Potassium Nitrate

PreclinicalSmall molecule

GSK

Potassium Nitrate is one of 4 small molecule programs targeting Experimental. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

ExperimentalCompleted

Dentin HypersensitivityCompleted

ExperimentalPreclinical

Completed

Dentin HypersensitivityPreclinical

Completed

Competition

Competitive Landscape

7 competitors in Experimental

#DrugCompanyPhaseTrials

Active Ethanol

YYale University

Phase 1

1 2

Intravenous Infusion of DMT

UUniversity Hospital, Basel, Switzerland

Phase 1

1 3

Potassium Nitrate

GSK

Preclinical

1 4

Nalbuphine Plus Naloxone

UUniversity of California, San Francisco

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 2Recruiting

Hfpef

NCT04913805

Clinical

Trials by Indication[1]

Dentinal Hypersensitivity1 trial

The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity

Completed· GSK logo

GSK·Phase 1·NCT01587950·12 enrolled

Tooth Sensitivity1 trial

Anti-inflammatory Steroids in the Prevention of Tooth Sensitivity

Completed·UUniversidade Federal Fluminense·N/A·NCT02956070·70 enrolled

Nephropathy1 trial

The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy

Completed·BBarts & The London NHS Trust·Phase 2·NCT03627130·640 enrolled

Experimental1 trial

Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion

Completed· GSK logo

GSK·N/A·NCT01657903·56 enrolled

Aortic Stenosis1 trial

Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)

Completed·UUniversity of Pennsylvania·Phase 2·NCT03483051·5 enrolled

5 more indications

Heart Failure1 trial

Effect of KNO3 Compared to KCl on Oxygen UpTake in Heart Failure With Preserved Ejection Fraction (KNO3CK OUT HFPEF)

Completed·UUniversity of Pennsylvania·Phase 2·NCT02840799·84 enrolled

Treatment1 trial

Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization

Not yet recruiting·—·N/A·NCT07056855·48 enrolled

TED1 trial

Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth

Not yet recruiting·—·N/A·NCT06896565·48 enrolled

Dentin Hypersensitivity1 trial

Combined Use of Potassium Nitrate Gel and Diode Laser for Dentin Hypersensitivity

Completed·UUniversity of Pavia·N/A·NCT06967818·23 enrolled

HFpEF1 trial

Matching Perfusion and Metabolic Activity in HFpEF

Recruiting·UUniversity of Pennsylvania·Phase 2·NCT04913805·53 enrolled

Sources

References

[1]
ClinicalTrials.gov — 10 trial records for Potassium Nitrate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Potassium Nitrate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Potassium Nitrate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — GSK company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: GSK

Potassium Nitrate

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Trials by Indication[1]

Dentinal Hypersensitivity1 trial

Tooth Sensitivity1 trial

Nephropathy1 trial

Experimental1 trial

Aortic Stenosis1 trial

Heart Failure1 trial

Treatment1 trial

TED1 trial

Dentin Hypersensitivity1 trial

HFpEF1 trial

References

Drug Info

Quick Facts

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