Platinol
(Cisplatin)ApprovedSmall molecule
Cisplatin is a chemotherapy drug used to treat various types of cancer, including testicular, ovarian, bladder, and lung cancers by damaging cancer cell DNA and stopping them from growing.[2] Platinol is currently approved and in use across 267 indications[4].[1]
Platinol is one of 1863 small molecule programs targeting Seminoma. It is currently in Approved.
267
Indications
2,420
Total Trials
26
Active Trials
1,862
Competitors
1
FDA Application
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 266 indications
Competition
Competitive Landscape
744 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Platinol
MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
Approved
Zolymbus
AbbViePreclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Duragesic-100
CCephalon
Preclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Spravato
WWim Janssens
Preclinical
Cortef
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Preclinical
Acupan
YYonsei University
Preclinical
Nubain
AAultman Health Foundation
Preclinical
Rilvegostomig
AstraZenecaPreclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Non-Small Cell Lung Cancer14 trials
Show 11 more trials
Cervical Cancer11 trials
Serplulimab Plus Chemoradiotherapy for Stage III-IVA Cervical Cancer
Active, not recruiting·—·Phase 2·NCT06419673·240 enrolled
Show 8 more trials
Phase II Clinical Trial of Concurrent Chemoradiotherapy Combined Nimotuzumab for Stage IIB-IVA Cervical Cancer
Unknown status·—·Phase 2·NCT02705612·60 enrolled
Nasopharyngeal Carcinoma10 trials
KL-A167 Injection Combined With Cisplatin and Gemcitabine vs Placebo Combined With Cisplatin and Gemcitabine in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma
Active, not recruiting·SSichuan Kelun-Biotech Biopharmaceutical Co., Ltd.·Phase 3·NCT05294172·295 enrolled
Show 7 more trials
Squamous Cell Carcinoma10 trials
Study of Docetaxel in Combination With Cisplatin and 5-Fluorouracil in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Completed·—·Phase 1/2·NCT00139269·38 enrolled
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Small Cell Lung Cancer9 trials
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Trial of Belotecan/Cisplatin in Chemotherapy Naive Small Cell Lung Cancer Patient
Completed·—·Phase 3·NCT00826644·147 enrolled
85 more indications
Gastric Cancer6 trials
Taxotere, Cisplatin and Irinotecan (CPT-11) for Esophagogastric Cancer
Completed·—·Phase 2·NCT00165464·54 enrolled
Show 3 more trials
Cisplatin, Irinotecan and Bevacizumab (PCA) Versus Docetaxel, Cisplatin, Irinotecan and Bevacizumab (TPCA) in Metastatic Esophageal and Gastric Cancer
Completed·—·Phase 2·NCT00911820·88 enrolled
Preoperative Dose-dense Chemotherapy With Weekly Cisplatin, Epirubicin and Paclitaxel to Treat Patients With Locally Gastric Cancer
Terminated·—·Phase 2·NCT01830270·30 enrolled
Radiation Therapy6 trials
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Patients With Advanced Solid Tumors5 trials
Breast Cancer5 trials
Pancreatic Cancer4 trials
Bladder Cancer4 trials
Endometrial Cancer4 trials
Show 1 more trial
Neuroblastoma4 trials
Lung Cancer4 trials
Esophageal Carcinoma3 trials
Urothelial Carcinoma3 trials
Intravesical Cabazitaxel, Gemcitabine, and Cisplatin (CGC) in the Treatment Urothelial Carcinoma of the Bladder
Active, not recruiting·—·Phase 1/2·NCT02202772·51 enrolled
PD1 Inhibitors Combined With Clostridium Butyricum for Urothelial Carcinoma
Recruiting·TThe First Affiliated Hospital with Nanjing Medical University·Phase 2·NCT06696742·60 enrolled
Ovarian Cancer3 trials
Chemotherapy With or Without Surgery in Treating Patients With Recurrent Ovarian Cancer
Terminated·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00006356·38 enrolled
Head and Neck Cancer3 trials
Biliary Tract Cancer3 trials
Perioperative Gemcitabine, Cisplatin, and Pembrolizumab in Potentially Resectable Biliary Tract Cancers
Recruiting·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT06001658·27 enrolled
GAMBIT Trial: Cisplatin Plus Irinotecan in the Treatment of Gallbladder or Biliary Tract Cancer
Unknown status·—·Phase 2·NCT01859728·48 enrolled
Lymphoma3 trials
Cisplatin3 trials
Advanced Head and Neck Cancer2 trials
Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer
Completed·SSidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·Phase 1·NCT00405405·13 enrolled
Gemcitabine2 trials
Cisplatin, Gemcitabine and Bevacizumab in Combination for Metastatic Transitional Cell Cancer
Completed·—·Phase 2·NCT00234494·45 enrolled
Cisplatin, Gemcitabine Hydrochloride, and Sorafenib Tosylate in Treating Patients With Transitional Cell Cancer of the Bladder
Unknown status·FFondazione IRCCS Istituto Nazionale dei Tumori, Milano·Phase 2·NCT01222676·45 enrolled
Malignant Pleural Mesothelioma2 trials
Medulloblastoma2 trials
Hepatocellular Carcinoma2 trials
Esophageal Cancer2 trials
Fallopian Tube Cancer2 trials
First Line Therapy2 trials
Gemcitabine Hydrochloride, Cisplatin, and Temsirolimus as First-Line Therapy in Treating Patients With Locally Advanced and/or Metastatic Transitional Cell Cancer of the Urothelium
Completed·—·Phase 1/2·NCT01090466·15 enrolled
Advanced Cancer2 trials
Adenocarcinoma2 trials
Cholangiocarcinoma2 trials
Peritoneal Cancer2 trials
Surgery and Chemotherapy With or Without Chemotherapy After Surgery in Treating Patients With Ovarian, Fallopian Tube, Uterine, or Peritoneal Cancer
Active, not recruiting·—·Phase 1·NCT01970722·40 enrolled
Locally Advanced Cancer2 trials
Chemotherapy2 trials
Combination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx
Unknown status·—·Phase 2·NCT00004164
Combination Chemotherapy in Treating Men With Germ Cell Cancer
Unknown status·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2/3·NCT00003643·498 enrolled
Thyroid Cancer1 trial
Cervical Squamous Cell Carcinoma1 trial
Stage III1 trial
Gastric Carcinoma1 trial
Stage II1 trial
Chemoradiotherapy1 trial
Gastroesophageal Junction1 trial
Stem Cell Transplant1 trial
Intraperitoneal1 trial
Individualized Intraperitoneal and System Chemotherapy Versus System Chemotherapy as First-line Chemotherapy for AGC
Unknown status·TThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School·Phase 3·NCT03061058·240 enrolled
Stomach Cancer1 trial
Oesophagus Cancer1 trial
Radiochemotherapy in Elderly Patients With Oesophagus Cancer
Completed·—·Phase 2·NCT02879227·23 enrolled
Induction Chemotherapy1 trial
Bone Marrow Transplantation1 trial
Repeated Bone Marrow Transplantation in Treating Women With Advanced Breast Cancer
Terminated·LLouisiana State University Health Sciences Center Shreveport·Phase 1/2·NCT00003086·12 enrolled
Pancreatic Adenocarcinoma1 trial
Colorectal Cancer1 trial
Nasopharyngeal Cancer1 trial
Fluorouracil, Cisplatin, and Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Nasopharyngeal Cancer
Unknown status·—·Phase 2·NCT00093665·90 enrolled
Germ Cell Tumor1 trial
Melanoma1 trial
Oropharynx Cancer1 trial
Urinary Tract Cancer1 trial
Cisplatin Plus Gemcitabine With or Without Paclitaxel in Treating Patients With Stage IV Urinary Tract Cancer
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00022191·608 enrolled
Prostate Cancer1 trial
Central Nervous System1 trial
Cervical Carcinoma1 trial
Ocular Melanoma1 trial
Lung Adenocarcinoma1 trial
Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinoma
Active, not recruiting·—·Phase 4·NCT05689671·136 enrolled
Anal Cancer1 trial
Gastroesophageal Junction Cancer1 trial
Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer
Completed·—·Phase 2·NCT00258323·80 enrolled
Osteosarcoma1 trial
Safety and Efficacy1 trial
Phase II1 trial
A Phase III Study of SKB264 for EGFR Mutant NSCLC Patients
Active, not recruiting·SSichuan Kelun-Biotech Biopharmaceutical Co., Ltd.·Phase 3·NCT05870319·376 enrolled
Oral Cavity Cancer1 trial
Pembrolizumab1 trial
Head and Neck Squamous Cell Carcinoma1 trial
Accelerated Fractionation Radiotherapy (AFRT) Versus Concurrent Chemoradiotherapy (Crt) In Locally Advanced Head And Neck Squamous Cell Carcinoma
Unknown status·—·Phase 2·NCT01291095·80 enrolled
Cancer of the Esophagus1 trial
Stem Cell Transplantation1 trial
Testicular Germ Cell Tumor1 trial
Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors
Recruiting·—·Phase 1·NCT07218913·44 enrolled
Metastatic Urothelial Cancer1 trial
Ovarian Carcinoma1 trial
Head and Neck Squamous Cell Cancer1 trial
Recurrent or Metastatic1 trial
Pancreas Cancer1 trial
Regulatory
FDA Approval Timeline[5]
Nov 8, 1988
CISPLATIN
NDA NDA018057
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Platinol drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Cisplatin. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details