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Other/Stress

Stress

48

Pipeline Programs↗

90

Active Trials↗

35

Companies Involved↗

Stress is a moderately active landscape with 48 programs across 35 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

68/100

Pipeline Velocity

78/100

Mech. Concentration

15/100

Completion Rate

92/100

Attrition Rate

5/100

Pipeline

Programs by Phase

Preclinical45

Morphine

Hikma Pharmaceuticals LLC

Dexamethasone Supplementation

Dr. Nils Gassen

Psychopharmacological Intervention

Sameera Shafiq

Aminoguanidine

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Blood Collection

Assistance Publique - Hôpitaux de Paris

Phase 1

No programs

Phase 22

Psilocybin

COMPASS Pathways

Cisplatin

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 31

Finerenone

Bayer

Approved

No programs

Analysis

Modality Breakdown

98%

Small molecule

42 of 43 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 43 classified programs, each share of the total. Modality classified for 100% of 48 pipeline programs.

Analysis

Trial Status

283

clinical trials

Completed146 · 52%

Recruiting43 · 15%

Unknown status34 · 12%

Not yet recruiting30 · 11%

Active, not recruiting12 · 4%

Terminated7 · 2%

Other11 · 4%

Clinical Trials

Trial Activity

283 trials

Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program for Low-income and Minoritized Young Adolescents

Recruiting·PPenn State University·Preclinical·NCT05789446·360 enrolled

State-Dependent Interoception, Value-Based Decision Making, and Introspection

Recruiting·National Institute of Mental Health (NIMH)·Preclinical·NCT05666726·900 enrolled

Cerebrovascular Health and Resilience in Midlife

Recruiting·UUniversity of Pittsburgh·Preclinical·NCT06029348·450 enrolled

Effects of Maternal Stress on Human Milk Composition and Subsequent Infant Outcomes

Recruiting·University of Idaho·Preclinical·NCT06919718·80 enrolled

A Randomized, Double-blind, Dose-escalation, Sham-controlled Trial to Evaluate the Safety and Feasibility of Extracorporeal Shockwave Therapy (ESWT) for the Management of Stress Fractures and High-grade Bone Stress Injuries (BSIs)

Recruiting·UUniversity of California, Los Angeles·Preclinical·NCT06609265·140 enrolled

The Effect of Using a Stress Ball During Transrectal Ultrasound-Guided Prostate Biopsy on Anxiety, Pain, and Hemodynamic Variables: A Randomized Controlled Trial

Recruiting·MMersin University·Preclinical·NCT07507617·72 enrolled

A Randomized Controlled Evaluation of Sensory Motor Arousal Regulation Treatment (SMART) for Youth With Developmental Trauma and Self-regulation Difficulties

Recruiting·VVestre Viken Hospital Trust·Preclinical·NCT07200713·120 enrolled

Role of Presurgical Illustration on Patients' Psychological Stress Monitored by Salivary Cortisol in Mandibular Third Molar Surgery

Recruiting·DDelta University for Science and Technology·Preclinical·NCT07803510·80 enrolled

A Randomized, Open-Label, Parallel Proof-of-Concept Study to Assess the Effect of AP-Brain Collagen Peptides on the Improvement of Attention, Focus, and Memory in Stressed But Otherwise Healthy Individuals

Recruiting·RRousselot BVBA·Preclinical·NCT07572240·72 enrolled

STRess Assessment of INterventional Cardiology Fellows and Attendings

Recruiting·MMinneapolis Heart Institute Foundation·N/A·NCT07804927·15 enrolled

Empowering Autistic College Students: Mental Health Skill Building at a Hispanic-Serving Institution

Recruiting·UUniversity of Texas Rio Grande Valley·Preclinical·NCT07682753·30 enrolled

A Randomised, Placebo-controlled, Double-blind Clinical Trial to Evaluate the Efficacy of Three Months Daily Ingestion of Humiome® Post LB on Wellbeing in 50 - 75 Year-old Adults in France

Recruiting·Ddsm-firmenich Switzerland AG·Preclinical·NCT07471659·200 enrolled

Minority Stress Counseling for LGBTQ+ Individuals

Recruiting·UUniversity of Alabama at Birmingham·Preclinical·NCT06614868·80 enrolled

Electrophysiological, Autonomic, and Psychological Responses to Acute Physical and Emotional Stress: A Within-Subject Experimental EEG Study

Recruiting·UUniversity of Pavia·Preclinical·NCT07781670·30 enrolled

Aromatherapy and Music Impact on Nurses' Stress at Work

Recruiting·NNorthwestern University·Preclinical·NCT07732179·25 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)