Intrathecal injection of pemetrexed

Phase 3Small molecule

UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

Intrathecal injection of pemetrexed is one of 12 small molecule programs targeting Leptomeningeal Metastases. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Leptomeningeal MetastasesRecruiting

Leptomeningeal MetastasesPhase 3

Recruiting

Competition

Competitive Landscape

12 competitors in Leptomeningeal Metastases

#DrugCompanyPhaseTrials

Lorbrena

Pfizer

Approved

1 2

Firmonertinib

AAllist Pharmaceuticals, Inc.

Phase 3

1 3

Alimta

SShawn Eagle

Phase 2

3 4

Desferal

Jazz Pharmaceuticals

Phase 1

1 5

Avastin

Roche

Phase 1

1 6

Furmonertinib

AAllist Pharmaceuticals, Inc.

Phase 2

1 7

Intrathecal Chemotherapy

PPrincess Maxima Center for Pediatric Oncology

Phase 2

1 8

Intrathecal Pemetrexed

HHunan Province Tumor Hospital

Phase 2

1 9

Intrathecal injection of pemetrexed

UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

Phase 3

1 10

Ivonescimab Combined With Chemotherapy

SSun Yat-sen University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Post-ApprovalRecruiting

Leptomeningeal Metastases

NCT07092202

Clinical

Trials by Indication[1]

Leptomeningeal Metastases1 trial

Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases

Recruiting·UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology·Phase 4·NCT07092202·40 enrolled

Sources

References

[1]
ClinicalTrials.gov — 1 trial record for Intrathecal injection of pemetrexed. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Intrathecal injection of pemetrexed compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Intrathecal injection of pemetrexed. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Union Hospital, Tongji Medical College, Huazhong University of Science and Technology company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

Intrathecal injection of pemetrexed

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Trials by Indication[1]

Leptomeningeal Metastases1 trial

References

Drug Info

Quick Facts

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