Actos

(Pioglitazone)

ApprovedSmall molecule

Pioglitazone is used to help control blood sugar levels in people with type 2 diabetes by making the body more sensitive to insulin. It is often prescribed when diet, exercise, and other diabetes medications alone are not enough to manage blood sugar.[2] Actos is currently approved and in use across 103 indications[4].[1]

Actos is one of 2075 small molecule programs targeting Insulin resistance. It is currently in Approved.

103

Indications

342

Total Trials

Active Trials

2,074

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Insulin ResistanceActive, not recruiting

HyperinsulinemiaActive, not recruiting

Hepatic SteatosisApproved

CachexiaActive, not recruiting

Metabolic SyndromeApproved

GastroparesisActive, not recruiting

HIV InfectionActive, not recruiting

Systemic Lupus ErythematosusApproved

Cardiovascular DiseaseActive, not recruiting

Chronic PancreatitisActive, not recruiting

Insulin ResistanceApproved

Active, not recruiting

HyperinsulinemiaPhase 1

Active, not recruiting

Hepatic SteatosisApproved

Approved

CachexiaPhase 2

Active, not recruiting

Metabolic SyndromeApproved

Approved

GastroparesisPhase 1

Active, not recruiting

HIV InfectionPhase 2

Active, not recruiting

Systemic Lupus ErythematosusApproved

Approved

Cardiovascular DiseasePhase 3

Active, not recruiting

Chronic PancreatitisPhase 2

Active, not recruiting

Showing 10 of 103 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Actos

Takeda

Approved

2 2

Adriamycin

GGynecologic Oncology Group

Preclinical

87 3

Prolia

Amgen

Preclinical

14 4

Lexiscan

Astellas

Preclinical

1 5

Blenoxane

Bristol-Myers Squibb

Preclinical

1 6

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 7

Effexor

WWyeth-Lederle Vaccines

Preclinical

2 8

Spravato

WWim Janssens

Preclinical

2 9

Chirocaine

PPurdue Pharma LP

Preclinical

1 10

Chantix

PPrism Pharmaceuticals

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Recruiting

Lip

NCT03866408

Q1 2027

Post-ApprovalRecruiting

Mitochondria

NCT05305287

Q2 2027

Phase 2Recruiting

Chronic Pancreatitis

NCT06729996

Q3 2027

N/ARecruiting

Impaired Glucose Tolerance

NCT02969798

Phase 2Recruiting

NASH

NCT04501406

Clinical

Trials by Indication[1]

Type 2 Diabetes28 trials

Efficacy and Safety of Vildagliptin in Combination With Pioglitazone in Patients With Type 2 Diabetes

Completed· Novartis logo

Novartis·Phase 3·NCT00099853·362 enrolled

Metformin and Pioglitazone Effects on YKL-40 Concentrations in Type 2 Diabetes Patients

Completed·TTehran University of Medical Sciences·N/A·NCT01963663·84 enrolled

Comparison of the Efficacy and Safety Between Pioglitazone and Placebo Added to Combination Therapy in Type 2 Diabetes

Unknown status·NNational Cheng-Kung University Hospital·Phase 4·NCT00991055·40 enrolled

Show 25 more trials

A Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION - 2)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00637273·514 enrolled

A Dose-Range Finding Study in Participants With Type 2 Diabetes (MK-3102-006)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT01217073·685 enrolled

Placebo and Active Controlled Study of Rivoglitazone in Type 2 Diabetes

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 2/3·NCT00143520·441 enrolled

Safety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00676338·820 enrolled

A Phase 3 Study of BMS-477118 in Combination With Metformin in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00327015·1,306 enrolled

Comparison of Biphasic Insulin Aspart 70/30 With Anti-Diabetic Drugs in Subjects With Type 2 Diabetes

Completed· Novo Nordisk logo

Novo Nordisk·Phase 3·NCT00097279·230 enrolled

Comparison of Pioglitazone Versus Glimepiride in Type 2 Diabetes Inadequately Controlled With Metformin Plus Alogliptin

Unknown status·PPusan National University Hospital·Phase 4·NCT02426294·154 enrolled

Effect of Pioglitazone on TIMP-3 and TACE in Type 2 Diabetes

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT01223196·60 enrolled

Pioglitazone Versus Metformin in Type 2 Diabetes

Completed·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT00815399·150 enrolled

Safety and Efficacy Study to Compare Vildagliptin to Pioglitazone as Adding on Metformin in Type 2 Diabetes

Completed·PPusan National University Hospital·Phase 4·NCT01882907·287 enrolled

Targeting Beta-cell Failure in Lean Patients With Type 2 Diabetes

Completed·UUniversity of Leeds·Phase 4·NCT04657939·57 enrolled

Biphasic Insulin Aspart 30 in Type 2 Diabetes Failing OAD Therapy

Completed· Novo Nordisk logo

Novo Nordisk·Phase 3·NCT00598793·242 enrolled

A Study of Aleglitazar in Type 2 Diabetes Patients With Moderate Renal Impairment

Completed· Roche logo

Roche·Phase 2·NCT01043029·302 enrolled

Comparison of Metformin and Pioglitazone Effects on Adipokines Concentrations in Newly Diagnosed Type 2 Diabetes Patients

Completed·TTehran University of Medical Sciences·N/A·NCT01593371·98 enrolled

Metformin and Pioglitazone Effects on Fetuin-A and Osteoprotegrin Concentrations in Type 2 Diabetes Patients

Completed·TTehran University of Medical Sciences·N/A·NCT02027103·102 enrolled

GLAD: Dose-Finding, Efficacy, and Safety of AZ 242 (Tesaglitazar) in Subjects With Type 2 Diabetes

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00280865·500 enrolled

Effect of Pioglitazone on Cardiovascular Outcome on Higashi-Saitama Trial in Patients With Type 2 Diabetes

Completed·—··NCT00419484·1,000 enrolled

Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes.

Active, not recruiting·FFundación para la Investigación del Hospital Clínico de Valencia·Phase 4·NCT06851962·504 enrolled

A Study of Taspoglutide Versus Pioglitazone in Patients With Type 2 Diabetes

Completed· Roche logo

Roche·Phase 3·NCT00909597·756 enrolled

Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone.

Completed· Takeda logo

Takeda·Phase 4·NCT00672919·305 enrolled

Study In Patients With Type 2 Diabetes Who Are Taking Metformin And Sulfonylurea, Metformin And Insulin, Or Insulin

Completed· GSK logo

GSK·Phase 1·NCT00269061·32 enrolled

A Placebo Controlled Safety and Efficacy Study of MSDC-0160 in Type 2 Diabetes With Active Comparator

Completed·MMetabolic Solutions Development Company·Phase 2·NCT00760578·86 enrolled

A Study to Determine the Safety and Efficacy of Albiglutide in Subjects With Type 2 Diabetes

Completed· GSK logo

GSK·Phase 3·NCT00839527·685 enrolled

Effect of Inhaled Insulin (AERx® iDMS) on Blood Glucose Control in Type 2 Diabetes

Terminated· Novo Nordisk logo

Novo Nordisk·Phase 3·NCT00411892·196 enrolled

Efficacy of Pioglitazone on Microcirculation in Type 2 Diabetes Patients Treated With Insulin

Completed· Takeda logo

Takeda·Phase 2·NCT00676260·29 enrolled

Type 2 Diabetes Mellitus18 trials

A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Plus Pioglitazone.

Completed· Roche logo

Roche·Phase 3·NCT00744367·326 enrolled

Efficacy of Pioglitazone Compared to Glyburide in Treating Subjects With Type 2 Diabetes Mellitus and Mild Cardiac Disease

Completed· Takeda logo

Takeda·Phase 3·NCT00521742·300 enrolled

Dose-Ranging Study in Treatment Naive Type 2 Diabetes Mellitus(T2DM)

Completed· GSK logo

GSK·Phase 2·NCT00500331·334 enrolled

Show 15 more trials

Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus.

Completed· Takeda logo

Takeda·Phase 3·NCT00727857·600 enrolled

Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus

Completed· Takeda logo

Takeda·Phase 3·NCT00432276·803 enrolled

Effects of Pioglitazone in Type 2 Diabetes Mellitus and Coronary Heart Disease

Completed·IIKFE Institute for Clinical Research and Development·Phase 4·NCT00479986·92 enrolled

Hydroxychloroquine Versus Pioglitazone in Combination Treatment for Type 2 Diabetes Mellitus

Terminated·—·Phase 2·NCT02303405·22 enrolled

Efficacy of Alogliptin With Pioglitazone (Actos®) in Subjects With Type 2 Diabetes Mellitus

Completed· Takeda logo

Takeda·Phase 3·NCT00395512·655 enrolled

Efficacy and Safety of Alogliptin Combined With Pioglitazone in Treating Subjects With Type 2 Diabetes Mellitus.

Completed· Takeda logo

Takeda·Phase 3·NCT00328627·1,554 enrolled

Investigate the Effect of AZD1656 on the Pharmacokinetics of Pioglitazone and Vice Versa in Type 2 Diabetes Mellitus

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01082120·28 enrolled

Molecular Mechanisms of Type 2 Diabetes Mellitus

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT00816218·39 enrolled

Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus

Completed· Takeda logo

Takeda·Phase 3·NCT00225277·547 enrolled

Study of Alogliptin Combined With Pioglitazone in Subjects With Type 2 Diabetes Mellitus

Completed· Takeda logo

Takeda·Phase 3·NCT00286494·493 enrolled

A Study in Participants With Type 2 Diabetes Mellitus

Completed· Eli Lilly logo

Eli Lilly·Phase 3·NCT01064687·978 enrolled

Efficacy and Safety of TAK-379 in Adult Subjects With Type 2 Diabetes Mellitus

Terminated· Takeda logo

Takeda·Phase 2·NCT00722917·323 enrolled

A Study to Evaluate the Safety and Efficacy of CCX140-B in Subjects With Type 2 Diabetes Mellitus

Completed· Amgen logo

Amgen·Phase 2·NCT01028963·159 enrolled

Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT01588470·130 enrolled

Efficacy, Safety and Tolerability of Pioglitazone-Azilsartan in Subjects With Type 2 Diabetes Mellitus

Terminated· Takeda logo

Takeda·Phase 3·NCT00376181·96 enrolled

Treatment6 trials

A Trial With Metronomic Low-dose Treosulfan, Pioglitazone and Clarithromycin Versus Standard Treatment in NSCLC

Unknown status·UUniversity Hospital Regensburg·Phase 2·NCT02852083·86 enrolled

Effect of Thiazolidinedione Treatment Vascular Risk Markers

Completed·UUniversity of Arkansas·Phase 4·NCT00571506·25 enrolled

The Impact of Actos Treatment of Diabetes on Glucose Transporters in Muscle

Completed·—·Phase 4·NCT01799850·12 enrolled

Show 3 more trials

Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes

Completed·—·Phase 4·NCT01432405·24 enrolled

A Study Assessing Saxagliptin Treatment in Type 2 Diabetic Subjects Who Are Not Controlled With TZD Therapy Alone

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00295633·565 enrolled

Pioglitazone Tablets Special Drug Use Surveillance "Combined Use of Biguanides / Long-term Treatment"

Completed· Takeda logo

Takeda··NCT02003014·899 enrolled

Insulin resistance6 trials

Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 4·NCT00835120·34 enrolled

Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin Resistance

Completed·MMayo Clinic·Phase 2·NCT00443755·28 enrolled

Obesity, Sleep Apnea, and Insulin Resistance

Completed·SStanford University·N/A·NCT02192684·45 enrolled

Show 3 more trials

Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 4·NCT00212290·140 enrolled

Effect of Pioglitazone on Insulin Resistance and Atherosclerosis in Renal Allograft Recipients Without Diabetes

Completed·YYonsei University·N/A·NCT00598013·83 enrolled

Insulin Resistance and Androgen Deprivation Therapy

Withdrawn·SSt. Louis University·Phase 2·NCT04995978

Metabolic Syndrome5 trials

Effects of Pioglitazone Treatment on Sympathetic Nervous System Function in Metabolic Syndrome Obesity

Unknown status·—·Phase 3·NCT00408850·44 enrolled

Myocardial Function & FFA Metabolism in HIV Metabolic Syndrome

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·N/A·NCT00656851·24 enrolled

Mechanisms Underlying Metabolic Syndrome in Obesity

Completed·PPhilip Kern·Phase 4·NCT00579813·70 enrolled

Show 2 more trials

The Effects of Peroxisome Proliferators Activated Receptor-Gamma (PPAR-γ) Agonists on Certain Biochemical and Inflammatory Markers in Metabolic Syndrome

Completed·—·Phase 4·NCT00926341·110 enrolled

Exercise and Pioglitazone for HIV-Metabolic Syndromes

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·N/A·NCT00639457·44 enrolled

95 more indications

Type 2 Diabetic Patients5 trials

Abdominal Adipose Tissue Distribution in Type 2 Diabetic Patients Treated During 6 Months With Pioglitazone or Insulin

Terminated·AAssistance Publique - Hôpitaux de Paris·N/A·NCT00159211·28 enrolled

Triple Therapy in Type 2 Diabetic Patients

Unknown status·UUniversity of Pavia·Phase 4·NCT01895569·64 enrolled

A Randomized, Double-Blind, Comparator- and Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Patients

Completed·MMetabolic Solutions Development Company·Phase 2·NCT01280695·129 enrolled

Show 2 more trials

Effect of Different Interventions on Glycemic Control and β-cell Function in Newly Diagnosed Type 2 Diabetic Patients

Completed·SSun Yat-sen University·N/A·NCT01147627·416 enrolled

Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of Mitoglitazone in Type 2 Diabetic Patients

Completed·MMetabolic Solutions Development Company·Phase 2·NCT01103414·356 enrolled

Diabetes4 trials

Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes

Completed·UUniversity of Miami·Phase 3·NCT01156597·30 enrolled

Ketosis Prone Diabetes in African-Americans

Completed·EEmory University··NCT00426413·44 enrolled

Role of Pioglitazone in Preventing Diabetes

Completed·—·Phase 1·NCT00276497

Show 1 more trial

Normal-weight Diabetes: Adipocyte-directed Therapy with Pioglitazone or Tirzepatide

Not yet recruiting·SStanford University·Phase 4·NCT06657209·104 enrolled

Alcohol4 trials

Effects of Pioglitazone on Stress Reactivity and Alcohol Craving

Completed·TThe University of Texas Health Science Center, Houston·Phase 1/2·NCT05107765·67 enrolled

A Study of Pleiotropic Pioglitazone Effects on the Alcoholic Lung (APPEAL Study)

Terminated·EEmory University·Phase 2·NCT03060772·50 enrolled

Role of Proinflammatory Signaling in Alcohol Craving

Terminated·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT01631630·16 enrolled

Show 1 more trial

Pentoxifylline Versus Pioglitazone In Non-Alcoholic Steatohepatiti (NASH)

Unknown status·GGovind Ballabh Pant Hospital·N/A·NCT00681733·20 enrolled

Polycystic Ovary Syndrome3 trials

Pioglitazone Treatment in Polycystic Ovary Syndrome

Completed·OOdense University Hospital·Phase 4·NCT00145340·30 enrolled

Polycystic Ovary Syndrome (PCOS) and Sleep Apnea

Terminated·UUniversity of Chicago·Phase 4·NCT00203996·37 enrolled

Effects of Pioglitazone on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome (PCOS)

Terminated·VVirginia Commonwealth University·N/A·NCT00868140·51 enrolled

Prevention3 trials

Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention

Recruiting·TThe University of Texas Health Science Center, Houston·Phase 2·NCT04843046·60 enrolled

Prevention of Instent Renarrowing With Aggressive Glucose Lowering With Pioglitazone in Diabetic Patients

Completed·QQueen Elizabeth II Health Sciences Centre·Phase 4·NCT00819325·50 enrolled

Actos Now for Prevention of Diabetes (ACT NOW)

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 3·NCT00220961·602 enrolled

Non-Alcoholic Fatty Liver Disease3 trials

Insulin Resistance in Non-alcoholic Fatty Liver Disease

Terminated·VVA Office of Research and Development·N/A·NCT01289639·11 enrolled

Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease

Completed·XXin Gao·Phase 2·NCT00633282·184 enrolled

Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Hispanics With Diabetes Mellitus Type 2 (T2DM) and Role of Treatment

Completed·VVA Office of Research and Development·Phase 4·NCT01002547·105 enrolled

Function3 trials

Safety Study of Pioglitazone Compared To Glyburide on Liver Function

Completed· Takeda logo

Takeda·Phase 4·NCT00494312·2,120 enrolled

Optimizing Body Composition for Function in Older Adults

Completed·WWake Forest University Health Sciences·Phase 4·NCT00315146·88 enrolled

Pioglitazone on Cardiac Function and Large Arteries (PICCOLA Study)

Completed·IImperial College London·Phase 4·NCT00485056·24 enrolled

Alcoholic Fatty Liver Disease3 trials

Effect of Canagliflozin on Liver Inflammation Damage in Type 2 Diabetes Patients With Nonalcoholic Fatty Liver Disease

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University··NCT05513729·80 enrolled

A Prospective, Randomized Trial to Compare saroGLitazar With pioglitAZone in Nonalcoholic Fatty livEr Disease

Unknown status·—·Phase 3·NCT02265276·100 enrolled

Canagliflozin on Liver Inflammation Damage in Type 2 Diabetes Patients With Nonalcoholic Fatty Liver Disease

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·N/A·NCT05422092·80 enrolled

Impaired glucose tolerance3 trials

Pioglitazone in Impaired Glucose Tolerance

Withdrawn·UUniversity of Leipzig·Phase 4·NCT00306826·120 enrolled

Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance

Completed·UUS Department of Veterans Affairs·Phase 4·NCT00108615·48 enrolled

Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

Recruiting·TThe University of Texas Health Science Center at San Antonio·N/A·NCT02969798·700 enrolled

Metformin3 trials

Glycemic Durability After Metformin Failure

Unknown status·UUniversity of Campania Luigi Vanvitelli·Phase 4·NCT02142309·450 enrolled

Study Assessing Saxagliptin Treatment In Type 2 Diabetic Subjects Who Are Not Controlled With Metformin Alone

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00121667·1,462 enrolled

Sitagliptin (MK-0431) vs. Placebo in Patients With Inadequate Glycemic Control on Metformin With Pioglitazone (MK-0431-128)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00885352·313 enrolled

Lip2 trials

Influence of Glitazones on the Vasodilatory Effect of High-density Lipoprotein (HDL) Lipoproteins

Completed·—·Phase 4·NCT00953498·40 enrolled

Insulin Regulation of Lipolysis and Lipolysis Proteins

Recruiting·MMayo Clinic·Phase 1·NCT03866408·64 enrolled

Fatty Liver2 trials

Effect of Oral Anti-diabetic Medication on Liver Fat in Subjects With Type II Diabetes and Non-alcoholic Fatty Liver

Unknown status·GGetz Pharma·Phase 4·NCT04976283·123 enrolled

Fatty Liver Study in Patients With Type II Diabetes

Terminated·TThe University of Texas Medical Branch, Galveston·Phase 4·NCT02365233·5 enrolled

Chronic Pancreatitis2 trials

Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality

Completed·UUniversity of Michigan·Phase 2·NCT00782795·64 enrolled

Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis Associated Diabetes Mellitus

Recruiting·MMayo Clinic·Phase 2·NCT06729996·40 enrolled

Mitochondria2 trials

"TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM

Completed·PPennington Biomedical Research Center·Phase 4·NCT00402012·24 enrolled

Quantifying Hepatic Mitochondrial Fluxes in Humans

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT05305287·60 enrolled

Chronic Myelogenous Leukemia2 trials

Safety and Efficiency Study of Pioglitazone in Combination With Imatinib Mesylate to Treat Chronic Myelogenous Leukemia

Unknown status·MMeng Li·Phase 2·NCT02687425·20 enrolled

Therapies in Combination or Sequentially With Tyrosine Kinase Inhibitors (TKIs) in Chronic Phase Chronic Myelogenous Leukemia Patients in CCR (ACTIW)

Unknown status·VVersailles Hospital·Phase 1/2·NCT02767063·100 enrolled

Subcutaneous Fat2 trials

Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women

Completed·PPennington Biomedical Research Center·N/A·NCT01748994·63 enrolled

"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat

Completed·PPennington Biomedical Research Center·Phase 2·NCT00377975·96 enrolled

Hepatitis C2 trials

Pioglitazone to Treat Fatty Liver in Patients With HIV and Hepatitis C Infections

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00742326·13 enrolled

Pioglitazone in Hepatitis C

Completed·UUniversity of Michigan·Phase 4·NCT00189163·40 enrolled

Cognitive impairment2 trials

AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease

Terminated· Takeda logo

Takeda·Phase 3·NCT02284906·40 enrolled

Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI)

Completed·UUniversity of Colorado, Denver·Phase 2·NCT00736996·78 enrolled

Rheumatoid Arthritis2 trials

Inflammation and Insulin Resistance in Rheumatoid Arthritis

Completed·VVanderbilt University·N/A·NCT00763139·34 enrolled

Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA)

Completed·OOhio State University·Phase 1·NCT02535832·16 enrolled

Hepatitis2 trials

Safety and Efficacy of Roflumilast and Pioglitazone in Treating Adults With Nonalcoholic SteatoHepatitis

Terminated· AstraZeneca logo

AstraZeneca·Phase 2·NCT01703260·20 enrolled

The Efficacy and Safety of Pioglitazone in Patients With Nonalcoholic Steatohepatitis

Completed·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 2·NCT01068444·90 enrolled

Obesity2 trials

Mediators of Abnormal Reproductive Function in Obesity (MARO)

Completed·UUniversity of Colorado, Denver·Phase 1·NCT01817400·10 enrolled

Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle

Completed·UUniversity of Nottingham·N/A·NCT02305069·26 enrolled

Diabetes Mellitus2 trials

Cohort Study of Pioglitazone and Cancer Incidence in Participants With Diabetes Mellitus.

Completed· Takeda logo

Takeda··NCT02958956·236,507 enrolled

Pioglitazone Protects Diabetes Mellitus (DM) Patients Against Re-Infarction (PPAR Study)

Terminated·NNational Cerebral and Cardiovascular Center, Japan·Phase 4·NCT00212004·630 enrolled

Cardiac Allograft Vasculopathy1 trial

Clinical Trial of Pioglitazone for Prevention of Cardiac Allograft Vasculopathy After Heart Transplantation

Completed·SStanford University·Phase 2·NCT01186250·18 enrolled

Adrenomyeloneuropathy1 trial

Effect of Pioglitazone Administered to Patients With Adrenomyeloneuropathy

Completed·—·Phase 2·NCT03864523·18 enrolled

Volume1 trial

The Effect of Pioglitazone on Neointima Volume and Inflammatory Markers

Completed·KKorea University Anam Hospital·Phase 4·NCT00494559·240 enrolled

Terminated·EEmory University·Phase 2·NCT02730195·9 enrolled

Pressure Ulcers1 trial

Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI

Withdrawn·JJames J. Peters Veterans Affairs Medical Center·Phase 2·NCT02585765

Opioid Withdrawal1 trial

Pioglitazone to Treat Opioid Withdrawal Symptoms

Terminated·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT01517165·24 enrolled

Thyroid Cancer1 trial

Pioglitazone in Thyroid Cancers

Completed·UUniversity of Michigan·Phase 2·NCT01655719·1 enrolled

Randomized Controlled Trial1 trial

A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers

Unknown status·NNational Taiwan University Hospital·Phase 4·NCT02429232·160 enrolled

Refractory AML1 trial

Low-dose AZA, Pioglitazone, ATRA Versus Standard-dose AZA in Patients >=60 Years With Refractory AML

Terminated·UUniversity Hospital Regensburg·Phase 2·NCT02942758·10 enrolled

Chronic Hepatitis1 trial

Retreatment of Chronic Hepatitis C Non-responders With Pegylated Interferon Alpha Plus Ribavirin Plus Pioglitazone

Completed·UUniversity Hospital, Geneva·Phase 2·NCT00433069·5 enrolled

CLE1 trial

Insulin Signaling in Skeletal Muscle

Withdrawn·WWayne State University·Phase 2/3·NCT03452267

Androgen Deprivation Therapy1 trial

Androgen Deprivation Therapy Study

Terminated·NNational Institute on Aging (NIA)··NCT00743327·1 enrolled

Hypoxia1 trial

GlitazOne Treatment for Coronavirus HypoxiA, a Safety and Tolerability Open Label With Matching Cohort Pilot Study

Completed·SSamaritan Health Services·Phase 4·NCT04473274·10 enrolled

Asthma1 trial

Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics

Completed·FFernando Holguin·Phase 2·NCT00634036·23 enrolled

HIV infection1 trial

Pioglitazone to Treat Fatty Liver in People With HIV Infection

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00441272·100 enrolled

Chronic Kidney Disease1 trial

Metabolic Effects of Thiazolidinediones in Chronic Kidney Disease

Terminated·VVanderbilt University·Phase 2·NCT00368017·12 enrolled

Bone1 trial

Effect of Thiazolidinediones on Human Bone

Completed·EEmory University·N/A·NCT00927355·10 enrolled

Bone Health1 trial

Pioglitazone on Pancreatic Steatosis and Bone Health

Completed·UUniversity of Texas Southwestern Medical Center·N/A·NCT00855010·42 enrolled

Lipodystrophy1 trial

HIV Acquired Lipodystrophy (HAL) Classification, Measurement and Fat Response to Thiazolidinedione (TZD) (Pioglitazone)

Completed·UUniversity of Texas Southwestern Medical Center·N/A·NCT01023620·4 enrolled

Platelet Function1 trial

Effects of Pioglitazone on Platelet Function

Completed·UUniversity of Rochester·Phase 2·NCT00861341·40 enrolled

T2DM1 trial

Canagliflozin (Invokana™) vs. Standard Dual Therapy Regimen for T2DM During Ramadan

Completed·UUniversity of Leicester·Phase 4·NCT02694263·25 enrolled

Spironolactone1 trial

Effects of Cyproterone Compound-spironolactone, Metformin and Pioglitazone on Inflammatory Markers in PCOS

Completed·SShiraz University of Medical Sciences·Phase 1·NCT02689843·90 enrolled

Peritoneal Dialysis (PD)1 trial

Pioglitazone Attenuates Dysmetabolism in Peritoneal Dialysis (PD) Patients

Completed·HHuashan Hospital·N/A·NCT01258322·70 enrolled

Cirrhosis1 trial

Effect of Pioglitazone on Portal and Systemic Hemodynamics in Patients With Advanced Cirrhosis

Completed·MMedical University of Vienna·Phase 4·NCT00570622·20 enrolled

Cerebral Infarction1 trial

Pioglitazone Tablets Specified Drug-use Survey <Survey on Glycemic Control in Type 2 Diabetic Patients With a History of Cerebral Infarction>

Completed· Takeda logo

Takeda··NCT02181842·246 enrolled

Pulmonary Arterial Hypertension1 trial

Insulin Resistance in Pulmonary Arterial Hypertension

Terminated·SStanford University·Phase 2·NCT00825266·2 enrolled

Non-Alcoholic Steatohepatitis1 trial

Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH)

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT00227110·55 enrolled

Adipokines1 trial

Phielix et al.: Hepatic Fat Content and Adipokines

Completed·GGerman Diabetes Center·N/A·NCT01570660·24 enrolled

Atrophy1 trial

Effect of Pioglitazone on HIV-1 Related Lipoatrophy: a Randomized, Double Blind, Placebo-Controlled Trial in 130 Patients

Terminated·FFrench National Agency for Research on AIDS and Viral Hepatitis·Phase 3·NCT00148850·130 enrolled

Renal Transplant1 trial

Influence of Pioglitazone for Renal Transplant Function in Diabetics

Completed·TTechnische Universität Dresden·Phase 3·NCT00507494

Psoriasis1 trial

Efficacy and Safety of Acitretin Plus Pioglitazone in Patients With Psoriasis

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2·NCT00395941·40 enrolled

Female1 trial

Bioavailability of BI 1356 With and Without Co-administration of Pioglitazone and the Bioavailability of Pioglitazone With and Without Coadministration of BI 1356 in Healthy Male and Female Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02183337·20 enrolled

Pilot Study1 trial

Response To Oral Agents in Diabetes (ROAD)- Pilot Study

Completed·UUniversity of Dundee·Phase 4·NCT00780715·29 enrolled

Prostate Cancer1 trial

Combined Antiinflammatory and Angiostatic Therapy in Patients With Hormone-refractory Prostate Cancer

Completed· Novartis logo

Novartis·Phase 2·NCT00427999·67 enrolled

NASH1 trial

Low-Dose Pioglitazone in Patients With NASH (AIM 2)

Recruiting·UUniversity of Florida·Phase 2·NCT04501406·166 enrolled

Vitamin D1 trial

Thiazolidinedione Intervention With Vitamin D Evaluation

Terminated· GSK logo

GSK·Phase 4·NCT00879970·1,332 enrolled

Combination Therapy1 trial

Efficacy Study of Pioglitazone and Ramipril Combination Therapy in Treating Non-diabetic Hypertensive Patients.

Completed· Takeda logo

Takeda·Phase 2·NCT00770497·172 enrolled

Amyotrophic Lateral Sclerosis1 trial

Study of Pioglitazone in Patients With Amyotrophic Lateral Sclerosis

Terminated·UUniversity of Ulm·Phase 2·NCT00690118·219 enrolled

Adult Subject1 trial

A Study to Investigate the Effect of GSK1605786 on Hepatic Cytochrome P450, and BCRP and OATP1B1 Transport in Healthy Adult Subjects

Completed· GSK logo

GSK·Phase 1·NCT01489943·24 enrolled

Interaction1 trial

Drug-drug Interaction Study With MDV3100 and a Cocktail of Substrates

Completed· Astellas logo

Astellas·Phase 1·NCT01911728·14 enrolled

Concentration1 trial

Effects of Administration of Fostamatinib on Blood Concentrations of Pioglitazone in Healthy Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01309854·15 enrolled

Inclusion Body Myositis1 trial

Study of Pioglitazone in Sporadic Inclusion Body Myositis

Completed·JJohns Hopkins University·Phase 1·NCT03440034·19 enrolled

Coronary Atherosclerosis1 trial

Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients

Unknown status·NNational Taiwan University Hospital·Phase 4·NCT00155350·120 enrolled

Ischemic stroke1 trial

Neuroprotection of Pioglitazone in Acute Ischemic Stroke

Terminated·TTaipei Medical University Shuang Ho Hospital·Phase 2·NCT02195791·4 enrolled

CKD1 trial

Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients

Recruiting·TThe University of Texas at Arlington·Phase 4·NCT03471117·28 enrolled

Congestive Heart Failure1 trial

Safety Comparison of Pioglitazone and Glyburide in Type 2 Diabetes Subjects With Mild to Moderate Congestive Heart Failure

Terminated· Takeda logo

Takeda·Phase 3·NCT00521820·518 enrolled

Autism Spectrum Disorder1 trial

Dose Finding Study of Pioglitazone in Children With Autism Spectrum Disorders (ASD) (PIO)

Completed·EEvdokia Anagnostou·Phase 2·NCT01205282·28 enrolled

Autosomal Dominant Polycystic Kidney Disease1 trial

Use of Low Dose Pioglitazone to Treat Autosomal Dominant Polycystic Kidney Disease

Completed·IIndiana University·Phase 2·NCT02697617·18 enrolled

Schizophrenia1 trial

Pioglitazone as a Treatment for Lipid and Glucose Abnormalities In Patients With Schizophrenia

Completed·NNathan Kline Institute for Psychiatric Research·Phase 4·NCT00231894·56 enrolled

Intracerebral Hemorrhage1 trial

Safety of Pioglitazone for Hematoma Resolution In Intracerebral Hemorrhage

Completed·TThe University of Texas Health Science Center, Houston·Phase 2·NCT00827892·84 enrolled

Imaging1 trial

Evaluation of Rosiglitazone Anti-inflammatory Effect With FDG-PET Imaging

Completed·WWashington University School of Medicine·Phase 1·NCT01174056·39 enrolled

Hyperinsulinemia1 trial

A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer.

Recruiting·RRambam Health Care Campus·Phase 1·NCT05753657·30 enrolled

Trial1 trial

An Extension Study of PEAK Trial

Terminated·KKun-Ho Yoon·Phase 4·NCT02763007·41 enrolled

Endometriosis1 trial

Endometriosis: Immunomodulation

Withdrawn·UUniversity of Wisconsin, Madison·Phase 2/3·NCT01184144

Dialysis Patients1 trial

Effect of Adipokines in Hemodialysis Patients

Completed·UUniversity of Utah·N/A·NCT01301027·95 enrolled

Myxoid Liposarcoma1 trial

Study on Trabectedin in Combination With Pioglitazone in Patients Myxoid Liposarcomas With Stable Disease After T Alone.

Completed· Mario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research·Phase 2·NCT04794127·10 enrolled

Endothelial Function1 trial

Does Thiazolidinedione Therapy Improve Endothelial Function and Preserve Renal Function

Terminated·MMayo Clinic·N/A·NCT00586261·36 enrolled

Autoimmune Pulmonary Alveolar Proteinosis1 trial

Pioglitazone Therapy of Autoimmune Pulmonary Alveolar Proteinosis Autoimmune Pulmonary Alveolar Proteinosis

Completed·—·Phase 1·NCT03231033·3 enrolled

Cystic Fibrosis1 trial

Effect of Pioglitazone on Inflammation in Cystic Fibrosis

Completed·PPaul Beringer·Phase 1·NCT00719381·24 enrolled

Optical Coherence Tomography1 trial

The Effect of Pioglitazone on Neointima Volume and Characteristics Observed by Optical Coherence Tomography (OCT)

Completed·KKorea University Anam Hospital·Phase 4·NCT01331967·94 enrolled

Parkinson's Disease1 trial

Pioglitazone in Early Parkinson's Disease

Completed·UUniversity of Rochester·Phase 2·NCT01280123·210 enrolled

Congenital Adrenal Hyperplasia1 trial

Effects of Pioglitazone in Congenital Adrenal Hyperplasia

Completed·RRadboud University Medical Center·N/A·NCT00151710

Oxidative Stress1 trial

Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes

Unknown status·KKorea University Anam Hospital·Phase 4·NCT01339143·80 enrolled

Peritoneal Dialysis1 trial

Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients

Completed·TThe University of Hong Kong·Phase 4·NCT00745225·160 enrolled

Major Depressive Disorder1 trial

Pioglitazone for the Treatment of Major Depressive Disorder Comorbid With Metabolic Syndrome

Completed·—·Phase 2·NCT00671515·23 enrolled

Bipolar Depression1 trial

Pioglitazone for the Treatment of Bipolar Depression

Terminated·UUniversity Hospitals Cleveland Medical Center·Phase 4·NCT01717040·37 enrolled

Liver Disease1 trial

Antidiabetic Drugs for Steatotic Liver Disease

Completed·YYonsei University·Phase 4·NCT03646292·51 enrolled

Immunomodulation1 trial

Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Completed·NNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)·Phase 1/2·NCT02338999·88 enrolled

Blood Pressure1 trial

Effect of Pioglitazone on Ambulatory Blood Pressure

Completed·UUniversity of Erlangen-Nürnberg Medical School·Phase 3·NCT00328393·2 enrolled

Unspecified7 trials

Pioglitazone vs Placebo in Combination With Niacin Extended Release on Low HDL

Completed·UUniversity of Pennsylvania·Phase 2·NCT00300365·38 enrolled

Ghrelin Regulation and Structure: Effect of Thiazolidinedione Therapy on Ghrelin

Terminated·OOregon Health and Science University·N/A·NCT00843791·6 enrolled

Bioavailability of BI 10773 and Pioglitazone in Healthy Male Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02276365·20 enrolled

Show 4 more trials

Pharmacogenomics of Thiazolidinediones

Completed·UUniversity of Maryland, Baltimore·N/A·NCT01135394·114 enrolled

Pioglitazone Incretin Study

Completed·UUniversity of Vermont·Phase 4·NCT00656864·24 enrolled

Evaluation of Glucose Lowering Effect, Safety and Tolerability of CS-917

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 2·NCT00290940·400 enrolled

Brown Fat Activation Study

Completed·PPhilip Kern·Phase 1·NCT02919176·39 enrolled

Regulatory

FDA Approval Timeline[5]

Jul 15, 1999

ACTOS

NDA NDA021073

Sources

References

[1]
ClinicalTrials.gov — 342 trial records for Pioglitazone. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Actos drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Pioglitazone compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Pioglitazone. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA021073). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Takeda company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Peroxisome Proliferator-Activated Receptor Gamma Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Takeda

Actos

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Q3 2027

Trials by Indication[1]

Type 2 Diabetes28 trials

Type 2 Diabetes Mellitus18 trials

Treatment6 trials

Insulin resistance6 trials

Metabolic Syndrome5 trials

Type 2 Diabetic Patients5 trials

Diabetes4 trials

Alcohol4 trials

Polycystic Ovary Syndrome3 trials

Prevention3 trials

Non-Alcoholic Fatty Liver Disease3 trials

Function3 trials

Alcoholic Fatty Liver Disease3 trials

Impaired glucose tolerance3 trials

Metformin3 trials

Lip2 trials

Fatty Liver2 trials

Chronic Pancreatitis2 trials

Mitochondria2 trials

Chronic Myelogenous Leukemia2 trials

Subcutaneous Fat2 trials

Hepatitis C2 trials

Cognitive impairment2 trials

Rheumatoid Arthritis2 trials

Hepatitis2 trials

Obesity2 trials

Diabetes Mellitus2 trials

Cardiac Allograft Vasculopathy1 trial

Adrenomyeloneuropathy1 trial

Volume1 trial

Nephrolithiasis1 trial

Body Weight1 trial

Statin1 trial

Myeloid Leukemia1 trial

Pressure Ulcers1 trial

Opioid Withdrawal1 trial

Thyroid Cancer1 trial

Randomized Controlled Trial1 trial

Refractory AML1 trial

Chronic Hepatitis1 trial

CLE1 trial

Androgen Deprivation Therapy1 trial

Hypoxia1 trial

Asthma1 trial

HIV infection1 trial

Chronic Kidney Disease1 trial

Bone1 trial

Bone Health1 trial

Lipodystrophy1 trial

Platelet Function1 trial

T2DM1 trial

Spironolactone1 trial

Peritoneal Dialysis (PD)1 trial

Cirrhosis1 trial

Cerebral Infarction1 trial

Pulmonary Arterial Hypertension1 trial

Non-Alcoholic Steatohepatitis1 trial

Adipokines1 trial

Atrophy1 trial

Renal Transplant1 trial

Psoriasis1 trial

Female1 trial

Pilot Study1 trial

Prostate Cancer1 trial

NASH1 trial

Vitamin D1 trial

Combination Therapy1 trial

Amyotrophic Lateral Sclerosis1 trial

Adult Subject1 trial

Interaction1 trial

Concentration1 trial