Hyperthermic Intraperitoneal Chemotherapy

Phase 3Small molecule

Hyperthermic Intraperitoneal Chemotherapy is one of 55 small molecule programs targeting Peritoneal Malignant Mesothelioma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Peritoneal Malignant MesotheliomaRecruiting

Clinical Stage I Gastric Cancer AJCC V8Enrolling by invitation

Fallopian Tube Endometrioid AdenocarcinomaActive, not recruiting

Gastric CancerActive, not recruiting

Intraperitoneal ChemotherapyNot yet recruiting

Peritoneal Malignant MesotheliomaPhase 2

Recruiting

Clinical Stage I Gastric Cancer AJCC V8Phase 2

Enrolling by invitation

Fallopian Tube Endometrioid AdenocarcinomaPhase 1

Active, not recruiting

Gastric CancerPhase 3

Active, not recruiting

Intraperitoneal ChemotherapyPhase 2

Not yet recruiting

Competition

Competitive Landscape

193 competitors in Gastric Cancer

#DrugCompanyPhaseTrials

Platinol

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 3

55 2

Taxotere

AAvyxa

Phase 3

45 3

Cyramza

Eli Lilly

Phase 3

10 4

Beyfortus

BeiGene

Phase 3

10 5

Elunate

Takeda

Phase 3

7 6

Tuoyi

SSun Yat-sen University

Phase 3

18 7

Yervoy

Bristol-Myers Squibb

Phase 3

5 8

S-1

Taiho Oncology, Inc.

Phase 3

45 9

Apatinib

LLaNova Medicines Zhejiang Co., Ltd.

Mfolfox6

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Not yet recruiting

Intraperitoneal Chemotherapy

NCT06544460

Phase 1Active, not recruiting

Fallopian Tube Endometrioid Adenocarcinoma

NCT05415709

Q3 2027

Phase 2Recruiting

Peritoneal Malignant Mesothelioma

NCT05001880

Q4 2027

Phase 3Active, not recruiting

Gastric Cancer

NCT03348150

Q1 2028

Phase 2Recruiting

Gastric Cancer

NCT05753306

Clinical

Trials by Indication[1]

Gastric Cancer4 trials

Adjuvant Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Gastric Cancer

Completed·LLoma Linda University·Phase 1·NCT02672865·4 enrolled

Gastrectomy + Cytoreductive Surgery + HIPEC for Gastric Cancer With Peritoneal Dissemination.

Active, not recruiting·TThe Netherlands Cancer Institute·Phase 3·NCT03348150·102 enrolled

Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study

Recruiting·MMayo Clinic·Phase 2·NCT05753306·40 enrolled

Show 1 more trial

Hyperthermic Intraperitoneal Chemotherapy for Advanced Gastric Cancer With Peritoneal Metastatis

Unknown status·GGuangdong Provincial Hospital of Traditional Chinese Medicine·Phase 2·NCT03604614·56 enrolled

Intraperitoneal Chemotherapy1 trial

Secondary Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for PARP Inhibitors Resistance Patients

Not yet recruiting·FFudan University·Phase 2·NCT06544460·94 enrolled

Pediatric Patients1 trial

Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients

Terminated·MMayo Clinic·Phase 1·NCT04213794·2 enrolled

Esophageal Cancer1 trial

Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT02891447·24 enrolled

Oxaliplatin1 trial

Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix

Completed·WWake Forest University Health Sciences·Phase 2·NCT01580410·136 enrolled

4 more indications

Metastatic Pancreatic Carcinoma1 trial

A Phase II Study of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Patients With Pancreatic Cancer and Peritoneal Metastasis

Recruiting·MMayo Clinic·Phase 2·NCT04858009·40 enrolled

Fallopian Tube Endometrioid Adenocarcinoma1 trial

Randomized Phase I Study Assessing the Safety and Tolerability Hyperthermic Intraperitoneal Chemotherapy (HIPEC) at Completion of Interval Cytoreductive Surgery Compared to Surgery and Chemotherapy Prior to Surgery for Patients With Stage III/IV Ovarian Cancer Undergoing Neoadjuvant Chemotherapy.

Active, not recruiting·OOhio State University Comprehensive Cancer Center·Phase 1·NCT05415709·35 enrolled

Peritoneal Malignant Mesothelioma1 trial

Phase 2 Randomized Trial of Neoadjuvant or Palliative Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma

Recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT05001880·66 enrolled

Clinical Stage I Gastric Cancer AJCC v81 trial

Prophylactic Hyperthermic IntraperitOneal Chemotherapy (p-HIPEC) for pRevention of perItONeal Recurrence in Gastric Cancer: MC240402 (HORIZON) Trial

Enrolling by invitation·MMayo Clinic·Phase 2·NCT07139951·16 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for Hyperthermic Intraperitoneal Chemotherapy. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Hyperthermic Intraperitoneal Chemotherapy compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Hyperthermic Intraperitoneal Chemotherapy. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Mayo Clinic company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: MMayo Clinic

Hyperthermic Intraperitoneal Chemotherapy

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q3 2027

Q4 2027

Q1 2028

Trials by Indication[1]

Gastric Cancer4 trials

Intraperitoneal Chemotherapy1 trial

Pediatric Patients1 trial

Esophageal Cancer1 trial

Oxaliplatin1 trial

Metastatic Pancreatic Carcinoma1 trial

Fallopian Tube Endometrioid Adenocarcinoma1 trial

Peritoneal Malignant Mesothelioma1 trial

Clinical Stage I Gastric Cancer AJCC v81 trial

References

Drug Info

Quick Facts

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