AstPlayer
(Guadecitabine)Phase 3Small molecule
Guadecitabine is used to treat certain types of blood cancers, particularly myelodysplastic syndromes (a condition where bone marrow doesn't make enough healthy blood cells). It works by helping to reactivate genes that have been turned off in cancer cells.[1] AstPlayer is currently being investigated across 17 indications[3], with its most advanced program in Phase 3.[1]
AstPlayer is one of 449 small molecule programs targeting Kidney Cancer. It is currently in Phase 3.
17
Indications
21
Total Trials
7
Active Trials
448
Competitors
Pipeline
Status by Indication[3][1]
Indication
Showing 10 of 17 indications
Competition
Competitive Landscape
804 competitors in Acute Myeloid Leukemia
#DrugCompanyPhaseTrials
1Idamycin
PfizerPhase 3
Clolar
GGenzyme, a Sanofi Company
Phase 3
Novantrone
EMD SeronoPhase 3
Tibsovo
SServier
Phase 3
Alkeran
AApotex Inc.
Phase 3
AstPlayer
AAstex Pharmaceuticals, Inc.
Phase 3
Tabloid
Akero TherapeuticsPhase 3
Bicnu
MMelissa K Accordino
Phase 3
Campath
GGenzyme, a Sanofi Company
Phase 3
Active Comparator
ModernaPhase 3
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Acute Myeloid Leukemia3 trials
Myelodysplastic Syndromes2 trials
Urothelial Carcinoma1 trial
Kidney Cancer1 trial
Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer
Active, not recruiting·—·Phase 1/2·NCT03308396·57 enrolled
13 more indications
Lung Cancer1 trial
Fallopian Tube Cancer1 trial
Germ Cell Tumor1 trial
Metastatic Colorectal Cancer1 trial
Primary Peritoneal Cancer1 trial
Allogeneic Stem Cell Transplantation1 trial
Chondrosarcoma1 trial
Gallbladder Cancer1 trial
Small Cell Lung Cancer1 trial
Treatment1 trial
Chronic Myelomonocytic Leukemia1 trial
Unspecified1 trial
Sources
References
- [1]
- [2]
- [3]Open Targets Platform — Drug–disease associations for Guadecitabine. EMBL-EBI & Wellcome Sanger Institute.
- [4]
Details
Drug Info
Quick Facts
- Modality
- Small molecule[2]
- Highest Phase
- Phase 3[1]
- Company
- AAstex Pharmaceuticals, Inc.