Proton Pump Inhibitors

ApprovedSmall molecule

Proton Pump Inhibitors is one of 53 small molecule programs targeting Acute Myocardial Infarction. It is currently in Approved.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Acute Myocardial InfarctionActive, not recruiting

Esophageal VaricesActive, not recruiting

Acute Myocardial Infarction (AMI)Recruiting

Acute Myocardial InfarctionApproved

Active, not recruiting

Esophageal VaricesApproved

Active, not recruiting

Acute Myocardial Infarction (AMI)Phase 3

Recruiting

Competition

Competitive Landscape

216 competitors in Acute Myocardial Infarction

#DrugCompanyPhaseTrials

Farxiga

AstraZeneca

Phase 3

4 2

Adenocard

Astellas

Phase 3

2 3

Lovenox

Sanofi

Phase 3

2 4

Aldactone

Pfizer

Phase 3

1 5

Lovenox

Sanofi

Phase 3

1 6

Byetta

AstraZeneca

Phase 3

1 7

MS Contin

HHikma Pharmaceuticals LLC

Phase 3

3 8

Kineret

SSwedish Orphan Biovitrum

Phase 3

2 9

Jardiance

Boehringer Ingelheim

Phase 3

1 10

Xarelto

WWim Janssens

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2028

N/ANot yet recruiting

Randomized Controlled Trial

NCT07488299

Q4 2028

Post-ApprovalNot yet recruiting

Acute Variceal Bleeding

NCT05624229

Q4 2030

Phase 3Recruiting

Acute Myocardial Infarction (AMI)

NCT07467213

Clinical

Trials by Indication[1]

Randomized Controlled Trial2 trials

The Effect of PPI on Endoscopic Treatment of WON: a Multicenter Randomized Controlled Trial.

Not yet recruiting·QQilu Hospital of Shandong University·N/A·NCT07488299·120 enrolled

A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD

Completed·MMcMaster University·N/A·NCT00182260·216 enrolled

Acute Variceal Bleeding1 trial

Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal Bleeding

Not yet recruiting·WWest China Hospital·Phase 4·NCT05624229·672 enrolled

Esophageal Varices1 trial

PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)

Completed·YYanjing Gao·Phase 4·NCT03175731·106 enrolled

Acute Myocardial Infarction (AMI)1 trial

Routine Use of Potassium Competitive Acid Blocker Versus Guideline-Directed Gastrointestinal Protection Strategy in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention on Dual Antiplatelet Therapy: A Randomized Trial

Recruiting·SSamsung Medical Center·Phase 3·NCT07467213·5,000 enrolled

Sources

References

[1]
ClinicalTrials.gov — 5 trial records for Proton Pump Inhibitors. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Proton Pump Inhibitors compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Proton Pump Inhibitors. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Samsung Medical Center company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: SSamsung Medical Center

Proton Pump Inhibitors

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2028

Q4 2028

Q4 2030

Trials by Indication[1]

Randomized Controlled Trial2 trials

Acute Variceal Bleeding1 trial

Esophageal Varices1 trial

Acute Myocardial Infarction (AMI)1 trial

References

Drug Info

Quick Facts

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