hCG

Phase 3Small molecule

Changchun GeneScience Pharmaceutical Co., Ltd.

hCG is one of 73 small molecule programs targeting Hypogonadism. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

HypogonadismActive, not recruiting

Polycystic Ovary SyndromeActive, not recruiting

Embryo TransferRecruiting

Frozen Embryo Transfer (FET)Completed

BlastocystCompleted

Luteal Phase InsufficiencyRecruiting

Ovarian Hyperstimulation SyndromeActive, not recruiting

HypogonadismPreclinical

Active, not recruiting

Polycystic Ovary SyndromePreclinical

Active, not recruiting

Embryo TransferPhase 3

Recruiting

Frozen Embryo Transfer (FET)Preclinical

Completed

BlastocystPreclinical

Completed

Luteal Phase InsufficiencyPreclinical

Recruiting

Ovarian Hyperstimulation SyndromePreclinical

Active, not recruiting

Competition

Competitive Landscape

71 competitors in Polycystic Ovary Syndrome

#DrugCompanyPhaseTrials

Femara

Novartis

Approved

10 2

Victoza

Novo Nordisk

Approved

4 3

Ozempic

Novo Nordisk

Approved

2 4

Calciferol

Onglyza

Glucophage

3 7

Meridia

AAbbott

Approved

1 8

Januvia

ZZydus Therapeutics Inc.

Approved

1 9

Invokana

WWim Janssens

Approved

1 10

Gynorest

SSolvay Pharmaceuticals

Approved

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Post-ApprovalRecruiting

Embryo Transfer

NCT07004192

Q2 2030

PreclinicalRecruiting

Study completion

NCT07028710

Clinical

Trials by Indication[1]

Pregnancy8 trials

Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712)

Completed·OOrganon and Co··NCT00703014·541 enrolled

Pregnancy Rate by HCG Administration Versus Urinary LH Surge Method in Patients Undergoing IUI

Completed·SShiraz University of Medical Sciences·Phase 4·NCT02638285·86 enrolled

HOPE Trial hCG or Progesterone Effect on Recurrent Pregnancy Loss

Withdrawn·WWake Forest University Health Sciences·Phase 2·NCT05365464

Show 5 more trials

Two Different Types of Luteal Phase Support in Natural Cycle Frozen Embryo Transfer and Its Effect on Pregnancy Rates

Unknown status·SShaare Zedek Medical Center·N/A·NCT05838105·144 enrolled

Pregnancy Outcome of Women Using Low Molecular Weight Heparin Before Frozen-thawed Embryo Transfer

Unknown status·NNanfang Hospital, Southern Medical University·Phase 4·NCT03120715·342 enrolled

Effect of Intrauterine Injection of HCG on Clinical Pregnancy Outcome in Repeated Implantation Failure Patients

Completed·RReproductive & Genetic Hospital of CITIC-Xiangya·N/A·NCT03682614·47 enrolled

Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05714 (Care Program)(P05715)

Completed·OOrganon and Co··NCT00702234·268 enrolled

Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH

Completed·EEugonia··NCT00417157·135 enrolled

Ovarian Stimulation4 trials

Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART

Terminated·NNational and Kapodistrian University of Athens·Phase 3·NCT03423537·80 enrolled

To Investigate Efficacy and Safety of a Single Injection of GenSci094 for Ovarian Stimulation Using Daily Recombinant FSH as Reference

Completed· Changchun GeneScience Pharmaceutical Co., Ltd. logo

Changchun GeneScience Pharmaceutical Co., Ltd.·Phase 3·NCT06091436·176 enrolled

A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)

Completed·OOrganon and Co·Phase 3·NCT00696800·1,509 enrolled

Show 1 more trial

Synchronization of Follicle Wave Emergence and Ovarian Stimulation

Completed·UUniversity of Saskatchewan·Phase 4·NCT00439829·80 enrolled

Oocyte Maturation4 trials

A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation

Completed·AART Fertility Clinics LLC··NCT04417569·10 enrolled

Gene Expression Profile After Gonadotropin Releasing Hormone (GnRH) Agonist Trigger of Oocyte Maturation

Terminated·UUConn Health·Phase 4·NCT01606709·7 enrolled

Dual Trigger in the Final Oocyte Maturation in Poor Ovarian Responders

Completed·—·Phase 3·NCT04224818·140 enrolled

Show 1 more trial

COMPARING TWO PROTOCOLS FOR FINAL OOCYTE MATURATION IN POOR RESPONDERS UNDERGOING GnRH-ANTAGONIST ICSI CYCLES

Unknown status·—·Phase 3·NCT05397795·160 enrolled

Embryo Transfer3 trials

Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)

Completed·OOrganon and Co··NCT00702273·344 enrolled

Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak?

Completed·UUniversitair Ziekenhuis Brussel·Phase 4·NCT02145819·240 enrolled

The Role of hCG in Thawed Embryo Transfer

Recruiting·FFertility Center of Las Vegas·Phase 4·NCT07004192·220 enrolled

CLE3 trials

Booster Dose of HCG for Unruptured Follicle in Non IVF/ICSI Cycles

Completed·TTanta University·Phase 4·NCT03580031·110 enrolled

Timing of HCG Administration in IUI Cycles

Unknown status·MMohamed Ibrahem Eid·Phase 4·NCT02330705·225 enrolled

Combination of Gonadotropin-releasing Hormone Agonist and Human Chorionic Gonadotropin Triggered by Normal Responder in GnRH-antagonist Cycles

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT02862782·1,000 enrolled

24 more indications

Ovulation2 trials

Study of Dual Trigger Ovulation in Oocyte Donors

Terminated·WWeill Medical College of Cornell University·Phase 4·NCT01443546·26 enrolled

Role of Aromatase Inhibitor to Enhance Ovulation in Poor Responder During Induction With Short Antagonist Protocol in Cases of ICSI

Completed·MMinia University·Phase 4·NCT02741154·50 enrolled

Progesterone2 trials

Agonist Trigger With HCG Luteal Supplementation vs HCG Trigger With Progesterone Luteal Supplementation in Antagonist Controlled HyperstimulationCycle

Completed·—·N/A·NCT04846218·100 enrolled

The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Pilot Study in Normo-responder IVF Patients

Completed·PPeter Humaidan·Phase 4·NCT01980680·50 enrolled

Intrauterine Insemination2 trials

HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles

Completed·UUniversitair Ziekenhuis Brussel·Phase 1·NCT01414673·300 enrolled

GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination.

Completed·HHue University of Medicine and Pharmacy·N/A·NCT03825445·197 enrolled

Hypogonadotropic Hypogonadism2 trials

Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043)

Completed·OOrganon and Co·Phase 3·NCT03019575·17 enrolled

A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937)

Completed·OOrganon and Co·Phase 3·NCT01709331·18 enrolled

PCOS1 trial

Response of VEGF and AT-II to HCG in PCOS

Completed·NNanjing University School of Medicine·Phase 1·NCT02265861·60 enrolled

Prevention1 trial

Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS

Completed·UUConn Health·Phase 4·NCT01815138·89 enrolled

Infertility1 trial

Timing and Intrauterine Insemination in Unexplained Infertility

Unknown status·SSohag University·Phase 4·NCT03920514·80 enrolled

Polycystic Ovary Syndrome1 trial

Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)

Completed·UUniversity of California, San Diego·N/A·NCT02145247·39 enrolled

Breast Cancer1 trial

Prevention of Breast Cancer: As Simple as hCG-A Randomized Clinical Trial in High Risk Women

Unknown status·NNew York Presbyterian Hospital·Phase 3·NCT00808522·84 enrolled

Ovarian Hyperstimulation Syndrome1 trial

Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome

Unknown status·CChenshiling·N/A·NCT02022228·200 enrolled

Effectiveness1 trial

Effectiveness of Estradiol Valerate Pretreatment in Antagonist Protocol for Poor Ovarian Response Patient

Completed·RReproductive & Genetic Hospital of CITIC-Xiangya·N/A·NCT03300518·552 enrolled

Endometrial1 trial

Endometrial Receptivity After GnRH Agonist Triggering

Completed·IIVI Madrid·Phase 4·NCT01500863·35 enrolled

Flushing1 trial

Effects of Intrauterine Flushing With Human Chorionic Gonadotropin on ICSI Outcome

Completed·OOmayma Ismail Khalaf·Phase 4·NCT06684951·90 enrolled

Hypogonadism1 trial

The Effects of Gonadotropin Replacement Therapy in Patients With Hypogonadism

Completed·GGulhane School of Medicine··NCT02042638·16 enrolled

Testosterone1 trial

HOP-3 Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone

Completed·UUniversity of Washington·Phase 1/2·NCT00839319·59 enrolled

In Vitro Fertilization1 trial

HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization)

Unknown status·UUniversitair Ziekenhuis Brussel·Phase 4·NCT01768247·15 enrolled

Controlled Ovarian Stimulation1 trial

Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714)

Completed·OOrganon and Co·Phase 3·NCT00696878·682 enrolled

IVF1 trial

Injection Free IVF

Withdrawn·IInsel Gruppe AG, University Hospital Bern·Phase 2·NCT04850261

Oocyte1 trial

Freeze All on Oocyte Maturatin by Gonadotropin Agonist Versus Human Chorionic Gonadotroipin

Unknown status·—·N/A·NCT04749979·100 enrolled

Frozen Embryo Transfer (FET)1 trial

Frozen Embryo Transfer (FET) in Natural Cycles or in Natural Cycles Controlled by Human Chorionic Gonadotropin (hCG) Administration

Completed·UUniversitair Ziekenhuis Brussel·N/A·NCT00809107·150 enrolled

Corticosteroids1 trial

Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated Corticosteroids

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 1/2·NCT05123040·10 enrolled

Intracytoplasmic Sperm Injection1 trial

Efficacy of Low Dose hCG on Oocyte Maturity in Poor Responder Women Undergoing Intracytoplasmic Sperm Injection

Completed·RRoyan Institute·Phase 3·NCT01509833·73 enrolled

Blastocyst1 trial

Frozen Blastocyst Transfer in Natural Cycle

Completed·UUniversitair Ziekenhuis Brussel·N/A·NCT01892826·120 enrolled

Unspecified3 trials

ITT-5 Mechanisms of Spermatogenesis in Man

Withdrawn·UUniversity of Washington·Phase 2·NCT02147964

Intrauterine Injection of HCG and Implantation Rate

Unknown status·—·N/A·NCT01933126·100 enrolled

Evolution of Luteal Progesteronemia in a Modified Natural Cycle (Ovulation Triggered by hCG): Pilot Study

Recruiting·UUniversity Hospital, Montpellier·Preclinical·NCT07028710·40 enrolled

Sources

References

[1]
ClinicalTrials.gov — 52 trial records for hCG. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — hCG compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for hCG. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Changchun GeneScience Pharmaceutical Co., Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Changchun GeneScience Pharmaceutical Co., Ltd.

hCG

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Q2 2030

Trials by Indication[1]

Pregnancy8 trials

Ovarian Stimulation4 trials

Oocyte Maturation4 trials

Embryo Transfer3 trials

CLE3 trials

Ovulation2 trials

Progesterone2 trials

Intrauterine Insemination2 trials

Hypogonadotropic Hypogonadism2 trials

PCOS1 trial

Prevention1 trial

Infertility1 trial

Polycystic Ovary Syndrome1 trial

Breast Cancer1 trial

Ovarian Hyperstimulation Syndrome1 trial

Effectiveness1 trial

Endometrial1 trial

Flushing1 trial

Hypogonadism1 trial

Testosterone1 trial

In Vitro Fertilization1 trial

Controlled Ovarian Stimulation1 trial

IVF1 trial

Oocyte1 trial

Frozen Embryo Transfer (FET)1 trial

Corticosteroids1 trial

Intracytoplasmic Sperm Injection1 trial

Blastocyst1 trial

Unspecified3 trials

References

Drug Info

Quick Facts

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