Interferon-Gamma

ApprovedSmall molecule

SSPP Pharmaclon Ltd.

Interferon-Gamma is one of 254 small molecule programs targeting Pneumonia. It is currently in Approved.

Indications

Total Trials

Active Trials

253

Competitors

Pipeline

Status by Indication[3][1]

Indication

PneumoniaActive, not recruiting

Pulmonary TuberculosisActive, not recruiting

Breast CancerActive, not recruiting

MelanomaActive, not recruiting

Ovarian CancerActive, not recruiting

GlioblastomaActive, not recruiting

COVID-19Active, not recruiting

TuberculosisActive, not recruiting

Pneumonia, Ventilator-AssociatedRecruiting

Reactive ArthritisActive, not recruiting

PneumoniaPreclinical

Active, not recruiting

Pulmonary TuberculosisPreclinical

Active, not recruiting

Breast CancerPhase 1/Phase 2

Active, not recruiting

MelanomaPhase 3

Active, not recruiting

Ovarian CancerPhase 2

Active, not recruiting

GlioblastomaPhase 1

Active, not recruiting

COVID-19Preclinical

Active, not recruiting

TuberculosisPhase 2

Active, not recruiting

Pneumonia, Ventilator-AssociatedPhase 3

Recruiting

Reactive ArthritisPhase 2

Active, not recruiting

Showing 10 of 12 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Interferon-Gamma

SSPP Pharmaclon Ltd.

Approved

1 2

Trodelvy

Gilead

Preclinical

37 3

Megace

Bristol-Myers Squibb

Preclinical

4 4

Lexiscan

Astellas

Preclinical

1 5

Adenocard

Astellas

Preclinical

1 6

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 7

Zinecard

CChildren's Oncology Group

Preclinical

2 8

Spravato

WWim Janssens

Preclinical

2 9

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 10

Aquasol E

NNational Eye Institute (NEI)

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Phase 3Recruiting

Pneumonia, Ventilator-Associated

NCT05843786

Q4 2032

Recruiting

Tumor

NCT06222801

Clinical

Trials by Indication[1]

Pulmonary Tuberculosis3 trials

Study on the Use of Interferon Gamma (Ingaron) Injections in Patients With Drug-resistant Pulmonary Tuberculosis

Unknown status·SSPP Pharmaclon Ltd.··NCT05359315·84 enrolled

Effects of Interferon-Gamma on Cavitary Pulmonary Tuberculosis in the Lungs

Completed·NNYU Langone Health·Phase 2·NCT00201123·89 enrolled

A Multicenter Clinical Trial of Ingaron in Pulmonary Tuberculosis

Unknown status·SSPP Pharmaclon Ltd.··NCT06118619·350 enrolled

Tuberculosis2 trials

Study of Interferon-Gamma in the Complex Treatment of Patients Infected With HIV and Tuberculosis

Completed·SSPP Pharmaclon Ltd.·Phase 1/2·NCT05065905·78 enrolled

Interferon Gamma for Drug Resistant Tuberculosis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00001407·30 enrolled

Melanoma1 trial

A Randomized Phase III Trial of Hyperthermic Isolated Limb Perfusion With Melphalan, Tumor Necrosis Factor, and Interferon-Gamma in Patients With Locally Advanced Extremity Melanoma

Completed·NNational Cancer Institute (NCI)·Phase 3·NCT00001296·122 enrolled

Chronic Granulomatous Disease1 trial

A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00001317·100 enrolled

Breast Cancer1 trial

Phase I-II Study of Interferon-gamma in Patients With HER-2 Positive Breast Cancer

Completed·HH. Lee Moffitt Cancer Center and Research Institute·Phase 1/2·NCT03112590·51 enrolled

10 more indications

Glioblastoma1 trial

DNX-2401 With Interferon Gamma (IFN-γ) for Recurrent Glioblastoma or Gliosarcoma Brain Tumors

Completed·DDNAtrix, Inc.·Phase 1·NCT02197169·37 enrolled

COVID-191 trial

Study of the Use of the Drug Ingaron in Patients With COVID-19

Completed·SSPP Pharmaclon Ltd.··NCT05386459·36 enrolled

Reactive Arthritis1 trial

New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis

Unknown status·—·Phase 2·NCT00244179·40 enrolled

Ovarian Cancer1 trial

Chemoimmunotherapy Study for Patients With Epithelial Ovarian Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00501644·59 enrolled

Pneumonia1 trial

Study of Ingaron's Effect on Efficacy and Resistance to Antibiotics in Community-acquired Pneumonia

Completed·SSPP Pharmaclon Ltd.·N/A·NCT05395702·114 enrolled

Tumor1 trial

The 1st Tumor CytokinoTherapy Database (TCTD-1)

Recruiting·OOncoCareClinic 308 Ltd··NCT06222801·5,000 enrolled

Bacterial Infections1 trial

Treatment of Non-Tuberculous Mycobacterial Infections With Interferon Gamma

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00001318·60 enrolled

Osteopetrosis1 trial

Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital Osteopetrosis

Completed·FFDA Office of Orphan Products Development·Phase 3·NCT00004402·30 enrolled

Pneumonia, Ventilator-Associated1 trial

Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients

Recruiting·HHospices Civils de Lyon·Phase 3·NCT05843786·132 enrolled

Unspecified1 trial

Interferon Gamma to Treat Leukocyte Adhesion Deficiency Type I

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00001905·5 enrolled

Sources

References

[1]
ClinicalTrials.gov — 18 trial records for Interferon-Gamma. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Interferon-Gamma compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Interferon-Gamma. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — SPP Pharmaclon Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: SSPP Pharmaclon Ltd.

Interferon-Gamma

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Q4 2032

Trials by Indication[1]

Pulmonary Tuberculosis3 trials

Tuberculosis2 trials

Melanoma1 trial

Chronic Granulomatous Disease1 trial

Breast Cancer1 trial

Glioblastoma1 trial

COVID-191 trial

Reactive Arthritis1 trial

Ovarian Cancer1 trial

Pneumonia1 trial

Tumor1 trial

Bacterial Infections1 trial

Osteopetrosis1 trial

Pneumonia, Ventilator-Associated1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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