Matulane

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Anaplastic AstrocytomaOligodendroglioma

13 competitors in Anaplastic Astrocytoma

#DrugCompanyPhaseTrials

1

Gilenya

Novartis

Approved

—2

Cialis

Eli Lilly

Approved

—3

Istodax

Teva

Approved

—4

Actos

Takeda

Approved

—5

Paraplatin

AAvyxa

Approved

—6

Ixempra

RR-Pharm

Approved

—7

Valtrex

GGlaxo Dba Glaxosmithkline

Approved

—8

Revlimid

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Approved

—9

Temodar

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 3

710

Mekinist

Novartis

Phase 2

1Show 3 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Lymphoma17 trials

Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma

Completed·UUniversity College, London·Phase 2·NCT00666484·47 enrolled

Intravenous Chemotherapy or Oral Chemotherapy in Treating Patients With Previously Untreated Stage III-IV HIV-Associated Non-Hodgkin Lymphoma

Completed·AAIDS Malignancy Consortium·Phase 2·NCT01775475·7 enrolled

Chemotherapy Based on Positron Emission Tomography Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT01132807·164 enrolled

Show 14 more trials

Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma

Unknown status·CChildren's Cancer and Leukaemia Group·Phase 2·NCT00025064·260 enrolled

Combination Chemotherapy and/or Radiation Therapy in Treating Young Patients With Hodgkin's Lymphoma

Unknown status·CChildren's Cancer and Leukaemia Group·N/A·NCT00417014·358 enrolled

Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma

Completed·UUniversity College, London·Phase 3·NCT00678327·1,202 enrolled

Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma

Active, not recruiting·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00379041·1,158 enrolled

Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Hodgkin's Lymphoma

Completed·CChristine Mauz-Körholz·Phase 2·NCT00416832·648 enrolled

Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma

Completed·CChristine Mauz-Körholz·Phase 3·NCT00433459·2,134 enrolled

Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma

Unknown status·CChildren's Cancer and Leukaemia Group·N/A·NCT00416377·353 enrolled

Methotrexate, Procarbazine, Lomustine, Dexamethasone, and Cytarabine in Treating Patients With Primary CNS Lymphoma

Completed·OOHSU Knight Cancer Institute·Phase 2·NCT00074191·1 enrolled

A Phase II Study VEPEMB In Patients With Hodgkin's Lymphoma Aged ≥ 60 Years

Completed·NNewcastle-upon-Tyne Hospitals NHS Trust·Phase 2·NCT00079105·175 enrolled

Combination Chemotherapy Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or High-Risk Primary Refractory Hodgkin Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00574496·25 enrolled

Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin's Lymphoma

Completed·—·Phase 2·NCT00049439·54 enrolled

Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or High-Grade Non-Hodgkin's Lymphomas

Terminated·—·Phase 2·NCT00003113·6 enrolled

S0816 Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G-CSF in Treating Patients With Stage III or Stage IV Hodgkin Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00822120·371 enrolled

Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Stage III or Stage IV Hodgkin's Lymphoma

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00049595·552 enrolled

Hodgkin's Disease4 trials

RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease

Active, not recruiting·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00002462·615 enrolled

Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease

Completed·MMedical Research Council·Phase 3·NCT00003421·800 enrolled

Combination Chemotherapy in Treating Patients With AIDS-Related Hodgkin's Disease

Completed·—·Phase 2·NCT00003114·5 enrolled

Show 1 more trial

Combination Chemotherapy and Radiation Therapy in Treating Children With Previously Untreated Stage II, Stage III, or Stage IV Hodgkin's Disease

Completed·CChildren's Oncology Group·Phase 2·NCT00004010·99 enrolled

Glioma3 trials

Surgery, Radiation Therapy, and Chemotherapy With or Without Photodynamic Therapy in Treating Patients With Newly Diagnosed or Recurrent Malignant Supratentorial Gliomas

Unknown status·CColorado Health Foundation·Phase 3·NCT00003788·270 enrolled

Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00002806·43 enrolled

Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma

Completed·Radiation Therapy Oncology Group·Phase 2/3·NCT00003375·370 enrolled

Malignant Glioma3 trials

Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma

Completed·IInstitute of Cancer Research, United Kingdom·Phase 3·NCT00052455·500 enrolled

Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas

Withdrawn·MM.D. Anderson Cancer Center·Phase 3·NCT00003564

Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant Glioma

Completed·WWake Forest University Health Sciences·Phase 2·NCT00079092·18 enrolled

Chemotherapy2 trials

Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors

Completed·IIndiana University·Phase 1·NCT00005796·10 enrolled

Combination Chemotherapy in Treating Children With Progressive Brain Tumors

Completed·CChildren's Oncology Group·Phase 3·NCT00002944·428 enrolled

8 more indications

Anaplastic Oligodendroglioma2 trials

Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma

Completed·Radiation Therapy Oncology Group·Phase 3·NCT00002569·299 enrolled

Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00002840·350 enrolled

Immunotherapy1 trial

Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL

Withdrawn·NNorthwestern University·Phase 1·NCT00734773

Brain Tumor1 trial

Procarbazine in Treating Patients With Recurrent Brain Tumor

Completed·NNew Approaches to Brain Tumor Therapy Consortium·Phase 1/2·NCT00004004

Glioblastoma Multiforme1 trial

SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme

Completed·Pfizer·Phase 3·NCT00003293

Bone Marrow Transplantation1 trial

Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With Oligodendroglioma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00003101·60 enrolled

Central Nervous System Lymphoma1 trial

Chemotherapy, Filgrastim, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Withdrawn·—·Phase 2·NCT00003929

Primitive Neuroectodermal Tumor1 trial

Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00002463·4 enrolled

Hodgkin Lymphoma1 trial

A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy With Immuno-oncology Therapy for Children and Adults With Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma

Recruiting·NNational Cancer Institute (NCI)·Phase 3·NCT05675410·1,875 enrolled

Regulatory

FDA Approval Timeline[4]

Details

Drug Info

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