tPA

Phase 3Small molecule

UUniversity of Florida

tPA is one of 48 small molecule programs targeting Empyema. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

EmpyemaActive, not recruiting

StrokeActive, not recruiting

COVID-19Active, not recruiting

EmpyemaPhase 3

Active, not recruiting

StrokePhase 2

Active, not recruiting

COVID-19Preclinical

Active, not recruiting

Competition

Competitive Landscape

1931 competitors in COVID-19

#DrugCompanyPhaseTrials

tPA

UUniversity of Florida

Phase 3

1 2

Aldactone

Pfizer

Preclinical

1 3

Vit D

PPost Graduate Institute of Medical Education and Research, Chandigarh

Preclinical

1 4

Blood Taken

HHospices Civils de Lyon

Preclinical

1 5

Pfizer-Biontech COVID-19 MRNA Vaccine

Pfizer

Preclinical

1 6

Stools

VVersailles Hospital

Preclinical

1 7

JT001

SShanghai Vinnerna Biosciences Co., Ltd.

Preclinical

3 8

Coronavac COVID-19 Vaccine

HHospital Moinhos de Vento

Preclinical

2 9

SARS-Cov-2 Bivalent MRNA Vaccine

AAIM Vaccine Co., Ltd.

Preclinical

2 10

AZD 1222

UUniversity Medicine Greifswald

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Stroke2 trials

Safety of Intravenous Thrombolytics in Stroke on Awakening

Completed·JJohns Hopkins University·Phase 2·NCT01643902·20 enrolled

Helping Stroke Patients With ThermoSuit Cooling

Terminated·LLife Recovery Systems·N/A·NCT02453373·14 enrolled

Thoracoscopy1 trial

Fibrinolytic Therapy Versus Medical Thoracoscopy

Completed·UUniversity of Florida·Phase 4·NCT03213834·5 enrolled

Complication1 trial

Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMD

Completed·KKing's College Hospital NHS Trust·Phase 2/3·NCT01835067·55 enrolled

COVID-191 trial

In Situ Thrombolysis With tPA and Inflow Perfusion Analysis in Patient With Severe Covid-19 Infection

Completed·GGrupo Mexicano para el Estudio de la Medicina Intensiva·N/A·NCT04926428·15 enrolled

Infusion1 trial

Rt-PA Infusion Versus Catheter Exchange for Dialysis Catheter Malfunction Due to Fibrin Sheath

Terminated·UUniversity of Pennsylvania·N/A·NCT00194181·40 enrolled

1 more indication

Empyema1 trial

Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)

Completed·TThe Hospital for Sick Children·Phase 3·NCT01717742·97 enrolled

Sources

References

[1]
ClinicalTrials.gov — 7 trial records for tPA. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — tPA compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for tPA. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of Florida company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: UUniversity of Florida

tPA

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Stroke2 trials

Thoracoscopy1 trial

Complication1 trial

COVID-191 trial

Infusion1 trial

Empyema1 trial

References

Drug Info

Quick Facts

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