Artemether-lumefantrine combination

PreclinicalSmall molecule

LLondon School of Hygiene and Tropical Medicine

Artemether-lumefantrine combination is one of 15 small molecule programs targeting Plasmodium falciparum malaria. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Plasmodium Falciparum MalariaActive, not recruiting

Plasmodium Falciparum MalariaPreclinical

Active, not recruiting

Competition

Competitive Landscape

14 competitors in Plasmodium Falciparum Malaria

#DrugCompanyPhaseTrials

Aralen

Avandia

Methylthioninium Chloride

PProvepharm SAS

Approved

—4

Aldara

BBausch Health Americas, Inc.

Approved

—5

Daraprim

FFondazione Matilde Tettamanti Menotti De Marchi Onlus

Approved

—6

Mepron

GGlaxo Dba Glaxosmithkline

Approved

—7

Trental

VValidus Pharmaceuticals

Lariam

Camoquin Hydrochloride

KLU156

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Malaria12 trials

A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh

Completed·MMenzies School of Health Research·Phase 4·NCT02389374·181 enrolled

Pyronaridine-artesunate and Artemether-lumefantrine for the Treatment of Paediatric Malaria

Completed·RRoyal Tropical Institute·Phase 3·NCT02411994·197 enrolled

Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission

Completed·RRadboud University Medical Center·N/A·NCT01575613·17,506 enrolled

Show 9 more trials

Artemisinin-Based Antimalarial Combinations and Clinical Response in Cameroon

Completed·UUniversity of Yaounde 1·Phase 3·NCT01845701·720 enrolled

Adherence to Antimalarial Drugs in Sierra Leone

Completed·LLondon School of Hygiene and Tropical Medicine·N/A·NCT01967472·1,145 enrolled

Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana

Completed·CCentre for Global Health Research, Ghana·Phase 4·NCT01651416·2,400 enrolled

Safety of Primaquine + Artemether-lumefantrine in G6PD Deficient Males With an Asymptomatic Malaria Infection (SAFEPRIM)

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 2/3·NCT02174900·70 enrolled

Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy 2 (TRANSACT2)

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT01939886·219 enrolled

Safety and Effectiveness of Artemisinin-based Combination Therapies (ACTs) With Repeated Treatments for Uncomplicated Falciparum Malaria Over a Three-year Period

Unknown status·LLiverpool School of Tropical Medicine·Phase 4·NCT01038063·1,200 enrolled

Ethiopia Antimalarial in Vivo Efficacy Study 2012

Completed·CCenters for Disease Control and Prevention·Phase 4·NCT01680406·398 enrolled

Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria Transmission

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 1/2·NCT01603251·120 enrolled

Artemether-lumefantrine for Treatment of P. Falciparum Malaria in Brazil

Completed·CCenters for Disease Control and Prevention·N/A·NCT02600767·79 enrolled

Trial1 trial

P. Knowlesi Trial of Artemether-lumefantrine vs Chloroquine

Completed·MMenzies School of Health Research·Phase 3·NCT02001012·123 enrolled

Age1 trial

Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs

Completed·—·N/A·NCT00720811·6,456 enrolled

Effectiveness1 trial

Artemether-Lumefantrine Clinical Effectiveness Study

Completed·PPapua New Guinea Institute of Medical Research·Phase 4·NCT01599000·159 enrolled

CLE1 trial

Low Dose Primaquine for Clearance of Gametocytes

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 2/3·NCT01935882·360 enrolled

2 more indications

Plasmodium falciparum malaria1 trial

Efficacy of Artemether-lumefantrine, Artesunate-amodiaquine and Dihydroartemisinin-piperaquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Malawi

Completed·CCenters for Disease Control and Prevention·N/A·NCT01326754·498 enrolled

Interaction1 trial

Dolutegravir Interactions With Artemisinin-based Combination Therapies

Completed·UUniversity of Liverpool·Phase 1·NCT02242799·46 enrolled

Sources

References

[1]
ClinicalTrials.gov — 18 trial records for Artemether-lumefantrine combination. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Artemether-lumefantrine combination compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Artemether-lumefantrine combination. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — London School of Hygiene and Tropical Medicine company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: LLondon School of Hygiene and Tropical Medicine

Artemether-lumefantrine combination

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Malaria12 trials

Trial1 trial

Age1 trial

Effectiveness1 trial

CLE1 trial

Plasmodium falciparum malaria1 trial

Interaction1 trial

References

Drug Info

Quick Facts

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