidocaine on Blood Pressure and Heart Rate Response

Completed·UUniversitas Padjadjaran·N/A·NCT06573957·42 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy

Not yet recruiting·IIVO JURISIC·N/A·NCT07084753·36 enrolled

Major Abdominal Surgery1 trial

Evaluation of Plasma Concentrations of Intravenous Lidocaine and Epidural Ropivacaine When Used in Combination in Major Abdominal Surgery

Completed·—·Phase 4·NCT05368753·51 enrolled

Overactive Bladder1 trial

Evaluation of Intradetrusor AbobotulinumtoxinA and IncobotulinumtoxinA in Women With Overactive Bladder

Completed·NNiko Kavcic·Phase 4·NCT06250543·64 enrolled

Hemodynamic Stability1 trial

Effect of Topical Airway Block on Hemodynamic Stability Post Induction of Anaesthesia in Cardiac Surgeries

Completed·—·Phase 4·NCT06395727·106 enrolled

Treatment1 trial

Effects of Pretreatment with Different Doses of Lidocaine on Injection Pain

Completed·GGiresun University·N/A·NCT06865300·210 enrolled

Ondansetron1 trial

Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection

Completed·IIndonesia University·Phase 2·NCT03134612·104 enrolled

Gastrointestinal Function1 trial

Effect of Perioperative Lidocaine on Gastrointestinal Function Recovery After Lumbar Spine Surgery in Adults

Unknown status·PPeking University People's Hospital·N/A·NCT04922359·96 enrolled

Knee Osteoarthritis1 trial

Comparison of the Efficacy of Ultrasound-Guided Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve in Patients With Knee Osteoarthritis

Completed·GGaziler Physical Medicine and Rehabilitation Education and Research Hospital·Preclinical·NCT06265675·88 enrolled

Chronic pain1 trial

"Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study."

Not yet recruiting·NNantes University Hospital·Phase 3·NCT07869173·266 enrolled

Intrauterine Device Migration1 trial

The Role of Lidocaine Spray in Reducing Pain During Intrauterine Device Application

Completed·KKanuni Sultan Suleyman Training and Research Hospital·Preclinical·NCT07155785·90 enrolled

Vaso-Occlusive Pain Episode in Sickle Cell Disease1 trial

Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease

Recruiting·NNantes University Hospital·Phase 3·NCT07274254·104 enrolled

Unspecified1 trial

Effectiveness of 10% Lidocaine Spray on Relieving Local Pain Caused by Intravenous (IV) Intubation: a Randomized Control Trial

Completed·PPhenikaa University·Phase 3·NCT07212192·150 enrolled

Sources

References

[1]
ClinicalTrials.gov — 28 trial records for Lidocain. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Lidocain compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Lidocain. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Bayer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: Bayer

Lidocain

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2028

Q3 2029

Trials by Indication[1]

Ultrasound2 trials

Anesthesia2 trials

After Cardiac Surgery1 trial

Femur Fracture1 trial

Migraine1 trial

Periodontal Pocket1 trial

Laparoscopic Cholecystectomy1 trial

Local Anesthetic1 trial

Neuropathic Pain1 trial

Bariatric Surgery1 trial

Common Cold1 trial

Spinal Fusion1 trial

Pain Perception1 trial

Dexmedetomidine1 trial

Laparoscopic Sleeve Gastrectomy1 trial

Major Abdominal Surgery1 trial

Overactive Bladder1 trial

Hemodynamic Stability1 trial

Treatment1 trial

Ondansetron1 trial

Gastrointestinal Function1 trial

Knee Osteoarthritis1 trial

Chronic pain1 trial

Intrauterine Device Migration1 trial

Vaso-Occlusive Pain Episode in Sickle Cell Disease1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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