Interleukin-12

PreclinicalProtein / enzyme

NNational Institute of Allergy and Infectious Diseases (NIAID)

Interleukin-12 is one of 68 small molecule programs targeting Glioma. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

GliomaActive, not recruiting

Breast CancerActive, not recruiting

CryptosporidiosisActive, not recruiting

GliomaPhase 1/Phase 2

Active, not recruiting

Breast CancerPhase 1/Phase 2

Active, not recruiting

CryptosporidiosisPreclinical

Active, not recruiting

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Halaven

Eisai

Preclinical

38 2

Blenoxane

Bristol-Myers Squibb

Preclinical

1 3

Zinecard

CChildren's Oncology Group

Preclinical

2 4

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 5

Zoladex

Luye Pharma Group Ltd.

Preclinical

8 6

Apatinib Mesylate

BBukwang Pharmaceutical

Preclinical

3 7

Neoadjuvant Therapy

SSun Yat-sen University

Preclinical

3 8

Metfomin

UUniversity of Texas Southwestern Medical Center

Preclinical

1 9

Neoadjuvant Treatment

SShanghai Zhongshan Hospital

Preclinical

1 10

Bisphosphonate

Amgen

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Terminated·—·Phase 1/2·NCT00622401·8 enrolled

Interleukin1 trial

A Study to Evaluate the Effects of Interleukin-12 (rhIL-12) in HIV-Positive Patients With CD4 Cell Counts Less Than 50 Cells/mm3 or 300-500 Cells/mm3

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000857·65 enrolled

Bacterial Infections1 trial

Interleukin-12 in the Treatment of Severe Nontuberculous Mycobacterial Infections

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00001911·10 enrolled

5 more indications

Kaposi's sarcoma1 trial

Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma

Completed·NNational Cancer Institute (NCI)·Phase 1/2·NCT00019188

Drug Therapy1 trial

Safety of the Candidate Vaccine C4-V3 Alone or With Interleukin-12 (IL-12) in HIV-Infected Patients Receiving Effective Anti-HIV Drug Therapy

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00005779·12 enrolled

Cryptosporidiosis1 trial

Treatment of Chronic Cryptosporidiosis in AIDS Patients

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00001128·16 enrolled

Glioma1 trial

Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-naïve GBM Patients.

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1/2·NCT04388033·10 enrolled

Effectiveness1 trial

A Study to Compare the Effectiveness of a Four Drug Anti-HIV Regimen Given Alone or in Combination With GM-CSF or IL-12 to HIV-Positive Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000896·24 enrolled

Sources

References

[1]
ClinicalTrials.gov — 10 trial records for Interleukin-12. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Interleukin-12 compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Interleukin-12. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — National Institute of Allergy and Infectious Diseases (NIAID) company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Protein / enzyme[2]
Highest Phase: Preclinical[1]
Company: NNational Institute of Allergy and Infectious Diseases (NIAID)

Interleukin-12

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Disseminated Mycobacterium Avium Complex Infection1 trial

Immunogenicity1 trial

Breast Cancer1 trial

Interleukin1 trial

Bacterial Infections1 trial

Kaposi's sarcoma1 trial

Drug Therapy1 trial

Cryptosporidiosis1 trial

Glioma1 trial

Effectiveness1 trial

References

Drug Info

Quick Facts

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