D-PLEX

Phase 3Small molecule

PPolyPid Ltd.

D-PLEX is one of 3 small molecule programs targeting Surgical Site Infection. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Surgical Site InfectionTerminated

Surgical Site InfectionPhase 3

Terminated

Competition

Competitive Landscape

5 competitors in Surgical Site Infection

#DrugCompanyPhaseTrials

D-PLEX

PPolyPid Ltd.

Phase 3

2 2

Garamycin

SSchering-Plough

Preclinical

1 3

Standard Antibiotic Prophylaxis

WWestern Galilee Hospital-Nahariya

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Safety and Efficacy3 trials

Safety and Efficacy of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery

Completed·PPolyPid Ltd.·Phase 1/2·NCT02731573·80 enrolled

D-PLEX 311: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection

Completed·PPolyPid Ltd.·Phase 3·NCT04233424·977 enrolled

D-PLEX 310: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection

Completed·PPolyPid Ltd.·Phase 2·NCT03633123·202 enrolled

Surgical Site Infection2 trials

D-PLEX 312 - Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to Assess Efficacy and Safety of D-PLEX In Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)

Completed·PPolyPid Ltd.·Phase 3·NCT04411199·975 enrolled

Prospective, Multicenter, Randomized, Parallel Controlled, Two Arms, Single Blind, Study to Assess the Efficacy and Safety of D-PLEX Administered Concomitantly With the SOC IV Prophylactic Antibiotic Treatment vs. SOC in Prevention of Post-Cardiac Surgery Sternal Infections

Terminated·PPolyPid Ltd.·Phase 3·NCT03558984·2 enrolled

Sources

References

[1]
ClinicalTrials.gov — 5 trial records for D-PLEX. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — D-PLEX compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for D-PLEX. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — PolyPid Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: PPolyPid Ltd.

D-PLEX

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Safety and Efficacy3 trials

Surgical Site Infection2 trials

References

Drug Info

Quick Facts

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