MS Contin

(Morphine)

ApprovedSmall molecule

Morphine is a strong painkiller used to treat moderate to severe pain, such as pain from cancer, heart attacks, or major injuries. It can also be used to help people breathe easier when they have severe shortness of breath.[2] MS Contin is currently approved and in use across 75 indications[4].[1]

MS Contin is one of 908 small molecule programs targeting Cesarean Section. It is currently in Approved.

Indications

451

Total Trials

Active Trials

907

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Cesarean SectionCompleted

Advanced Malignant NeoplasmActive, not recruiting

Acute Coronary SyndromeActive, not recruiting

Pulmonary EdemaActive, not recruiting

DeliriumActive, not recruiting

HysterectomyActive, not recruiting

Adverse EffectActive, not recruiting

Colorectal CancerActive, not recruiting

Cardiac ArrestApproved

Premature BirthApproved

Cesarean SectionApproved

Completed

Advanced Malignant NeoplasmPreclinical

Active, not recruiting

Acute Coronary SyndromeApproved

Active, not recruiting

Pulmonary EdemaApproved

Active, not recruiting

DeliriumApproved

Active, not recruiting

HysterectomyApproved

Active, not recruiting

Adverse EffectApproved

Active, not recruiting

Colorectal CancerApproved

Active, not recruiting

Cardiac ArrestApproved

Approved

Premature BirthApproved

Approved

Showing 10 of 68 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

MS Contin

HHikma Pharmaceuticals LLC

Approved

3 2

Voltaren

Novartis

Preclinical

1 3

Zolymbus

AbbVie

Preclinical

1 4

Blenoxane

Bristol-Myers Squibb

Preclinical

1 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 6

Spravato

WWim Janssens

Preclinical

2 7

Tricor

JJagotec

Preclinical

1 8

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 9

Acupan

YYonsei University

Preclinical

1 10

Chantix

PPrism Pharmaceuticals

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Postoperative Analgesia

NCT06990893

Recruiting

Extracorporeal Membrane Oxygenation

NCT03593408

Phase 2Recruiting

Drug Abuse

NCT05006079

Q3 2027

Post-ApprovalNot yet recruiting

Scoliosis

NCT07229495

Q1 2028

Phase 3Recruiting

Pediatric

NCT06464146

Q3 2028

Phase 3Not yet recruiting

Analgesic

NCT06315920

Clinical

Trials by Indication[1]

Morphine8 trials

Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine

Completed·—·N/A·NCT04672382·26 enrolled

The Effects of Morphine on Desflurane Consumption and Recovery Time

Completed·—·Phase 4·NCT02362022·90 enrolled

Pre-hospital Morphine Titration : Comparison of 0,05 Versus 0,1 mg/kg

Completed·UUniversity Hospital, Toulouse·Phase 4·NCT00237731·106 enrolled

Show 5 more trials

Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics

Completed·UUniversity of Southern Denmark·Phase 1·NCT03425084·86 enrolled

Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients

Unknown status·SStony Brook University·Phase 4·NCT02620631·54 enrolled

Optimizing the Use of Morphine in Pre-Term Neonates

Completed·JJohn van den Anker·Phase 2·NCT00494429·33 enrolled

Morphine Slow-release Capsules in Substitution Therapy

Completed·MMundipharma Medical Company·Phase 3·NCT01079117·276 enrolled

A Relation of Morphine-induced Itch and Pain Processing

Completed·—·N/A·NCT04115462·24 enrolled

Cesarean Section6 trials

Comparing Protocols for Analgesia Following Elective Cesarean Section

Unknown status·WWolfson Medical Center·Phase 4·NCT03622489·120 enrolled

Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section

Unknown status·—·Phase 4·NCT02279628·150 enrolled

The Effect of the Transversus Abdominis Plane Block to Postoperative Analgesia for Cesarean Section

Completed·GGia Dinh People Hospital·N/A·NCT03634111·60 enrolled

Show 3 more trials

Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia

Completed·—·Phase 2·NCT02622126·60 enrolled

Hemodynamic Effects of Low Dose Spinal Anesthesia for Cesarean Section

Terminated·UUniversity of Manitoba·N/A·NCT02036697·30 enrolled

Comparison of Two Pain-treatment Techniques After Cesarean Section

Completed·MMichał Borys·Phase 4·NCT02804126·232 enrolled

Postoperative Analgesia5 trials

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Terminated·UUniversity of Parma·Phase 4·NCT00681174·22 enrolled

Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy

Completed·GG.Gennimatas General Hospital·Phase 4·NCT01526525·70 enrolled

Adding Intra-articular Dexmedetomidine to Levobupivacaine for Postoperative Analgesia in Arthroscopic Knee Surgery

Completed·TTC Erciyes University·Phase 4·NCT01918917·60 enrolled

Show 2 more trials

Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.

Terminated·RRennes University Hospital·Phase 4·NCT01882530·223 enrolled

Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial

Recruiting·—·N/A·NCT06990893·90 enrolled

Renal Colic5 trials

Comparing the Analgesic Effect of Intravenous Acetaminophen and Morphine on Patients With Renal Colic Pain Reffering to the Emergency Department: A Randomized Controlled Trial

Completed·SSeyed Mehdi Pourafzali·Phase 2·NCT01906762·124 enrolled

Pramipexole and Morphine for Renal Colic

Completed·—·Phase 1/2·NCT04160520·19 enrolled

An Analgesia Protocol for Acute Renal Colic in the Emergency Department

Completed·—·N/A·NCT00504283·45 enrolled

Show 2 more trials

Buprenorphine in Acute Renal Colic Pain Management

Completed·TTehran University of Medical Sciences·Phase 4·NCT01546701·80 enrolled

Morphine Versus Ketorolac in Renal Colic

Unknown status·LLoredana Ghinea·Phase 4·NCT02782273·100 enrolled

Postoperative Pain Control5 trials

Intrathecal Morphine Versus Morphine-dexmedetomidine Combination for Postoperative Pain Control After Total Knee Replacement

Completed·TTanta University·N/A·NCT05439564·105 enrolled

Postoperative Pain Control After Hip Hemiarthroplasty: Intrathecal Morphine vs Periarticular Infiltration of Bupivacaine

Terminated·MMahidol University·Phase 4·NCT01219062·10 enrolled

Post Operative Pain Control: Morphine vs Fentanyl

Completed·—·N/A·NCT02146638·60 enrolled

Show 2 more trials

Post Operative Pain Control After Pediatric Hip Surgery

Terminated·SSeattle Children's Hospital·N/A·NCT03435692·42 enrolled

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

Terminated·—·N/A·NCT01430182·17 enrolled

123 more indications

Cancer Pain5 trials

Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain

Completed· Mario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research··NCT01946555·150 enrolled

Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients

Terminated·UUniversity Hospital, Basel, Switzerland·Phase 3·NCT02591017·11 enrolled

Methadone Associated With Morphine for Cancer Pain

Unknown status·FFederal University of São Paulo·N/A·NCT03324815·40 enrolled

Show 2 more trials

Immediate-Release Oxycodone Capsules Study in Cancer Pain

Completed·MMundipharma (China) Pharmaceutical Co. Ltd·Phase 3·NCT01675622·242 enrolled

Morphine Versus Methadone As First Line Strong Opioid for Cancer Pain

Terminated·MM.D. Anderson Cancer Center·Phase 3·NCT00634010·36 enrolled

Analgesic4 trials

Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department

Not yet recruiting·OOman Medical Speciality Board·Phase 3·NCT06315920·226 enrolled

Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function

Completed·VVanderbilt University Medical Center·N/A·NCT02469077·117 enrolled

Clinical Evaluation of the ReLeaf Analgesic Infusion Catheter & Wound Drain

Withdrawn·VVital 5, LLC·N/A·NCT02293525

Show 1 more trial

Comparison of Two Analgesic Strategies After Scheduled Caesarean

Completed·GGCS Ramsay Santé pour l'Enseignement et la Recherche·Phase 4·NCT04755712·104 enrolled

Total Knee Arthroplasty4 trials

Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty

Unknown status·RRegion Örebro County·N/A·NCT00992082·50 enrolled

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Completed·—·Phase 4·NCT00562627·102 enrolled

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

Withdrawn·HHoly Cross Hospital, Florida·Phase 4·NCT02765815

Show 1 more trial

Intrathecal Morphine for Unilateral Total Knee Arthroplasty

Completed·MMahidol University·N/A·NCT03232957·131 enrolled

Withdrawal3 trials

Activity Monitoring Assessment of Opiate Withdrawal - 4

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00000335

How to Treat Opiate Withdrawal in Neonates

Completed·UUniversity of Zurich·Phase 3·NCT02810782·120 enrolled

Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal

Completed·—·Phase 4·NCT01804075·31 enrolled

Treatment3 trials

Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain

Terminated·WWashington University School of Medicine·N/A·NCT02430818·13 enrolled

NAS Treatment - Opiate Versus Non-Opiate

Completed·HHenrietta Bada·Phase 4·NCT01734551·31 enrolled

Methadone for 'Adenocarcinopathic' Pain Treatment

Withdrawn·OOttawa Hospital Research Institute·Phase 3·NCT05325164

Acute Pain3 trials

Low-dose Ketamine for Acute Pain in the Emergency Department

Unknown status·—·Phase 1·NCT03017248·125 enrolled

Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department

Terminated·UUniversity of Arizona·N/A·NCT01900847·17 enrolled

Comparison of Treatment by IN Ketamine to IV Morphine in Acute Pain

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT03511833·120 enrolled

Post Operative Pain3 trials

Intravenous Paracetamol for Postoperative Pain

Completed·LLithuanian University of Health Sciences·Phase 4·NCT02248493·54 enrolled

Oxycodone Hydrochloride Injection in the Postoperative Pain Relieving Treatment

Completed·MMundipharma (China) Pharmaceutical Co. Ltd·Phase 3·NCT01304134·240 enrolled

Postoperative Pain Therapy With Hydromorphone TCI-PCA vs. Morphine PCA

Completed·UUniversity of Erlangen-Nürnberg Medical School·Phase 4·NCT02483221·50 enrolled

Pediatric3 trials

Split Scripts for Pediatric Supracondylar Fracture Repairs

Completed·TThe Hospital for Sick Children·N/A·NCT05372133·175 enrolled

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine

Recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT06464146·300 enrolled

Sub-dissociative Ketamine for the Management of Acute Pediatric Pain

Completed·HHealthPartners Institute·Phase 4·NCT01951963·77 enrolled

Analgesia3 trials

Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

Completed·BBruno Minotti·Phase 4·NCT03843281·222 enrolled

The Optimal Dosage of Intrathecal Morphine for Peripartum Analgesia

Terminated·—·N/A·NCT01146457·83 enrolled

Serratus Intercostal Plane Block,New Analgesia in Supraumbilical Surgery

Completed·—··NCT04282291·105 enrolled

Cesarean Delivery3 trials

Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

Completed·MMayo Clinic·N/A·NCT02789410·134 enrolled

Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery

Completed·—·Phase 2·NCT03036384·40 enrolled

TAP Block With Intrathecal Fentanyl vs. Intrathecal Morphine in Cesarean Delivery

Completed·SSeoul National University Hospital·N/A·NCT04824274·80 enrolled

Laparoscopic Cholecystectomy3 trials

Post-operative Pain Relief in Laparoscopic Cholecystectomy

Unknown status·—·N/A·NCT03355716·120 enrolled

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT02327923·90 enrolled

Comparison of the Efficacy and Safety of NALDEBAIN With Conventional Treatment After Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT03713216·44 enrolled

Inflammatory Response3 trials

Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status

Unknown status·XXiangya Hospital of Central South University·Phase 4·NCT02135055·80 enrolled

Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier

Completed·NNova Scotia Health Authority·Phase 4·NCT00878371·35 enrolled

The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery

Completed·OOsijek University Hospital·Phase 2·NCT02848599·86 enrolled

Safety and Efficacy2 trials

Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department

Completed·—·N/A·NCT00910208·211 enrolled

A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects

Completed·BBioLineRx, Ltd.·Phase 1/2·NCT00374881·9 enrolled

Hyperalgesia2 trials

Mechanisms of Sleep Disruption Hyperalgesia

Completed·JJohns Hopkins University·N/A·NCT01794689·100 enrolled

Opiate-Induced Tolerance & Hyperalgesia in Pain Patients

Completed·NNational Institute of General Medical Sciences (NIGMS)·Phase 4·NCT00246532·139 enrolled

Sciatica2 trials

Prediction of Inter-individual Differences in the Response to Morphine Versus Milnacipran in Patients With Sciatica

Unknown status·RRambam Health Care Campus·Phase 2·NCT01914042·150 enrolled

Pain Treatment for Sciatica

Completed·NNational Institute of Dental and Craniofacial Research (NIDCR)·Phase 2·NCT00009672·80 enrolled

Interaction2 trials

Herb Drug Interaction of Traditional Chinese Herb and Commonly Used Drugs

Unknown status·TTri-Service General Hospital·Phase 1·NCT00923000·50 enrolled

The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

Completed·PProcare Riaya Hospital·N/A·NCT01366313·90 enrolled

Hysterectomy2 trials

0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy

Unknown status·MMahidol University·Phase 4·NCT01080911·72 enrolled

Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy

Completed·IInonu University·N/A·NCT04691856·66 enrolled

Thoracic Paravertebral Block2 trials

Thoracic Paravertebral Blocks in Open Nephrectomy

Completed·—·Phase 2·NCT03428633·60 enrolled

Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block

Completed·HHacettepe University·N/A·NCT07071012·98 enrolled

Methadone2 trials

Role of Methadone As Co-Opioid Analgesic

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT00558870·5 enrolled

Methadone in Pediatric and Adult Sickle Cell Patients

Completed·WWashington University School of Medicine·N/A·NCT00761085·47 enrolled

Injury2 trials

Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain

Completed·HHenrietta Bada·Phase 3·NCT03396588·120 enrolled

Stellate Ganglion Morphine Infiltration on Myocardial I/R Injury

Recruiting·TThe Second Hospital of Anhui Medical University·N/A·NCT07023679·2,588 enrolled

Efficacy and Safety2 trials

A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy

Completed·GGrünenthal GmbH·Phase 3·NCT00609466·291 enrolled

Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)

Completed·MMundipharma Pharmaceuticals srl·Phase 3·NCT03585374·272 enrolled

Cardiac Surgery2 trials

Intravenous Methadone for Sternotomy Pain Control in Cardiac Surgery

Recruiting·—·Phase 3·NCT06728371·86 enrolled

Oral Oxycodone After Major Cardiac Surgery

Completed·MMedical University of Vienna·Phase 4·NCT01816581·50 enrolled

Total Hip Arthroplasty2 trials

Psoas Compartment Block Versus Fascia Iliaca Block After Total Hip Arthroplasty

Unknown status·HHillel Yaffe Medical Center·N/A·NCT01378949·90 enrolled

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

Completed·CCorewell Health East·Phase 4·NCT02658149·100 enrolled

Laparoscopic2 trials

TQL-block for Laparoscopic Hemicolectomy

Completed·ZZealand University Hospital·Phase 4·NCT03570541·69 enrolled

Comparison of Paravertebral Block and Subcostal Transversus Abdominis Plane Block in Laparoscopic Nephrectomy

Completed·IIstanbul University·N/A·NCT05723341·91 enrolled

Acute Myocardial Infarction2 trials

Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction

Completed·CCollegium Medicum w Bydgoszczy·Phase 4·NCT02217878·74 enrolled

Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction

Not yet recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT07445737·700 enrolled

Spinal Fusion2 trials

Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery

Completed·UUniversity of Puerto Rico·Phase 4·NCT05413902·100 enrolled

Methadone for Spinal Fusion Surgery.

Terminated·UUniversity of Aarhus·Phase 4·NCT04764825·114 enrolled

Nerve Block2 trials

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Completed·—·N/A·NCT03041935·90 enrolled

Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting

Terminated·—·Phase 3·NCT01522534·26 enrolled

Caudal Anesthesia2 trials

Efficacy of Dexmedetomidine Versus Morphine as an Adjunct to Bupivacaine in Caudal Anesthesia.

Completed·—·N/A·NCT04445636·50 enrolled

Clonidine and Morphine in Caudal Anesthesia

Completed·FFederal University of Minas Gerais·Phase 1/2·NCT00672347·80 enrolled

Low back pain2 trials

Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT01129934·200 enrolled

Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms

Completed·—·Phase 4·NCT01502644·81 enrolled

Musculoskeletal Injuries1 trial

Oral Analgesic Utilization for CHildhood Musculoskeletal Injuries

Completed·SSt. Justine's Hospital·N/A·NCT02064894·501 enrolled

Nausea and vomiting1 trial

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Completed·VVanderbilt University·N/A·NCT02625181·27,034 enrolled

Caesarean Section1 trial

Ultrasound-Guided TAP Block and Spinal Morphine for Pain Relief After Caesarean Section

Completed·SSohag University·N/A·NCT05331781·60 enrolled

Myocardial Ischemia1 trial

Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury

Recruiting·TThe Second Hospital of Anhui Medical University·N/A·NCT06947135·166 enrolled

AIN1 trial

Brain Effects of Opiate Agonist and Antagonist

Completed·UUniversity of Rochester·Phase 4·NCT04342130·10 enrolled

Total Knee Replacement1 trial

The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)

Completed·HHospital for Special Surgery, New York·Phase 4·NCT02292082·111 enrolled

Shoulder pain1 trial

Impact of Epidural Morphine on Shoulder Pain Following Thoracotomy.

Terminated·—·N/A·NCT01984463·22 enrolled

Intravenous1 trial

Subcutaneous Versus Intravenous Morphine When Switching From Oral to Parenteral Route in Palliative Cancer Patients

Completed·UUniversity Hospital, Akershus·Phase 3·NCT05236647·60 enrolled

Morphine and Dexmedetomidine1 trial

Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Open Subcostal Renal Surgeries

Completed·KKafrelsheikh University·N/A·NCT07012590·147 enrolled

Opioid Use1 trial

A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05587998·45 enrolled

Outcome1 trial

Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome

Withdrawn·AASST Gaetano Pini-CTO·Phase 4·NCT02082067

Lumbar Spine Surgery1 trial

Peri-Incisional Drug Injection in Lumbar Spine Surgery

Withdrawn·UUniversity of Minnesota·Phase 3·NCT03513445

Opioid Withdrawal1 trial

5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence

Completed·SStanford University·N/A·NCT01549652·133 enrolled

Hernia1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Unknown status·—·N/A·NCT03041948·88 enrolled

Myocardial Infarction1 trial

Effects of Morphine on Loading-dose Ticagrelor in Patients With ST-segment Elevation Myocardial Infarction

Unknown status·GGeneral Hospital of Chinese Armed Police Forces·Phase 4·NCT02913469·128 enrolled

Abdominal pain1 trial

Morphine in Acute Abdominal Pain

Completed·—·Phase 4·NCT01112540

Knee Arthroplasty1 trial

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 3·NCT02540070·135 enrolled

Platelet Reactivity1 trial

Platelet Reactivity With Fentanyl, Morphine, or no Narcotic

Terminated·CCorewell Health South·Phase 2·NCT05367336·21 enrolled

Midazolam1 trial

Is Analgesic Effect of Low Dose Ketamine-midazolam the Same as Morphine

Completed·IIsfahan University of Medical Sciences·Phase 2/3·NCT01807429·236 enrolled

Adverse Effect1 trial

Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function

Terminated·MMaastricht University Medical Center·Phase 4·NCT03616639·8 enrolled

Orthopedic Surgery1 trial

A Study of SHR8554 Injection for the Treatment of Pain After Orthopedic Surgery

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 2/3·NCT05375305·320 enrolled

Medical Procedure1 trial

Decreasing REcurrent Pain and Anxiety in Medical Procedures With a Pediatric Population: Trial

Withdrawn·SSt. Justine's Hospital·N/A·NCT02947243

Prostatectomy1 trial

Spinal Morphine in Robotic Assisted Radical Prostatectomy

Completed·MMaasstad Hospital·Phase 4·NCT02924974·160 enrolled

Obstructive Sleep Apnea1 trial

Single Dose Morphine and Fentanyl Added to Intrathecal Mixture on Orthopedics Patients With Undiagnosed Obstructive Sleep Apnea

Unknown status·UUniversity of Malaya·Phase 1·NCT02014714·40 enrolled

Lumbar Erector Spinae Plane Block1 trial

Lumbar Erector Spinae Plane Block for Back Surgery

Unknown status·DDr M. B. Breebaart·Phase 3·NCT03825198·80 enrolled

Colorectal Surgery1 trial

PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery

Completed·UUniversiti Kebangsaan Malaysia Medical Centre·Phase 4·NCT06021717·60 enrolled

Minimal Residual Disease1 trial

Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery

Completed·TThe Institute of Molecular and Translational Medicine, Czech Republic·Phase 4·NCT02314871·60 enrolled

Pediatric Patients1 trial

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

Recruiting·—·N/A·NCT06326983·58 enrolled

Epidural Analgesia1 trial

Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.

Completed·—·Phase 4·NCT03007121·75 enrolled

Visceral Pain1 trial

Visceral Pain From the Upper Urinary Tract - a Trial on the Effect of Morphine and Oxycodone in Patients Undergoing PCNL

Completed·KKatja venborg Pedersen·Phase 3·NCT00784472·55 enrolled

Extracorporeal Membrane Oxygenation1 trial

Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

Recruiting·—··NCT03593408·20 enrolled

Cardiac Surgical Patients1 trial

Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical Patients

Active, not recruiting·—·Phase 3·NCT05913284·86 enrolled

Prospective1 trial

Nebulized Morphine in Chest Trauma Patients: A Prospective Study

Completed·UUniversity Hospital, Mahdia·Phase 3·NCT03580187·75 enrolled

Neostigmine1 trial

A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers

Completed·UUniversity of Nottingham·Phase 4·NCT01134848·10 enrolled

Analgesic Efficacy1 trial

RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder.

Completed· Mario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research·Phase 4·NCT01809106·518 enrolled

Postherpetic Neuralgia1 trial

Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia

Completed·NNational Center for Research Resources (NCRR)·Phase 3·NCT00004390·120 enrolled

Bariatric Surgery1 trial

Dexmedetomidine to Treat Bariatric Surgery-associated Pain

Completed·JJanelle Vaughns·Phase 3·NCT02880540·26 enrolled

Multimodal Analgesia1 trial

Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries

Completed·NNational Cancer Institute, Egypt·N/A·NCT03580980·90 enrolled

Knee Replacement Surgery1 trial

Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)

Completed·OOrganon and Co·Phase 3·NCT00820027·776 enrolled

Hemorrhage1 trial

Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine

Completed·UUniversity of Texas Southwestern Medical Center·Phase 1/2·NCT04138615·44 enrolled

Drug Abuse1 trial

Opioid/Benzodiazepine Polydrug Abuse: Aim 3

Recruiting·WWayne State University·Phase 2·NCT05006079·24 enrolled

Buprenorphine1 trial

Efficacy of Buprenorphine for Treatment of Acute Pain

Completed·TTehran University of Medical Sciences·Phase 4·NCT01298297·80 enrolled

Colorectal Cancer1 trial

Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery

Completed·TThe Institute of Molecular and Translational Medicine, Czech Republic·Phase 4·NCT03700411·125 enrolled

Postoperative Pain Relief1 trial

Efficacy of Fentanyl to Reduce the Time of Severe Postoperative Pain Relief Compared to Morphine

Completed·UUniversidad de Antioquia·Phase 3·NCT02145975·60 enrolled

Thoracoscopy1 trial

Postoperative Analgesic Effect of Hydromorphone on Partial Pulmonary Resection Under Video-assisted Thoracoscopy

Completed·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT03648008·171 enrolled

Rectus Sheath Block1 trial

Comparison of Surgical Rectus Sheath Block and Intrathecal Morphine

Completed·QQueen Mary Hospital, Hong Kong·Phase 4·NCT02790099·144 enrolled

Spinal Anesthesia1 trial

Fentanyl Versus Morphine in Spinal Anesthesia for Caesarian Section - Study on Analgesia, Side Effects and Patient 's Satisfaction

Completed·—··NCT05533229·160 enrolled

Abdominal Surgery1 trial

A Clinical Study of SHR8554 Injection for the Treatment of Pain After Abdominal Surgery.

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 3·NCT04766463·528 enrolled

Randomized1 trial

Randomized, Controlled, Double Blind, to Evaluate the Postpartum Analgesia With Epidural Morphine: Analgesic Effect of Two Different Doses Compared to Placebo

Completed·UUniversidad Nacional de Colombia·Phase 3·NCT04887649·114 enrolled

Opioid Analgesia1 trial

Assessment of Opioid Analgesia in Sickle Cell

Withdrawn·—·Phase 4·NCT00513864

Thoracotomy1 trial

Ketamine Improves Post-Thoracotomy Analgesia

Completed·TTel-Aviv Sourasky Medical Center·N/A·NCT00625911·44 enrolled

Laparotomy1 trial

Patient Re-education vs. Background Morphine to IV-PCA in Patient With Unsatisfactory Analgesia Post Laparotomy

Unknown status·—·Phase 4·NCT02523846·160 enrolled

Acute Chest Syndrome1 trial

Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally

Completed·CChildren's Healthcare of Atlanta·Phase 3·NCT01380197·40 enrolled

Nephrectomy1 trial

The Effects of TAP Block on Postsurgical Pain After Minimally Invasive Partial Nephrectomy:

Completed·RRegina Elena Cancer Institute·N/A·NCT02460640·96 enrolled

Dyspnea1 trial

Morphine, Dyspnea, Exercise and COPD

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT01718496·20 enrolled

Breast Cancer1 trial

Ultrasound-guided Erector Spinae Plane Block Versus Paravertebral Block in Breast Cancer Patients Undergoing Mastectomy With Immediate Reconstruction - a Non-inferiority Trial

Unknown status·TThe Netherlands Cancer Institute·N/A·NCT05590559·100 enrolled

General Anaesthesia1 trial

Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone and Post-operative Analgesia During Anal Sphincter Sparing Procedures Under General Anaesthesia

Completed·KKasr El Aini Hospital·N/A·NCT04651595·26 enrolled

Acetaminophen1 trial

Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain

Terminated·MMallinckrodt·Phase 4·NCT02746263·1 enrolled

Intensive Care Unit1 trial

Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects

Completed· GSK logo

GSK·Phase 4·NCT00158873·224 enrolled

Shoulder Arthroplasty1 trial

Multimodal Analgesia in Shoulder Arthroplasty

Withdrawn·RRush University Medical Center·Phase 3·NCT03586934

Quality of Recovery1 trial

QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE

Completed·PPontificia Universidade Catolica de Sao Paulo·Phase 4·NCT03045133·70 enrolled

Inguinal hernia1 trial

PRO-RSTAP: Effect of TAP and RS Blocks on Recovery After Inguinal Hernia Surgery (PRO-RSTAP)

Recruiting·TTampere University Hospital·N/A·NCT07423910·200 enrolled

Patient-Controlled Analgesia1 trial

Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia

Completed·KKyungpook National University Hospital·N/A·NCT02416115·90 enrolled

Ventilation1 trial

Study of Morphine in Postoperative Infants to Allow Normal Ventilation

Completed·SSeattle Children's Hospital·N/A·NCT00004696·100 enrolled

Erector Spinae Plane Block1 trial

NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block

Completed·IInstitutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu·N/A·NCT06070701·40 enrolled

Pain1 trial

Reduction of Bladder Injection Pain With Belladonna Opiate Suppository

Completed·—·Phase 4·NCT02600715·26 enrolled

Cancer1 trial

Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer

Terminated·MM.D. Anderson Cancer Center·Phase 1·NCT03579446·43 enrolled

Ketamine1 trial

Ketamine Versus Morphine Change Pain Profile

Completed·—·N/A·NCT03664622·160 enrolled

Interscalene Block1 trial

is There an Alternative to Ultrasound Guided Interscalene Block?

Unknown status·TTunisian Military Hospital·N/A·NCT02397330·60 enrolled

Spinal Cord Injury1 trial

Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT00488969·17 enrolled

Knee Arthroscopy1 trial

Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy

Completed·JJens Borglum Neimann·Phase 4·NCT01837394·60 enrolled

Intraoperative Pain1 trial

Analgesic Efficacy of Intrathecal Fentanyl-Morphine Combination Versus Morphine Alone for Intraoperative Pain During Elective Cesarean Delivery

Not yet recruiting·SSeoul National University Hospital·Phase 4·NCT06570343·186 enrolled

Opioid Use Disorder1 trial

Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine

Withdrawn·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT06784180

Acute Coronary Syndrome1 trial

Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia.

Completed·UUniversity Hospital, Toulouse·Phase 4·NCT02198378·680 enrolled

Hip Fracture1 trial

Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel

Unknown status·LLarissa University Hospital·N/A·NCT03596060·150 enrolled

Mucositis1 trial

Nalbuphine Versus Morphine for Mucositis Pain in Pediatric Cancer Patients

Completed·—·Phase 3·NCT03825887·80 enrolled

Double-blind1 trial

A Randomized, Double-blind Comparison of Morphine and Sufentanil for Prehospital Traumatic Severe Acute Pain

Completed·UUniversity Hospital, Toulouse·Phase 3·NCT00656773·108 enrolled

Bone Fracture1 trial

Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures

Withdrawn·TThe University of Texas Health Science Center, Houston·Phase 2·NCT04061330

Orthopedic Procedures1 trial

Does IVPCA Increase Opioid Consumption and Side Effects in Fast Track Orthopedic Procedures?

Unknown status·MMount Sinai Hospital, Canada·N/A·NCT02880800·80 enrolled

Terminated·AAlberto Dominguez-Rodriguez·Phase 4·NCT02856698·111 enrolled

Lidocaine Infusion1 trial

Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy

Terminated·WWashington University School of Medicine·Phase 2·NCT05017246·110 enrolled

Rib Fracture1 trial

Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture

Terminated·—·Phase 3·NCT02749409·17 enrolled

Interscalene Brachial Plexus Block1 trial

Ultrasound Guidance for Interscalene Brachial Plexus Block

Completed·UUniversity of Parma·Phase 4·NCT00702416·50 enrolled

Pain Management1 trial

Geriatric Ketamine for Pain Management Study

Completed·AAntonios Likourezos·Phase 4·NCT02673372·60 enrolled

Tonsillectomy1 trial

Opioid-Free Anesthetic for Tonsillectomy

Terminated·—·Phase 4·NCT04528173·35 enrolled

After Cardiac Surgery1 trial

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01966172·180 enrolled

Scoliosis1 trial

Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery

Not yet recruiting·PPeking Union Medical College Hospital·Phase 4·NCT07229495·171 enrolled

Delirium1 trial

Delirium in Elderly Patients With Trauma of the Hip

Terminated·—·Phase 4·NCT02689024·239 enrolled

Bone Graft1 trial

Effect of Local Administration of Morphine for Analgesia After Iliac Bone Graft Harvest

Withdrawn·TThe Cleveland Clinic·Phase 4·NCT01037335

Elderly Patients1 trial

Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain

Completed·MMontefiore Medical Center·Phase 2/3·NCT00305058·194 enrolled

Video-Assisted Thoracoscopic Surgery1 trial

Low-dose Spinal Morphine for Post-Thoracotomy Pain After Video-Assisted Thoracoscopic Surgery

Completed·MMahidol University·Phase 4·NCT01917448·36 enrolled

Unspecified4 trials

Genetic Effects on Dopamine Response to an Opiate

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT01878006·15 enrolled

Dose Finding Study of STR-324

Unknown status·AAlaxia SAS·Phase 2·NCT04582786·118 enrolled

VAS Correlation With BMI

Unknown status·IIstanbul University·Phase 4·NCT02017314·100 enrolled

Show 1 more trial

Serratus Posterior Superior Intercostal Plane Block

Completed·UUniversity of Gaziantep·N/A·NCT07330479·60 enrolled

Regulatory

FDA Approval Timeline[5]

Sep 18, 1984

DURAMORPH PF

NDA NDA018565

Sep 12, 1989

MS CONTIN

NDA NDA019516

Jul 12, 1990

MORPHINE SULFATE (AUTOINJECTOR)

NDA NDA019999

Oct 30, 1992

MORPHINE SULFATE

NDA NDA019917

Oct 30, 1992

MORPHINE SULFATE

NDA NDA019916

Nov 23, 1994

ORAMORPH SR

NDA NDA019977

Jul 3, 1996

MORPHINE SULFATE

NDA NDA020631

Mar 20, 2002

AVINZA

NDA NDA021260

May 18, 2004

DEPODUR

NDA NDA021671

Apr 20, 2007

KADIAN

NDA NDA020616

Mar 17, 2008

MORPHINE SULFATE

NDA NDA022207

Mar 17, 2008

MORPHINE SULFATE

NDA NDA022195

Jun 23, 2011

MORPHINE SULFATE

NDA NDA201517

Nov 14, 2011

MORPHINE SULFATE

NDA NDA202515

Oct 30, 2013

MORPHINE SULFATE

NDA NDA204223

Oct 2, 2015

MORPHABOND ER

NDA NDA206544

Jan 9, 2017

ARYMO ER

NDA NDA208603

Sources

References

[1]
ClinicalTrials.gov — 451 trial records for Morphine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — MS Contin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Morphine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Morphine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA208603). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for MS Contin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Hikma Pharmaceuticals LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Mu Opioid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: HHikma Pharmaceuticals LLC

Patent Landscape[6]

Patent Cliff

Aug 12, 2028

Earliest patent expiration — generic entry possible after this date

Patent #Expires

10314788Aug 12, 2028

9549899Jul 1, 2033

9044402Jul 1, 2033

9192608Mar 12, 2034

9248229Mar 12, 2034

1 more patents

9072781Mar 12, 2034