E2086

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

9 competitors in Narcolepsy

#DrugCompanyPhaseTrials

1

Biaxin

AbbVie

Approved

12

Romazicon

CConrado Roberto Hoffmann Filho

Approved

—3

Xyrem

Jazz Pharmaceuticals

Preclinical

—4

Wakix

HHarmony Biosciences Management, Inc.

Preclinical

15

E2086

Eisai

Phase 2

26

Lu AH69593

Lundbeck

Phase 1

17

JZP441

Jazz Pharmaceuticals

Phase 1

1

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Narcolepsy2 trials

A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1

Completed·Eisai·Phase 1·NCT06462404·22 enrolled

A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy

Not yet recruiting·Eisai·Phase 2·NCT07493265·64 enrolled

Adult1 trial

A Study of E2086 in Healthy Adult Participants

Completed·Eisai·Phase 1·NCT06481488·32 enrolled

Elderly Participants1 trial

A Study To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2086 in Healthy Adult and Elderly Participants

Completed·Eisai·Phase 1·NCT05745207·53 enrolled

Unspecified2 trials

An Open-Label, Single Dose Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Subjects

Completed·Eisai·Phase 1·NCT07308236·10 enrolled

A Phase 1, Open-label, 3-Part Study to Assess Potential Drug-Drug Interactions of E2086 When Coadministered Orally With Itraconazole, Carbamazepine, Midazolam, Dextromethorphan, Bupropion, or Combined Oral Contraceptives in Healthy Subjects

Not yet recruiting·Eisai·Phase 1·NCT07766369·93 enrolled

Details

Drug Info

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