VivoSeq
Other

Synovitis

13

Pipeline Programs↗

1

Active Trials↗

6

Companies Involved↗

Synovitis is an emerging landscape with 13 programs across 6 companies. The most active players are Novartis, Immunex, Pfizer. 5 therapies are approved.

Intelligence

Pipeline Metrics

Competitive Density

40/100

Pipeline Velocity

6/100

Mech. Concentration

63/100

Completion Rate

63/100

Attrition Rate

33/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Novartis logo

Novartis

2 programs

Phase 2I

Immunex

1 program

Phase 2Pfizer logo

Pfizer

1 program

Phase 2Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

1 program

Phase 2P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

ApprovedQ

Quince Therapeutics S.p.A.

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Modality Breakdown

86%

Small molecule

12 of 14 classified programs — the dominant modality here.

14%ALL OTHERSMonoclonal antibody17%Protein / enzyme17%

Small molecule leads; the ring shows all 14 classified programs, each share of the total. Modality classified for 100% of 14 pipeline programs.

Analysis

Trial Status

9

clinical trials

Completed5 · 56%
Terminated2 · 22%
Recruiting1 · 11%
Withdrawn1 · 11%

Clinical Trials

Trial Activity

9 trials

Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA
Recruiting·—·Phase 2·NCT07161336·70 enrolled
MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS)
Completed·Novartis logoNovartis·Phase 2·NCT01643850·36 enrolled
Intensive Replacement Treatment in Haemophilia Patients With Synovitis
Completed·FFederico II University·Phase 4·NCT04784988·64 enrolled
Evaluation of The Efficacy And Safety of Intra-Articular Etanercept in Patients With Refractory Knee Joint Synovitis
Completed·UUniversity of Padova·Phase 2·NCT00678782·31 enrolled
Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)
Completed·CCentre Leon Berard·Phase 2·NCT01261429·50 enrolled
Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome
Completed·PPeking Union Medical College Hospital·Phase 1·NCT02544659·30 enrolled
Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis
Terminated·NNational Taiwan University Hospital·Phase 1·NCT02060305·5 enrolled
MRI Evaluation Assessing Synovitis to Address the Unmet Need for Reliable Endpoints in SLE
Terminated·OOklahoma Medical Research Foundation·Phase 2·NCT03355482·9 enrolled
The Use of PET/CT to Evaluate Synovitis in the Temporomandibular Joint (TMJ)
Withdrawn·UUniversity of Pennsylvania·Phase 2·NCT01471418

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)