Levothyroxin

Phase 3Small molecule

BBerlin-Chemie AG Menarini Group

Levothyroxin is one of 54 small molecule programs targeting Hypothyroidism. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

HypothyroidismCompleted

Thyroid CancerActive, not recruiting

HypothyroidismPhase 3

Completed

Thyroid CancerPreclinical

Active, not recruiting

Competition

Competitive Landscape

62 competitors in Thyroid Cancer

#DrugCompanyPhaseTrials

Lenvima

Eisai

Approved

21 2

Tafinlar

Novartis

Approved

10 3

Keytruda

Merck & Co.

Approved

9 4

Cabometyx

Bristol-Myers Squibb

Approved

8 5

Mekinist

Novartis

Approved

7 6

Retevmo

Eli Lilly

Approved

3 7

Rozlytrek

Roche

Approved

2 8

Vitrakvi

Bayer

Approved

2 9

Caprelsa

GGenzyme, a Sanofi Company

Gemzar

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 3Not yet recruiting

Hypothyroidism

NCT06999278

Q4 2032

N/ANot yet recruiting

Thyroid Cancer

NCT06971965

Clinical

Trials by Indication[1]

Hypothyroidism4 trials

Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Terminated·UUniversity of Aarhus·N/A·NCT00770016

Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism

Completed·KKing Edward Medical University·Phase 3·NCT06276205·62 enrolled

LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss

Not yet recruiting·WWomen's Hospital School Of Medicine Zhejiang University·Phase 3·NCT06999278·200 enrolled

Show 1 more trial

The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism

Completed·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT04354896·322 enrolled

Congenital Hypothyroidism1 trial

Influence of Initial Levothyroxine Dose on Neurodevelopmental and Growth Outcomes in Congenital Hypothyroidism

Completed·FFederico II University·Phase 4·NCT05371262·72 enrolled

Pregnancy1 trial

Efficacy of Low Dose Levothyroxine During Pregnancy

Completed·—·Phase 3·NCT03391154·180 enrolled

Thyroid Dysfunction1 trial

The Prevalence and Risk Factors for Thyroid Dysfunction in Pregnant Women in Taiwan

Unknown status·—··NCT04936698·2,000 enrolled

Interaction1 trial

Interaction Between Levothyroxine and Probiotics in Hypothyroid Patients

Completed·AAzienda USL Modena·N/A·NCT03095963·80 enrolled

6 more indications

Pregnant Women1 trial

Correlation Between Levothyroxine and Blood Th17/Treg in Pregnant Women With Normal-high TSH and Positive TPOAb

Terminated·—··NCT06527859·64 enrolled

Single Dose1 trial

Levothyroxine-sodium Bioequivalence Trial With Oral Single Dose Administration

Completed·BBerlin-Chemie AG Menarini Group·Phase 1·NCT06547242·132 enrolled

Thyroid1 trial

Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients

Completed·AAzienda USL Modena·Phase 2/3·NCT03053115·160 enrolled

Thyroid Cancer1 trial

Necessity of TSH Suppression Therapy in Active Surveillance for Thyroid Cancer Patients.

Not yet recruiting·NNational Cancer Center, Korea·N/A·NCT06971965·578 enrolled

Screening1 trial

Final Height in Patients With CH Diagnosed by the Screening

Unknown status·—··NCT04734457·60 enrolled

Unspecified1 trial

Identification of Non-responders to Levothyroxine Therapy

Completed·OOslo University Hospital·Phase 2·NCT03627611·69 enrolled

Sources

References

[1]
ClinicalTrials.gov — 14 trial records for Levothyroxin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Levothyroxin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Levothyroxin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Berlin-Chemie AG Menarini Group company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: BBerlin-Chemie AG Menarini Group

Levothyroxin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Q4 2032

Trials by Indication[1]

Hypothyroidism4 trials

Congenital Hypothyroidism1 trial

Pregnancy1 trial

Thyroid Dysfunction1 trial

Interaction1 trial

Pregnant Women1 trial

Single Dose1 trial

Thyroid1 trial

Thyroid Cancer1 trial

Screening1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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