MS Contin

(Morphine)

ApprovedSmall molecule

Morphine is a strong painkiller used to treat moderate to severe pain, such as pain from cancer, heart attacks, or major injuries. It can also be used to help people breathe easier when they have severe shortness of breath.[2] MS Contin is currently approved and in use across 86 indications[4].[1]

MS Contin is one of 1264 small molecule programs targeting Premature Birth. It is currently in Approved.

Indications

448

Total Trials

Active Trials

1,263

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Premature BirthApproved

AbscessActive, not recruiting

Chronic PancreatitisActive, not recruiting

Neuropathic PainApproved

Cardiac ArrestApproved

Low Back PainActive, not recruiting

Rib FractureActive, not recruiting

Wound HealingActive, not recruiting

Rheumatic DiseaseApproved

Hip FractureActive, not recruiting

Premature BirthApproved

Approved

AbscessPhase 3

Active, not recruiting

Chronic PancreatitisPreclinical

Active, not recruiting

Neuropathic PainApproved

Approved

Cardiac ArrestApproved

Approved

Low Back PainApproved

Active, not recruiting

Rib FracturePhase 3

Active, not recruiting

Wound HealingPreclinical

Active, not recruiting

Rheumatic DiseaseApproved

Approved

Hip FracturePreclinical

Active, not recruiting

Showing 10 of 76 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

MS Contin

HHikma Pharmaceuticals LLC

Approved

3 2

Halaven

Eisai

Preclinical

38 3

Blenoxane

Bristol-Myers Squibb

Preclinical

1 4

Lexiscan

Astellas

Preclinical

1 5

Voltaren

Novartis

Preclinical

1 6

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 7

Zinecard

CChildren's Oncology Group

Preclinical

2 8

Neoadjuvant Therapy

SSun Yat-sen University

Preclinical

3 9

QS21

MMemorial Sloan Kettering Cancer Center

Preclinical

3 10

Neoadjuvant Treatment

SShanghai Zhongshan Hospital

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/AActive, not recruiting

Renal Colic

NCT07378904

Q4 2026

N/ARecruiting

Postoperative Analgesia

NCT06990893

Recruiting

Extracorporeal Membrane Oxygenation

NCT03593408

N/ARecruiting

Idiopathic Scoliosis

NCT06820190

Phase 2Not yet recruiting

Phase II Clinical Study

NCT07491146

Q1 2027

Phase 2Not yet recruiting

Intraoperative

NCT07201987

Clinical

Trials by Indication[1]

Morphine9 trials

Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine

Completed·—·N/A·NCT04672382·26 enrolled

Morphine PK Subgroup Analysis

Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 4·NCT01322191·48 enrolled

First Evaluation of Morphine Hydrochloride by Nebulisation in Healthy Volunteers

Completed·UUniversity Hospital, Rouen·Phase 1/2·NCT01975753·35 enrolled

Show 6 more trials

Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers

Completed· Pfizer logo

Pfizer·Phase 1·NCT01119222·19 enrolled

IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia

Unknown status·—·Phase 4·NCT02504996·300 enrolled

Intraosseous Morphine in Primary TKA

Completed·TThe Methodist Hospital Research Institute·Phase 4·NCT04388111·65 enrolled

Morphine Slow-release Capsules in Substitution Therapy

Completed·MMundipharma Medical Company·Phase 3·NCT01079117·276 enrolled

Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects

Completed·TTrevena Inc.·Phase 1·NCT02083315·30 enrolled

Optimizing the Use of Morphine in Pre-Term Neonates

Completed·JJohn van den Anker·Phase 2·NCT00494429·33 enrolled

Postoperative Analgesia7 trials

Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial

Recruiting·—·N/A·NCT06990893·90 enrolled

Analgesic Effect of Intrathecal Morphine Combined With Low Dose Local Anesthetics on Postoperative Analgesia After Liver Resection

Completed·YYonsei University·N/A·NCT05208801·90 enrolled

Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery

Completed·—·Phase 2/3·NCT02213159·60 enrolled

Show 4 more trials

Comparison of Efficacy and Safety of the Postoperative Analgesia Methods

Unknown status·IIstanbul University·Phase 4·NCT02929147·90 enrolled

Adding Intra-articular Dexmedetomidine to Levobupivacaine for Postoperative Analgesia in Arthroscopic Knee Surgery

Completed·TTC Erciyes University·Phase 4·NCT01918917·60 enrolled

Intraoperative and Postoperative Analgesia for Laparoscopic Surgery.

Completed·RRambam Health Care Campus·Phase 4·NCT00772187·40 enrolled

Ultrasound Guided TAP Block for Postoperative Analgesia After Abdominal Surgery.

Completed·—·Phase 2/3·NCT02976597·90 enrolled

Post Operative Pain5 trials

Intravenous Paracetamol for Postoperative Pain

Completed·LLithuanian University of Health Sciences·Phase 4·NCT02248493·54 enrolled

Postoperative Pain Therapy With Hydromorphone TCI-PCA vs. Morphine PCA

Completed·UUniversity of Erlangen-Nürnberg Medical School·Phase 4·NCT02483221·50 enrolled

Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain

Completed·IINSYS Therapeutics Inc·Phase 2·NCT03254459·100 enrolled

Show 2 more trials

The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01953978·160 enrolled

Oxycodone Hydrochloride Injection in the Postoperative Pain Relieving Treatment

Completed·MMundipharma (China) Pharmaceutical Co. Ltd·Phase 3·NCT01304134·240 enrolled

Treatment5 trials

Methadone for 'Adenocarcinopathic' Pain Treatment

Withdrawn·OOttawa Hospital Research Institute·Phase 3·NCT05325164

Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain

Terminated·WWashington University School of Medicine·N/A·NCT02430818·13 enrolled

A Study of TRV130 for the Treatment of Pain After Bunionectomy

Completed·TTrevena Inc.·Phase 2·NCT02100748·333 enrolled

Show 2 more trials

A Trial of SHR0410 Injection for the Treatment of Pain After Endoscopic Surgery of the Lower Abdominal

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 3·NCT04852003·228 enrolled

NAS Treatment - Opiate Versus Non-Opiate

Completed·HHenrietta Bada·Phase 4·NCT01734551·31 enrolled

Efficacy and Safety5 trials

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery

Completed·JJavelin Pharmaceuticals·Phase 2·NCT00388011·187 enrolled

Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)

Completed·MMundipharma Pharmaceuticals srl·Phase 3·NCT03585374·272 enrolled

To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain

Completed·YYuwei Qiu·Phase 4·NCT06458400·75 enrolled

Show 2 more trials

Efficacy and Safety of Ultra-low Dose Methadone as Adjuvant Analgesic in Cancer Patients With Pain

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT02687347·204 enrolled

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction

Completed·JJavelin Pharmaceuticals·Phase 2·NCT00390312·225 enrolled

123 more indications

Intravenous5 trials

Intranasal Sufentanil Versus Intravenous Morphine for the Management of Acute Pain

Unknown status·—·Phase 4·NCT03224039·40 enrolled

Oral Pregabalin Effect to the Intravenous Morphine in Multiple Fracture Ribs

Unknown status·—·Phase 1·NCT03473093·80 enrolled

CAUDAL BUPIVACAINE VERSUS INTRAVENOUS MORPHINE ON TIME TO FIRST ANALGESIC REQUIREMENT

Completed·MMakerere University·Phase 4·NCT02456142·70 enrolled

Show 2 more trials

Efficacy Study of Nebulized Morphine and Intravenous Morphine in Post Traumatic Pain

Completed·UUniversity of Monastir·Phase 3·NCT01123551·200 enrolled

Intravenous vs Oral Analgesia in Cancer Patients With Severe Pain After Successful Titration

Completed·FFujian Cancer Hospital·Phase 2·NCT04243954·95 enrolled

Total Knee Arthroplasty4 trials

Effects of Perioperative Intravenous Dexamethasone in Clinical Outcomes After Total Knee Arthroplasty in a Hispanic Population

Unknown status·UUniversity of Puerto Rico·Phase 4·NCT06042426·100 enrolled

Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty

Unknown status·RRegion Örebro County·N/A·NCT00992082·50 enrolled

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Completed·NNational University Hospital, Singapore·Phase 3·NCT02954484·116 enrolled

Show 1 more trial

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

Withdrawn·HHoly Cross Hospital, Florida·Phase 4·NCT02765815

Cesarean Section4 trials

Serum Serotonin and Pruritus After Intrathecal Morphine in Cesarean Section

Completed·—·Phase 4·NCT03209427·40 enrolled

Hemodynamic Effects of Low Dose Spinal Anesthesia for Cesarean Section

Terminated·UUniversity of Manitoba·N/A·NCT02036697·30 enrolled

Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone

Withdrawn·—·N/A·NCT02091297

Show 1 more trial

The Effect of the Transversus Abdominis Plane Block to Postoperative Analgesia for Cesarean Section

Completed·GGia Dinh People Hospital·N/A·NCT03634111·60 enrolled

Cesarean Delivery4 trials

Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

Completed·MMayo Clinic·N/A·NCT02789410·134 enrolled

Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose

Completed·MMayo Clinic·Phase 4·NCT02009722·84 enrolled

TAP vs QLB in Patients After Cesarean Delivery

Completed·MMedical University of Lublin·Phase 4·NCT03404908·105 enrolled

Show 1 more trial

Effect of Intrathecal Morphine on Urinary Bladder Function and Recovery in Patients Having a Cesarean Delivery

Completed·UUniversity of Liege·N/A·NCT05042817·56 enrolled

Neonatal Abstinence Syndrome3 trials

Buprenorphine for Treatment of Neonatal Abstinence Syndrome in Infants With In Utero Exposure to Benzodiazepines

Completed·TThomas Jefferson University·Phase 1·NCT01671410·11 enrolled

Buprenorphine for the Treatment of Neonatal Abstinence Syndrome

Completed·TThomas Jefferson University·Phase 1·NCT00521248·60 enrolled

Blinded Trial of Buprenorphine or Morphine in the Treatment of the Neonatal Abstinence Syndrome

Completed·TThomas Jefferson University·Phase 3·NCT01452789·63 enrolled

Cancer Pain3 trials

Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain

Completed· Mario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research··NCT01946555·150 enrolled

Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients

Terminated·UUniversity Hospital, Basel, Switzerland·Phase 3·NCT02591017·11 enrolled

Nasal Fentanyl for Chronic Cancer Pain

Withdrawn·NNorwegian University of Science and Technology·Phase 3·NCT01906073

Buprenorphine3 trials

Efficacy of Buprenorphine for Treatment of Acute Pain

Completed·TTehran University of Medical Sciences·Phase 4·NCT01298297·80 enrolled

Buprenorphine's Dose Response Curve

Completed·JJohns Hopkins University·Phase 2·NCT00460239·12 enrolled

Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence

Completed·WWayne State University·Phase 1/2·NCT03015246·26 enrolled

Colorectal Cancer3 trials

Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery

Completed·TThe Institute of Molecular and Translational Medicine, Czech Republic·Phase 4·NCT03700411·125 enrolled

Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery

Terminated·ÖÖrebro University, Sweden·Phase 3·NCT01318161·221 enrolled

Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery

Completed·TThe Institute of Molecular and Translational Medicine, Czech Republic·Phase 4·NCT03700541·71 enrolled

After Cardiac Surgery3 trials

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01966172·180 enrolled

Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.

Completed·SStanford University·Phase 1/2·NCT01094522·47 enrolled

Morphine IV vs Paracetamol IV in Neonates and Infants After Cardiac Surgery

Completed·EErasmus Medical Center·N/A·NCT05853263·208 enrolled

Total Hip Arthroplasty3 trials

Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

Completed·AAssistance Publique - Hôpitaux de Paris·N/A·NCT00797264·18 enrolled

Psoas Compartment Block Versus Fascia Iliaca Block After Total Hip Arthroplasty

Unknown status·HHillel Yaffe Medical Center·N/A·NCT01378949·90 enrolled

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

Completed·CCorewell Health East·Phase 4·NCT02658149·100 enrolled

Appendicitis2 trials

Morphine Analgesia in Patients With Acute Appendicitis

Completed·TTehran University of Medical Sciences·Phase 4·NCT00477061·71 enrolled

Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon

Completed·SSeoul National University Hospital·Phase 4·NCT00783016·234 enrolled

Inflammatory Response2 trials

Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier

Completed·NNova Scotia Health Authority·Phase 4·NCT00878371·35 enrolled

The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery

Completed·OOsijek University Hospital·Phase 2·NCT02848599·86 enrolled

Laparoscopic Cholecystectomy2 trials

Comparison of the Efficacy and Safety of NALDEBAIN With Conventional Treatment After Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT03713216·44 enrolled

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT02327923·90 enrolled

Fentanyl2 trials

Symptom-inhibited Fentanyl Induction

Completed·PPouya Azar·Phase 4·NCT05905367·48 enrolled

Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Cancer Patients

Completed·UUniversity of Cologne·Phase 2·NCT04635852·10 enrolled

Withdrawal2 trials

Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal

Completed·—·Phase 4·NCT01804075·31 enrolled

Activity Monitoring Assessment of Opiate Withdrawal - 4

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00000335

Low back pain2 trials

IV Paracetamol, Dexketoprofen or Morphine for the Treatment of Low Back Pain

Completed·PPamukkale University·Phase 4·NCT01422291·120 enrolled

Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT01129934·200 enrolled

Abdominoplasty2 trials

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty

Completed·TTrevena Inc.·Phase 3·NCT02820324·407 enrolled

A Study of TRV130 for the Treatment of Pain After Abdominoplasty

Completed·TTrevena Inc.·Phase 2·NCT02335294·200 enrolled

Oral Mucositis2 trials

Comparison of Transdermal Fentanyl and Morphine for Oral Mucositis Pain in Nasopharyngeal Cancer Patients

Unknown status·—·Phase 4·NCT04292990·300 enrolled

Evaluation of Oral Morphine Gel in Oral Mucositis Induced by Chemotherapy in Children and Young Adults

Terminated·UUniversity Hospital, Strasbourg, France·Phase 3·NCT02173756·25 enrolled

Idiopathic Scoliosis2 trials

Analgesic Efficacy of Multiple Mid-Transverse Process to Pleura (MTP) Block and PCA in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion

Recruiting·TTanta University·N/A·NCT06820190·40 enrolled

Analgesic Efficacy of Mid-Transverse Process to Pleura (MTP) Block and Intrathecal Morphine in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion

Completed·TTanta University·N/A·NCT06331143·40 enrolled

Breast Cancer2 trials

Metabolomic Profiling of Erector Spinae Plane Block* for Breast Cancer Surgery

Completed·—··NCT04689945·91 enrolled

Erector Spinae Plane Block Versus General Anesthesia in Breast Cancer Surgeries

Completed·NNational Cancer Institute, Egypt·N/A·NCT05429489·126 enrolled

Epidural Analgesia2 trials

A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair

Terminated·—·Phase 4·NCT02056301·62 enrolled

Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.

Completed·—·Phase 4·NCT03007121·75 enrolled

Analgesic2 trials

Comparative Analysis of Analgesic Approaches in the Early Period After CABG

Recruiting·PPrimorsky Regional General Hospital #1·N/A·NCT07451522·100 enrolled

Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department

Not yet recruiting·OOman Medical Speciality Board·Phase 3·NCT06315920·226 enrolled

Inguinal hernia2 trials

PRO-RSTAP: Effect of TAP and RS Blocks on Recovery After Inguinal Hernia Surgery (PRO-RSTAP)

Recruiting·TTampere University Hospital·N/A·NCT07423910·200 enrolled

Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries

Completed·—·Phase 3·NCT06319859·50 enrolled

Dyspnea2 trials

Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer Patients

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 3·NCT04188418·150 enrolled

Morphine for Treatment of Dyspnea in Patients With COPD

Completed·MMaastricht University Medical Center·Phase 4·NCT02429050·124 enrolled

Obstructive Sleep Apnea2 trials

Investigating the Safety of Post-surgical Analgesics in Children With Obstructive Sleep Apnea

Unknown status·HHamilton Health Sciences Corporation·Phase 3·NCT01680939·120 enrolled

Single Dose Morphine and Fentanyl Added to Intrathecal Mixture on Orthopedics Patients With Undiagnosed Obstructive Sleep Apnea

Unknown status·UUniversity of Malaya·Phase 1·NCT02014714·40 enrolled

Renal Colic2 trials

Sterile Water Injection vs Morphine for Renal Colic

Active, not recruiting·UUniversity Tunis El Manar·N/A·NCT07378904·150 enrolled

Morphine Versus Ketorolac in Renal Colic

Unknown status·LLoredana Ghinea·Phase 4·NCT02782273·100 enrolled

Ibuprofen2 trials

Post-operative Oral Morphine Versus Ibuprofen

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2·NCT01686802·132 enrolled

Oral Morphine Versus Ibuprofen

Completed·NNaveen Poonai·N/A·NCT01690780·183 enrolled

Erector Spinae Plane Block2 trials

Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries

Completed·NNational Cancer Institute, Egypt·N/A·NCT05591417·68 enrolled

Erector Spinae Plane Block in Radical Cystectomy

Completed·KKafrelsheikh University·N/A·NCT06422182·60 enrolled

Headache1 trial

Incidence of Headache Following an Unintentional Dural Puncture

Completed·NNorthwestern University·N/A·NCT01977898·68 enrolled

Sickle Cell Disease1 trial

Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease

Terminated·—·Phase 3·NCT03933397·328 enrolled

Acute Coronary Syndrome1 trial

Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia.

Completed·UUniversity Hospital, Toulouse·Phase 4·NCT02198378·680 enrolled

Hip Fracture1 trial

Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel

Unknown status·LLarissa University Hospital·N/A·NCT03596060·150 enrolled

Pain Management1 trial

Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management

Completed·HHamad Medical Corporation·Phase 4·NCT02187614·1,645 enrolled

Mucositis1 trial

Nalbuphine Versus Morphine for Mucositis Pain in Pediatric Cancer Patients

Completed·—·Phase 3·NCT03825887·80 enrolled

Double-blind1 trial

A Randomized, Double-blind Comparison of Morphine and Sufentanil for Prehospital Traumatic Severe Acute Pain

Completed·UUniversity Hospital, Toulouse·Phase 3·NCT00656773·108 enrolled

Midazolam1 trial

Is Analgesic Effect of Low Dose Ketamine-midazolam the Same as Morphine

Completed·IIsfahan University of Medical Sciences·Phase 2/3·NCT01807429·236 enrolled

Opioid Analgesia1 trial

Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain

Active, not recruiting·KKK Women's and Children's Hospital·Phase 2/3·NCT04011163·40 enrolled

Visceral Pain1 trial

Visceral Pain From the Upper Urinary Tract - a Trial on the Effect of Morphine and Oxycodone in Patients Undergoing PCNL

Completed·KKatja venborg Pedersen·Phase 3·NCT00784472·55 enrolled

Methadone1 trial

Methadone in Pediatric and Adult Sickle Cell Patients

Completed·WWashington University School of Medicine·N/A·NCT00761085·47 enrolled

Extracorporeal Membrane Oxygenation1 trial

Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

Recruiting·—··NCT03593408·20 enrolled

Pediatric1 trial

Split Scripts for Pediatric Supracondylar Fracture Repairs

Completed·TThe Hospital for Sick Children·N/A·NCT05372133·175 enrolled

Analgesia1 trial

Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

Completed·BBruno Minotti·Phase 4·NCT03843281·222 enrolled

Intraoperative Pain1 trial

Analgesic Efficacy of Intrathecal Fentanyl-Morphine Combination Versus Morphine Alone for Intraoperative Pain During Elective Cesarean Delivery

Not yet recruiting·SSeoul National University Hospital·Phase 4·NCT06570343·186 enrolled

Neostigmine1 trial

A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers

Completed·UUniversity of Nottingham·Phase 4·NCT01134848·10 enrolled

Injury1 trial

Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain

Completed·HHenrietta Bada·Phase 3·NCT03396588·120 enrolled

Analgesic Efficacy1 trial

RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder.

Completed· Mario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research·Phase 4·NCT01809106·518 enrolled

Caudal Anesthesia1 trial

Efficacy of Dexmedetomidine Versus Morphine as an Adjunct to Bupivacaine in Caudal Anesthesia.

Completed·—·N/A·NCT04445636·50 enrolled

Sciatica1 trial

Pain Treatment for Sciatica

Completed·NNational Institute of Dental and Craniofacial Research (NIDCR)·Phase 2·NCT00009672·80 enrolled

AIN1 trial

Brain Effects of Opiate Agonist and Antagonist

Completed·UUniversity of Rochester·Phase 4·NCT04342130·10 enrolled

Postoperative Pain Relief1 trial

Efficacy of Fentanyl to Reduce the Time of Severe Postoperative Pain Relief Compared to Morphine

Completed·UUniversidad de Antioquia·Phase 3·NCT02145975·60 enrolled

Total Knee Replacement1 trial

The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)

Completed·HHospital for Special Surgery, New York·Phase 4·NCT02292082·111 enrolled

Abdominal Surgery1 trial

A Clinical Study of SHR8554 Injection for the Treatment of Pain After Abdominal Surgery.

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 3·NCT04766463·528 enrolled

Thoracotomy1 trial

Ketamine Improves Post-Thoracotomy Analgesia

Completed·TTel-Aviv Sourasky Medical Center·N/A·NCT00625911·44 enrolled

Rib Fracture1 trial

Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture

Terminated·—·Phase 3·NCT02749409·17 enrolled

Spinal Fusion1 trial

Methadone for Spinal Fusion Surgery.

Terminated·UUniversity of Aarhus·Phase 4·NCT04764825·114 enrolled

Outcome1 trial

Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome

Withdrawn·AASST Gaetano Pini-CTO·Phase 4·NCT02082067

Thoracic Paravertebral Block1 trial

Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block

Completed·HHacettepe University·N/A·NCT07071012·98 enrolled

Major Trauma1 trial

Pain Multidisciplinar Intervention in Major Trauma Patients

Completed·NNuria Llorach-Perucho··NCT05355441·38 enrolled

Nerve Block1 trial

Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting

Terminated·—·Phase 3·NCT01522534·26 enrolled

Post-craniotomy1 trial

Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.

Active, not recruiting·TTel-Aviv Sourasky Medical Center·N/A·NCT05117034·115 enrolled

Delirium1 trial

Delirium in Elderly Patients With Trauma of the Hip

Terminated·—·Phase 4·NCT02689024·239 enrolled

Bone Graft1 trial

Effect of Local Administration of Morphine for Analgesia After Iliac Bone Graft Harvest

Withdrawn·TThe Cleveland Clinic·Phase 4·NCT01037335

Postoperative Pain Management1 trial

Ibuprofen Compared to Morphine as a Pediatric Postoperative Pain Management Tool Following Inguinal Surgery

Unknown status·MMcMaster University·N/A·NCT02603848·100 enrolled

Anxiolytic Effect1 trial

Analgetic and Anxiolytic Effect of Preoperative Pregabalin

Completed·—·Phase 4·NCT00353704·50 enrolled

Femoral Nerve Block1 trial

Ultrasound Guided Femoral Nerve Block

Completed·—·N/A·NCT02381717·44 enrolled

TED1 trial

Robot-assisted Lobectomy Versus Video-assisted Lobectomy

Completed·—··NCT03111797·200 enrolled

Advanced Cancer1 trial

Cordotomy in Reducing Pain in Patients With Advanced Cancer

Active, not recruiting·MM.D. Anderson Cancer Center·N/A·NCT04119037·27 enrolled

Pain1 trial

Visual Pain Score and Perfusion Index in Postoperative Patients

Completed·TTokat Gaziosmanpasa University·N/A·NCT03151369·89 enrolled

Side Effects1 trial

a Small Dose of Naloxone,Minimize Intrathecal Morphine Side Effects

Completed·—·N/A·NCT03230474·100 enrolled

Ultrasound1 trial

MORphine Use in the Fascia Iliaca Compartment Block With UltraSound

Terminated·ZZuyderland Medisch Centrum·Phase 4·NCT03846102·55 enrolled

Dementia1 trial

Pain in Patients With Dementia and Behavioural Disturbances

Completed·UUniversity of Bergen·Phase 2/3·NCT01021696·352 enrolled

Breast Surgery1 trial

PVB vs PECS Block in Breast Surgery

Completed·IIstituti Ospitalieri di Cremona·N/A·NCT02677571·55 enrolled

Ketorolac1 trial

Intrathecal Ketorolac in Patients With Intrathecal Morphine Dose Escalation

Withdrawn·WWake Forest University Health Sciences·Phase 2·NCT00349401

Neonatal Opioid Withdrawal Syndrome1 trial

CHF6563 in Babies With Neonatal Opioid Withdrawal Syndrome

Terminated· Chiesi Farmaceutici S.p.A. logo

Chiesi Farmaceutici S.p.A.·Phase 2·NCT04104646·7 enrolled

Ankle Fracture1 trial

Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures

Completed·UUniversity of Iowa·Phase 4·NCT02967172·100 enrolled

Orthostatic Intolerance1 trial

Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty

Unknown status·—··NCT04902222·26 enrolled

Quadratus Lumborum Block1 trial

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.

Completed·ZZealand University Hospital·Phase 4·NCT03068260·72 enrolled

Vaso-occlusive Crisis1 trial

Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers

Completed·MMakerere University·Phase 4·NCT02434939·240 enrolled

Liver Disease1 trial

Altered Drug Disposition and Biomarkers for Diagnosis of Chronic Inflammatory Liver Disease

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT01766960·22 enrolled

Nausea and vomiting1 trial

Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia for Caesarean Section

Completed·UUniversity of Parma·Phase 4·NCT00921102·216 enrolled

Sedation1 trial

Compare the Efficacy and Outcome Between Fentanyl and Morphine as Analgo-sedation in Mechanically Ventilated Patients

Recruiting·UUniversiti Sains Malaysia·Phase 4·NCT06479655·116 enrolled

Oliceridine1 trial

Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study

Recruiting·TTongji Hospital·N/A·NCT06409689·80 enrolled

Video-Assisted Thoracoscopic Surgery1 trial

Comparison Paravertebral and Serratus Anterior Plane Block in Video-assisted Thoracoscopic Surgery.

Active, not recruiting·HHacettepe University·N/A·NCT07002788·122 enrolled

Single Dose1 trial

A Study to Assess the Safety, Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants

Completed· Astellas logo

Astellas·Phase 1·NCT04448561·24 enrolled

Elective1 trial

Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries

Completed·GGrace Shih, MD·Phase 1·NCT01866254·45 enrolled

Minimal Residual Disease1 trial

Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery

Completed·TThe Institute of Molecular and Translational Medicine, Czech Republic·Phase 4·NCT02314871·60 enrolled

Thoracoscopic Surgery1 trial

Intrathecal Morphine for Thoracoscopic Surgery

Completed·—·Phase 4·NCT05588336·46 enrolled

Phase II Clinical Study1 trial

Phase II Clinical Study of the Efficacy and Safety of HSK55718 in the Treatment of Abdominal Postoperative Pain

Not yet recruiting·YYingyong Zhou,MD,PhD·Phase 2·NCT07491146·200 enrolled

Brain Injury1 trial

Problems With Morphine Use in Patients With a Severe Brain Injury

Unknown status·—·Phase 1/2·NCT00196131·20 enrolled

Cancer-related Pain1 trial

Methadone Versus Morphine for Cancer-Related Pain

Terminated·MMayo Clinic·Phase 2·NCT00573937·1 enrolled

Pediatric Patients1 trial

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

Recruiting·—·N/A·NCT06326983·58 enrolled

Elderly1 trial

Opioid Effects on Swallowing Comparing Younger and Elderly Volunteers

Completed·RRegion Örebro County·Phase 4·NCT01924234·18 enrolled

Musculoskeletal Injuries1 trial

Oral Analgesic Utilization for CHildhood Musculoskeletal Injuries

Completed·SSt. Justine's Hospital·N/A·NCT02064894·501 enrolled

Acetaminophen1 trial

Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy

Completed· AbbVie logo

AbbVie·Phase 2·NCT01038609·250 enrolled

Scoliosis1 trial

Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery.

Not yet recruiting·UUniversity of Malaya·N/A·NCT07452705·114 enrolled

Opioid Use Disorder1 trial

Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder

Terminated·MM. Eugenia Socias·Phase 3·NCT03948464·27 enrolled

Dexmedetomidine1 trial

Dexmedetomidine Versus Morphine During Cooling Therapy in Neonates

Not yet recruiting·IIpsita Goswami·Phase 2·NCT06985290·50 enrolled

Neuropathic Pain1 trial

Methadone in Neuropathic Pain

Terminated·NNova Scotia Health Authority·Phase 4·NCT01205516·14 enrolled

Intravenous Lidocaine1 trial

Intravenous Lidocaine Versus Morphine for Severe Pain in the ED

Completed·—·Phase 4·NCT02912195·32 enrolled

Wound Healing1 trial

Analgesia and Wound Healing Assessment Following Topical Morphine Applied to Patients With Cutaneous Cancer Related Pain

Withdrawn·SSoroka University Medical Center·N/A·NCT00306020

Abscess1 trial

Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children

Completed·—·Phase 3·NCT01549002·20 enrolled

Hemodynamic Changes1 trial

Comparison of Hemodynamic Changes With Morphine Versus Esmolol During Induction of Anaesthesia

Completed·PPakistan Navy Station Shifa Hospital·Phase 1/2·NCT06065956·110 enrolled

Severe Pain1 trial

CORAL - Cebranopadol Versus Morphine Prolonged-release in Patients With Chronic Moderate to Severe Pain Related to Cancer

Terminated·TTris Pharma, Inc.·Phase 3·NCT01964378·200 enrolled

Hepatectomy1 trial

Transversus Abdominus Plane Block in Living Donor Hepatectomy

Completed·AAlRefaey Kandeel·N/A·NCT02708459·90 enrolled

Spinal Cord Injury1 trial

Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT00488969·17 enrolled

Cardiac Surgery1 trial

ESP Block in Robotic Cardiac Surgery

Unknown status·HHospital Clinic of Barcelona·N/A·NCT05702151·50 enrolled

Intensive Care Unit1 trial

Comparison of Morphine and Fentanyl/Midazolam in Intensive Care Unit

Completed·CClínica de Los Andes IPS·N/A·NCT01602640·90 enrolled

Dexamethasone1 trial

Comparison Between Dexamethasone and Morphine as an Adjuvant to Bupivacaine for Post-operative Analgesia

Completed·IIndonesia University·N/A·NCT03051022·64 enrolled

Adolescent1 trial

A Study to Look at Tapentadol Tablets in Children and Adolescents in Pain

Completed·GGrünenthal GmbH·Phase 2/3·NCT02151682·73 enrolled

Chronic Wounds1 trial

Efficacy of Topical Morphine in the Treatment of Severe Local Pain of Chronic Wounds

Terminated·IInstitut Curie·Phase 3·NCT02028923·126 enrolled

Emergency Department Patient1 trial

Study to Explore Effectiveness of Sublingual Fentanyl Spray in Emergency Department Patients With Acute Pain

Withdrawn·IINSYS Therapeutics Inc·Phase 2·NCT02137525

Post-cesarean Pain1 trial

Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management

Completed·SStanford University·N/A·NCT02605187·160 enrolled

Intraoperative1 trial

Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes

Not yet recruiting·GGanesh M. Shankar·Phase 2·NCT07201987·100 enrolled

Caesarean Section1 trial

Ultrasound-Guided TAP Block and Spinal Morphine for Pain Relief After Caesarean Section

Completed·SSohag University·N/A·NCT05331781·60 enrolled

Orthopedic Procedures1 trial

Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?

Unknown status·MMount Sinai Hospital, Canada·N/A·NCT02880800·80 enrolled

Orthopedic Surgery1 trial

A Study of SHR8554 Injection for the Treatment of Pain After Orthopedic Surgery

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 2/3·NCT05375305·320 enrolled

Postoperative Pain Control1 trial

Postoperative Pain Control After Hip Hemiarthroplasty: Intrathecal Morphine vs Periarticular Infiltration of Bupivacaine

Terminated·MMahidol University·Phase 4·NCT01219062·10 enrolled

Myocardial Ischemia1 trial

Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury

Recruiting·TThe Second Hospital of Anhui Medical University·N/A·NCT06947135·166 enrolled

Medical Procedure1 trial

Decreasing REcurrent Pain and Anxiety in Medical Procedures With a Pediatric Population: Trial

Withdrawn·SSt. Justine's Hospital·N/A·NCT02947243

Prostatectomy1 trial

Spinal Morphine in Robotic Assisted Radical Prostatectomy

Completed·MMaasstad Hospital·Phase 4·NCT02924974·160 enrolled

Chronic pain1 trial

Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain

Suspended·FFondazione IRCCS Policlinico San Matteo di Pavia·Phase 4·NCT00916890·320 enrolled

Patient-Controlled Analgesia1 trial

Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia

Completed·KKyungpook National University Hospital·N/A·NCT02416115·90 enrolled

Unspecified4 trials

Dose Finding Study of STR-324

Unknown status·AAlaxia SAS·Phase 2·NCT04582786·118 enrolled

Genetic Effects on Dopamine Response to an Opiate

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT01878006·15 enrolled

VAS Correlation With BMI

Unknown status·IIstanbul University·Phase 4·NCT02017314·100 enrolled

Show 1 more trial

Serratus Posterior Superior Intercostal Plane Block

Completed·UUniversity of Gaziantep·N/A·NCT07330479·60 enrolled

Regulatory

FDA Approval Timeline[5]

Sep 18, 1984

DURAMORPH PF

NDA NDA018565

Sep 12, 1989

MS CONTIN

NDA NDA019516

Jul 12, 1990

MORPHINE SULFATE (AUTOINJECTOR)

NDA NDA019999

Oct 30, 1992

MORPHINE SULFATE

NDA NDA019917

Oct 30, 1992

MORPHINE SULFATE

NDA NDA019916

Nov 23, 1994

ORAMORPH SR

NDA NDA019977

Jul 3, 1996

MORPHINE SULFATE

NDA NDA020631

Mar 20, 2002

AVINZA

NDA NDA021260

May 18, 2004

DEPODUR

NDA NDA021671

Apr 20, 2007

KADIAN

NDA NDA020616

Mar 17, 2008

MORPHINE SULFATE

NDA NDA022207

Mar 17, 2008

MORPHINE SULFATE

NDA NDA022195

Jun 23, 2011

MORPHINE SULFATE

NDA NDA201517

Nov 14, 2011

MORPHINE SULFATE

NDA NDA202515

Oct 30, 2013

MORPHINE SULFATE

NDA NDA204223

Oct 2, 2015

MORPHABOND ER

NDA NDA206544

Jan 9, 2017

ARYMO ER

NDA NDA208603

Sources

References

[1]
ClinicalTrials.gov — 448 trial records for Morphine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — MS Contin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Morphine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Morphine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA208603). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for MS Contin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Hikma Pharmaceuticals LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Mu Opioid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: HHikma Pharmaceuticals LLC

Patent Landscape[6]

Patent Cliff

Aug 12, 2028

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10314788Aug 12, 2028

9549899Jul 1, 2033

9044402Jul 1, 2033

9192608Mar 12, 2034

9248229Mar 12, 2034

1 more patents

9072781Mar 12, 2034