pentamidine

ApprovedSmall molecule

OOncozyme Pharma Inc.

pentamidine is one of 228 small molecule programs targeting Lymphoma. It is currently in Approved.

Indications

Total Trials

Active Trials

227

Competitors

Pipeline

Status by Indication[3][1]

Indication

LymphomaActive, not recruiting

Kidney TransplantActive, not recruiting

PneumoniaActive, not recruiting

Visceral LeishmaniasisActive, not recruiting

MelanomaActive, not recruiting

Pancreatic CancerActive, not recruiting

Hepatocellular CarcinomaActive, not recruiting

Type 1 DiabetesActive, not recruiting

TrypanosomiasisActive, not recruiting

LymphomaPhase 1

Active, not recruiting

Kidney TransplantPhase 1/Phase 2

Active, not recruiting

PneumoniaApproved

Active, not recruiting

Visceral LeishmaniasisPhase 3

Active, not recruiting

MelanomaPhase 2

Active, not recruiting

Pancreatic CancerPhase 1/Phase 2

Active, not recruiting

Hepatocellular CarcinomaPhase 1

Active, not recruiting

Type 1 DiabetesPhase 2

Active, not recruiting

TrypanosomiasisPhase 2

Active, not recruiting

Competition

Competitive Landscape

1774 competitors in Lymphoma

#DrugCompanyPhaseTrials

pentamidine

OOncozyme Pharma Inc.

Approved

2 2

Velban

EEastern Cooperative Oncology Group

Preclinical

15 3

Oncaspar

SServier

Preclinical

15 4

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 5

Kenalog

BBausch Health Americas, Inc.

Preclinical

1 6

Nuvigil

NNuvo Research GmbH

Preclinical

1 7

Decadron

QQuince Therapeutics S.p.A.

Preclinical

—8

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Systemic Therapy

1 10

PEG-Intron

Merck & Co.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2029

Post-ApprovalNot yet recruiting

Pneumonia

NCT07357103

Clinical

Trials by Indication[1]

Lymphoma2 trials

Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00002524·46 enrolled

Pentamidine + Salvage Chemo for Relapsed/Refractory Classical Hodgkin Lymphoma

Completed·RReinhold Munker·Phase 1·NCT03730363·1 enrolled

Pneumonia2 trials

Intravenous Pentamidine for Pneumocystis Jirovecii Pneumonia

Completed·UUniversity of Illinois at Chicago··NCT02669706·50 enrolled

Positioning Second-line Therapies for Pneumocystis Jirovecii Pneumonia (PCP Alternatives)

Not yet recruiting·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 4·NCT07357103·416 enrolled

Metastatic Colon Cancer1 trial

A Safety Study of Pentamidine in Patients With Metastatic Colon Cancer Undergoing Standard Chemotherapy as Second-line and/or Third-line Treatment

Completed·OOncozyme Pharma Inc.·Phase 1/2·NCT00809796·15 enrolled

Type 1 Diabetes1 trial

Islet Transplantation for Type 1 Diabetes

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00014911·36 enrolled

Pancreatic Cancer1 trial

A Safety Study Using Pentamidine in Patients With Pancreatic Cancer Undergoing Standard Therapy

Completed·OOncozyme Pharma Inc.·Phase 1/2·NCT00810953·10 enrolled

5 more indications

Hepatocellular Carcinoma1 trial

A Phase I Clinical Study on a New Oral Pentamidine Formulation in Hepatocellular Carcinoma

Completed·OOncozyme Pharma Inc.·Phase 1·NCT02210182·29 enrolled

Visceral Leishmaniasis1 trial

Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study

Completed·IInstitute of Tropical Medicine, Belgium·Phase 3·NCT01360762·74 enrolled

Melanoma1 trial

0794GCC: Pentamidine in Treating Patients With Relapsed or Refractory Melanoma

Terminated·UUniversity of Maryland, Baltimore·Phase 2·NCT00729807·6 enrolled

Trypanosomiasis1 trial

Trial of DB289 for the Treatment of Stage I African Trypanosomiasis

Completed·IImmtech Pharmaceuticals, Inc·Phase 2·NCT00803933·111 enrolled

Kidney Transplant1 trial

Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults

Completed·UUniversity of Wisconsin, Madison·Phase 1/2·NCT00078559·10 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for pentamidine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — pentamidine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for pentamidine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Oncozyme Pharma Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: OOncozyme Pharma Inc.

pentamidine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2029

Trials by Indication[1]

Lymphoma2 trials

Pneumonia2 trials

Metastatic Colon Cancer1 trial

Type 1 Diabetes1 trial

Pancreatic Cancer1 trial

Hepatocellular Carcinoma1 trial

Visceral Leishmaniasis1 trial

Melanoma1 trial

Trypanosomiasis1 trial

Kidney Transplant1 trial

References

Drug Info

Quick Facts

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