Biodentine

Phase 3Small molecule

IIstanbul University

Biodentine is one of 12 small molecule programs targeting Medication. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

MedicationActive, not recruiting

Indirect Pulp CapRecruiting

Single Rooted TeethRecruiting

MedicationPreclinical

Active, not recruiting

Indirect Pulp CapPhase 3

Recruiting

Single Rooted TeethPhase 3

Recruiting

Competition

Competitive Landscape

12 competitors in Medication

#DrugCompanyPhaseTrials

Ozempic

Novo Nordisk

Approved

1 2

Advil

KKenvue Brands

Approved

2 3

Biodentine

IIstanbul University

Phase 3

1 4

Methylphenidate /kg

FFlorida International University

Phase 3

1 5

Vyvanse

Takeda

Preclinical

1 6

Tianeptine

Pfizer

Preclinical

1 7

Glycyrrhizin

MMansoura University

Preclinical

1 8

Antiretroviral Drugs

NNational Institute of Allergy and Infectious Diseases (NIAID)

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Active, not recruiting

Genetic Polymorphism

NCT07130214

Clinical

Trials by Indication[1]

Pulpotomy6 trials

Pulpotomy Materials in Primary Molars

Completed·SSacide Duman·N/A·NCT07120321·22 enrolled

Pulpotomy Technique Preserving Vitality of Traumatized Anterior Permanent Immature Teeth

Completed·GGihan M Abuelniel ,PhD·Phase 2/3·NCT03838068·33 enrolled

Comparison of The Success Rates of Four Different Pulpotomy Techniques

Completed·IIstanbul University·Phase 3·NCT03135626·38 enrolled

Show 3 more trials

Evaluation of MTA Versus Biodentine as Pulpotomy Agents in Immature First Permanent Molars

Completed·GGihan M Abuelniel ,PhD·Phase 1/2·NCT03838094·30 enrolled

Efficacy of Combination of Biodentine and Simvastatin as a Pulp Capping Materials in Vital Pulpotomy of Primary Molars

Completed·SSuez Canal University·N/A·NCT05582317·20 enrolled

A Comparative Clinical and Radiographic Study of Collagen Based Pulpotomy Versus Biodentine Pulpotomy in Children With Cariously Exposed Vital Primary Molars

Unknown status·—·Phase 1·NCT05479877·40 enrolled

Mineral Trioxide Aggregate5 trials

Comparative Study Between Biodentine and Mineral Trioxide Aggregate in Sealing Root Perforations

Completed·—·N/A·NCT02805101·30 enrolled

Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth

Completed·—·N/A·NCT03589560·26 enrolled

Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth

Completed·UUniversidad de los Andes, Chile·Phase 2/3·NCT02492841·169 enrolled

Show 2 more trials

Comparative Study Between Biodentine and Mineral Trioxide Aggregate in Direct Pulp Capping

Completed·—·N/A·NCT02803528·30 enrolled

Effectiveness of Mineral Trioxide Aggregate and Platelet Rich Fibrin Along With Biodentine. .

Completed·MMaharishi Markendeswar University (Deemed to be University)·Phase 4·NCT04773886·60 enrolled

Indirect Pulp Cap2 trials

Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth

Recruiting·—·Phase 4·NCT06683833·35 enrolled

Indirect Pulp Capping Using Biodentine and Theracal Light-cured in Primary Molars

Completed·TTanta University·Phase 4·NCT06020911·17 enrolled

Medication1 trial

New Vital Pulpotomy Medications in Primary Molars

Active, not recruiting·MMansoura University·N/A·NCT05937100·48 enrolled

MPA1 trial

Comparison of Biodentine and MTA Pulpotomies in the Primary Molar Teeth 3 Year Follow up

Completed·IIstanbul University·Phase 1·NCT03395496·200 enrolled

6 more indications

Genetic Polymorphism1 trial

The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy

Active, not recruiting·—··NCT07130214·96 enrolled

Single Rooted Teeth1 trial

Socket Preservation Using Biodentin Versus Xeno Graft for Single Rooted Teeth

Recruiting·—·Phase 4·NCT06695208·11 enrolled

Treatment1 trial

Evaluation of Biodentine Versus Glass Ionomer Cement in Treatment of Very Deep Carious Lesions

Completed·—·Phase 3·NCT02868918·120 enrolled

Clinical Trial1 trial

Prospective Clinical Trial of Three Apical Sealing Materials

Completed·UUniversity of the Pacific·Phase 4·NCT04198298·59 enrolled

Age1 trial

Direct Pulp Capping Agent on Human Pulp Tissue

Recruiting·DDR SURINDER SACHDEVA·Phase 4·NCT06435065·40 enrolled

Primary Teeth1 trial

Regenerative Ability of TAMP BG and BD in Pulpotomized Primary Teeth

Terminated·NNourhan M.Aly·Phase 2·NCT03786302·102 enrolled

Sources

References

[1]
ClinicalTrials.gov — 21 trial records for Biodentine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Biodentine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Biodentine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Istanbul University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: IIstanbul University

Biodentine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Pulpotomy6 trials

Mineral Trioxide Aggregate5 trials

Indirect Pulp Cap2 trials

Medication1 trial

MPA1 trial

Genetic Polymorphism1 trial

Single Rooted Teeth1 trial

Treatment1 trial

Clinical Trial1 trial

Age1 trial

Primary Teeth1 trial

References

Drug Info

Quick Facts

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