Isotonic Sodium Chloride

ApprovedSmall molecule

Isotonic Sodium Chloride is one of 150 small molecule programs targeting Orthostatic Intolerance. It is currently in Approved.

Indications

Total Trials

Active Trials

149

Competitors

Pipeline

Status by Indication[3][1]

Indication

Orthostatic IntoleranceActive, not recruiting

Acute Myocardial InfarctionActive, not recruiting

Lateral EpicondylitisActive, not recruiting

Brain InjuryActive, not recruiting

SchizophreniaActive, not recruiting

Orthostatic IntolerancePhase 2/Phase 3

Active, not recruiting

Acute Myocardial InfarctionApproved

Active, not recruiting

Lateral EpicondylitisApproved

Active, not recruiting

Brain InjuryPhase 2/Phase 3

Active, not recruiting

SchizophreniaPhase 3

Active, not recruiting

Competition

Competitive Landscape

583 competitors in Schizophrenia

#DrugCompanyPhaseTrials

Isotonic Sodium Chloride

Eli Lilly

Approved

1 2

Celexa

AbbVie

Preclinical

4 3

Ozempic

Novo Nordisk

Preclinical

1 4

Resotran

Takeda

Preclinical

1 5

Zocor

OOrganon and Co

Preclinical

6 6

Comtan

Orion Corporation, Orion Pharma

Preclinical

1 7

Persantine

Boehringer Ingelheim

Preclinical

1 8

Permax

VValeant Pharmaceuticals

Preclinical

1 9

Luvox

SSolvay Pharmaceuticals

Preclinical

1 10

Catapres

Boehringer Ingelheim

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 3Recruiting

Agitation

NCT05541276

Q1 2028

N/ARecruiting

Cardiac Surgery

NCT05635227

Clinical

Trials by Indication[1]

Methylprednisolone4 trials

Effect of Methylprednisolone on Immune Signaling in Hip-arthroplasty Patients

Completed·RRigshospitalet, Denmark·Phase 2/3·NCT02542592·64 enrolled

Effect of Methylprednisolone on Glucose Homeostasis in Patients Undergoing Total Hip- and Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02332603·134 enrolled

Effect of Methylprednisolone on Complement Activation in Patients Undergoing Total Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02332616·70 enrolled

Show 1 more trial

Effect of Methylprednisolone on Quadriceps Muscle Function in Patients Undergoing Total Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02319343·70 enrolled

Acute Myocardial Infarction1 trial

Impact of Morphine Treatment on Platelet Inhibition in Acute Myocardial Infarction

Completed·UUniversity of Luebeck·Phase 4·NCT02627950·138 enrolled

Opioid Consumption1 trial

The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients

Completed·RRigshospitalet, Denmark·Phase 4·NCT02085577·147 enrolled

Brain Injury1 trial

Preventive Sodium Lactate and Traumatic Brain Injury

Completed·IInstitut d'Anesthesiologie des Alpes Maritimes·Phase 2/3·NCT00995683·60 enrolled

Orthostatic Intolerance1 trial

Effect of Methylprednisolone on Orthostatic Intolerance and Heart Rate Variability in Hip-arthroplasty Patients

Completed·RRigshospitalet, Denmark·Phase 2/3·NCT02445898·64 enrolled

7 more indications

Lateral Epicondylitis1 trial

Low and High Dose Dextrose Prolotherapy in the Treatment of Lateral Epicondylitis

Completed·—·Phase 4·NCT04680936·75 enrolled

General Anesthesia1 trial

Physostigmine After General Anesthesia

Unknown status·—·N/A·NCT00850850·50 enrolled

Agitation1 trial

MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children

Recruiting·RRigshospitalet, Denmark·Phase 3·NCT05541276·400 enrolled

Schizophrenia1 trial

A Study Comparing Rapid Acting Intramuscular Olanzapine and Placebo in Agitated Patients With Schizophrenia

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT00640510·34 enrolled

Cardiac Surgery1 trial

Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery

Recruiting·RRigshospitalet, Denmark·N/A·NCT05635227·1,200 enrolled

Immunogenicity1 trial

Immunogenicity and Safety of Hecolin® in HIV Positive/Negative Adults and in Children

Recruiting·IInternational Vaccine Institute·Phase 2·NCT06306196·1,040 enrolled

Endothelial Function1 trial

Effect of Methylprednisolone on Endothelial Function in Patients Undergoing Total Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02332629·70 enrolled

Sources

References

[1]
ClinicalTrials.gov — 15 trial records for Isotonic Sodium Chloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Isotonic Sodium Chloride compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Isotonic Sodium Chloride. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Eli Lilly company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Eli Lilly

Isotonic Sodium Chloride

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Q1 2028

Trials by Indication[1]

Methylprednisolone4 trials

Acute Myocardial Infarction1 trial

Opioid Consumption1 trial

Brain Injury1 trial

Orthostatic Intolerance1 trial

Lateral Epicondylitis1 trial

General Anesthesia1 trial

Agitation1 trial

Schizophrenia1 trial

Cardiac Surgery1 trial

Immunogenicity1 trial

Endothelial Function1 trial

References

Drug Info

Quick Facts

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